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Topic Review
Neuropeptides in Anxiety and Depression
In modern society, there has been a rising trend of depression and anxiety. This trend heavily impacts the population’s mental health and thus contributes significantly to morbidity and, in the worst case, to suicides. Modern medicine, with many antidepressants and anxiolytics at hand, is still unable to achieve remission in many patients. The pathophysiology of depression and anxiety is still only marginally understood, which encouraged researchers to focus on neuropeptides, as they are a vast group of signaling molecules in the nervous system. Neuropeptides are involved in the regulation of many physiological functions
  • 2.2K
  • 13 Sep 2022
Topic Review
Paranoid Personality Disorder
Paranoid personality disorder (PPD) is a mental illness characterized by paranoid delusions, and a pervasive, long-standing suspiciousness and generalized mistrust of others. People with this personality disorder may be hypersensitive, easily insulted, and habitually relate to the world by vigilant scanning of the environment for clues or suggestions that may validate their fears or biases. They are eager observers. They think they are in danger and look for signs and threats of that danger, potentially not appreciating other interpretations or evidence. They tend to be guarded and suspicious and have quite constricted emotional lives. Their reduced capacity for meaningful emotional involvement and the general pattern of isolated withdrawal often lend a quality of schizoid isolation to their life experience. People with PPD may have a tendency to bear grudges, suspiciousness, tendency to interpret others' actions as hostile, persistent tendency to self-reference, or a tenacious sense of personal right. Patients with this disorder can also have significant comorbidity with other personality disorders, such as schizotypal, schizoid, narcissistic, avoidant and borderline.
  • 2.2K
  • 08 Nov 2022
Topic Review
Dried Fruits
Dried fruits contain many bioactive compounds broadly classified as phytochemicals including phenolics, flavonoids, carotenoids, proanthocyanidins, stilbenes, chalcones/dihydrochalcones, and phytoestrogens. These compounds have antioxidant effects that may benefit health. Dried fruits are also a diverse group of foods with varying fibre contents. The evaluation of the biological activity of these bioactive compounds, including their bioaccessibility and bioavailability, may contribute to the understanding of the health effects of dried fruits.
  • 2.2K
  • 20 Jun 2023
Topic Review
Monoceros
Monoceros, Latin for "unicorn," is a constellation located in the celestial equator. Despite lacking ancient mythological roots, it was introduced in the 17th century by the astronomer Jakob Bartsch and later included in Johann Bayer's Uranometria, symbolizing the unicorn, a creature of myth and fantasy.
  • 2.2K
  • 15 Mar 2024
Topic Review
Childhood Asthma
Asthma is a complex and multifactorial respiratory disease with a high prevalence in the pediatric population. Variation in treatment response to asthma therapies has been described among patients, and difficult-to-treat asthma carries both high healthcare and socioeconomic burden to the patients and society. Omic studies can be used to discover the molecular mechanisms underlying asthma susceptibility and treatment response, contributing to a better knowledge and definition of asthma pathogenesis and therefore, to the development of precision medicine. This entry aims to summarize the recent findings of omic studies of treatment response in childhood asthma. Between 2018-2019 a total of 13 omic studies has been performed involving genomics, epigenomics, transcriptomics, metabolomics, and the microbiome. These have been focused on the response to three common asthma medications: short-acting beta agonists, inhaled corticosteroids, and leukotriene receptor antagonists. Novel associations of different biomarkers with asthma treatment response have been described. However, stronger evidence and more consistent results are required to implement these molecular biomarkers into clinical practice by establishing the most appropriate therapy for each patient.
  • 2.2K
  • 29 Oct 2020
Topic Review
Hydrosilylation Reactions Catalyzed by Rhenium
Hydrosilylation is a very versatile transformation consisting of the addition of a hydrosilane (H-SiR3) to an unsaturated bond. Organosilicon compounds have found widespread applications in our daily lives in silicon-based materials such as silicon rubbers, adhesives, paper release coating, and so forth. In addition, hydrosilylation is an atom economic reaction to access valuable organosilane intermediates for fine chemical synthesis
  • 2.2K
  • 20 May 2021
Topic Review
3D Printing at Micro-Level
Laser-induced forward transfer (LIFT) and two-photon polymerization (TPP) have proven their abilities to produce 3D complex microstructures at an extraordinary level of sophistication. Indeed, LIFT and TPP have supported the vision of providing a whole functional laboratory at a scale that can fit in the palm of a hand. This is only possible due to the developments in manufacturing at micro- and nano-scales. In a short time, LIFT and TPP have gained popularity, from being a microfabrication innovation utilized by laser experts to become a valuable instrument in the hands of researchers and technologists performing in various research and development areas, such as electronics, medicine, and micro-fluidics. In comparison with conventional micro-manufacturing methods, LIFT and TPP can produce exceptional 3D components. To gain benefits from LIFT and TPP, in-detail comprehension of the process and the manufactured parts’ mechanical–chemical characteristics is required. 
  • 2.2K
  • 01 Jul 2021
Topic Review
Environmental and Lifestyle Risk Factors in Gallbladder Carcinogenesis
Gallbladder cancer (GBC) is an aggressive neoplasm that in an early stage is generally asymptomatic and, in most cases, is diagnosed in advanced stages with a very low life expectancy because there is no curative treatment. Therefore, understanding the early carcinogenic mechanisms of this pathology is crucial to proposing preventive strategies for this cancer. The main risk factor is the presence of gallstones, which are associated with some environmental factors such as a sedentary lifestyle and a high-fat diet. Other risk factors such as autoimmune disorders and bacterial, parasitic and fungal infections have also been described. All these factors can generate a long-term inflammatory state characterized by the persistent activation of the immune system, the frequent release of pro-inflammatory cytokines, and the constant production of reactive oxygen species that result in a chronic damage/repair cycle, subsequently inducing the loss of the normal architecture of the gallbladder mucosa that leads to the development of GBC.
  • 2.2K
  • 18 Feb 2022
Topic Review
Sugar Transporters in Plants
Phytohormone transporters, alkaloid transporters, ion and ion chelator transporters, sugar transporters, and amino acid transporters are common active transporters in plants. The examples of phytohormone transporters, alkaloid transporters, and ion and ion chelator transporters include ATP-binding cassette (ABC) transporters and Multidrug And Toxic compound Extrusion (MATE) transporters, while the examples of sugar transporters include MonoSaccharide Transporters (MSTs) and SUcrose Transporters (SUTs). These transporters have been reported to play important roles in various biological processes including cellular detoxification, nutrient transport, and stress adaptation. 
  • 2.2K
  • 17 Mar 2022
Topic Review
O2O Commerce and Consumer Behavior
Online-to-offline (O2O) commerce is a popular business model which links offline business activities with online channels. Consumer behavior in O2O commerce is more complex than in other traditional business models as both online and offline channels are involved.
  • 2.2K
  • 07 Jul 2022
Topic Review
Scalable Distributed Hyperledger Fabric
Blockchain technology, with its decentralization characteristics, immutability, and traceability, is well-suited for facilitating secure storage, sharing, and management of data in decentralized Internet of Things (IoT) applications. Despite the increasing development of blockchain platforms, there is still no comprehensive approach for adopting blockchain technology in IoT systems. This is due to the blockchain’s limited capability to process substantial transaction requests from a massive number of IoT devices. Hyperledger Fabric (HLF) is a popular open-source permissioned blockchain platform hosted by the Linux Foundation. 
  • 2.2K
  • 26 Jul 2022
Topic Review
Na'vi Language
The Naʼvi language (Naʼvi: Lìʼfya leNaʼvi) is the constructed language of the Naʼvi, the sapient humanoid indigenous inhabitants of the fictional moon Pandora in the 2009 film Avatar. It was created by Paul Frommer, a professor at the USC Marshall School of Business with a doctorate in linguistics. Naʼvi was designed to fit James Cameron's conception of what the language should sound like in the film, to be realistically learnable by the fictional human characters of the film, and to be pronounceable by the actors, but to not closely resemble any single human language. When the film was released in 2009, Naʼvi had a growing vocabulary of about a thousand words, but understanding of its grammar was limited to the language's creator. However, this has changed subsequently as Frommer has expanded the lexicon to more than 2900 words and has published the grammar, thus making Naʼvi a relatively complete, learnable and serviceable language.
  • 2.2K
  • 09 Oct 2022
Topic Review
European Single Market
The European Single Market, Internal Market or Common Market is a single market comprising the 27 member states of the European Union (EU) as well as – with certain exceptions – Iceland, Liechtenstein, and Norway through the Agreement on the European Economic Area, and Switzerland through bilateral treaties. The single market seeks to guarantee the free movement of goods, capital, services, and people, known collectively as the "four freedoms". A number of potential EU accession candidates have Stabilisation and Association Agreements with the EU, which allow for limited participation in selected sectors of the Single Market, including Albania, Bosnia and Herzegovina, Kosovo, Montenegro, North Macedonia, and Serbia. In addition, through three individual agreements on a Deep and Comprehensive Free Trade Area (DCFTA) with the EU, the post-Soviet countries of Georgia, Moldova, and Ukraine have also been granted limited access to the Single Market in selected sectors. Turkey has access to the free movement of some goods via its membership in the European Union–Turkey Customs Union. The United Kingdom left the European Single Market on 31 December 2020. An agreement was reached between the UK Government and European Commission to align Northern Ireland on rules for goods with the European Single Market, to maintain an open border on the island of Ireland. The market is intended to increase competition, labour specialisation, and economies of scale, allowing goods and factors of production to move to the area where they are most valued, thus improving the efficiency of the allocation of resources. It is also intended to drive economic integration whereby the once separate economies of the member states become integrated within a single EU-wide economy. The creation of the internal market as a seamless, single market is an ongoing process, with the integration of the service industry still containing gaps. According to a 2019 estimate, because of the single market the GDP of member countries is on average 9 percent higher than it would be if tariff and non-tariff restrictions were in place.
  • 2.2K
  • 21 Oct 2022
Topic Review
SCORE
SCORE is a scorewriter program, written in FORTRAN for MS-DOS by Stanford University Professor Leland Smith (1925–2013) with a reputation for producing very high-quality results. It was widely used in engraving during the 1980s and 1990s and continues to have a small, dedicated following of engravers, many of whom regard it as the world's best music-engraving program due to its ability to position symbols precisely on the page. Several publications set using SCORE have earned Paul Revere and German Musikpresse engraving awards.
  • 2.2K
  • 08 Nov 2022
Topic Review
Seahorse Male Pregnancy
Seahorses, together with sea dragons and pipefishes, belong to the Syngnathidae family of teleost fishes. Seahorses and other Syngnathidae species have a very peculiar feature: male pregnancy. Among different species, there is a gradation of paternal involvement in carrying for the offspring, from a simple attachment of the eggs to the skin surface, through various degrees of egg coverage by skin flaps, to the internal pregnancy within a brood pouch, which resembles mammalian uterus with the placenta. Because of the gradation of parental involvement and similarities to mammalian pregnancy, seahorses are a great model to study the evolution of pregnancy and the immunologic, metabolic, cellular, and molecular processes of pregnancy and embryo development. Seahorses are also very useful for studying the effects of pollutants and environmental changes on pregnancy, embryo development, and offspring fitness. 
  • 2.2K
  • 15 Jun 2023
Topic Review
S-PRG Filler for Dental Treatment and Care
Surface Pre-Reacted Glass-ionomer (S-PRG) filler, which releases strontium (Sr2+), borate (BO33−), fluoride (F−), sodium (Na+), silicate (SiO32−), and aluminum (Al3+) ions at high concentrations, is a unique glass filler that are utilized in dentistry. Because of its multiple-ion releasing characteristics, S-PRG filler exhibits several bioactivities such as tooth strengthening, acid neutralization, promotion of mineralization, inhibition of bacteria and fungi, inhibition of matrix metalloproteinases, and enhancement of cell activity. Therefore, S-PRG filler per se and S-PRG filler-containing materials have the potential to be beneficial for various dental treatments and care.
  • 2.2K
  • 28 Jun 2023
Topic Review
Therapeutic Potential of Royal Jelly in Gastrointestinal Diseases
Royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. 
  • 2.2K
  • 08 Feb 2024
Topic Review
Flecainide
Flecainide is an IC antiarrhythmic drug approved in 1984 from Food and Drug Administration for the suppression of sustained ventricular tachycardia and later for acute cardioversion of atrial fibrillation (AF) and for sinus rhythm maintenance. It is categorized as a Vaughn-Williams Class IC agent based upon its properties of causes a strong degree of sodium channel blockage with slowing cardiac conduction and a minimal effect on ventricular repolarization. Currently, flecainide is mostly used for sinus rhythm maintenance in atrial fibrillation patients without structural cardiomyopathy although recent studies enrolling different patient population demonstrated a good effectiveness and safety profile. 
  • 2.2K
  • 13 Nov 2021
Topic Review
Corrosion-Induced Deterioration of Reinforced Concrete
Steel corrosion in reinforced concrete structures is critical to structural performance and also causes spalling of concrete cover, which poses a risk to occupants and any other person passing under the structure. It is well established that corrosion is initiated after the depassivation of the steel surface caused by the carbonation of the cover concrete and chloride ingress. For real structures in the field, it has been reported that corrosion was unlikely to be observed when the concrete was directly kept from moisture exposure, even when carbonation reached the reinforcing steel; however, corrosion can occur because of rainfall moisture and other sources. In this study, he cover depth effect on corrosion-induced deterioration on-site in different Asian countries was surveyed focusing on the water penetration rather than the classical corrosion factors, such as carbonation and chloride ingress, and then to experimentally and numerically investigate the threshold of water penetration and drying in cover concrete to support the survey findings.
  • 2.2K
  • 09 Oct 2021
Topic Review
BMSC Osteogenic or Adipogenic Differentiation
Bone marrow stromal cells (BMSCs) are multipotent cells in the bone marrow which can differentiate into chondrocytes, osteoblasts, adipocytes (fat cells) and other cell types. Many factors have been identified to control the process of BMSC osteogenic or adipogenic differentiation in the bone.
  • 2.2K
  • 12 Aug 2021
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