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Topic Review
Naturally alkaloids as Antimicrobial agents
Antibiotic resistance is a serious threat to public health and new antimicrobial compounds are urgently needed. One of the most promising classes for the development of new antimicrobials are plant-derived alkaloids.
  • 2.7K
  • 25 Aug 2020
Topic Review
Structure and Physicochemical Properties of Konjac Glucomannan
Konjac glucomannan (KGM), can not only be applied as a food additive, which greatly improves the taste and flavor of food and extends the shelf life of food but also occupies an important role in T2DM (Type 2 Diabetes Mellitus). KGM can extend gastric emptying time, increase satiety, and promote liver glycogen synthesis, and also has the potential to improve intestinal flora and the metabolic system through a variety of molecular pathways in order to positively regulate oxidative stress and immune inflammation, and protect the liver and kidneys.
  • 2.7K
  • 01 Feb 2023
Topic Review Video
New Drip Irrigation Technologies in Upper Egypt
Saving fresh water is a big challenge for the next generation due to enhanced living standards and population growth. In addition, the expansion of agricultural and industrial activities is causing unmatched demands for fresh water supplies across Egypt. The Nile River is Egypt’s main water resource, representing 69.4% of the total water resources, while rainwater, torrential water and groundwater, as well as recycled agricultural and sanitary drainage water and desalinated seawater, are estimated at about 30.6%. Smart drip irrigation systems are in great demand, especially in Upper Egypt. SDG’s of the circular economy and the WEF nexus lead to full implementation of drip irrigation systems, achieving ~6.6 BM3/year of direct saving from fresh water and/or doubling the cultivated area. In addition to PV tubes and other utilities, renewable energy, e.g, photovoltaic panels, will posses an important role in low-energy driven drip irrigation systems, reducing fossil-uses, CO2 emissions and devolving more sustainable processes that are less dependent on conventional energy sources.
  • 2.7K
  • 01 Nov 2022
Topic Review
Y RNA
Y RNA are a class of small non-coding RNA that are largely conserved. Although their discovery was almost 40 years ago, their function is still under investigation. This is evident in cancer biology, where their role was first studied just a dozen years ago. Since then, only a few contributions were published, mostly scattered across different tumor types and, in some cases, also suffering from methodological limitations. Nonetheless, these sparse data may be used to make some estimations and suggest routes to better understand the role of Y RNA in cancer formation and characterization.
  • 2.7K
  • 30 Oct 2020
Topic Review
Primary Cilia
Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical extracellular signal sensors. Primary cilia coordinate a series of signaling pathways during development. Cilia dysfunction leads to a pleiotropic group of developmental disorders, termed ciliopathy. Phosphoinositides (PIs), a group of signaling phospholipids, play a crucial role in development and tissue homeostasis by regulating membrane trafficking, cytoskeleton reorganization, and organelle identity. Accumulating evidence implicates the involvement of PI species in ciliary defects and ciliopathies. The abundance and localization of PIs in the cell are tightly regulated by the opposing actions of kinases and phosphatases, some of which are recently discovered in the context of primary cilia. 
  • 2.7K
  • 15 Dec 2022
Topic Review
Main Raw Materials from Pineapple Biomass
Pineapple is a highly demanded fruit in international markets due to its unique appearance and flavor, high fiber content, vitamins, folic acid, and minerals. It makes pineapple production and processing a significant source of income for producing countries. The lignocellulosic biomass obtained from pineapple agro-industrial residues is mainly composed of cellulose, hemicellulose, and lignin; a compilation of information for these three compounds is presented below, with a specific focus on treatments and pretreatments that can be employed to obtain and purify them, as well as the most common applications of each.
  • 2.7K
  • 18 Jan 2023
Topic Review
Value
In social sciences, value refers to a deeply held belief or principle that guides individuals' attitudes, behaviors, and decision-making processes. Values are subjective and culturally influenced, reflecting what individuals consider important, desirable, or morally significant in their lives and interactions with others. They serve as guiding principles that shape social norms, institutions, and collective identities within society.
  • 2.7K
  • 02 Feb 2024
Topic Review
Neurological Disorders
Neurological disorders are the most devastating and challenging diseases associated with the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of the brain and contributes towards the maintenance of a very delicate microenvironment, impairing the transport of many therapeutics into the CNS and making the management of common neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebrovascular diseases (CVDs) and traumatic brain injury (TBI), exceptionally complicated.  Nanoparticle (NP) technology offers a platform for the design of tissue-specific drug carrying systems owing to its versatile and modifiable nature. The prospect of being able to design NPs capable of successfully crossing the BBB, and maintaining a high drug bioavailability in neural parenchyma, has spurred much interest in the field of nanomedicine. NPs, which also come in an array of forms including polymeric NPs, solid lipid nanoparticles (SLNs), quantum dots and liposomes, have the flexibility of being conjugated with various macromolecules, such as surfactants to confer the physical or chemical property desired. These nanodelivery strategies represent potential novel and minimally invasive approaches to the treatment and diagnosis of these neurological disorders. Most of the strategies revolve around the ability of the NPs to cross the BBB via various influx mechanisms, such as adsorptive-mediated transcytosis (AMT) and receptor-mediated transcytosis (RMT), targeting specific biomarkers or lesions unique to that pathological condition, thereby ensuring high tissue-specific targeting and minimizing off-target side effects. In this article, insights into common neurological disorders and challenges of delivering CNS drugs due to the presence of BBB is provided, before an in-depth review of nanoparticle-based theranostic strategies.
  • 2.7K
  • 05 Feb 2022
Topic Review
CD44 Receptor
CD44 is a receptor described as a single span transmembrane glycoprotein without kinase activity whose ubiquitous and constitutive expression has been observed on many different cells.
  • 2.7K
  • 18 Mar 2021
Topic Review
PEDOT:PSS Layer and Perovskite Solar Cells
Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is the most successful conducting polymer, which has been widely used in displays, transistors, various sensors and photovoltaics (PVs). It has high optical  transparency in the visible light range and low-temperature processing condition, making it one of the most widely used polymer hole transport materials inverted perovskite solar cells (PSCs), because of its high optical transparency in the visible light range and low-temperature processing condition. However, the stability of PSCs based on pristine PEDOT:PSS is far from satisfactory, which is ascribed to the acidic and hygroscopic nature of PEDOT:PSS, and property differences between PEDOT:PSS and perovskite materials, such as conductivity, work function and surface morphology. 
  • 2.7K
  • 10 Feb 2022
Topic Review
Apricot
Fruits maintain the image as the richest sources of vitamins. Focusing on apricots, utilization of apricot species for many applications is possible due to its various benefits. Many research studies demonstrated different perspectives of apricot, especially in medical used as it can act as antioxidant, anti-inflammatory, and antimicrobial agents. Moreover, in the industrial sectors, apricots can be used in the production of biofuels and batteries.
  • 2.7K
  • 18 Aug 2022
Topic Review
Hotel Food and Beverage Department Engagement with Sustainability
In the hospitality sector, particularly in the food and beverage department, pollution and consumption of scarce resources remain issues. The hotel industry has increasingly recognized the importance of addressing sustainability issues, particularly in the food and beverage (F&B) department. However, while environmental problems remain pressing, sustainability is a complex concept that is often subject to varying interpretations and lacks a clear, consistent definition.
  • 2.7K
  • 29 Jun 2023
Topic Review
Beetroot, A Remarkable Vegetable
The cardioprotective effects of dietary nitrate from beetroot in healthy and hypertensive individuals are undeniable and irrefutable. Nitrate and nitrate-derived nitrite are precursors for nitric oxide synthesis, which promotes positive effects on cardiomyocytes and myocardial ischemia/reperfusion, improving endothelial function, reducing arterial stiffness and stimulating smooth muscle relaxation, consequently decreasing systolic and diastolic blood pressures.
  • 2.7K
  • 24 Oct 2020
Topic Review
Stereoselective Synthesis of Chiral Molecules
Metal/lipase-combo catalyzed dynamic kinetic resolution (DKR) of racemic chiral alcohols is a general and practical process to obtain the corresponding enantiopure esters R with quantitative conversion. The use of known Ru-catalysts as well as newly developed homogeneous and heterogeneous metal catalysts (Fe, V) contributed to make the DKR process more sustainable and to expand the substrate scope of the reaction. In addition to classical substrates, challenging allylic alcohols, tertiary alcohols, C1-and C2-symmetric biaryl diols turned out to be competent substrates. Synthetic utility further emerged from the integration of this methodology into cascade reactions leading to linear/cyclic chiral molecules with high ee through the formation of multiple bonds, in a one-pot procedure. 
  • 2.7K
  • 08 Oct 2021
Topic Review
Responsive Traffic Signaling System Using Graph Theory/VDM-SL
The Responsive Traffic Signaling System Using Graph Theory and Vienna Development Method Specification Language (VDM-SL) is a robust traffic monitoring and signaling system that improves signal efficiency by providing a responsive scheme; appropriate routes; a mechanism for emergency vehicles and pedestrians in real-time using VDM-SL formal method and graph theory. A formal model is constructed by considering objects, such as wireless sensors and cameras that are used for collecting information. Graph theory is used to represent the network and find appropriate routes. Unified Modeling Language is used to design the system requirements. The graph-based framework is converted into a formal model by using VDM-SL. The model has been validated and analyzed using many facilities available in the VDM-SL toolbox. 
  • 2.7K
  • 01 Nov 2021
Topic Review
The Complexity of the Human–Animal Bond
The human–animal relationship is ancient, complex and multifaceted. It may have either positive effects on humans and animals or poor or even negative and detrimental effects on animals or both humans and animals. A large body of literature has investigated the beneficial effects of this relationship in which both human and animals appear to gain physical and psychological benefits from living together in a reciprocated interaction. However, analyzing the literature with a different perspective it clearly emerges that not rarely are human–animal relationships characterized by different forms and levels of discomfort and suffering for animals and, in some cases, also for people. The negative physical and psychological consequences on animals’ well-being may be very nuanced and concealed, but there are situations in which the negative consequences are clear and striking, as in the case of animal violence, abuse or neglect. Empathy, attachment and anthropomorphism are human psychological mechanisms that are considered relevant for positive and healthy relationships with animals, but when dysfunctional or pathological determine physical or psychological suffering, or both, in animals as occurs in animal hoarding.
  • 2.7K
  • 26 Oct 2022
Topic Review
Sustainable HRM in Hotels: Best Practise Model
Sustainable human resource management (SHRM) practices are still under research. It achieves a strategic advantage for the hotel business. However, a growing body of evidence indicates that SHRM practices are related to superior organization-level outcomes. There are many calls for companies to be more sustainable than traditional by transforming their resource usage intelligently to achieve added value. Hotels are investing in diverse sustainability practices to obtain returns. 
  • 2.7K
  • 28 May 2022
Topic Review
Grid-Forming Virtual Power Plants
Virtual Power Plants (VPPs) are efficient structures for attracting private investment, increasing the penetration of renewable energy and reducing the cost of electricity for consumers. It is expected that the number of VPPs will increase rapidly as their financial return is attractive to investors. VPPs will provide added value to consumers, to power systems and to electricity markets by contributing to different services such as the energy and load-following services. Grid forming inverters (GFM) are used to connect distributed energy sources and devices into a unique resource and convert it to Alternating Current. GFMs are especially suited to connecting VPPs to the main power grid.
  • 2.7K
  • 20 Dec 2022
Topic Review
Sustainable Use of RAP Materials for Pavement Construction
RAP is suitable for re-construction or re-surfacing roads. RAP contains well-graded fine aggregates covered with asphalt cement and must be properly crushed and categorised. The four most frequently used processes for recycling RAP conserve natural resources and make pavement construction sustainable.
  • 2.7K
  • 24 Jun 2022
Topic Review
Texture (Crystalline)
In materials science, texture is the distribution of crystallographic orientations of a polycrystalline sample (it is also part of the geological fabric). A sample in which these orientations are fully random is said to have no distinct texture. If the crystallographic orientations are not random, but have some preferred orientation, then the sample has a weak, moderate or strong texture. The degree is dependent on the percentage of crystals having the preferred orientation. Texture is seen in almost all engineered materials, and can have a great influence on materials properties. Also, geologic rocks show texture due to their thermo-mechanic history of formation processes. One extreme case is a complete lack of texture: a solid with perfectly random crystallite orientation will have isotropic properties at length scales sufficiently larger than the size of the crystallites. The opposite extreme is a perfect single crystal, which likely has anisotropic properties by geometric necessity.
  • 2.7K
  • 04 Nov 2022
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