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Topic Review
Factors Influencing Choices Intention of Online Learning COVID-19
Since the COVID-19 outbreak, online learning has become the norm. Primary school students require parental assistance and supervision due to their lack of digital media capabilities and safety concerns. Online learning experiences during the pandemic will affect future parents' choices of online learning, so it is necessary to further clarify the key factors influencing parents' perceptions and attitudes towards online learning during the pandemic. In the post-pandemic era, blended learning, which combines traditional school learning with online learning, is likely to become a common and acceptable way of learning, and parents may face multiple choices of their parents' way of learning.
  • 1.9K
  • 27 Jul 2022
Topic Review
Autophagy in β-Thalassemic Erythropoiesis
β-Thalassemia is one of the most common genetically inherited disorders worldwide, and it is characterized by defective β-globin chain synthesis leading to reduced or absent β-globin chains. The excess α-globin chains are the key factor leading to the death of differentiating erythroblasts in a process termed ineffective erythropoiesis, leading to anemia and associated complications in patients. The mechanism of ineffective erythropoiesis in β-thalassemia is complex and not fully understood. Autophagy is primarily known as a cell recycling mechanism in which old or dysfunctional proteins and organelles are digested to allow recycling of constituent elements.
  • 1.9K
  • 08 Oct 2022
Topic Review
GM H Platform (1986)
The H platform, or H-body designates a General Motors front-wheel-drive full-sized automobile platform beginning in 1986. It is related to the C, G and K platforms. Many H-bodies used GM's Buick 3800 V6, and supercharged versions of this engine were available from 1991 to 1999. They originally came in both 2-door and 4-door versions, but the four-door sedans were dramatically more popular, and two-door models were dropped by 1992. Previously, the H platform designation was used for unrelated rear-wheel-drive compact cars. According to one source, the H-body sedans were the next "big thing" for GM, and development cost more than $3 billion, which is on par with roughly how much Ford invested in the Ford Taurus. Both the H-body sedans and the Taurus (based on the D186 platform) were launched fully in 1986. Starting in 2000, all H-body vehicles moved to the G platform, however GM continued to call it the H platform. Most H-body cars had Buick's 3.8 liter (231 cubic-inch) V6 engine standard.
  • 1.9K
  • 12 Oct 2022
Topic Review
PPAR-γ Partial Agonists in Disease-Fate Decision
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most extensively studied transcription factors since its discovery in 1990, highlighting its importance in the etiology and treatment of numerous diseases involving various types of cancer, type 2 diabetes mellitus, autoimmune, dermatological and cardiovascular disorders. Ligands are regarded as the key determinant for the tissue-specific activation of PPAR-γ. However, the mechanism governing this process is merely a contradictory debate which is yet to be systematically researched. Either these receptors get weakly activated by endogenous or natural ligands or leads to a direct over-activation process by synthetic ligands, serving as complete full agonists. Therefore, fine-tuning on the action of PPAR-γ and more subtle modulation can be a rewarding approach which might open new avenues for the treatment of several diseases.
  • 1.9K
  • 14 Nov 2022
Topic Review
List of Tropical Cyclone-spawned Tornadoes
Intense tropical cyclones usually produce tornadoes, the majority of those weak, especially upon landfall.
  • 1.9K
  • 03 Nov 2022
Topic Review
Lactobacillus Rhamnosus
Lacticaseibacillus rhamnosus (previously: Lactobacillus rhamnosus) is a bacterium that originally was considered to be a subspecies of L. casei, but genetic research found it to be a separate species in the L. casei clade, which also includes L. paracasei and L. zeae. It is a short Gram-positive homofermentative facultative anaerobic non-spore-forming rod that often appears in chains. Some strains of L. rhamnosus bacteria are being used as probiotics, and are particularly useful in treating infections of the female urogenital tract, most particularly very difficult to treat cases of bacterial vaginosis (or "BV"). The species Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri are commonly found in the healthy female genito-urinary tract and are helpful to regain control of dysbiotic bacterial overgrowth during an active infection. L. rhamnosus sometimes is used in dairy products such as fermented milk and as non-starter-lactic acid bacterium (NSLAB) in long-ripened cheese. While frequently considered a beneficial organism, L. rhamnosus may not be as beneficial to certain subsets of the population; in rare circumstances, especially those primarily involving weakened immune system or infants, it may cause endocarditis. Despite the rare infections caused by L. rhamnosus, the species is included in the list of bacterial species with qualified presumed safety (QPS) status of the European Food Safety Agency.
  • 1.9K
  • 08 Nov 2022
Topic Review
Lens (Anatomy)
The lens, or crystalline lens is a transparent biconvex structure in the eye that, along with the cornea, helps to refract light to be focused on the retina. By changing shape, it functions to change the focal length of the eye so that it can focus on objects at various distances, thus allowing a sharp real image of the object of interest to be formed on the retina. This adjustment of the lens is known as accommodation (see also below). Accommodation is similar to the focusing of a photographic camera via movement of its lenses. The lens is flatter on its anterior side than on its posterior side. In humans, the refractive power of the lens in its natural environment is approximately 18 dioptres, roughly one-third of the eye's total power.
  • 1.9K
  • 21 Nov 2022
Topic Review
Heaviside Condition
The Heaviside condition, named for Oliver Heaviside (1850–1925), is the condition an electrical transmission line must meet in order for there to be no distortion of a transmitted signal. Also known as the distortionless condition, it can be used to improve the performance of a transmission line by adding loading to the cable.
  • 1.9K
  • 22 Nov 2022
Topic Review
Beneficial Roles of Fungi
Besides plants and animals, the Fungi kingdom describes several species characterized by various forms and applications. They can be found in all habitats and play an essential role in the excellent functioning of the ecosystem, for example, as decomposers of plant material for the cycling of carbon and nutrients or as symbionts of plants. Furthermore, fungi have been used in many sectors for centuries, from producing food, beverages, and medications. 
  • 1.9K
  • 28 Jun 2023
Topic Review
Asterixis
Asterixis is a subtype of negative myoclonus characterized by brief, arrhythmic lapses of sustained posture due to involuntary pauses in muscle contraction. Asterixis is not specific to any pathophysiological process, but it is more commonly reported in hepatic encephalopathy, renal and respiratory failure, cerebrovascular diseases, as well as associated with drugs that could potentially lead to hyperammonemia, such as valproic acid, carbamazepine, and phenytoin. 
  • 1.9K
  • 28 Feb 2024
Topic Review
Aeromonas
It is well known that correct identification of recovered Aeromonas strains at the genus and species level is a complex process.  Biochemical or phenotypic identification tests and specially those included in miniaturized and/or semi-automatic commercial identification systems (API, Vitek, BBLCrystal, MicroScan etc) produce confusion with the Vibrio genus and an erroneous overestimation of the species Aeromonas hydrophila. Correct identification requires the use of molecular techniques, like the detection of the gene that encode for the GCAT (glycerophospholopid-cholesterol acyltransferase) that can discriminate the genus or the analysis of the sequences of housekeeping genes (gyrB, rpoD, etc) to correctly identifying the species. The latter genes are necessary because the 16S rRNA gene does not show enough resolution to discriminate closely related species (i.e. A. salmonicida from A. bestiarum). In fact many new species were discovered thanks to the use of gyrB and rpoD genes for identification, and the construction of a multilocus phylogenetic analysis with the concatenated sequences of five housekeeping genes was used as a tool in their descriptions. The progress in the techniques used to obtain bacteria genomes had an spectacular impact on the genus Aeromonas  because the genome of the type strain of the different species are available at the GenBank. Tools developed for bacterial identification based on the comparison of genomes like the in silico DNA-DNA hybridization (isDDH) and the Average Nucleotide Identity (ANI) provides objective criteria to define if two genomes belong or not to the same species. This review aims to guide microbiologists in the correct identification of the Aeromonas spp.
  • 1.9K
  • 23 Oct 2020
Topic Review
Big Data
Big data has become a very frequent research topic, due to the increase in data availability. Here we make the linkage between the use of big data and Econophysics, a research field which uses a large amount of data and deals with complex systems.
  • 1.9K
  • 25 Dec 2021
Topic Review
Bartha K61 Strain
Pseudorabies virus (PRV) is a member of the alphaherpesvirus subfamily of the herpesviruses and is the causative agent of Aujeszky’s disease in pigs, causing respiratory, neurological, and reproductive symptoms. Given the heavy economic losses associated with Aujeszky’s disease epidemics, great efforts were made to develop efficacious vaccines. One of the best modified live vaccines to this day is the attenuated Bartha K61 strain. The use of this vaccine in extensive vaccination programs worldwide has assisted considerably in the eradication of PRV from the domesticated pig population in numerous countries. The Bartha K61 strain was described in 1961 by Adorján Bartha in Budapest and was obtained by serial passaging in different cell cultures. Ever since, it has been intensively studied by several research groups, for example, to explore its efficacy as a vaccine strain, to molecularly and mechanistically explain its attenuation, and to use it as a retrograde neuronal tracer and as a vector vaccine. Given that the Bartha K61 vaccine strain celebrates its 60th birthday in 2021 with no sign of retirement, this review provides a short summary of the knowledge on its origin, characteristics, and use as a molecular tool and as a vaccine.
  • 1.9K
  • 17 Nov 2020
Topic Review
Promising Lead Compounds for Resistant-Tuberculosis
According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second-line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. To explore and identify the most potential antitubercular drug candidate among various reported compounds, here we focused to highlight the promising lead derivatives of isoniazid, coumarin, griselimycin, and antimicrobial peptides. The aim of the present review is to fascinate significant lead compounds in the development of potential clinical drug candidates that might be more precise and effective against drug-resistant tuberculosis, the world research looking for a long time.
  • 1.9K
  • 10 Dec 2020
Topic Review
FGFRs in Brain Tumors
Despite pharmacological treatments and surgical practice options, the mortality rate of astrocytomas and glioblastomas remains high, thus representing a medical emergency for which it is necessary to find new therapeutic strategies. Fibroblast growth factors (FGFs) act through their associated receptors (FGFRs), a family of tyrosine kinase receptors consisting of four members (FGFR1–4), regulators of tissue development and repair. In particular, FGFRs play an important role in cell proliferation, survival, and migration, as well as angiogenesis, thus their gene alteration is certainly related to the development of the most common diseases, including cancer. FGFRs are subjected to multiple somatic aberrations such as chromosomal amplification of FGFR1; mutations and multiple dysregulations of FGFR2; and mutations, translocations, and significant amplifications of FGFR3 and FGFR4 that correlate to oncogenesis process. Therefore, the in-depth study of these receptor systems could help to understand the etiology of both astrocytoma and glioblastoma so as to achieve notable advances in more effective target therapies. Furthermore, the discovery of FGFR inhibitors revealed how these biological compounds improve the neoplastic condition by demonstrating efficacy and safety.
  • 1.9K
  • 29 Dec 2020
Topic Review
Carbon Dots
Carbon dots (CDs) are part of the nanocarbon family including quasi-spherical nanoparticles with sizes around 10 nm. They consist of amorphous and crystalline parts, mainly composed of carbon with a fringe spacing of 0.34 nm, which corresponds to the (002) interlayer spacing of graphite. Since their first discovery in 2006, CDs have gained ever-increasing attention due to their fascinating properties like distinctive optical behaviour, tunable emission, different functional groups, good biocompatibility, chemical and photo-stability, low toxicity, and low-cost production. More importantly, CDs properties can be changed by controlling their size, shape, and heteroatom doping and by modifying the surfaces. They are considered promising Green alternatives to traditional fluorescent dyes and have been proposed for different optoelectronic applications such as sensing, bioimaging, fingerprint detection, gene delivery, solar cells, or printing inks
  • 1.9K
  • 08 Mar 2021
Topic Review
Climate Change affects Tourism Development
Tourism-related carbon dioxide (CO2) emissions are a central driver of anthropogenic climate change. At the same time, climate change has both direct and indirect impacts on tourism, varying from damages of tourist assets due to extreme weather events, to losses of biodiversity.
  • 1.9K
  • 28 Apr 2021
Topic Review
Changes in Homeostasis of the Dermal Extracellular Matrix
Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and function. With age, an impairment of structures, quality characteristics, and functions of the dermal extracellular matrix (ECM) occurs in the skin, which leads to disrupted functioning of dermal fibroblasts (DFs), the main cells supporting morphofunctional organization of the skin. The DF functioning directly depends on the state of the surrounding collagen matrix (CM). The intact collagen matrix ensures proper adhesion and mechanical tension in DFs, which allows these cells to maintain collagen homeostasis while ECM correctly regulates cellular processes. When the integrity of CM is destroyed, mechanotransduction is disrupted, which is accompanied by impairment of DF functioning and destruction of collagen homeostasis, thereby contributing to the progression of aging processes in skin tissues. 
  • 1.9K
  • 21 Jun 2022
Topic Review
Safety and Risk Perceptions in Tourism
Given the global character of the COVID-19 pandemic, tourism recovery should be addressed by enhancing the governmental safety measures, as well as studying the perceived travel risks and individual coping behavior. In public health crisis contexts, people deal with their fear by employing different coping strategies, which foster individual adaptability and mitigate related contextual losses. Addressing the main constructs under analysis, perceived risks and tourism safety perceptions are discussed, as well as the resulting coping behavior in post-pandemic times, namely the acceptance of restrictions and adaptative behavioral intentions.
  • 1.9K
  • 12 Jul 2022
Topic Review
AI-Based Wormhole Attack Detection Techniques
The popularity of wireless sensor networks for establishing different communication systems is increasing daily. A wireless network consists of sensors prone to various security threats. These sensor nodes make a wireless network vulnerable to denial-of-service attacks. One of them is a wormhole attack that uses a low latency link between two malicious sensor nodes and affects the routing paths of the entire network. This attack is brutal as it is resistant to many cryptographic schemes and hard to observe within the network. 
  • 1.9K
  • 12 Aug 2022
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