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Topic Review
Fourier Lightfield Microscope
Fourier lightfield microscopy (FLMic) is a technique aimed to capture and process 3D information of microscopic samples. Due to its optical design, FLMic has the inherent capacity of capturing a collection of orthographic perspectives of samples in a single shot. Consequently, FLMic is especially suited for capturing and processing 3D images of dynamic processes, being potentially addressed for real-time applications in both life and material sciences.
  • 2.3K
  • 10 Mar 2022
Topic Review
Ciguatoxins in Fish
Ciguatoxins are very potent marine neurotoxins, that accumulate to toxic levels in edible fish in certain circumtropical areas, and are associated with ciguatera fish poisoning worldwide. Ciguatoxins are produced by specific benthic dinoflagellates, enter the marine food chain via herbivorous fish and invertebrates, and eventual are biotransformed in herbivorous, omnivorous, and carnivorous fishes to more poisonous forms. Ciguatoxins cause risks to human health at very low concentrations. To decrease the risk of ciguatera fish poisoning, it is important to know fishing areas with low concentrations of ciguatoxins, as well as to test fish tissue for toxins before consumption. Modern laboratories use several detection techniques, such as mouse bioassay, cell-based assays, receptor-binding assays, antibody-based immunoassays, electrochemical methods, and analytical techniques, to obtain information about the total toxicity of fish tissue samples, as well as to identify toxins and to determine the toxin profile. State-of-the-art ciguatoxin detection involves the combination of a cell-based assay or receptor-binding assay to screen total toxicity, and liquid chromatography coupled with mass spectrometry to confirm toxins and provide toxin profiles. 
  • 2.3K
  • 25 Aug 2020
Topic Review
The Chromosome Organization in the Cell Nuclei
The spatial organization of the genome into the cell nucleus plays a central role in controlling several genome functions, such as gene expression and DNA replication timing during the S-phase of the cell cycle. Here we show how chromosomes are organized in the cell nucleus according to the gene density and to the GC-level of the various chromosomal bands, allowing a corrected and coordinated gene expression during cell life. The human genome, such as the genome of the other mammals, is composed by two very different parts: one very gene-dense, replicated at the onset of the S-phase, very GC-rich and the other endowed with opposite features. These two genomic compartments are localized far apart within a chromosome, with regions having intermediate properties located between them. This determines a zig-zag organization of the larger chromosomes, to position the gene-poorest genome compartment at the nuclear periphery and the gene-richest one at the nuclear interior.
  • 2.3K
  • 05 Jan 2022
Topic Review
Beta-3 Adrenergic Receptor
The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on the subject has built up in the last three decades and the physiology of β3-AR is unraveling quickly. As will become evident in this work, β3-AR is emerging as an appealing target for novel pharmacological approaches in several clinical areas involving metabolic, cardiovascular, urinary, and ocular disease.
  • 2.3K
  • 05 May 2022
Topic Review
Systems Thinking
Systems thinking is an evolving field, and there is growing demand to integrate systems thinking into many fields. As this demand increases, so does the need for and importance of identifying systems thinkers.
  • 2.3K
  • 16 May 2022
Topic Review
Self-Help Groups for Mental Health
Self-help groups for mental health, or mutual aid groups are voluntary associations of people who share a common desire to overcome mental illness or otherwise increase their level of cognitive or emotional wellbeing. Despite the different approaches, many of the psychosocial processes in the groups are the same. Self-help groups have had varying relationships with mental health professionals but generally is shown in research to provide additional support alongside mental health professionals. Due to the nature of these groups, self-help groups can help defray the costs of mental health treatment and implementation into the existing mental health system could help provide treatment to a greater number of the mentally-ill population. Although this article specifically defines mental health as relating to mental illness diagnoses or cognitive/behavioral processes, it should be noted that mental health is an important focus of other categories of self-help groups that are not listed below, such as 12-step groups like Alcoholics Anonymous, support groups for those who have undergone trauma like Survivors Network of those Abused by Priests. These self-help groups aim towards improving the mental health surrounding trauma or addiction in order to facilitate recovery.
  • 2.3K
  • 14 Oct 2022
Topic Review
Deep Learning towards Digital Additive Manufacturing
Machine learning is a type of deep learning. First in the machine learning (ML) process is the manual extraction of relevant image characteristics. These characteristics are also used to classify the image according to its particular characteristics. Researchers focused primarily on digital additive manufacturing, one of the most significant emerging topics in Industry 4.0.
  • 2.3K
  • 19 Dec 2022
Topic Review
Genetic Engineering Strategies for Seedlessness Breeding
Seedless fruit occurs naturally and can be produced using hormone application, crossbreeding, or ploidy breeding. However, the two types of breeding are time-consuming and sometimes ineffective due to interspecies hybridization barriers or the absence of appropriate parental genotypes to use in the breeding process. The genetic engineering approach provides a better prospect, which can be explored based on an understanding of the genetic causes underlying the seedlessness trait. 
  • 2.3K
  • 24 Mar 2023
Topic Review
CMS Membranes for Olefin/Paraffin Separation
Carbon molecular sieve (CMS) membranes have been developed to replace or support energy-intensive cryogenic distillation for olefin/paraffin separation. Olefin and paraffin have similar molecular properties, but can be separated effectively by a CMS membrane with a rigid, slit-like pore structure. A variety of polymer precursors can give rise to different outcomes in terms of the structure and performance of CMS membranes.
  • 2.3K
  • 26 Aug 2021
Topic Review
The Jahn-Teller Effects
The fundamental property of a polyatomic system to undergo spontaneous symmetry breaking was first formulated by L. Landau in 1934 as follows: the configuration of any nonlinear polyatomic system in a degenerate electronic state undergoes spontaneous distortions that remove the degeneracy. This groundbreaking idea, appended with proof, was published by H. Jahn and E. Teller, resulting in what is presently known as the Jahn-Teller effect (JTE). Since then, many extensions of this groundbreaking idea were revealed and developed. Presently, four types of electronic structures that lead to spontaneous symmetry breaking are revealed: in addition to electronic degeneracy resulting in the proper Jahn-Teller effect, two or more close in energy (pseudodegenerate) electronic states may lead to similar instability and distortions, called the pseudo-JTE (PJTE), and the same spontaneous distortion effects may take place when there is neither degeneracy, nor pseudodegeneracy in the fground state of the high-symmetry configuration, but a strong JTE or pseudo-JTE take place in a low-lying excited state, that penetrates the ground state, distorting the system; these are the hidden -JTE and hidden-PJTE, respectively.
  • 2.3K
  • 26 Oct 2021
Topic Review
Eyelash Extensions
Eyelash extensions are used to enhance the length, curliness, fullness, and thickness of natural eyelashes. The extensions may be made from several materials including mink, synthetic, or horse hair. The main method of applying the extensions is by using an adhesive glue to individually stick the extensions to the eyelash line. False eyelashes and eyelash extensions are not the same.
  • 2.3K
  • 28 Nov 2022
Topic Review
Canis Minor
Canis Minor, Latin for "Lesser Dog," is a small constellation in the northern celestial hemisphere. Named for one of the hunting dogs of Orion in Greek mythology, Canis Minor is characterized by its two brightest stars, Procyon and Gomeisa, which shine brightly in the night sky. 
  • 2.3K
  • 29 Feb 2024
Topic Review
Palladium-Plated Copper Bonding Wire
Wire-bonding technology is the most commonly used chip interconnection technology in microelectronic packaging. Metal bonding wire is the key material for wire bonding and plays an important role in the reliability of electronic devices. Palladium-plated copper (PdCu) bonding wire has been widely used because of its low cost, good electrical and thermal conductivity, the fact that it is not easy to oxidize, and its high reliability.
  • 2.3K
  • 21 Aug 2023
Topic Review
Extrusion Bioprinting for Skin Applications
Skin is a large and complex organ that serves protective and regulatory functions and is responsible for communication between the external environment and the inner organism. To fulfill these functions, skin has evolved as an organ with a complex anatomy derived from both the ectoderm (epidermis) and mesoderm (dermis). The skin includes not only these two major compartments but also important appendages, including hair follicles, sweat and sebaceous glands, nerve endings, and blood vessels, all of which have intricate spatial arrangements that render fabrication of the full skin organ challenging.
  • 2.3K
  • 26 Oct 2020
Topic Review
History of Global Germplasm Conservation System
Conservation of plant genetic resources has become an urgent activity as these resources are quickly disappearing, both in the wild as well as on farmers’ fields. In particular crop wild relatives and farmers varieties, also known as landraces, which are of particular interest for plant breeding, are under severe threat of extinction. As crop genetic resources are quite dispersed, regionally and even globally, germplasm conservation efforts require regional and, in many instances, global coordination. Thus, since the 1950s FAO has been actively involved, together with institutions such as IBPGR in the establishment and operation of a global ex situ conservation system, and where possible, effectively linked with in situ and on-farm management activities. This global system has somewhat spontaneously evolved and thus, the current system reflects still strongly the history of its ‘evolution’. To improve the present global system and make it more efficient, it is necessary to analyse and understand the historical and political aspects of its development and ‘evolution’ and this is the focus of the present paper. 
  • 2.3K
  • 19 Oct 2021
Topic Review
Computer Emergency Response Team
A computer emergency response team (CERT) is an expert group that handles computer security incidents. Alternative names for such groups include computer emergency readiness team and computer security incident response team (CSIRT).
  • 2.3K
  • 31 Oct 2022
Topic Review
ArchiCAD
ARCHICAD is an architectural BIM CAD software for Macintosh and Windows developed by the Hungarian company Graphisoft. ARCHICAD offers computer aided solutions for handling all common aspects of aesthetics and engineering during the whole design process of the built environment — buildings, interiors, urban areas, etc. Development of ARCHICAD started in 1982 for the Apple Lisa, the predecessor of the original Apple Macintosh. Following its launch in 1987, with Graphisoft's "Virtual Building" concept, ARCHICAD became regarded by some as the first implementation of BIM. ARCHICAD has been recognized as the first CAD product on a personal computer able to create both 2D and 3D geometry, as well as the first commercial BIM product for personal computers and considered "revolutionary" for the ability to store large amounts of information within the 3D model. Today, it has over 120,000 users.
  • 2.3K
  • 11 Nov 2022
Topic Review
Chitosan Nanoparticles-Based Cancer Drug Delivery
Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system.
  • 2.3K
  • 10 May 2023
Topic Review
Bat-eared Fox
The Bat-eared Fox (Otocyon megalotis) is a unique canid species found in the arid savannas and grasslands of Africa. Renowned for its large ears, which resemble those of a bat, this fox species has adapted to a specialized diet consisting primarily of insects, particularly termites. Despite its small size, the Bat-eared Fox plays a significant role in ecosystem dynamics by controlling insect populations and contributing to soil health through its foraging activities.
  • 2.3K
  • 08 Mar 2024
Topic Review
Microalgae Impact on Oral Health
Microalgae and cyanobacteria could represent a potential natural alternative to antibiotic, antiviral, or antimycotic therapies, as well as a good supplement for the prevention and co-adjuvant treatment of different oral diseases.
  • 2.3K
  • 24 Nov 2020
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