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Topic Review
Efferocytosis and Biological Barriers
Similar to previous pandemics, COVID-19 has been succeeded by well-documented post-infectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and concentration difficulties. Dysfunctional efferocytosis has been associated with biological barrier disruption, inflammatory bowel disease (IBD), and a constellation of symptoms reminiscent of long COVID and other fatiguing illnesses.
  • 1.2K
  • 15 Nov 2022
Topic Review
NADPH Oxidases
NADPH oxidases (NOXs), mostly known as respiratory burst oxidase homologs (RBOHs), are the key producers of reactive oxygen species (ROS) in plants. A lot of literature has addressed ROS signaling in plant development regulation and stress responses as well as on the enzyme’s structure, evolution, function, regulation and associated mechanisms, manifesting the role of NOXs/RBOHs as the vital performers and center hubs during plant growth and signaling.
  • 1.2K
  • 20 May 2021
Topic Review
Autophagy in Human Diseases
Autophagy, a process of cellular self-digestion, delivers intracellular components including superfluous and dysfunctional proteins and organelles to the lysosome for degradation and recycling and is important to maintain cellular homeostasis. In recent decades, autophagy has been found to help fight against a variety of human diseases, but, at the same time, autophagy can also promote the procession of certain pathologies, which makes the connection between autophagy and diseases complex but interesting.
  • 1.2K
  • 06 Dec 2021
Topic Review
Beneficial Effects of Ursolic Acid against Lung Cancer
Lung cancer is the leading cause of cancer-related deaths globally. Despite current treatment approaches that include surgery, chemotherapy, radiation and immunotherapies, lung cancer accounted for 1.79 million deaths worldwide in 2020, emphasizing the urgent need to find novel agents and approaches for more effective treatment. Traditionally, chemicals derived from plants, such as paclitaxel and docetaxel, have been used in cancer treatment, and in recent years, research has focused on finding other plant-derived chemicals that can be used in the fight against lung cancer. Ursolic acid is a polyphenol found in high concentrations in cranberries and other fruits and has been demonstrated to have anti-inflammatory, antioxidant and anticancer properties. Here, researchers summarize studies examining the effects of ursolic acid and its derivatives on lung cancer. Data from in vitro cell culture and in vivo animal studies show potent anticancer effects of ursolic acid and indicate the need for clinical studies.
  • 1.2K
  • 15 Dec 2022
Topic Review
B-Cell Receptor Signaling Regulation and Aggressive B-Cell Lymphomas
The proliferation and survival signals emanating from the B-cell receptor (BCR) constitute a crucial aspect of mature lymphocyte’s life. Dysregulated BCR signaling is considered a potent contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B-NHLs). The emergence of BCR-associated kinases as rational therapeutic targets has led to the development and approval of several small molecule inhibitors targeting either Bruton’s tyrosine kinase (BTK), spleen tyrosine kinase (SYK), or phosphatidylinositol 3 kinase (PI3K), offering alternative treatment options to standard chemoimmunotherapy, and making some of these drugs valuable assets in the anti-lymphoma armamentarium. Despite their initial effectiveness, these precision medicine strategies are limited by primary resistance in aggressive B-cell lymphoma such as diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), especially in the case of first generation BTK inhibitors. In these patients, BCR-targeting drugs often fail to produce durable responses, and nearly all cases eventually progress with a dismal outcome, due to secondary resistance. 
  • 1.2K
  • 03 Mar 2022
Topic Review
SARS-CoV-2 spike protein
The article by Suresh & Suzuki (2021) describes the finding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein affecting human lung vascular cells and explains how the spike protein possibly increases the incidence of pulmonary arterial hypertension (PAH). Since the SARS-CoV-2 spike protein will be administered to millions of people as vaccines, it is critical to understand the effects of this protein on human cells to ensure that it does not promote long-term adverse health consequences.
  • 1.2K
  • 06 Jan 2021
Topic Review
Microparticles in Vascular Inflammation
Microparticles (MPs) are extracellular vesicles with a size ranging from 0.1 to 1.0 μm. They carry cargo (mRNA, DNA, lipid and specific proteins) from originating cells and transfer to recipient cells, allowing cell-to-cell communication.
  • 1.2K
  • 05 Nov 2020
Topic Review
Alternative Splicing in Cancer and Immune Cells
Splicing is a phenomenon enabling the excision of introns from pre-mRNA to give rise to mature mRNA. All the 20,000 genes of the human genome are concerned by this mechanism. Nevertheless, it is estimated that the proteome is composed of more than 100,000 proteins. How to go from 20,000 genes to more than 100,000 proteins? Alternative splicing (AS) is in charge of this diversity of proteins. AS which is found in most of the cells of an organism, participates in normal cells and in particular in immune cells, in the regulation of cellular behavior. In cancer, AS is highly dysregulated and involved in almost all of the hallmarks that characterize tumor cells.
  • 1.2K
  • 06 Apr 2022
Topic Review
Taxonomic List of Viruses
This is a taxonomic list of viruses according to the most recent (2014) taxonomy release by the International Committee on Taxonomy of Viruses (ICTV), placed into the groups of the Baltimore classification system. Though not used by the ICTV, Baltimore classification, which groups viruses together based on how they produce mRNA, is used in conjunction with the ICTV's work in modern virus classification.
  • 1.2K
  • 03 Nov 2022
Topic Review
HO-1 in Cancer Cell Survival
Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative stress for its downstream effects particularly under pro-oxidative status. Subcellular traffics of HO-1 to different organelles constitute a network of interactions compromising a variety of effectors such as pro-oxidants, ROS, mitochondrial enzymes, and nucleic transcription factors. Some of the compartmentalized HO-1 have been demonstrated as functioning in the progression of cancer. Emerging data show the multiple roles of HO-1 in tumorigenesis from pathogenesis to the progression to malignancy, metastasis, and even resistance to therapy. However, the role of HO-1 in tumorigenesis has not been systematically addressed.
  • 1.2K
  • 28 Sep 2021
Topic Review
Deciphering Tumour Heterogeneity
Decoding tumour heterogeneity is a major clinical challenge, considering that it immensely contributes to cancer progression, treatment failure and emergence of drug resistance. Emerging technical and sampling strategies have been developed in order to deeply characterise tumour complexity and clonal architecture, including single-cell profiling, multi-region sampling, representative sampling and longitudinal analysis of liquid biopsy samples.
  • 1.2K
  • 25 Mar 2022
Topic Review
Hypoxia-Inducible Factor-1α
Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process accompanied by the development of aging-related conditions such as weakness, slower metabolism, and stiffness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1α as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging.
  • 1.2K
  • 04 Aug 2021
Topic Review
TRP Channels on the Progression of Liver Diseases
The liver serves as a vital organ with a primary metabolic function. In addition, it possesses the ability to synthesize and decompose proteins, regulate overall blood volume, eliminate toxins, and regulate immunity, all of which are crucial for maintaining normal physiological activities in the human body. 
  • 1.2K
  • 25 Aug 2023
Topic Review
The Proteasome Activator PA200/PSME4
Proteasomes comprise a family of proteasomal complexes essential for maintaining protein homeostasis. Accordingly, proteasomes represent promising therapeutic targets in multiple human diseases. Several proteasome inhibitors are approved for treating hematological cancers. Their side effects impede their efficacy and broader therapeutic applications. Therefore, understanding the biology of the different proteasome complexes present in the cell is crucial for developing tailor-made inhibitors against specific proteasome complexes. 
  • 1.2K
  • 09 Sep 2022
Topic Review
Cytokinesis in Eukaryotic Cells
The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the steps of cell division must be properly coordinated with each other to faithfully segregate the genetic material and this task is fundamental for generating viable cells. Given the importance of this process, molecular pathways and proteins that are involved in cytokinesis are conserved from yeast to humans.
  • 1.2K
  • 20 May 2021
Topic Review
Activin B - Biomaker of ME/CFS
Reliable serum biomarkers are of immense need for diagnostic purposes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a disabling and complex disease for which diagnosis is mainly based on clinical symptoms. The aim of this study was to evaluate a possible diagnostic potential of activin B by directly comparing 134 cases of ME/CFS with 54 healthy controls. Analyses of human activin B level in plasma samples were performed using a validated human activin B ELISA assay. 
  • 1.2K
  • 17 Dec 2021
Topic Review
Autophagy in Parenchymal and Non-Parenchymal Liver Cells
Autophagy is a highly conserved intracellular process for the ordered degradation and recycling of cellular components in lysosomes. In the liver this process is relevant for maintaining liver homeostasis, especially in conditions of hepatic insults.
  • 1.2K
  • 17 Jan 2022
Topic Review
Astrocyte Functions
Astrocytes are stellated glial cells that interface with nearly every functional element of the brain. They are the most abundant glial cells in the brain and can comprise up to 50% of the tissue volume in some regions. Their branch-like processes surround neurons, axons, synapses, and blood vessels, and perform numerous functions that are essential for brain homeostasis and neural functioning.
  • 1.2K
  • 17 Jun 2022
Topic Review
Ribosomal Gene Loci
Nucleoli form around actively transcribed ribosomal RNA (rRNA) genes (rDNA), and the morphology and location of nucleolus-associated genomic domains (NADs) are linked to the RNA Polymerase I (Pol I) transcription status. The number of rDNA repeats (and the proportion of actively transcribed rRNA genes) is variable between cell types, individuals and disease state. Substantial changes in nucleolar morphology and size accompanied by concomitant changes in the Pol I transcription rate have long been documented during normal cell cycle progression, development and malignant transformation. 
  • 1.2K
  • 29 Jul 2021
Topic Review
Mathematical Models of Apoptosis
Apoptosis is one of the most well-studied and characterized programmed cell death mechanisms. The detailed characterization of molecular interactions involved in apoptosis, and the growing amount of related quantitative data, has encouraged computational and systems biologists to develop mathematical models of apoptosis.
  • 1.2K
  • 20 Oct 2022
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