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Topic Review
FAHFAs
Fatty Acid esters of Hydroxy Fatty Acids (FAHFAs) are ester derivatives of fatty acids (FAs) with hydroxy fatty acids (HFAs) carrying the hydroxyl group at different positions. This novel class of endogenously generated lipids, discovered in 2014, has attracted the interest, because such lipids have been found to exhibit anti-diabetic and anti-inflammatory effects. The great number of possible combinations of FAs with HFAs together with the great number of possible positional isomers makes the analysis of FAHFAs very challenging. FAHFAs have been detected and quantified in a variety of human and animal tissues, as well as in plant tissues and foods. Analytical methodologies, either targeted or untargeted, may highly contribute in studying FAHFA levels under various biomedical conditions, and in understanding their role in physiological and pathological conditions.
  • 2.0K
  • 04 Aug 2020
Topic Review
Nanomaterials in Dentistry
       Nanomaterials are commonly considered as those materials in which the shape and molecular composition at a nanometer scale can be controlled. Subsequently, they present extraordinary properties that are being useful for the development of new and improved applications in many fields, including medicine. In dentistry, several research efforts are being conducted, especially during the last decade, for the improvement of the properties of materials used in dentistry.
  • 2.0K
  • 29 Oct 2020
Topic Review
Piezoelectric Material
Piezoelectric materials can be called“the top of the crop” of smart materials. Piezoelectric materials have emerged as the most researched materials for practical applications among the numerous smart materials. They owe it to a few main reasons, including low cost, high bandwidth of service, availability in a variety of formats, and ease of handling and execution. Several authors have used piezoelectric materials as sensors and actuators to effectively control structural vibrations, noise, and active control, as well as for structural health monitoring, over the last three decades. These studies cover a wide range of engineering disciplines, from vast space systems to aerospace, automotive, civil, and biomedical engineering.
  • 2.0K
  • 24 May 2021
Topic Review
Inorganic Scintillation Crystals
Scintillators play a crucial role as radiation detection materials in various nuclear technologies and radiation applications, such as medical imaging, well logging, homeland security, marine and space exploration, and high energy physics (HEP).
  • 2.0K
  • 25 Jun 2021
Topic Review
Fetal Acidosis
Fetal acidosis or intrauterine hypoxia refers to a condition of deprived short supply of oxygen below the physiologic level of normal blood, which is defined as pH ≤ 7.25.
  • 2.0K
  • 18 Feb 2022
Topic Review
The Insulin Receptor
The insulin receptor (IR) is a transmembrane protein that is activated by ligands in insulin signaling pathways. The IR has been considered as a novel therapeutic target for clinical intervention, considering the overexpression of its protein and A-isoform in multiple cancers, Alzheimer’s disease, and Type 2 diabetes mellitus in humans. Meanwhile, it may also serve as a potential target in pest management due to its multiple physiological influences in insects.
  • 2.0K
  • 01 Aug 2022
Topic Review
Sri Sarada Math
Sri Sarada Math is named after Sri Sarada Devi, the consort of Sri Ramakrishna and founded on 2 December 1954. Built by a group of eight nuns, as per the instructions given by Swami Vivekananda, it serves as a monastic order for women. Headquartered at Dakshineshwar, Kolkata, the organisation has branch centres all over India, in Sri Lanka and Australia.
  • 2.0K
  • 17 Oct 2022
Topic Review
Imaging of Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is a complicated and heterogeneous interstitial lung disease (ILD) caused by an excessive immune response to an inhaled antigen in susceptible individuals. HP, also previously known as extrinsic allergic alveolitis, is the culmination of a dysregulated immune response to a provocative inhaled antigen appearing as inflammation and/or fibrosis of the lung parenchyma and small airways.
  • 2.0K
  • 24 Nov 2022
Topic Review
Structuralism
Biological or process structuralism is a school of biological thought that objects to an exclusively Darwinian or adaptationist explanation of natural selection such as is described in the 20th century's modern synthesis. It proposes instead that evolution is guided differently, basically by more or less physical forces which shape the development of an animal's body, and sometimes implies that these forces supersede selection altogether. Structuralists have proposed different mechanisms that might have guided the formation of body plans. Before Darwin, Étienne Geoffroy Saint-Hilaire argued that animals shared homologous parts, and that if one was enlarged, the others would be reduced in compensation. After Darwin, D'Arcy Thompson hinted at vitalism and offered geometric explanations in his classic 1917 book On Growth and Form. Adolf Seilacher suggested mechanical inflation for "pneu" structures in Ediacaran biota fossils such as Dickinsonia. Günter P. Wagner argued for developmental bias, structural constraints on embryonic development. Stuart Kauffman favoured self-organisation, the idea that complex structure emerges holistically and spontaneously from the dynamic interaction of all parts of an organism. Michael Denton argued for laws of form by which Platonic universals or "Types" are self-organised. Stephen J. Gould and Richard Lewontin proposed biological "spandrels", features created as a byproduct of the adaptation of nearby structures. Gerd B. Müller and Stuart A. Newman argued that the appearance in the fossil record of most of the current phyla in the Cambrian explosion was "pre-Mendelian"[lower-alpha 1] evolution caused by physical factors. Brian Goodwin, described by Wagner as part of "a fringe movement in evolutionary biology", denies that biological complexity can be reduced to natural selection, and argues that pattern formation is driven by morphogenetic fields. Darwinian biologists have criticised structuralism, emphasising that there is plentiful evidence both that natural selection is effective and, from deep homology, that genes have been involved in shaping organisms throughout evolutionary history. They accept that some structures such as the cell membrane self-assemble, but deny the ability of self-organisation to drive large-scale evolution.
  • 2.0K
  • 30 Nov 2022
Topic Review
Versatile Applications of Cyanobacteria in Biotechnology
Cyanobacteria are blue-green Gram-negative and photosynthetic bacteria which are seen as one of the most morphologically numerous groups of prokaryotes. Because of their ability to fix gaseous nitrogen and carbon dioxide to organic materials, they are known to play important roles in the universal nutrient cycle. Cyanobacteria has emerged as one of the promising resources to combat the issues of global warming, disease outbreaks, nutrition insecurity, energy crises as well as persistent daily human population increases. Cyanobacteria possess significant levels of macro and micronutrient substances which facilitate the versatile popularity to be utilized as human food and protein supplements in many countries such as Asia. Cyanobacteria has been employed as a complementary dietary constituent of feed for poultry and as vitamin and protein supplement in aquatic lives. They are effectively used to deal with numerous tasks in various fields of biotechnology, such as agricultural (including aquaculture), industrial (food and dairy products), environmental (pollution control), biofuel (bioenergy) and pharmaceutical biotechnology (such as antimicrobial, anti-inflammatory, immunosuppressant, anticoagulant and antitumor).
  • 2.0K
  • 06 Dec 2022
Topic Review
Bayesian Nonlinear Mixed Effects Models
Nonlinear mixed effects models have become a standard platform for analysis when data is in the form of continuous and repeated measurements of subjects from a population of interest, while temporal profiles of subjects commonly follow a nonlinear tendency. While frequentist analysis of nonlinear mixed effects models has a long history, Bayesian analysis of the models has received comparatively little attention until the late 1980s, primarily due to the time-consuming nature of Bayesian computation. Since the early 1990s, Bayesian approaches for the models began to emerge to leverage rapid developments in computing power, and have recently received significant attention due to (1) superiority to quantify the uncertainty of parameter estimation; (2) utility to incorporate prior knowledge into the models; and (3) flexibility to match exactly the increasing complexity of scientific research arising from diverse industrial and academic fields. 
  • 2.0K
  • 23 Mar 2022
Topic Review
Nervous Necrosis Virus
Nervous necrosis virus (NNV) can infect many species of fish and caused an 80~100% mortality rate. NNV capsid protein (NNVCP) was the only structural proteins of NNV, but there are few studies on the protein-protein interaction between NNVCP and host cell. Here, we demonstrated 49 proteins in optic nerve tissue that could interact with NNVCP. A new mechanism of NNV morphogenesis is clarified by exploring the interaction between NNVCP and host cells. Moreover, CKB was identified as a novel enhancer for NNV through interacting with NNVCP. These findings may provide more accurate target proteins to understand NNV morphogenesis and provide new insights into the antiviral infection.
  • 2.0K
  • 26 Oct 2020
Topic Review
Neurodegeneration-Associated Protein TAU in Cancer
Neurodegenerative disorders and cancer may appear unrelated illnesses. Yet, epidemiologic studies indicate an inverse correlation between their respective incidences for specific cancers. Possibly explaining these findings, increasing evidence indicates that common molecular pathways are involved, often in opposite manner, in the pathogenesis of both disease families. Genetic mutations in the MAPT gene encoding for TAU protein cause an inherited form of frontotemporal dementia, a neurodegenerative disorder, but also increase the risk of developing cancer. Assigning TAU at the interface between cancer and neurodegenerative disorders, two major aging-linked disease families, offers a possible clue for the epidemiological observation inversely correlating these human illnesses. In addition, the expression level of TAU is recognized as a prognostic marker for cancer, as well as a modifier of cancer resistance to chemotherapy. Because of its microtubule-binding properties, TAU may interfere with the mechanism of action of taxanes, a class of chemotherapeutic drugs designed to stabilize the microtubule network and impair cell division. Indeed, a low TAU expression is associated to a better response to taxanes. Although TAU main binding partners are microtubules, TAU is able to relocate to subcellular sites devoid of microtubules and is also able to bind to cancer-linked proteins, suggesting a role of TAU in modulating microtubule-independent cellular pathways associated to oncogenesis. This concept is strengthened by experimental evidence linking TAU to P53 signaling, DNA stability and protection, processes that protect against cancer.
  • 2.0K
  • 26 Nov 2020
Topic Review
Arundo donax L.
Arundo donax L., the giant reed—being a long-duration, low-cost, non-food energy crop able to grow in marginal lands—has emerged as a potential alternative to produce biomass for both energy production, with low carbon emissions, and industrial bioproducts.
  • 2.0K
  • 07 Dec 2020
Topic Review
Focused-Ion-Beam for chiral photonics
Focused ion beam (FIB) processing which enabled scientific and technological advances in the realization and study of micro- and nano-systems in many research areas, such as nanotechnology, material science, and the microelectronic industry. Recently, its applications have been extended to the photonics field, owing to the possibility of developing systems with complex shapes, including 3D chiral shapes. Micro-/nano-structured elements with precise geometrical features at the nanoscale can be realized by FIB processing, with sizes that can be tailored in order to tune optical responses over a broad spectral region. In this entry, we give an overview of the recent efforts in this field which have involved FIB processing as a nanofabrication tool for photonics applications. In particular, we focus on FIB-induced deposition and FIB milling, employed to build 3D nanostructures and metasurfaces exhibiting intrinsic chirality. 
  • 2.0K
  • 18 Mar 2021
Topic Review
Bruton’s Kinase Inhibitors in Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) is an indolent form of B-cell lymphoid malignancy that predominantly affects older individuals. Bruton’s tyrosine kinase (BTK) is a member of the TEC kinase family. It plays an important role in treatment of malignant B lymphocyte proliferation and improvement of survival of patients with CLL.
  • 2.0K
  • 16 Mar 2022
Topic Review
Kar-go
Kar-go, is an autonomous delivery vehicle, designed and built by British company, Academy of Robotics Ltd, a UK company, registered in Wales. The vehicle uses self-drive / driverless car technology to drive itself to locations where it delivers packages autonomously.
  • 2.0K
  • 18 Oct 2022
Topic Review Peer Reviewed
The Emergence of Neuroleadership in the Knowledge Economy
“The Emergence of Neuroleadership in the Knowledge Economy” explores the field of neuroleadership in today’s constantly changing economy, highlighting the transition from traditional leadership to neuroleadership. Neuroleadership renders itself as a novel approach to the leadership theory, which brings together insights from neuroscience, psychology, and leadership studies. It emphasizes understanding the workings of the brain and human behavior in order to drive leadership effectiveness, at individual, team, and organizational levels. Additionally, the knowledge economy is characterized by the significant role of knowledge and intellectual capital when it comes to driving economic growth and organizational development. It highlights the creation, dissemination, and sharing of knowledge as important pillars for productivity and competitive advantage, shaping industries and transforming leadership traditional models. Through an extensive literature review and by employing the Dulewicz and Higgs leadership model, the authors showcase what are the intellectual, managerial, and emotional competencies that make neuroleadership the next natural step in leading teams and organizations. This article proposes a comparative matrix between traditional leaders and neuroleaders, and highlights a novel framework for better understanding neuroleadership.
  • 2.0K
  • 02 Jul 2024
Topic Review
Hallmarks of Senescence
Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; the chronic accumulation of senescent cells contributes to tissue dysfunction and aging. Recognizing the hallmarks of senescence is crucial for the research and development of therapies against aging.
  • 2.0K
  • 20 Feb 2023
Topic Review
Aortic Dissection
Acute aortic syndromes (AAS) represent a spectrum of interrelated disorders characterized by the disruption of the aortic integrity, and are associated with high morbidity and mortality. These conditions include aortic dissection (AD), accounting for the majority of AAS (80%), intramural hematoma (IMH, ~15%), and penetrating aortic ulcer (PAU, ~5%).
  • 2.0K
  • 21 Feb 2023
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