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Topic Review
Plant Xyloglucan Xyloglucosyl Transferases
Plant xyloglucan xyloglucosyl transferases or xyloglucan endo-transglycosylases (XET; EC 2.4.1.207) catalogued in the glycoside hydrolase family 16 constitute cell wall-modifying enzymes that play a fundamental role in the cell wall expansion and re-modelling. Over the past thirty years, it has been established that XET enzymes catalyse homo-transglycosylation reactions with xyloglucan (XG)-derived substrates and hetero-transglycosylation reactions with neutral and charged donor and acceptor substrates other than XG-derived. This broad specificity in XET isoforms is credited to a high degree of structural and catalytic plasticity that has evolved ubiquitously in algal, moss, fern, basic Angiosperm, monocot, and eudicot enzymes. These XET isoforms constitute gene families that are differentially expressed in tissues in time- and space-dependent manners during plant growth and development, and in response to biotic and abiotic stresses.
  • 1.4K
  • 03 Dec 2020
Topic Review
Ribosomal Protein L10
Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and human models have made it possible to identify RPL10 (ribosomal protein L10), which is a constituent of the large subunit of the ribosome, as an important player in the final stages of ribosome biogenesis and in ribosome function.
  • 1.4K
  • 30 Nov 2020
Topic Review
Ribosome Interactions with SARS-CoV-2 and COVID-19 mRNA Vaccine
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causing pathogen of the unprecedented global Coronavirus Disease 19 (COVID-19) pandemic. Upon infection, the virus manipulates host cellular machinery and ribosomes to synthesize its own proteins for successful replication and to facilitate further infection. SARS-CoV-2 executes a multi-faceted hijacking of the host mRNA translation and cellular protein synthesis. Viral nonstructural proteins (NSPs) interact with a range of different ribosomal states and interfere with mRNA translation. Concurrent mutations on NSPs and spike proteins contribute to the epidemiological success of variants of concern (VOCs). The interactions between ribosomes and SARS-CoV-2 represent attractive targets for the development of antiviral therapeutics and vaccines.
  • 1.4K
  • 18 Feb 2022
Topic Review
The Relation of KLF11 to Cancers
KLF11 (Krüppel-like factor 11) belongs to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues. In carcinogenesis, KLF11 can show diverse effects. Its function as a tumor suppressor gene can be suppressed by phosphorylation of its binding domains via oncogenic pathways. However, KLF 11 itself can also show tumor-promoting effects and seems to have a crucial role in the epithelial-mesenchymal transition (EMT) process. 
  • 1.4K
  • 29 Apr 2020
Topic Review
Acridine-Based Antimalarials
Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites.
  • 1.4K
  • 19 Mar 2021
Topic Review
Protein Nanotubes
Nanobiotechnology involves the study of structures found in nature to construct nanodevices for biological and medical applications with the ultimate goal of commercialization. Within a cell most biochemical processes are driven by proteins and associated macromolecular complexes. Evolution has optimized these protein-based nanosystems within living organisms over millions of years. Among these are flagellin and pilin-based systems from bacteria, viral-based capsids, and eukaryotic microtubules and amyloids. While carbon nanotubes (CNTs), and protein/peptide-CNT composites, remain one of the most researched nanosystems due to their electrical and mechanical properties, there are many concerns regarding CNT toxicity and biodegradability. Therefore, proteins have emerged as useful biotemplates for nanomaterials due to their assembly under physiologically relevant conditions and ease of manipulation via protein engineering. 
  • 1.4K
  • 30 Aug 2021
Topic Review
Extracellular vesicles from adipose-derived stem-cells
Adipose tissue-derived stem cells (ADSCs) are pluripotent mesenchymal stem cells found in relatively high percentages in the adipose tissue and able to self-renew and differentiate into many different types of cells. Extracellular vesicles (EVs), small membrane vesicular structures released during cell activation, senescence, or apoptosis, act as mediators for long distance communication between cells, transferring their specific bioactive molecules into host target cells.  Metabolic syndrome and type 2 diabetes mellitus (T2DM) are mainly caused by abnormal adipose tissue size, distribution and metabolism and so ADSCs and their secretory factors such as EVs are currently investigated as therapeutics in these diseases. Here we provide a comprehensive summary of the current knowledge on EVs secreted from ADSCs both as diagnostic biomarkers and therapeutics in diabetes and associated cardiovascular disease, the molecular mechanisms involved, as well as on the use of ADSC differentiation potential in cardiovascular tissue repair and prostheses.
  • 1.4K
  • 06 Jan 2021
Topic Review
Outer Membrane Vesicles
OMVs are rounded nanostructures released during their growth by Gram-negative bacteria. Biologically active toxins and virulence factors are often entrapped within these vesicles that behave as molecular carriers. Recently, OMVs have been reported to contain DNA molecules, but little is known about the vesicle packaging, release, and transfer mechanisms.
  • 1.4K
  • 15 Jun 2021
Topic Review
Genetic and Genomic Alterations in Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is a brain tumor characterized by high heterogeneity, diffuse infiltration, aggressiveness, and formation of recurrences. Patients with this kind of tumor suffer from cognitive, emotional, and behavioral problems, beyond exhibiting dismal survival rates. Current treatment comprises surgery, radiotherapy, and chemotherapy with the methylating agent, temozolomide (TMZ). GBMs harbor intrinsic mutations involving major pathways that elicit the cells to evade cell death, adapt to the genotoxic stress, and regrow.
  • 1.4K
  • 23 May 2022
Topic Review
Immune-Mediated Drug-Induced Liver Injury
Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries.
  • 1.4K
  • 12 Oct 2021
Topic Review
Metabolic Enzymes in Saccharomyces cerevisiae
Condensate formation by a group of metabolic enzymes in the cell is an efficient way of regulating cell metabolism through the formation of “membrane-less organelles.” Because of the use of green fluorescent protein (GFP) for investigating protein localization, various enzymes were found to form condensates or filaments in living Saccharomyces cerevisiae, mammalian cells, and in other organisms, thereby regulating cell metabolism in the certain status of the cells. 
  • 1.4K
  • 26 Jan 2022
Topic Review
Nanomaterials for Wound Healing and Infection Control
Wound healing has been intensely studied in order to develop an "ideal" technique that achieves expeditious recovery and reduces scarring to the minimum, thus ensuring function preservation. The classic approach to wound management is represented by topical treatments, such as antibacterial or colloidal agents, in order to prevent infection and promote a proper wound-healing process. Nanotechnology studies submicroscopic particles (maximum diameter of 100 nm), as well as correlated phenomena. Metal nanoparticles (e.g., silver, gold, zinc) are increasingly being used in dermatology, due to their beneficial effect on accelerating wound healing, as well as treating and preventing bacterial infections. Other benefits include: ease of use, less frequent dressing changes and a constantly moist wound environment. This entry highlights recent findings regarding nanoparticle application in wound management.
  • 1.4K
  • 18 Jan 2022
Topic Review
SnRK2 in Plants
Reversible phosphorylation is a major mechanism for regulating protein function and controls a wide range of cellular functions including responses to external stimuli. The plant-specific SNF1-related protein kinase 2s (SnRK2s) function as central regulators of plant growth and development, as well as tolerance to multiple abiotic stresses. 
  • 1.4K
  • 26 Jul 2021
Topic Review
AT1R Antagonists
Hypertension is a medical condition where the blood pressure in the arteries is elevated. However, even if one does not exhibit symptoms, long-term high blood pressure is the major risk factor for numerous pathologies, such as stroke or heart failure. Angiotensin II (AII) receptor blockers are a class of molecules that act in the Renin Angiotensin System (RAS) through binding to the AT1 receptor (Angiotensin II receptor type 1, AT1R) and preventing its activity. AT1R is a G-protein-coupled receptor that is responsible for AII pathophysiological actions.
  • 1.4K
  • 19 May 2021
Topic Review
Biology of Cancer Stem Cells
Cancer stem cells have claimed to be one of the most important group of cells for the development of several common cancers as they dictate features, such as resistance to radio- and chemotherapy, metastasis, and secondary tumor formation. Therapies which could target these cells may develop into an effective strategy for tumor eradication and a hope for patients for whom this disease remains uncurable.
  • 1.4K
  • 06 Dec 2022
Topic Review Peer Reviewed
Brainstem fMRI
The human brainstem plays important roles in maintaining basic vital functions. In comparison with brain functional magnetic resonance imaging (fMRI), only a few fMRI studies investigating the brainstem have been reported because of a number of technical challenges. This entry briefly introduces technical difficulties, recent advances, and further directions of brainstem fMRI in humans. 
  • 1.4K
  • 13 Apr 2022
Topic Review
PET Radiotracers for CNS-Adrenergic Receptors
Epinephrine (E) and norepinephrine (NE) play diverse roles in our body’s physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health.
  • 1.4K
  • 27 Oct 2020
Topic Review
Endolysosomal TRPMLs
Lysosomes, the membrane-bound digestive cell organelles, are well-known for their catabolic function.
  • 1.4K
  • 04 Feb 2021
Topic Review
Methods to Eliminate Viruses from Lily
Lilies are important crops that are commonly used as cut flowers (Lilium spp.) and edible bulb crops (Lilium davidii var. unicolor). However, virus infections can significantly impact the quantity and quality of lily production. Various methods have been developed to eliminate viruses in lilies, including in vitro culture and virus detection techniques. Meristem culture is the most effective method, which can be combined with other techniques such as thermotherapy and chemotherapy. Nonetheless, virus elimination is affected by several factors, including cultivar, explants used, virus type, and duration of treatments. Efficient diagnostic methods, such as serological and molecular techniques, have been developed to detect viral infections in lilies, including enzyme-linked immunosorbent assay (ELISA) and real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR).
  • 1.4K
  • 07 Aug 2023
Topic Review
MRNA Export in Cancer
Export of mRNAs from the nucleus to the cytoplasm is a key regulatory step in the expression of proteins. mRNAs are transported through the nuclear pore complex (NPC) in association with key co-factors.  Export of selected subsets of mRNAs permits targeted elevation of specific protein expression. Indeed, there are different export pathways depending on the mRNA underpinning this selectivity.  Export of mRNAs can respond to a variety of cellular stimuli making it a dynamic means to respond to extracellular stimuli. mRNA export can be dysregulated in, and contribute to, human diseases including cancer and neurodegeneration. This entry focuses on its role in cancer.
  • 1.4K
  • 08 Jan 2021
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