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Topic Review
Magnetic Resonance Imaging for Sjögren’s Syndrome
Primary Sjögren’s Syndrome (pSS) is a chronic autoimmune exocrinopathy affecting 0.3–3.0% of the population. Its main clinical hallmarks are the sicca symptoms (mucosal dryness manifesting mainly ocularly and orally) and extra-glandular symptoms, among which joint pain and chronic fatigue are the most important. Besides these symptoms, pSS may also manifest in the central nervous system (CNS), as noted in the original description of the disease by Sjögren himself in 1933. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these magnetic resonance imaging (MRI) alterations are expectedly related to them. 
  • 2.4K
  • 31 Jan 2023
Topic Review
Social Sequence Analysis
Social sequence analysis is a special application of sequence analysis, a set of methods that were originally designed in bioinformatics to analyze DNA, RNA, and peptide sequences. Social sequence analysis involves the examination of ordered social processes, ranging from microsocial interaction patterns (for example, turn-taking dynamics in conversations) and interpersonal contact dynamics to the development of social hierarchies and macrosocial temporal patterns. The analysis of such patterns can involve descriptive accounts of sequence patterns, statistical event history analysis, optimal matching analysis, narrative or event structure analysis, and dynamic social network sequencing. After being introduced to the social sciences in the 1980s and a period of slow growth during the 1990s, social sequence methods have become increasingly prevalent.
  • 2.4K
  • 01 Nov 2022
Topic Review
Live, Virtual, and Constructive
Live, Virtual, & Constructive (LVC) Simulation is a broadly used taxonomy for classifying Models and Simulation (M&S). However, categorizing a simulation as a live, virtual, or constructive environment is problematic since there is no clear division between these categories. The degree of human participation in a simulation is infinitely variable, as is the degree of equipment realism. The categorization of simulations also lacks a category for simulated people working real equipment.
  • 2.4K
  • 02 Dec 2022
Topic Review
Polymeric Nanocapsules
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.
  • 2.4K
  • 28 Oct 2020
Topic Review
Barriers to Industrial Symbiosis
Industrial symbiosis (IS) can contribute to achieving a win-win situation between industry and environment for local and regional circular economies. Many authors have recognized that a variety of barriers can hinder the implementation of industrial symbiosis (IS). It is imperative to understand and prioritize the barriers which will provide guidance for the realization of IS projects and assist practitioners and stakeholders with more effective implementation. This, in turn, will contribute to development of circular economies. 
  • 2.4K
  • 01 Jul 2022
Topic Review
Graphene and Graphene-Related Materials
Graphene is the most outstanding material among the new nanostructured carbonaceous species discovered and produced. Graphene’s astonishing properties (i.e., electronic conductivity, mechanical robustness, large surface area) have led to a deep change in the material science field.
  • 2.4K
  • 17 Mar 2021
Topic Review
Global Storm Activity of 2009
Global storm activity of 2009 profiles the major worldwide storms, including blizzards, ice storms, and other winter events, from January 1, 2009 to December 31, 2009. Wintery storms are events in which the dominant varieties of precipitation are forms that only occur at cold temperatures, such as snow or sleet, or a rainstorm where ground temperatures are cold enough to allow ice to form (i.e. freezing rain). It may be marked by strong wind, thunder and lightning (a thunderstorm), heavy precipitation, such as ice (ice storm), or wind transporting some substance through the atmosphere (as in a dust storm, snowstorm, hailstorm, etc.). Summer storms including flooding, severe thunderstorms and extratropical cyclones (which can occur in summer or winter) are also included in this list to a certain extent. As this occurred a heat wave and/or unforeseen monsoon weather also hit parts of Australia in 2009 and 2010. Victoria, the scene of horrific bushfires the year before, had a far colder summer, with hot weather arriving more than a month later than usual in 2009. August 17 saw a dust storm at Laguna Mar Chiquita as a major drought hit Argentina , and flooding and hailstorms hit southeastern Australia and Queensland in March 2010. The lack of winter precipitation in parts of China, however, contributed to a severe drought in the southwest. Bolivia, Venezuela, Mali, Mauritania, Morocco and Spain have also seen periods of drought in 2009 and 2010. On between May 12 and 26, both Mauritania, the Sénégal River Area and neighbouring parts of both Senegal and Mali faced both a drought and famine in 2010. A storm (from Proto-Germanic *sturmaz "noise, tumult") is any disturbed state of an astronomical body's atmosphere, especially affecting its surface, and strongly implying severe weather. Storms are created when a centre of low pressure develops, with a system of high pressure surrounding it. This combination of opposing forces can create winds and result in the formation of storm clouds, such as the cumulonimbus. Small, localized areas of low pressure can form from hot air rising off hot ground, resulting in smaller meteorological disturbances such as dust devils and whirlwinds.
  • 2.4K
  • 09 Nov 2022
Topic Review
Neuroinflammatory Diseases
Frequent diseases of the CNS, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and psychiatric disorders (e.g., schizophrenia), elicit a neuroinflammatory response that contributes to the neurodegenerative disease process itself. The immune and nervous systems use the same mediators, receptors, and cells to regulate the immune and nervous systems as well as neuro-immune interactions. In various neurodegenerative diseases, peripheral inflammatory mediators and infiltrating immune cells from the periphery cause exacerbation to current injury in the brain. Acetylcholine (ACh) plays a crucial role in the peripheral and central nervous systems, in fact, other than cells of the CNS, the peripheral immune cells also possess a cholinergic system. 
  • 2.4K
  • 28 Apr 2021
Topic Review
Biological Activity of Cinnamomum Camphora Essential Oils
Camphor tree (Cinnamomum camphora) is an ornamental plant that has been cultivated for a long time to obtain wood or camphor. Furthermore, its essential oil can be used as an alternative medicine and is an important source of perfume. Camphor obtained from camphor trees has long been used as a treatment for various symptoms such as inflammation, infection, congestion, muscle pain, and irritation in various regions. Despite many studies focused on the essential oil of the camphor tree, there is a lack of systematic studies of its extraction or separation. Besides, various components of camphor are not fully understood, and further research is needed on the medicinal effects of individual components of C. camphor. The genus Cinnamomum has crucial economic value and theoretical significance.
  • 2.4K
  • 28 Jun 2022
Topic Review
Radix-16 Floating Point
IBM hexadecimal floating point is number representation. IBM System/360 computers, and subsequent machines based on that architecture (mainframes), support a hexadecimal floating-point format (HFP). In comparison to IEEE 754 floating-point, the IBM floating-point format has a longer significand, and a shorter exponent. All IBM floating-point formats have 7 bits of exponent with a bias of 64. The normalized range of representable numbers is from 16−65 to 1663 (approx. 5.39761 × 10−79 to 7.237005 × 1075). The number is represented as the following formula: (−1)sign × 0.significand × 16exponent−64.
  • 2.4K
  • 16 Nov 2022
Topic Review
Fucoidan Structure
Fucoidans are complex polysaccharides derived from brown seaweeds. The search for novel and natural bioproduct derived drugs (due to toxicity issues associated with chemotherapeutic drugs) has led to an extensive study of fucoidan, as it has several bioactive characteristics. Among the various bioactivities of fucoidan, antidiabetic and anticancer properties have received extensive attention. However, the elucidation of the fucoidan structure and its biological activity is still vague. In addition, research has suggested that there is a link between diabetes and cancer; however, limited data exist where dual chemotherapeutic efforts are elucidated. This review provides an overview of glucose metabolism, which is the central process involved in the progression of both diseases. Potential therapeutic targets are highlighted and the relevance of fucoidan and its derivatives as a candidate for both cancer and diabetes therapy is shown.
  • 2.4K
  • 04 Feb 2021
Topic Review
The SSHPA Project
Social Sciences & Humanities Peer Awards (SSHPA) is an ecosystem of a scientific database and a science communication website. The project was funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under the National Research Grant No. 502.01-2018.19. The SSHPA database was validated by Nature's Scientific Data.
  • 2.4K
  • 30 Jul 2021
Topic Review
House of Jamalullail (Perak)
The House of Jamalullail of Perak is one of the oldest Syed (Saiyid) clans in Malaysia. It was established in early 16th century when Syed Husain Al Faradz Jamalullail from Hadramaut arrived in Perak to spread Islam. He flourished as an ulama in the state during the reign of Sultan Muzaffar Shah I (1528 - 1549), the first sultan of Perak. According to R.O. Winstedt in his article titled "The Hadramaut Saiyids of Perak and Siak", Journal of the Straits Branch of the Royal Asiatic Society, No. 79 (September 1918), the Sayid family of Perak exercised great influence on the history of Perak from its founding in the 16th century. The Saiyid family acquired the highest state offices, those of Orang Kaya Besar and of Menteri. One of its members, Syed Abu Bakar bin Syed Jalaluddin was made a Bendahara during the reign of Sultan Muzzafar Shah III (1728-1744). The Jamalullails of Perak held the position of the Orang Kaya Menteri six times in the period from the founding of Perak in 1528 until 1862, reflecting the special position given to them. This hereditary tradition in Perak was interrupted upon the death of menteri Syed Usman in 1862, during the reign of Sultan Jaafar Muazzam Shah (Marhum Waliullah) (1857-1865). According to Buyong Adil, "Sejarah Perak", Dewan Bahasa dan Pustaka, Kuala Lumpur, (2020:156) this change in tradition was a part solution to ending the Larut Wars of 1861-1862.
  • 2.4K
  • 07 Nov 2022
Topic Review
Andromeda
Andromeda, named after the mythical princess in Greek mythology, is one of the 88 constellations officially recognized by the International Astronomical Union (IAU). Located in the northern celestial hemisphere, Andromeda is renowned for hosting the Andromeda Galaxy (M31), the closest spiral galaxy to our own Milky Way, making it a captivating subject for both amateur stargazers and professional astronomers alike.
  • 2.4K
  • 29 Feb 2024
Topic Review
Bagarius bagarius (Hamilton, 1822)
B. bagarius (Hamilton, 1822) is a fish species that has huge potential as food and game fish in Bangladesh, Bhutan, India, and Nepal, but is encountering the threat of extinction in Bangladesh and throughout the world, which can be inferred from its alarming conservation status in Bangladesh as well as throughout the world. It is known as “Baghair” or “Bagh mach” in Bangladesh. In Bangla, the term “Bagh” refers to a tiger. 
  • 2.4K
  • 22 Apr 2022
Topic Review
Hydra
Hydra, known as the Water Snake, is a prominent constellation located in the southern celestial hemisphere. It is the largest of the 88 modern constellations in terms of area and is best observed from the Southern Hemisphere during the months of February and March. 
  • 2.4K
  • 15 Mar 2024
Topic Review
Physical Exercise among College Students in China
The status of the physical exercise of college students has been a popular topic in China. It has been established that adults engaging in regular physical activity will improve their health. For college students, maintaining good exercise habits can effectively reduce their risk of chronic diseases. Moreover, the academic years are the optimum time for university students to learn the fundamentals of exercise, form the proper participation habits in sports, and cultivate a lifelong sports consciousness.
  • 2.4K
  • 15 Nov 2022
Topic Review
Polar Bear
The Polar Bear (Ursus maritimus) is a majestic apex predator native to the Arctic region, known for its distinctive white fur and massive size, making it the largest land carnivore on Earth. Excellently adapted to its harsh habitat, the Polar Bear possesses specialized features such as a thick layer of insulating blubber and large, powerful limbs for traversing sea ice in search of prey, primarily seals. As an iconic symbol of the Arctic, the Polar Bear faces significant challenges due to climate change, including habitat loss and diminishing sea ice, posing grave threats to its survival.
  • 2.4K
  • 08 Mar 2024
Topic Review
Citrus Canker
Xanthomonas citri subsp. citri, a causative agent of the citrus canker (CC) disease, belongs to one of the essential groups of the bacterial phytopathogen family, Xanthomonadaceae. It has been a potential threat to the globally significant citrus fruit crop, which has remained under investigation for disease management and epidemiology since the 1980s. In Pakistan, the average yield of citrus is 11 t/ha, which is lower than other countries, including China, Brazil, and India, having average productions of 27, 26, and 22 tons/hectare, respectively. Citrus canker is one of the most devastating diseases, posing a significant threat to crop yield and fruit quality. To date, five distinct types (or forms) of the citrus canker have been recognized; the Asiatic (Canker A) form is most destructive and affects most citrus cultivars. Severe infection outcomes include dieback, defoliation, severely blemished fruit, premature fruit drop, and reduced fruit quality. The infection increases under humid, warm, cloudy climate, wind, and heavy rainfall.
  • 2.4K
  • 20 May 2022
Topic Review
Billing (Performing Arts)
Billing is a performing arts term used in referring to the order and other aspects of how credits are presented for plays, films, television, or other creative works. Information given in billing usually consists of the companies, actors, directors, producers, and other crew members.
  • 2.4K
  • 14 Oct 2022
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