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Topic Review
Luteolin
Luteolin (3′,4′,5,7-tetrahydroxyflavone), a member of the flavonoid family derived from plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti-inflammatory, antioxidant and immunomodulatory activities, Asian medicine has been using luteolin for centuries to treat several human diseases, including arthritis, rheumatism, hypertension, neurodegenerative disorders and various infections. Of note, luteolin displays many anti-cancer/anti-metastatic properties.
  • 2.5K
  • 01 Jun 2023
Topic Review
Challenges and Opportunities of Hydrogen Production
Hydrogen’s wide availability and versatile production methods establish it as a primary green energy source, driving substantial interest among the public, industry, and governments due to its future fuel potential. Notable investment is directed toward hydrogen research and material innovation for transmission, storage, fuel cells, and sensors. Ensuring safe and dependable hydrogen facilities is paramount, given the challenges in accident control. 
  • 2.5K
  • 17 Oct 2023
Topic Review
Extraction, Isolation and Characterization of Bioactive Compounds
Diverse medicinal plants such as those from the genus Artemisia have been employed globally for centuries by individuals belonging to different cultures. Universally, Artemisia species have been used to remedy various maladies that range from simple fevers to malaria. 
  • 2.5K
  • 03 Dec 2021
Topic Review
Horseradish Breeding
Horseradish cultivars are highly heterozygous clones and are maintained through asexual propagation, using root cuttings.
  • 2.5K
  • 18 Mar 2021
Topic Review
Poguli
Poguli or Pugali is an Indo-Aryan language spoken in parts of the Jammu region of Jammu and Kashmir, India. Its area encompasses the Pogal and Paristan valleys, and currently falls within the boundaries of Ramban district's Pogal Paristan tehsil. Like its neighbours Sarazi and Rambani, Poguli is intermediate between Kashmiri and Western Pahari.
  • 2.5K
  • 17 Oct 2022
Topic Review
List of Nuclear Reactors
This is a list of all the commercial nuclear reactors in the world, sorted by country, with operational status. The list only includes civilian nuclear power reactors used to generate electricity for a power grid. All commercial nuclear reactors use nuclear fission. As of April 2020, there are 440 operable power reactors in the world, with a combined electrical capacity of 390 GW. Additionally, there are 55 reactors under construction and 109 reactors planned, with a combined capacity of 63 GW and 118 GW, respectively. 329 more reactors are proposed. For non-power reactors, see List of nuclear research reactors. Where not otherwise specified, all information is sourced from the Power Reactor Information System (PRIS) of the International Atomic Energy Agency (IAEA).
  • 2.5K
  • 29 Nov 2022
Topic Review Peer Reviewed
Empowering Healthcare Leaders: Coaching for Leadership Development
Coaching is a dynamic, evolving field that seeks to unlock individuals’ potential to achieve their personal and professional best. It has gained widespread recognition across various sectors as an effective means of leadership skills development, including in the vital healthcare sector, which requires innovative strategies to build leadership skills that can sustain high-quality services and maintain patient safety. Many healthcare organizations have thus embraced coaching as a valuable tool for leadership development. This review presents the definitions, concepts, methodology, and applications of coaching, and identifies its salient characteristics in relation to other professions. The second section of this study focuses on a literature review, specifically examining coaching in the healthcare industry and its role as a method for leadership development. The outcome from the review offers insights and results from a review of related research, specifically identifying the potential for coaching within healthcare and its effectiveness in leadership development. The information gathered from this study provides valuable guidance to healthcare leaders and organizations seeking to implement coaching practices in their leadership development programs.
  • 2.5K
  • 08 Jan 2025
Topic Review
Benchmarking the Performance of a Quantum Computer
The quantum computer has been claimed to show more quantum advantage than the classical computer in solving some specific problems. Many companies and research institutes try to develop quantum computers with different physical implementations. Currently, most people only focus on the number of qubits in a quantum computer and consider it as a standard to evaluate the performance of the quantum computer intuitively. However, it is quite misleading in most times, especially for investors or governments. This is because the quantum computer works in a quite different way than classical computers. Thus, quantum benchmarking is of great importance. Currently, many quantum benchmarks are proposed from different aspects.
  • 2.5K
  • 07 Nov 2022
Topic Review
Kinesin-1
The most of the transportations in cells are realized through a kind of proteins, the molecular motor. Molecular motor can be classed into three families, myosin, kinesin and dynein. Kinesin-1 (also called conventional kinesin) is the founding member of the kinesin family and mainly exists in the nerve axons to transport membranous organelles along the microtubule lattice. By using the energy stored in the ATP molecule, kinesin-1 can “walk” along the microtubule lattice in a hand-over-hand manner. In the walking process of the kinesin-1, the conformational changes of the compact motor domain transmit and amplify the small changes of the nucleotide-binding site to the force-generation element to produce the processive movement. The chemical cycle and mechanical cycle of kinesin-1 are highly coupled to ensure the processivity of the kinesin-1 and to avoid the futile ATP hydrolysis.
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  • 27 Oct 2020
Topic Review
Blood-Brain Barrier
The blood-brain barrier (BBB) limits pharmacotherapy of several brain disorders. In addition to structural and metabolic characteristics of the BBB, the ATP-driven, drug efflux transporter P-glycoprotein (Pgp) is a selective gatekeeper of the BBB, and thus, a primary hindrance to drug delivery into the brain.
  • 2.5K
  • 26 Oct 2020
Topic Review
Carbon-Oxygen (C–O) Bond Formation
Various noble metal and nonprecious metal or metal oxide nanoparticles have been utilized to exploit the C–H activation process to promote the formation of a new C–O bond and access alcohols or carbonyls. 
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  • 03 Jan 2023
Topic Review
Additives Used in Anaerobic Digestion
Anaerobic digestion involves the degradation of a biodegradable substance, such as sewage sludge by anaerobic microorganisms in an oxygen-free system.
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  • 13 Mar 2023
Topic Review
Nanobiosensors in Therapeutic Drug Monitoring
Due to the high bacterial resistance to antibiotics (AB), it has become necessary to adjust the dose aimed at personalized medicine by means of therapeutic drug monitoring (TDM). TDM is a fundamental tool for measuring the concentration of drugs that have a limited or highly toxic dose in different body fluids, such as blood, plasma, serum, and urine, among others. Using different techniques that allow for the pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the drug, TDM can reduce the risks inherent in treatment. Among these techniques, nanotechnology focused on biosensors, which are relevant due to their versatility, sensitivity, specificity, and low cost. They provide results in real time, using an element for biological recognition coupled to a signal transducer.
  • 2.5K
  • 19 Oct 2020
Topic Review
Green Synthesis of Gold Nanoparticles (AuNPs) from Plants
Gold nanoparticles (AuNPs) are becoming promising cancer therapeutic and diagnostic metal NPs that attract researchers due to their unique physiochemical properties such as stability, biocompatibility, high thermal activity, optical, electrical, high surface area to volume ratio surface chemistry, and multifunctionalization, etc. By fine tuning the components and concentrations, AuNPs can be easily manufactured into various forms and sizes. AuNPs have also shown significant advancement in treating inflammatory diseases and bacterial infections.
  • 2.5K
  • 02 Nov 2021
Topic Review
Boeing CST-100 Starliner
The Boeing Starliner (CST-100 - Crew Space Transportation-100) is a crew capsule manufactured by Boeing as its participation in NASA's Commercial Crew Development (CCDev) program. Its primary purpose is to transport crew to the International Space Station (ISS) and to private space stations such as the proposed Bigelow Aerospace Commercial Space Station. The capsule has a diameter of 4.56 meters (15.0 ft), which is slightly larger than the Apollo command module and smaller than the Orion capsule. The Boeing Starliner is to support larger crews of up to seven people and is being designed to be able to remain in-orbit for up to seven months with reusability of up to ten missions. It is designed to be compatible with four launch vehicles: Atlas V, Delta IV, Falcon 9, and Vulcan. In the first phase of its CCDev program NASA awarded Boeing US$18 million in 2010 for preliminary development of the spacecraft. In the second phase Boeing was awarded a $93 million contract in 2011 for further spacecraft development. On 3 August 2012, NASA announced the award of $460 million to Boeing to continue work on the CST-100 under the Commercial Crew Integrated Capability (CCiCap) Program. On 16 September 2014, NASA selected the Boeing CST-100, along with SpaceX's Crew Dragon, for the Commercial Crew Transportation Capability (CCtCap) program, with an award of $4.2 billion. On 30 July 2019, NASA had no specific dates for Commercial Crew launches, stating that this was under review pending a leadership change. The Boeing Starliner Orbital Flight Test (uncrewed test flight) launched with the Atlas V N22, on 20 December 2019 from SLC-41 at Cape Canaveral Air Force Station , Florida. During the test, the Starliner experienced an anomaly that precluded a docking with the International Space Station. Two days after launch, on 22 December 2019 at 07:58 EST (12:58 UTC), with the successful landing at White Sands, New Mexico, the Boeing Starliner Calypso became the first-ever, crew-capable space capsule to make a land-based touchdown in the United States.
  • 2.5K
  • 30 Nov 2022
Topic Review
Early Childhood Education
Early Childhood Education (ECE) often is part of a broader educational disadvantage policy and offers institutional compensatory programs to young children who lack specific educational stimulation in the home environment. ECE typically aims at children from deprived socioeconomic backgrounds and those of immigrant origin. Although ECE nowadays is widespread and accepted as perhaps the most important means of preventing and combating educational disadvantage, the controversy surrounding the evidence of effects and thus the justification and foundation of ECE provisions still is not solved. This article focuses on the basis (or lack of it) of ECE in the Netherlands.
  • 2.5K
  • 03 Nov 2020
Topic Review
Fog and Edge Computing
The fourth industrial revolution heralds a paradigm shift in how people, processes, things, data and networks communicate and connect with each other. Conventional computing infrastructures are struggling to satisfy dramatic growth in demand from a deluge of connected heterogeneous end points located at the edge of networks while, at the same time, meeting quality of service levels. The complexity of computing at the edge makes it increasingly difficult for infrastructure providers to plan for and provision resources to meet this demand. While simulation frameworks are used extensively in the modelling of cloud computing environments in order to test and validate technical solutions, they are at a nascent stage of development and adoption for fog and edge computing. This paper provides an overview of challenges posed by fog and edge computing in relation to simulation.
  • 2.5K
  • 23 Dec 2020
Topic Review
ARDS
Acute respiratory distress syndrome (ARDS) is a serious clinical illness, defined by severe hypoxemic respiratory failure, which continues to be associated with significant morbidity, mortality, and healthcare resource utilization. 
  • 2.5K
  • 16 Dec 2020
Topic Review
EGFR Signaling in Lung Fibrosis
The epidermal growth factor (EGF) receptor (EGFR), belongs to the family of the ErbB tyrosine kinase receptors. EGFR is also known as ErbB1 or HER1. Other members of this family are ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
  • 2.5K
  • 30 Mar 2022
Topic Review
Histamine in Pharmacotherapy of Itch
Itching can decrease quality of life and exacerbate skin symptoms due to scratching. Itching not only contributes to disease progression but also triggers complications such as skin infections and eye symptoms. Therefore, controlling itching is very important in therapeutic management. In addition to the well-known histamine, IL-31, IL-4 and IL-13 have recently been reported as factors that induce itching. Histamine-dependent itching is literally itching caused by histamine. It acts on the “sensory nerve” that perceives pain and itching, and the stimulus is transmitted to the brain as itching, as well as to the nerve endings, causing the release of neurotransmitters called neuropeptides. This neuropeptide then stimulates mast cells to secrete histamine and other substances.
  • 2.5K
  • 29 Jun 2022
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