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Topic Review
Tapered Optical Fiber Configurations
Understanding environmental information is necessary for functions correlated with human activities to improve healthcare quality and reduce ecological risk. Tapered optical fibers reduce some limitations of such devices and can be considerably more responsive to fluorescence and absorption properties changes.
  • 2.2K
  • 05 Aug 2021
Topic Review
Green Innovation Performance
Green innovation performance refers to enterprise’s improvement of their product design or production process in terms of environmental protection and environmental management. Green innovation performance includes green product innovation performance and green process innovation performance from the perspective of innovation objects.
  • 2.2K
  • 06 Apr 2022
Topic Review
Structure and Reaction Mechanism of Li-CO2 Batteries
A typical type of Li–CO2 battery consists of a porous cathode, electrolyte (liquid, solid), and lithium metal anode.
  • 2.2K
  • 22 Jun 2022
Topic Review
Wave Race 64
Wave Race 64 is a racing video game developed by Nintendo EAD and published by Nintendo. It was released for the Nintendo 64 in 1996 and is a follow-up to the 1992 Game Boy title Wave Race. Most of the game involves the player racing on a Jet Ski on a variety of courses while successfully manoeuvring the vehicle around various buoys. A multiplayer mode where two players can compete against each other on a chosen course is also included. The game supports the Controller Pak, which allows players to transfer saved data from one game cartridge to another. Originally referred to as "F-Zero on water", the game was intended to feature high-speed boats with transforming capabilities, but these were ultimately replaced with Jet Skis as producer Shigeru Miyamoto felt that the game would not be differentiated enough from other titles on other systems. Wave Race 64 received acclaim from critics, who praised the game's satisfying controls and dynamic watery environments. The game is credited for helping Nintendo effectively make its paradigmatic leap from the 16-bit 2D graphics of the Super Nintendo Entertainment System to the Nintendo 64's 3D capabilities. It was re-released for the Wii and Wii U's Virtual Console in 2007 and 2016, respectively. A sequel, Wave Race, was released in 2001.
  • 2.2K
  • 13 Oct 2022
Topic Review
Refractometer
A refractometer is a laboratory or field device for the measurement of an index of refraction (refractometry). The index of refraction is calculated from the observed refraction angle using Snell's law. For mixtures, the index of refraction then allows to determine the concentration using mixing rules such as the Gladstone–Dale relation and Lorentz–Lorenz equation.
  • 2.2K
  • 20 Oct 2022
Topic Review
Aromatic Hydrocarbon
An aromatic hydrocarbon or arene (or sometimes aryl hydrocarbon) is a hydrocarbon with sigma bonds and delocalized pi electrons between carbon atoms forming a circle. In contrast, aliphatic hydrocarbons lack this delocalization. The term "aromatic" was assigned before the physical mechanism determining aromaticity was discovered, and referred simply to the fact that many such compounds have a sweet or pleasant odour; however, not all aromatic compounds have a sweet odour, and not all compounds with a sweet odour are aromatic. The configuration of six carbon atoms in aromatic compounds is called a "benzene ring", after the simplest possible such hydrocarbon, benzene. Aromatic hydrocarbons can be monocyclic (MAH) or polycyclic (PAH). Not all aromatic compounds are benzene-based; aromaticity can also manifest in heteroarenes, which follow Hückel's rule (for monocyclic rings: when the number of its π electrons equals 4n + 2, where n = 0, 1, 2, 3, ...). In these compounds, at least one carbon atom is replaced by one of the heteroatoms oxygen, nitrogen, or sulfur. Examples of non-benzene compounds with aromatic properties are furan, a heterocyclic compound with a five-membered ring that includes a single oxygen atom, and pyridine, a heterocyclic compound with a six-membered ring containing one nitrogen atom.
  • 2.2K
  • 25 Nov 2022
Topic Review
STAT3 and STAT5
A central characteristic of many types of cancer is altered energy metabolism processes such as enhanced glucose uptake and glycolysis and decreased oxidative metabolism. The regulation of energy metabolism is an elaborate process involving regulatory proteins such as HIF (pro-metastatic protein), which reduces oxidative metabolism, and some other proteins such as tumour suppressors that promote oxidative phosphorylation. In recent years, it has been demonstrated that signal transducer and activator of transcription (STAT) proteins play a pivotal role in metabolism regulation. STAT3 and STAT5 are essential regulators of cytokine- or growth factor-induced cell survival and proliferation, as well as the crosstalk between STAT signalling and oxidative metabolism. Several reports suggest that the constitutive activation of STAT proteins promotes glycolysis through the transcriptional activation of hypoxia-inducible factors and therefore, the alteration of mitochondrial activity. It seems that STAT proteins function as an integrative centre for different growth and survival signals for energy and respiratory metabolism.
  • 2.2K
  • 16 Jun 2021
Topic Review
Protein Glycosylation
Protein glycosylation is a highly conserved post-translational modification among organisms. It plays fundamental roles in many biological processes, ranging from protein trafficking and cell adhesion to host–pathogen interactions. According to the amino acid side chain atoms to which glycans are linked, protein glycosylation can be divided into two major categories: N-glycosylation and O-glycosylation. However, there are other types of modifications such as the addition of GPI to the C-terminal end of the protein. Besides the importance of glycoproteins in biological functions, they are a major component of the fungal cell wall and plasma membrane and contribute to pathogenicity, virulence, and recognition by the host immunity. Given that this structure is absent in host mammalian cells, it stands as an attractive target for developing selective compounds for the treatment of fungal infections.
  • 2.2K
  • 27 Oct 2021
Topic Review
Genetic Aspects of Seed Longevity
Seed longevity is the most important trait related to the management of gene banks because it governs the regeneration cycle of seeds. Thus, seed longevity is a quantitative trait. Prior to the discovery of molecular markers, classical genetic studies have been performed to identify the genetic determinants of this trait. Post-2000 saw the use of DNA-based molecular markers and modern biotechnological tools, including RNA sequence (RNA-seq) analysis, to understand the genetic factors determining seed longevity.
  • 2.2K
  • 06 May 2022
Topic Review
Imaging Findings of Mass-Forming Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, with mass-forming growth pattern being the most common. The typical imaging appearance of mass-forming ICC (mICC) consists of irregular ring enhancement in the arterial phase followed by the progressive central enhancement on portal venous and delayed phases. However, atypical imaging presentation in the form of hypervascular mICC might also be seen, which can be attributed to distinct pathological characteristics. Ancillary imaging features such as lobular shape, capsular retraction, segmental biliary dilatation, and vascular encasement favor the diagnosis of mICC.
  • 2.2K
  • 07 May 2022
Topic Review
RNA World Hypothesis
The RNA world hypothesis proposes that RNA was the first life-form on earth, later developing a cell membrane around it and becoming the first prokaryotic cell.
  • 2.2K
  • 07 Nov 2022
Topic Review
Operating-System-Level Virtualization
Operating-system-level virtualization, also known as containerization, refers to an operating system feature in which the kernel allows the existence of multiple isolated user-space instances. Such instances, called containers, partitions, virtual environments (VEs) or jails (FreeBSD jail or chroot jail), may look like real computers from the point of view of programs running in them. A computer program running on an ordinary operating system can see all resources (connected devices, files and folders, network shares, CPU power, quantifiable hardware capabilities) of that computer. However, programs running inside a container can only see the container's contents and devices assigned to the container. On Unix-like operating systems, this feature can be seen as an advanced implementation of the standard chroot mechanism, which changes the apparent root folder for the current running process and its children. In addition to isolation mechanisms, the kernel often provides resource-management features to limit the impact of one container's activities on other containers. System-level-virtualization is frequently implemented in remote access applications with dynamic cloud access, allowing for simultaneous two-way data streaming over closed networks.
  • 2.2K
  • 06 Dec 2022
Topic Review
Blood Ethanol Levels
In the interplay of the gut microbiota and endogenous ethanol production, the production of ethanol through the endogenous fermentation of carbohydrates is an inevitable result. “Alcohol-producing” processes may be succinctly abstracted to ethanol’s constant formation from acetaldehyde in the human body through various metabolic processes. In such cases where it is not introduced from the environment, it is called “endogenous ethanol”.
  • 2.2K
  • 28 Aug 2023
Topic Review
Fast Data Acquisition Systems
Data acquisition is the process by which physical phenomena from the real world are transformed into electrical signals that are measured and converted into a digital format for processing, analysis, and storage by a computer. In a large majority of applications, the data acquisition (DAQ) system is designed not only to acquire data but to act on it as well. In defining DAQ systems, it is, therefore, useful to extend this definition to include the control aspects of the total system. A DAQ system is comprised of a computer running specialized software and several data acquisition cards and/or instruments (from now on jointly referred to as DAQ devices). Data acquisition (DAQ) systems are intensively used in laboratory research, industrial facilities, aviation, automotive, etc. The applications include test and measurement, automation, etc.
  • 2.2K
  • 20 Oct 2023
Topic Review
Kinkajou
The Kinkajou (Potos flavus) is a fascinating mammal native to the tropical forests of Central and South America. Also known as the "honey bear" due to its fondness for sweet foods, the Kinkajou possesses a distinctive appearance with a prehensile tail, sharp claws, and a long, slender body. Primarily nocturnal and arboreal, the Kinkajou plays a vital role in forest ecosystems as a pollinator and seed disperser, making it an important species for conservation efforts in its native habitat.
  • 2.2K
  • 28 Feb 2024
Topic Review
Camelopardalis
Camelopardalis, recognized by the International Astronomical Union (IAU), is a constellation located in the northern celestial hemisphere. Its name is derived from the Latin word for "giraffe," reflecting its association with this graceful and majestic creature.
  • 2.2K
  • 29 Feb 2024
Topic Review
Enzymatic Activity
Enzymatic Activity is a sensitive indicator of changes in soil environment, and it changes depending on the farming system. 
  • 2.2K
  • 30 Oct 2020
Topic Review
Coronaviruses
There are various coronaviruses high and low pathogenicity. The first being associated with a high morbidity and mortality. The SARS-CoV-2 leading to COVID-19 has spread globally and is associated with a high mortality especially in elderly patients and with certain comorbidities (hypertension, obesity, diabetes, etc). Currently there are only limited evidence-based treatment options such as dexamethason, remdesivir, and ICU care. Multiple treatment strategies are being evaluated since the pandemic is still evolving in most countries. 
  • 2.2K
  • 10 Mar 2021
Topic Review
Diabetic Complications: Oxidative Stress/Inflammation
Oxidative stress and inflammation are considered major drivers in the pathogenesis of diabetic complications, including renal and cardiovascular disease. A symbiotic relationship also appears to exist between oxidative stress and inflammation. Several emerging therapies target these crucial pathways, to alleviate the burden of the aforementioned diseases. Oxidative stress refers to an imbalance between reactive oxygen species (ROS) and antioxidant defenses, a pathological state which not only leads to direct cellular damage but also an inflammatory cascade that further perpetuates tissue injury. Emerging therapeutic strategies tackle these pathways in a variety of ways, from increasing antioxidant defenses (antioxidants and Nrf2 activators) to reducing ROS production (NADPH oxidase inhibitors and XO inhibitors) or inhibiting the associated inflamma-tory pathways (NLRP3 inflammasome inhibitors, lipoxins, GLP-1 receptor agonists, and AT-1 re-ceptor antagonists).
  • 2.2K
  • 14 Jan 2021
Topic Review
Agate
Agate ‒ a spectacular form of SiO2 and a famous gemstone ‒ is commonly characterized as banded chalcedony. In detail, chalcedony layers in agates can be intergrown or intercalated with macro-crystalline quartz, quartzine, opal-C, opal-CT, cristobalite and/or moganite. In addition, agates often contain considerable amounts of mineral inclusions and water as both interstitial molecular H2O and silanol groups.
  • 2.2K
  • 16 Apr 2021
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