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Topic Review
Biofilm
A biofilm is a community of microorganisms, especially bacteria, that maintains an organized and structured strategy for growing and proliferating on any surface for their survival. The organization of the cells among the bacteria in the biofilm has primarily been revealed by examining single species. The survival of the bacteria present in the biofilm is feasible because of their orientation in the form of microcolonies, which are encapsulated in the extracellular polymeric substance of the matrix. These are separated by open water channels that serve as the primordial circulatory system for the transportation of nutrients and the disposal of metabolic waste products. All the specific bacteria maintain a microenvironment controlling the pH, nutrient availability, and temperature, which influence the biofilm growth. Biofilm maturation is a multi-stage developmental process with distinct characteristics that should be taken into account when developing antibiotic treatment regimens for biofilms. Biofilms have been extensively accepted as one of the main causes responsible for human diseases.
  • 2.0K
  • 25 May 2022
Topic Review
Why Is Airline Food Dreadful?
       Food waste generated on flights is emerging as an issue in the aviation industry. Passengers are pivotal actors in airline food consumption and responsible for their unsustainable actions towards the in-flight catering process. This research investigated factors affecting passengers’ food wasting behaviour by conducting an in-depth survey.
  • 2.0K
  • 02 Nov 2020
Topic Review
Nephronectin
Nephronectin (NPNT) was originally identified as an ECM protein by two independent research groups in 2001. Brandenberger et al. reported NPNT to be involved in the embryonic development of the kidney, hence the name nephronectin (nephron: unit within the kidney; nectin: cellular adhesion proteins). Morimura and colleagues discovered the same protein to be associated with osteoblast differentiation, and named it preosteoblast epidermal growth factor-like repeat protein with meprin, A5 protein and receptor protein-tyrosine phosphatase µ domain (POEM).
  • 2.0K
  • 08 Apr 2021
Topic Review
Cloud Computing
Cloud Computing (CC) provides a combination of technologies that allows the user to use the most resources in the least amount of time and with the least amount of money. CC semantics play a critical role in ranking heterogeneous data by using the properties of different cloud services and then achieving the optimal cloud service. Regardless of the efforts made to enable simple access to this CC innovation, in the presence of various organizations delivering comparative services at varying cost and execution levels, it is far more difficult to identify the ideal cloud service based on the user’s requirements.
  • 2.0K
  • 22 Jun 2022
Topic Review
Trichophyton indotineae
Trichophyton (T.) indotineae is a newly identified dermatophyte species that has been found in a near-epidemic form on the Indian subcontinent. There is evidence of its spread from the Indian subcontinent to a number of countries worldwide. The fungus is identical to genotype VIII within the T. mentagrophytes/T. interdigitale species complex, which was described in 2019 by sequencing the Internal Transcribed Spacer (ITS) region of ribosomal DNA of the dermatophyte.
  • 2.0K
  • 27 Jul 2022
Topic Review
Helicobacter Pylori-Induced Gastric Infections
Helicobacter pylori is the first formally recognized bacterial carcinogen and the most important single digestive pathogen responsible for the induction of gastroduodenal diseases such as gastritis, peptic ulcer, and, finally, gastric neoplasia. The recently reported high rates of antimicrobial drug resistance hamper the current therapies of H. pylori, with therapeutic failure reaching up to 40% of patients.
  • 2.0K
  • 27 Jul 2022
Biography
José António Tenreiro Machado
Professor José António Tenreiro Machado, (see figure 1) was passionate about science. This manuscript intends to present his main research interests, pointing to the most relevant work that was published throughout his life. Moreover, a brief description of his early life and international academic career are also presented. His contributions to control, robotics, modeling, complex systems a
  • 2.0K
  • 03 Nov 2022
Topic Review
BKCa Channels
Large Conductance Calcium and Voltage-Gated Potassium Channels (BKCa). Also known as Slowpoke, KCa1.1, and MaxiK channels. 
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  • 27 Oct 2020
Topic Review
Mesoporous Silica Nanoparticles
Mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Mesoporous material Solid and porous material, with natural or synthetic character, with an average pore size between microporous (less than 2 nm) and macroporous (more than 50 nm). The pore structure can be ordered or not and provides an extremely high surface area in a relatively small amount of material According to IUPAC notation, the mesoporous category is midway between the pore sizes that define microporous materials, up to 2 nm, and macroporous, pore diameters greater than 50 nm. They have a large number of applications in the fields of catalysis, molecular separation, drug release or chemical sensors among others, as a result of the network of porous cavities in their internal structure. - Examples: ordered mesoporous silica materials, carbon molecular sieves, porous organic / inorganic hybrid materials and porous metal oxides.
  • 2.0K
  • 13 Jan 2021
Topic Review
Informal Methods (Validation and Verification)
Informal methods of validation and verification are some of the more frequently used in modeling and simulation. They are called informal because they are more qualitative than quantitative. Whereas many methods of validation or verification rely on numerical results, informal methods tend to rely on the opinions of experts to draw a conclusion. While numerical results are not the primary focus, this does not mean that the numerical results are completely ignored. There are several reasons why an informal method might be chosen. In some cases, informal methods offer the convenience of quick testing to see if a model can be validated. In other instances, informal methods are the best available option. In all cases though it is important to note that informal does not mean it is any less of a true testing method. These methods should be performed with the same discipline and structure that one would expect in "formal" methods. When executed in such a way, solid conclusions can be made. In modeling and simulation, verification techniques are used to analyze the state of the model. Verification is completed by different methods with the focus of comparing different aspects of the executable model with the conceptual model. On the other hand, validation methods are the methods by which a model, either conceptual or executable is compared with the situation it is trying to model. Both are methods by which the model can be analyzed to help find defects in the modeling methods being used, or potential misrepresentations of the real-life situation.
  • 2.0K
  • 25 Oct 2022
Topic Review
Bricks and Clicks
Bricks and clicks (aka clicks and bricks; click and mortar; bricks, clicks and flips; Womble Store Method (WSM); or WAMBAM ('Web Application Meets Bricks and Mortar') is a jargon term for a business model by which a company integrates both offline (bricks) and online (clicks) presences, sometimes with the third extra flips (physical catalogs). Additionally, many will also offer telephone ordering and mobile phone apps, or at least provide telephone sales support. The advent of mobile web has made businesses operating bricks and clicks businesses especially popular, because it means customers can do tasks like shopping when they have spare time and do not have to be at a computer. Many of these users prefer to use mobile shopping sites. A popular example of the bricks and clicks model is when a chain of stores allows the customer to order products either online or physically in one of their stores, also allowing them to either pick-up their order directly at a local branch of the store or get it delivered to their home. There are many alternative combinations of this model. The success of the model in many sectors has lessened the credibility of some analysts who argued that the Internet would render traditional retailers obsolete through disintermediation.
  • 2.0K
  • 21 Nov 2022
Biography
Malik Peiris
Joseph Sriyal Malik Peiris (裴偉士), ( ඡීරිස්), ( பீறிஸ்), FRS, Légion d'Honneur, was born on 10 November 1949,[1] in Sri Lanka. He is referred to in scientific publications and media reports as JSM Peiris, JS Peiris, Joseph Peiris and, most commonly, as Malik Peiris. His close family and friends prefer to use the middle name Sriyal. He is a distinguished old boy of S
  • 2.0K
  • 27 Dec 2022
Topic Review
Artificial Intelligence in Edge-Based IoT Applications
Given its advantages in low latency, fast response, context-aware services, mobility, and privacy preservation, edge computing has emerged as the key support for intelligent applications and 5G/6G Internet of things (IoT) networks. This technology extends the cloud by providing intermediate services at the edge of the network and improving the quality of service for latency-sensitive applications. Many AI-based solutions with machine learning, deep learning, and swarm intelligence have exhibited the high potential to perform intelligent cognitive sensing, intelligent network management, big data analytics, and security enhancement for edge-based smart applications. 
  • 2.0K
  • 15 Feb 2023
Topic Review
Anti-inflammatory potential of Sesquiterpene Lactones
Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their ability to target and inhibit various key pro-inflammatory molecules enrolled in diverse inflammatory pathways, and prevent or reduce the inflammatory damage on tissues. Research on the anti-inflammatory mechanisms of SLs has thrived over the last years, and numerous compounds from diverse plants have been studied, using in silico, in vitro, and in vivo assays. Besides their anti-inflammatory potential, their cytotoxicity, structure–activity relationships, and pharmacokinetics have been investigated.
  • 2.0K
  • 14 Jul 2021
Topic Review
MS/MS-Based Molecular Networking
Natural products (NPs) have historically played a primary role in the discovery of small-molecule drugs. However, due to the advent of other methodologies and the drawbacks of NPs, the pharmaceutical industry has largely declined in interest regarding the screening of new drugs from NPs since 2000. There are many technical bottlenecks to quickly obtaining new bioactive NPs on a large scale, which has made NP-based drug discovery very time-consuming, and the first thorny problem faced by researchers is how to dereplicate NPs from crude extracts. Remarkably, with the rapid development of omics, analytical instrumentation, and artificial intelligence technology, in 2012, an efficient approach, known as tandem mass spectrometry (MS/MS)-based molecular networking (MN) analysis, was developed to avoid the rediscovery of known compounds from the complex natural mixtures. 
  • 2.0K
  • 03 Jan 2023
Topic Review
Microgrid Applications and Technical Challenges
In general, microgrids (MGs) can be described as integrated systems composed of distributed energy resources and electrical loads operating as a single, autonomous network, in parallel or “islanded” from the distribution network. Smart microgrids are small, modern systems that mimic to a lesser extent today’s large centralized electrical system. Similar to large electrical power systems (EPS), microgrids can generate, distribute, and regulate the flow of electricity to consumers. When operating in parallel, microgrids increase the main grid capacity, reliability, and efficiency. MGs are designed to provide reliable and efficient electricity to small communities, facilities, or even individual homes, and can be powered by a variety of energy sources, such as solar panels, wind turbines, diesel generators, or batteries. Energy storage systems are usually included to ensure security (possibility of islanded operation), reliability, and controllability. A microgrid can be formed by a decentralized group of electricity sources and loads that normally operates connected to a Smart grid or classic grid distribution infrastructure.
  • 2.0K
  • 05 May 2023
Topic Review
Aerogel Compounds
Aerogels have started to be considered as “advanced materials”; therefore, as a general consideration, aerogels’ toxicity testing should focus on their functionality which resides in their nanoscale open internal porosity. 
  • 2.0K
  • 28 Nov 2023
Topic Review
Sol–Gel Ceramics
The process of inorganic polymerization or the sol–gel method is an inexpensive, low-energy consuming, and stable process for obtaining high-purity ceramics, which offer versatility for the production of different kinds of devices, some of which can be used in surface-enhanced spectroscopy such as Surface Enhanced Infrared Absorption Spectroscopy (SEIRAS) and Surface Enhanced Raman Spectroscopy (SERS).
  • 2.0K
  • 22 Apr 2021
Topic Review
GNSS Denied Environments
The GNSS information is vulnerable to external interference and causes failure when unmanned aerial vehicles (UAVs) are in a fully autonomous flight in complex environments such as high-rise parks and dense forests. This paper presents a pan-tilt based visual servoing (PBVS) method for obtaining world coordinate information. The system is equipped with an Inertial Measurement Unit (IMU), an air pressure sensor, a magnetometer, and a pan-tilt-zoom(PTZ) camera. In this paper, we explain the physical model and the application method of the PBVS system which can be briefly summarized as follows. We track the operation target with a UAV carrying a camera and output the information about the UAV's position and the angle between the PTZ and the anchor point. In this way, we can obtain the current absolute position information of the UAV with its absolute altitude collected by the height sensing unit and absolute geographic coordinate information and altitude information of the tracked target. We have set up an actual UAV experimental environment. In order to meet the calculation requirements, some sensor data will be sent to the cloud through the network.Through the field tests, it can be concluded that the systematic deviation of the overall solution is less than the error of ordinary GNSS sensor equipment, and it can provide navigation coordinate information for the UAV in complex environments. Compared with traditional visual navigation systems, our scheme has the advantage of obtaining absolute, continuous, accurate and efficient navigation information in a short distance (within 15m from the target). This system can be used in scenarios that require autonomous cruise, such as self-powered inspections of UAVs, patrols in parks, etc.
  • 2.0K
  • 30 Oct 2020
Topic Review
Copper Chrome Arsenate Water-Borne Solution
Copper chrome arsenate (CCA) water-borne solution used to make timber is highly resistant to pests and fungi, in particular, wood products designed for outdoor use. Nowadays, CCA is a restricted chemical product in most countries, since potential environmental and health risks were reported due to dermal contact with CCA residues from treated structures and the surrounding soils. However, large quantities of CCA-treated timber are still in use in framings, outdoor playground equipment, landscaping, building poles, jetty piles, and fencing structures around the world, thus CCA remains a source of pollutants to the environment and of increasing toxic metal/metalloid exposure (mainly in children). International efforts have been dedicated to the treatment of materials impregnated with CCA, however not only does some reuse of CCA-treated timber still occur, but also existing structures are leaking the toxic compounds into the environment, with impacts on the environment and animal and human health.
  • 2.0K
  • 10 Jun 2021
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