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Topic Review
Postbiotics and Kidney Disease
Chronic kidney disease (CKD) is projected to become the fifth global cause of death by 2040 as a result of key shortcomings in the current methods available to diagnose and treat kidney diseases. In this regard, the novel holobiont concept, used to describe an individual host and its microbial community, may pave the way towards a better understanding of kidney disease pathogenesis and progression. Microbiota-modulating or -derived interventions include probiotics, prebiotics, synbiotics and postbiotics.
  • 1.9K
  • 13 Oct 2022
Topic Review
Apple Electric Car Project
The Apple electric car project (codenamed "Titan") is an electric car project undergoing research and development by Apple Inc. Apple has yet to openly discuss any of its self-driving research, but around 5,000 employees were reported to be working on the project (As of 2018). In May 2018, Apple reportedly partnered with Volkswagen to produce an autonomous employee shuttle van based on the T6 Transporter commercial vehicle platform. In August 2018, the BBC reported that Apple had 66 road-registered driverless cars, with 111 drivers registered to operate those cars. In 2020, it is believed that Apple is still working on self driving related hardware, software and service as a potential product, instead of actual Apple-branded cars. In December 2020, Reuters reported that Apple was planning on a possible launch date of 2024, but analyst Ming-Chi Kuo claimed it would not be launched before 2025 and might not be launched until 2028 or later.
  • 1.9K
  • 11 Oct 2022
Topic Review
Structure and Properties of Graphene Quantum Dots
Graphene quantum dot (GQD) is a new type of carbon nanometer material. In addition to the excellent properties of graphene, it is superior due to the quantum limit effect and edge effect. Because of its advantages such as water solution, strong fluorescent, small size, and low biological toxicity, it has important application potential in various fields, especially in sensors and biomedical areas, which are mainly used as optical electrical sensors as well as in biological imaging and tumor therapy. In addition, GQDs have very important characteristics, such as optical and electrical properties. There are many preparation methods, divided into top-down and bottom-up methods, which have different advantages and disadvantages, respectively. In addition, the modification methods include heterogeneous doping, surface heterogeneity, etc. 
  • 1.9K
  • 17 Jan 2024
Topic Review
Anthocyanin-Based Polymers for Healthcare Applications
Anthocyanins are a specific group of molecules found in nature that have recently received increasing attention due to their interesting biological and colorimetric properties that have been successfully applied in several fields such as food preservation and biomedicine. Meanwhile, the incorporation of anthocyanins into polymeric systems has become an interesting strategy to widen the applicability of these molecules and develop new smart and functional polymers in the above-cited areas. 
  • 1.9K
  • 14 Mar 2024
Topic Review
Friction Spot Stir Welding
In the last decade, the friction stir welding of polymers has been increasingly investigated by the means of more and more sophisticated approaches. Since the early studies, which were aimed at proving the feasibility of the process for polymers and identifying suitable processing windows, great improvements have been achieved. This owes to the increasing care of academic researchers and industrial demands. These improvements have their roots in the promising results from pioneer studies; however, they are also the fruits of the adoption of more comprehensive approaches and the multidisciplinary analyses of results. The introduction of instrumented machines has enabled the online measurement of processing loads and temperature, and critical understanding of the principal aspects affecting the material flow and welds quality. Such improvements are also clearly demonstrated by the increase of the strength of recent joints (up to 99% of joining efficiency) as compared to those reached in early researches (almost 47%). This article provides a comprehensive review of the recent progresses on the process fundamentals, quality assessment and the influence of process parameters on the mechanical behavior. In addition, emphasis is given to new developments and future perspectives.
  • 1.9K
  • 28 Oct 2020
Topic Review
Fake News in Social Networking
Fake news is defined as news that is intentionally and demonstrably false, or as any information presented as news that is factually incorrect and designed to mislead the news consumer into believing it to be true.
  • 1.9K
  • 17 Feb 2021
Topic Review Peer Reviewed
Machine Learning in Healthcare Communication
Machine learning (ML) is a study of computer algorithms for automation through experience. ML is a subset of artificial intelligence (AI) that develops computer systems, which are able to perform tasks generally having need of human intelligence. While healthcare communication is important in order to tactfully translate and disseminate information to support and educate patients and public, ML is proven applicable in healthcare with the ability for complex dialogue management and conversational flexibility. In this topical review, we will highlight how the application of ML/AI in healthcare communication is able to benefit humans. This includes chatbots for the COVID-19 health education, cancer therapy, and medical imaging. 
  • 1.9K
  • 13 Apr 2022
Topic Review
Female Germ Cell Development
In the present era, infertility is one of the major issues which restricts many couples to have their own children. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders, etc., may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. 
  • 1.9K
  • 10 Jun 2021
Topic Review
Bioactive Ceramic Scaffolds
A wide variety of bioactive ceramic scaffolds, which encompass CaP, doped HA and CS, bioactive glasses and ceramics, and their respective composites, have been used as the constructs for replacing cancellous bone (restoration of the bone loss), shown in. Synthetic HA, which is similar to the CaP minerals within bones and teeth, is successfully applied as a bone implant with suitable mechanical strength and osteoconductivity. Bioactive scaffolds processed through PBSLP with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors facilitate bone regeneration and ameliorate critical-sized bone defects based on the fracture site length for personalized medicine. The keyhole pores, apart from the designed porosity from the CAD design, usually affect the mechanical strength of the scaffolds when fabricated through powder bed selective laser processing techniques.
  • 1.9K
  • 24 Sep 2021
Topic Review
Sustainable Consumption Research and Role of Marketing
There is a causal relationship between existential dangers to biosphere and unsustainable consumption practices. For more than three decades, academics and researchers have explored ideas to make consumption practices sustainable. Still, a practical and widely accepted solution to the problem is missing. Sustainable consumption research has proliferated since 2015, indicating a heightened interest in the field. There are four major schools of thought in sustainable consumption research, employing three interdependent micro, meso, and macro levels of analysis to understand consumption practices. One innovative way to make consumption sustainable is consuming mindfully, a method that, along with sustainability, promotes subjective well-being, pro-sociality, and greater connectedness to nature, and decreases materialistic values. Temperance in consumption, resulting from a mindful attitude, connects self-care with societal and ecological care and adds to the consumer’s subjective well-being or quality of life, showing a direct relationship between sustainable behaviors and quality of life (QOL).
  • 1.9K
  • 11 May 2023
Topic Review
Dietary (Phyto)Nutrients for Glutathione Support
Glutathione is a tripeptide that plays a pivotal role in critical physiological processes resulting in effects relevant to diverse disease pathophysiology such as maintenance of redox balance, reduction of oxidative stress, enhancement of metabolic detoxification, and regulation of immune system function. The diverse roles of glutathione in physiology are relevant to a considerable body of evidence suggesting that glutathione status may be an important biomarker and treatment target in various chronic, age-related diseases. 
  • 1.9K
  • 26 Aug 2022
Topic Review
Applications of g-C3N4-Based Photocatalysts
The assembly of g-C3N4 with metal oxides is an effective strategy which can not only improve electron–hole separation efficiency by forming a polymer–inorganic heterojunction, but also compensate for the redox capabilities of g-C3N4 owing to the varied oxidation states of metal ions, enhancing its photocatalytic performance. Applications of g-C3N4-based materials in photocatalysis are discussed, including water splitting to generate H2 and O2, the degradation of pollutants, CO2 reduction and bacterial disinfection.
  • 1.9K
  • 29 Nov 2022
Topic Review
Air Addition in Hydraulic Turbines
The use of hydropower is rapidly increasing worldwide, however, achieving maximum efficiency in hydraulic turbines requires operating at the best efficiency point (QBEP). By mitigating the vortex phenomenon, one can reduce pressure pulsation amplitudes and therefore expand the range of stable operation of the hydroturbine. There are two basic approaches to surge mitigation, which are based on the operation turbine principle. The first one involves modifying the existing geometry through geometric optimization, seeking to improve performance over a wider range of operations by changing parametric dimensions. The second approach aims to reduce flow swirl and break up stagnant zones by injecting water or air into the flow.
  • 1.9K
  • 21 Jul 2023
Topic Review
Genetic Engineering of Actinomycetes
The first antibiotic-producing actinomycete (Streptomyces antibioticus) was described by Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which several species were identified and demonstrated to be a great source of bioactive compounds. However, the remarkable group of microorganisms and their potential for the production of bioactive agents were only partially exploited. This is caused by the fact that the growth of many actinomycetes cannot be reproduced on artificial media at laboratory conditions. In addition, sequencing, genome mining and bioactivity screening disclosed that numerous biosynthetic gene clusters (BGCs), encoded in actinomycetes genomes are not expressed and thus, the respective potential products remain uncharacterized. Therefore, a lot of effort was put into the development of technologies that facilitate the access to actinomycetes genomes and activation of their biosynthetic pathways. In this review  (Antibiotics 2020, 9(8), 494; https://doi.org/10.3390/antibiotics9080494), we mainly focus on molecular tools and methods for genetic engineering of actinomycetes that have emerged in the field in the past five years (2015–2020). In addition, we highlight examples of successful application of the recently developed technologies in genetic engineering of actinomycetes for activation and/or improvement of the biosynthesis of secondary metabolites.
  • 1.9K
  • 28 Dec 2020
Topic Review
β-Galactosidase Immobilization for Galacto-Oligosaccharide Production
Much attention has recently been paid to β-Galactosidases (β-D-galactoside galactohidrolase; EC 3.2.1.23), commonly known as lactases, due to the lactose intolerance of the human population and the importance of dairy products in the human diet. This enzyme, produced by microorganisms, is being used in the dairy industry for hydrolyzing the lactose found in milk to produce lactose-free milk (LFM). Conventionally, β-galactosidases catalyze the hydrolysis of lactose to produce glucose and galactose in LFM; however, they can also catalyze transgalactosylation reactions that produce a wide range of galactooligosaccharides (GOS), which are functional prebiotic molecules that confer health benefits to human health. In this field, different works aims to identify novel microbial sources of β-galactosidase for removing lactose from milk with the relative GOS production. Lactase extracted from thermophilic microorganisms seems to be more suitable for the transgalactosylation process at relatively high temperatures, as it inhibits microbial contamination. Different immobilization methods, such as adsorption, covalent attachment, chemical aggregation, entrapment and micro-encapsulation, have been used to synthesize lactose-derived oligosaccharides with immobilized β-galactosidases. 
  • 1.9K
  • 29 Apr 2022
Topic Review
Lincos (Artificial Language)
Lincos (an abbreviation of the Latin phrase lingua cosmica) is a constructed language first described in 1960 by Dr. Hans Freudenthal in his book Lincos: Design of a Language for Cosmic Intercourse, Part 1. It is a language designed to be understandable by any possible intelligent extraterrestrial life form, for use in interstellar radio transmissions. Freudenthal considered that such a language should be easily understood by beings not acquainted with any Earthling syntax or language. Lincos was designed to be capable of encapsulating "the whole bulk of our knowledge."
  • 1.9K
  • 09 Oct 2022
Topic Review
BLAST
In bioinformatics, BLAST (basic local alignment search tool) is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences. A BLAST search enables a researcher to compare a query sequence with a library or database of sequences, and identify library sequences that resemble the query sequence above a certain threshold. Different types of BLASTs are available according to the query sequences. For example, following the discovery of a previously unknown gene in the mouse, a scientist will typically perform a BLAST search of the human genome to see if humans carry a similar gene; BLAST will identify sequences in the human genome that resemble the mouse gene based on similarity of sequence. The BLAST algorithm and program were designed by Stephen Altschul, Warren Gish, Webb Miller, Eugene Myers, and David J. Lipman at the National Institutes of Health and was published in the Journal of Molecular Biology in 1990 and cited over 50,000 times.
  • 1.9K
  • 17 Oct 2022
Topic Review
Container Linux by CoreOS
Container Linux by CoreOS (formerly CoreOS Linux) is an open-source lightweight operating system based on the Linux kernel and designed for providing infrastructure to clustered deployments, while focusing on automation, ease of application deployment, security, reliability and scalability. As an operating system, Container Linux provides only the minimal functionality required for deploying applications inside software containers, together with built-in mechanisms for service discovery and configuration sharing. Container Linux shares foundations with Gentoo Linux, Chrome OS and Chromium OS, through a common software development kit (SDK). Container Linux adds new functionality and customization to this shared foundation to support server hardware and use cases.:7:02 (As of January 2015), CoreOS is actively developed, primarily by Alex Polvi, Brandon Philips and Michael Marineau, with its major features available as a stable release.
  • 1.9K
  • 02 Nov 2022
Topic Review
Bayés’ Syndrome
Interatrial block associated with atrial arrhythmias, mainly atrial fibrillation, define the Bayés’ Syndrome (called after Bayés de Luna, a proeminent cardiologist, who published the seminal paper about the problem of P-wave anomalies and interatrial blocks). Finding the signs of interatrial block on ECG represents a call for active screening of atrial fibrillation and starting of prophylactic anticoagulation in selected patients.  
  • 1.9K
  • 09 Sep 2020
Topic Review
Pepper vein banding virus (PVBV)
The entry talks about Pepper vein banding virus (PVBV) and its encoded proteins, particularly focusing on the polyprotein processing and its regulation. Moreover, PVBV as a nanoparticle and its potential applications in immunodiagnostics and therapeutics has also been discussed.
  • 1.9K
  • 20 Oct 2020
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