Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Overview of Ocular Delivery Systems
Many disorders of the anterior region of the eye may be efficiently treated via topical administration; however, it is more challenging to target conventional therapeutic doses to the posterior of the eye in this manner. Thus, various nanocarriers have been created and investigated for the transport of drugs and genes to the anterior or the posterior portions of the eyes. Liposomes, nanoparticles, micelles, inserts, implants, hydrogel, and emulsions are some of the most frequently utilized drug delivery systems.
  • 2.0K
  • 03 Jul 2023
Topic Review
Steel Structural Property Correlation
The behaviour of plain carbon, as well as, structural steel is qualitatively different at different regimes of strain rates and temperature when they are subjected to hot-working and impact-loading conditions. Ambient temperature and carbon content are the leading factors governing the deformation behaviour and substructural evolution of these steels.
  • 2.0K
  • 29 Jul 2022
Topic Review
Self-Healing Polymer, Metal, and Ceramic Matrix Composites
Composites can be divided into three groups based on their matrix materials, namely polymer, metal and ceramic. Composite materials fail due to micro cracks. Repairing is complex and almost impossible if cracks appear on the surface and interior, which minimizes reliability and material life. In order to save the material from failure and prolong its lifetime without compromising mechanical properties, self-healing is one of the emerging and best techniques. 
  • 2.0K
  • 07 Dec 2022
Topic Review
Mitochondrial Genetic and Epigenetic Regulations in Cancer
Mitochondria are dynamic organelles managing crucial processes of cellular metabolism and bioenergetics. Enabling rapid cellular adaptation to altered endogenous and exogenous environments, mitochondria play an important role in many pathophysiological states, including cancer. Being under the control of mitochondrial and nuclear DNA (mtDNA and nDNA), mitochondria adjust their activity and biogenesis to cell demands. In cancer, numerous mutations in mtDNA have been detected, which do not inactivate mitochondrial functions but rather alter energy metabolism to support cancer cell growth. Increasing evidence suggests that mtDNA mutations, mtDNA epigenetics and miRNA regulations dynamically modify signalling pathways in an altered microenvironment, resulting in cancer initiation and progression and aberrant therapy response. 
  • 2.0K
  • 10 Aug 2022
Topic Review
Spermine
In recent years, research on spermine (Spm) has turned up a lot of new information about this essential polyamine, especially as it is able to counteract damage from abiotic stresses. Spm has been shown to protect plants from a variety of environmental insults, but whether it can prevent the adverse effects of drought has not yet been reported. Drought stress increases endogenous Spm in plants and exogenous application of Spm improves the plants’ ability to tolerate drought stress. Spm's role in enhancing antioxidant defense mechanisms, glyoxalase systems, methylglyoxal (MG) detoxification, and creating tolerance for drought-induced oxidative stress is well documented in plants. However, the influences of enzyme activity and osmoregulation on Spm biosynthesis and metabolism are variable. Spm interacts with other molecules like nitric oxide (NO) and phytohormones such as abscisic acid, salicylic acid, brassinosteroids, and ethylene, to coordinate the reactions necessary for developing drought tolerance. This review focuses on the role of Spm in plants under severe drought stress. We have proposed models to explain how Spm interacts with existing defense mechanisms in plants to improve drought tolerance.
  • 2.0K
  • 23 Feb 2021
Topic Review
Aluminum Toxicity
Aluminum (Al) toxicity is a major environmental stress that inhibits plant growth and development in acidic soils. 
  • 2.0K
  • 13 Apr 2021
Topic Review
Singing Voice Detection
Singing voice detection or vocal detection is a classification task that determines whether there is a singing voice in a given audio segment. This process is a crucial preprocessing step that can improve the performance of other tasks such as automatic lyrics alignment, singing melody transcription, singing voice separation, vocal melody extraction, and many more.
  • 2.0K
  • 25 Jan 2022
Topic Review
Evolution and Interconnectedness of Corporate Sustainability Constructs
The concept of sustainable development (SD) was introduced in the “Our Common Future” report, launched in 1987, which influenced the emergence of many studies related to the role played by organizations as actors supporting SD. SD is a consolidated concept; however, since 1987, many political, social, and natural events have occurred on the planet, which have impacted companies’ behaviors. However, the diversity of research from different fields has provoked, among the academic community, a lack of clarity surrounding “sustainability” (S), “corporate sustainability” (CS) and “corporate social responsibility” (CSR) concepts. This lack of clarity can also be identified in companies, which have referred to “sustainability” only in the environmental field. Recently, increased discussions related to corporate sustainability metrics have shed light on the ESG criteria (environmental, social, and governance), increasing misperceptions associated with the concept. Ambiguous definitions and constructs may prevent managers from identifying sustainability goals for their companies.
  • 2.0K
  • 22 Apr 2022
Topic Review
Azithromycin
Azithromycin has become famous in the last two years, not for its main antimicrobial effect, but for its potential use as a therapeutic agent for COVID-19 infection. Initially, there were some promising results that supported its use, but it has become clear that scientific results are insufficient to support such a positive assessment.
  • 2.0K
  • 10 Aug 2022
Topic Review
Trachodon Mummy
The Trachodon mummy is a fossilized natural mummy of Edmontosaurus annectens (originally known as Trachodon annectens), a duckbilled dinosaur. One of the finest dinosaur specimens so far discovered, it was the first including a skeleton encased in skin impressions from large parts of the body. This specimen has considerably influenced the scientific conception of duckbilled dinosaurs. Skin impressions found in between the fingers have been interpreted as evidence for an aquatic lifestyle; this hypothesis is now rejected. The mummy was found by fossil hunter Charles Hazelius Sternberg and his three sons near Lusk, Wyoming, United States in 1908. Although Sternberg was working under contract to the British Museum of Natural History, Henry Fairfield Osborn of the American Museum of Natural History managed to secure the mummy.
  • 2.0K
  • 27 Oct 2022
Topic Review
SA-15 (Ship)
SA-15 is the project name for a series of icebreaking multipurpose cargo ships built in Finland for the Soviet Union in the 1980s. The ships, capable of independent operation in all prevailing arctic ice conditions, were the first merchant vessels designed for year-round operations in the Northern Sea Route. For this purpose they have hulls that resemble those of polar icebreakers and propulsion systems capable of withstanding ice loads. While the ships are also known as the Norilsk class after the first ship, Norilsk, they are usually referred to by their project name which denotes a subarctic 15,000 DWT cargo ship. Nineteen SA-15 class ships were delivered by Finnish shipbuilders Wärtsilä and Valmet in 1982–1987, and (As of 2020) two vessels remain in service.
  • 2.0K
  • 25 Nov 2022
Topic Review
Caseins
The milk of mammals is a complex fluid mixture of various proteins, minerals, lipids, and other micronutrients that play a critical role in providing nutrition and immunity to newborns. Casein proteins together with calcium phosphate form large colloidal particles, called casein micelles. Caseins belong to a class of proteins that exhibit open and flexible conformations.
  • 2.0K
  • 17 Mar 2023
Topic Review
Image-Based Malware Detection
Image conversion of malicious binaries, or binary visualisation, is a relevant approach in the security community. It has exceeded the role of a single-file malware analysis tool and has become a part of Intrusion Detection Systems (IDSs) thanks to the adoption of Convolutional Neural Networks (CNNs).
  • 2.0K
  • 16 Nov 2023
Topic Review
Lipoprotein Lipase Regulation in Atherosclerosis
Lipoprotein lipase (LPL) plays a major role in the lipid homeostasis mainly by mediating the intravascular lipolysis of triglyceride rich lipoproteins. Impaired LPL activity leads to the accumulation of chylomicrons and very low-density lipoproteins (VLDL) in plasma, resulting in hypertriglyceridemia. While low-density lipoprotein cholesterol (LDL-C) is recognized as a primary risk factor for atherosclerosis, hypertriglyceridemia has been shown to be an independent risk factor for cardiovascular disease (CVD) and a residual risk factor in atherosclerosis development.
  • 2.0K
  • 01 Aug 2021
Topic Review
PbS Quantum Dots
Quantum dots are very interesting materials for different opto-electronic applications.  Among the different quantum dots available, semiconductor quantum dots of PbS became very popular and are extensively studied. This chapter focuses on the current understanding of the superlattice formation process induced via self-assembly of PbS quantum dots as probed by the Grazing incidence small angle X-ray scattering techniques (GISAXS/GIWAXS).
  • 2.0K
  • 06 Dec 2021
Topic Review
Cooperative Learning
Cooperative learning is an educational approach which aims to organize classroom activities into academic and social learning experiences. . There is much more to cooperative learning than merely arranging students into groups, and it has been described as "structuring positive interdependence." Students must work in groups to complete tasks collectively toward academic goals. Unlike individual learning, which can be competitive in nature, students learning cooperatively can capitalize on one another's resources and skills (asking one another for information, evaluating one another's ideas, monitoring one another's work, etc.). Furthermore, the teacher's role changes from giving information to facilitating students' learning. Everyone succeeds when the group succeeds. Ross and Smyth (1995) describe successful cooperative learning tasks as intellectually demanding, creative, open-ended, and involve higher order thinking tasks. Cooperative learning has also been linked to increased levels of student satisfaction. Five essential elements are identified for the successful incorporation of cooperative learning in the classroom: According to Johnson and Johnson's meta-analysis, students in cooperative learning settings compared to those in individualistic or competitive learning settings, achieve more, reason better, gain higher self-esteem, like classmates and the learning tasks more and have more perceived social support.
  • 2.0K
  • 27 Oct 2022
Topic Review
Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury
Skeletal muscle injuries occur frequently in daily life and exercise. Understanding the mechanisms of regeneration is critical for accelerating the repair and regeneration of muscle. The process of regeneration is similar in different mouse strains and is inhibited by aging, obesity, and diabetes. Exercise, microcurrent electrical neuromuscular stimulation, and mechanical loading improve regeneration. The mechanisms of regeneration are complex and strain-dependent, and changes in functional proteins involved in the processes of necrotic fiber debris clearance, M1 to M2 macrophage conversion, SC activation, myoblast proliferation, differentiation and fusion, and fibrosis and calcification influence the final outcome of the regenerative activity.
  • 2.0K
  • 17 Nov 2022
Topic Review
Procedures and Applications of Epidural and Intrathecal Injection
Epidural and intrathecal routes are the most effective drug administration methods for pain management in clinical and experimental medicine to achieve quick results, reduce required drug dosages, and overcome the adverse effects associated with the oral and parenteral routes. Beyond pain management with analgesics, the intrathecal route is more widely used for stem cell therapy, gene therapy, insulin delivery, protein therapy, and drug therapy with agonist, antagonist, or antibiotic drugs in experimental medicine
  • 2.0K
  • 23 May 2023
Topic Review
Connexin 26
Connexin 26, one of the smallest connexins, is expressed in diverse epithelial tissue and mutations in this protein are associated with hearing loss, skin and eye conditions of differing severity.
  • 2.0K
  • 26 Jan 2021
Topic Review
Safety, Toxicity of Phage Therapy
Lytic bacteriophages (phages) have been known to be a potential antibacterial agent for over a century since their first formal discovery and application as a treatment against human bacterial infections in the 1920s. Though subsequent success of antibiotics had quelled investigations into phage as potential anti-infectives, increasing antibiotic resistance has hastened the reemergence of interest in phage therapy. Despite attractive advantages, including widespread prevalence, activity against multidrug-resistant (MDR) bacteria, high specificity, and activity against biofilms, phage therapy is still not considered a mainstream treatment due to several obstacles. First, the lack of reliable data regarding its safety and efficacy in clinical settings. Second, appropriate regulatory guidelines specific to phage therapeutics have not been developed. Finally, the pharmaceutical and biotech industries have not yet developed economical and scalable production processes for widespread adoption of phage therapy. While much progress has been made, many questions remain, such as the safety and toxicity of phage preparations.
  • 2.0K
  • 21 Jul 2021
  • Page
  • of
  • 2799
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback