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Topic Review
Plasma Proteins
Blood contains various plasma proteins and cells to which endogenous and exogenous molecules can bind together to be transported throughout the circulatory system. Among the different plasma proteins, the binding of small molecular weight drug molecules is mostly associated with serum albumin and alpha-1 acid glycoprotein and, to a lesser extent globulins and lipoproteins. Although linear binding applies for most clinically used drugs, some physiopathological factors and/or dietary-drug interactions may lead to alterations of the drug-protein binding, which in turn may result in clinically changes in the pharmacokinetics and pharmacodynamics of the drug. As polyphenols (flavonoids and non-flavonoids) are widely present in plant-derived feeds, beberages, herbal medicines, and dietary supplements, the knowledge of how they bind to plasma proteins can prevent/avoid such interactions.
  • 2.1K
  • 30 Dec 2020
Topic Review
Cannabis sativa
Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into Western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-type constituents. 
  • 2.1K
  • 18 May 2021
Topic Review
Tumour Hypoxia
Tumour hypoxia is significantly correlated with patient survival and treatment outcomes. At the molecular level, hypoxia is a major driving factor for tumour progression and aggressiveness. There have been extensive studies to target tumour hypoxia and here are some examples of historical methods as well as new approaches. 
  • 2.1K
  • 03 Nov 2021
Topic Review
Laser Welding Based on Digital Twins
The benefits of laser welding include higher production values, deeper penetration, higher welding speeds, adaptability, and higher power density. These characteristics make laser welding a superior process. Many industries are aware of the benefits of switching to lasers. Laser welding of aluminum alloys presents a daunting challenge, mainly because aluminum is a less reliable material for welding than other commercial metals such as steel, primarily because of its physical properties: high thermal conductivity, high reflectivity, and low viscosity.
  • 2.1K
  • 24 May 2022
Topic Review
Machine Learning Models for On-Street Parking Prediction
Due to massive urbanization, traffic volume in urban areas has grown, making urban life very congested and polluted, leading to many negative impacts on human life, such as higher energy consumption, global warming, and airborne diseases. The goal of sustainable transport in smart cities is to ensure efficient traffic movement while minimizing a negative impact on the environment and public health.
  • 2.1K
  • 28 Jun 2022
Topic Review
Integrated Landscape Management
Integrated landscape management is a way of managing a landscape that brings together multiple stakeholders, who collaborate to integrate policy and practice for their different land use objectives, with the purpose of achieving sustainable landscapes. Integrated landscape management is one approach to addressing the major global challenges of poverty, food security, climate change, water scarcity, deforestation and loss of biodiversity at the local level. Proponents of integrated landscape management argue that as these challenges are interconnected, coordinated approaches are needed to address them, in order for landscapes (heterogenous geographic areas) to generate multiple benefits. For example, one river basin can supply water for towns and agriculture, timber and food crops for smallholders and industry, and habitat for biodiversity; the way in which each one of these sectors pursues its goals can have impacts on the others. The integrated approach goes beyond traditional sector-based practices that manage these different land uses independently of each other, even where they depend on the same resource base. The intention is to manage landscapes in a joined-up way, so that society's needs can be met in the short term, and in the long term. Integrated landscape management is increasingly recognised and taken up by intergovernmental bodies, government initiatives, research institutes, and some of the world's largest conservation NGOs, resulting in an increase in the number of examples of the approach in practice. However, barriers to uptake include difficulties in monitoring integrated landscape management and the proliferation of definitions and terms relating to it.
  • 2.1K
  • 07 Oct 2022
Topic Review
Incorporating Glycosaminoglycans in Collagen Hydrogels
Collagen, the most abundant protein in mammals, has garnered the interest of scientists for over 50 years. Its ubiquitous presence in all body tissues combined with its excellent biocompatibility has led scientists to study its potential as a biomaterial for a wide variety of biomedical applications with a high degree of success and widespread clinical approval. More recently, in order to increase their tunability and applicability, collagen hydrogels have frequently been co-polymerized with other natural and synthetic polymers. Of special significance is the use of bioactive glycosaminoglycans—the carbohydrate-rich polymers of the ECM responsible for regulating tissue homeostasis and cell signaling. This review covers the recent advances in the development of collagen-glycosaminoglycan blend hydrogels for translational biomedical research.
  • 2.1K
  • 16 Dec 2020
Topic Review
Non-collagenous proteins in bone ECM
Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant importance since most of the outstanding properties of the bone are due to matrix constitution. Bone ECM is composed of a mineral part comprising hydroxyapatite and of an organic part of primarily collagen with the rest consisting on non-collagenous proteins. 
  • 2.1K
  • 14 Apr 2021
Topic Review
Bioactivities of Red Pitaya Fruits
Pitahaya, or the pitaya fruit, is a well-known member of the Cactaceae family and is widely cultivated in tropical and subtropical areas. Pitaya fruit is classified based on the colour of pulp and peel, namely white-pulp with pink peel pitaya (Hylocereus undatus), red-pulp with pink peel pitaya (Hylocereus polyrhizus) and white-pulp with yellow skin (Hylocereus megulanthus).
  • 2.1K
  • 22 Mar 2022
Topic Review
Bergenin
Bergenin (BER), a key constituent of Bergenia crassifolia (Saxifragaceae), has gained extensive attention, owing to its array of pharmacological actions, including anti-infective, anti-cancer, anti-diabetic, neuroprotective, hepatoprotective, anti-urolithiatic, anti-hyperuricemic, and anti-bradykinin properties. 
  • 2.1K
  • 29 Mar 2022
Topic Review
Proto-Hmong–Mien
Proto-Hmong–Mien (Chinese: 原始苗瑶语) is the reconstructed ancestor of the Hmong–Mien languages. The date of proto-Hmong-Mien has been estimated to be about 2500 BP by Sagart, Blench, and Sanchez-Mazas. It has been estimated to about 4243 BP by the Automated Similarity Judgment Program (ASJP), however, ASJP is not widely accepted among historical linguists as an adequate method to establish or evaluate relationships between language families. Lower-level reconstructions include Proto-Hmongic and Proto-Mienic.
  • 2.1K
  • 10 Oct 2022
Topic Review
Rhizome
Rhizome is an American not-for-profit arts organization that supports and provides a platform for new media art.
  • 2.1K
  • 14 Nov 2022
Topic Review
Kouvola
Kouvola (Finnish pronunciation: [ˈkou̯ʋolɑ]) is a city and municipality in southeastern Finland. It is located along the Kymijoki River in the region of Kymenlaakso, 62 kilometres (39 mi) kilometers east of Lahti, 87 kilometres (54 mi) west of Lappeenranta and 134 kilometres (83 mi) northeast of the capital, Helsinki. With Kotka, Kouvola is one of the capital centers and is the largest city in the Kymenlaakso region. Kouvola is bordered by the municipalities of Hamina, Heinola, Iitti, Kotka, Lapinjärvi, Loviisa, Luumäki, Miehikkälä, Mäntyharju, Pyhtää and Savitaipale. Kouvola, which had population growth as late as the 1980s, has suffered a loss of migration since the 1990s. Over time, the loss has only deepened, so that at the end of the 2010s Kouvola was Finland's worst migration loss area. Natural demographics have also trended downward; in 2017, more than 450 more people died in the city than new ones were born. The reasons for the emigration are thought to be largely due to job losses in the region.
  • 2.1K
  • 28 Nov 2022
Topic Review
Hospital Wastewater Treatment Processes
Hospital wastewater contains a considerably higher concentration of drug residues (antibiotics, β-receptor blockers, analgesics, etc.) than municipal wastewater. Each hospital wastewater treatment process has its own merits, but combinatory processes frequently achieve higher levels of treatment effectiveness.
  • 2.1K
  • 14 Feb 2023
Topic Review
Power Engineering
Power engineering, also called power systems engineering, is a subfield of electrical engineering that deals with the generation, transmission, distribution and utilization of electric power, and the electrical apparatus connected to such systems. Although much of the field is concerned with the problems of three-phase AC power – the standard for large-scale power transmission and distribution across the modern world – a significant fraction of the field is concerned with the conversion between AC and DC power and the development of specialized power systems such as those used in aircraft or for electric railway networks. Power engineering draws the majority of its theoretical base from electrical engineering.
  • 2.1K
  • 24 Oct 2022
Topic Review
"Zorbas" on Southeastern Sicily
Over the last few years, several authors have presented contrasting models to describe the response of boulders to extreme waves, but the absence of direct observation of movements has hindered the evaluation of these models. The recent development of online video-sharing platforms in coastal settings has provided the opportunity to monitor the evolution of rocky coastlines during storm events. In September 2018, a surveillance camera of the Marine Protected Area of Plemmirio recorded the movement of several boulders along the coast of Maddalena Peninsula (Siracusa, Southeastern Sicily) during the landfall of the Mediterranean tropical-like cyclone (Medicane) Zorbas. Unmanned autonomous vehicle (UAV) photogrammetric and terrestrial laser scanner (TLS) surveys were performed to reconstruct immersive virtual scenarios to geometrically analyze the boulder displacements recorded in the video. Analyses highlighted that the displacements occurred when the boulders were submerged as a result of the impact of multiple small waves rather than due to a single large wave. Comparison between flow velocities obtained by videos and calculated through relationships showed a strong overestimation of the models, suggesting that values of flow density and lift coefficient used in literature are underestimated.
  • 2.1K
  • 25 Aug 2021
Topic Review
Reconfigurable Microstrip Filter–Antenna Integration
       Reconfigurable and tunable radio frequency (RF) and microwave (MW) components have become exciting topics for many researchers and design engineers in recent years. Reconfigurable microstrip filter–antenna combinations have been studied in the literature to handle multifunctional tasks for wireless communication systems. Using such devices can reduce the need for many RF components and minimize the cost of the whole wireless system, since the changes in the performance of these applications are achieved using electronic tuning techniques. However, with the rapid development of current fourth-generation (4G) and fifth-generation (5G) applications, compact and reconfigurable structures with a wide tuning range are in high demand. Also, meeting these requirements comes with some challenges, namely the increased design complexity and system size. Accordingly, this paper aims to discuss these challenges and review the recent developments in the design techniques used for reconfigurable filters and antennas, as well as their integration. Various designs for different applications are studied and investigated in terms of their geometrical structures and operational performance. This paper begins with an introduction to microstrip filters, antennas, and filtering antennas (filtennas). Then, performance comparisons between the key and essential structures for these aspects are presented and discussed. Furthermore, a comparison between several RF reconfiguration techniques, current challenges, and future developments is presented and discussed in this review. Among several reconfigurable structures, the most efficient designs with the best attractive features are addressed and highlighted in this paper to improve the performance of RF and MW front end systems.
  • 2.1K
  • 20 Nov 2021
Topic Review
Coenzyme Q10 and Oocyte Quality
Acquiring oocyte competence requires optimal mitochondrial function and adequate ATP levels. In this context, CoQ10 supplementation may improve human oocyte quality and subsequent reproductive performance given its role in ATP synthesis and mitochondrial protection from ROS oxidative damage. In infertility treatments, CoQ10 therapy can be orally supplied to promote a more favorable environment for oocyte development in vivo or by its addition to culture media in an attempt to improve its quality in vitro. 
  • 2.1K
  • 16 Sep 2021
Topic Review
LACE Index Predicts High Risk of 30-Day Readmission
The LACE index accounts for: Length of stay (L), Acuity of admission (A), Comorbidities (C), and recent Emergency department use (E).  The incorporation of a high-risk LACE index showed favorable risk prediction and could be applied to predict 30-day readmission with chronic conditions. 
  • 2.1K
  • 12 May 2022
Topic Review
PbS and PbSe in Room-Temperature Infrared Photodetectors
Infrared photodetectors have received much attention for several decades due to their broad applications in the military, science, and daily life. However, for achieving an ideal signal-to-noise ratio and a very fast response, cooling is necessary in those devices, which makes them bulky and costly. The earliest information about lead-based semiconductor materials comes from a patent published in 1904 by Bose, who found and utilized the photovoltaic effect of a crystal of galena. Subsequently, Case carried out his research on thin films of thallous sulfide (Tl2S) in 1917 and 1920. Due to the military needs of infrared information in World War II, Germany developed lead salt (PbS, PbSe and lead telluride (PbTe)) materials vigorously in the 1930s. During that period, different methods for preparing lead salt thin films developed rapidly. Gudden and Kutzscher prepared lead salt films by evaporation and chemical deposition, respectively. Shortly after German scientists firstly studied it, the United States scientists also conducted research on it. Cashman of Northwestern University began work on Tl2S in 1941 and later turned his full attention to the preparation of thin films of PbS, PbSe and PbTe by vacuum evaporation. Among the three typical lead salts used in infrared detectors, PbS and PbSe have been developed and produced to some extent, but PbTe has not been adapted for production and has been gradually phased out.
  • 2.1K
  • 23 May 2022
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