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Topic Review
NASDAQ
The Nasdaq Stock Market (/ˈnæzˌdæk/ (listen), also known simply as Nasdaq) is an American stock exchange. It is the second-largest exchange in the world by market capitalization, behind only the New York Stock Exchange located in the same city. The exchange platform is owned by Nasdaq, Inc., which also owns the Nasdaq Nordic (formerly known as OMX) and Nasdaq Baltic stock market network and several U.S. stock and options exchanges
  • 2.9K
  • 30 Nov 2022
Biography
Peter C. Doherty
Peter Charles Doherty AC FRS FMedSci (born 15 October 1940)[1] is an Australian immunologist and Nobel laureate.[2] He received the Albert Lasker Award for Basic Medical Research in 1995, the Nobel Prize in Physiology or Medicine jointly with Rolf M. Zinkernagel[3] in 1996 and was named Australian of the Year in 1997.[4] In the Australia Day Honours of 1997, he was named a Companion of the Order
  • 2.9K
  • 08 Dec 2022
Topic Review
Bispecific Antibodies in Cancer Immunotherapy
Immunotherapy has redefined the treatment of cancer patients and it is constantly generating new advances and approaches. Among the multiple options of immunotherapy, bispecific antibodies (bsAbs) represent a novel thoughtful approach. These drugs integrate the action of the immune system in a strategy to redirect the activation of innate and adaptive immunity toward specific antigens and specific tumor locations.
  • 2.9K
  • 22 Jun 2022
Topic Review
Recent Advances in A3 Coupling with Metal Salts
Recent advances in the metal salt catalysed multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling, which yields propargylamines, a valuable organic scaffold.
  • 2.9K
  • 04 Jul 2022
Topic Review
Wonders of the World
Various lists of the Wonders of the World have been compiled from antiquity to the present day, to catalogue the world's most spectacular natural wonders and manmade structures. The Seven Wonders of the Ancient World is the first known list of the most remarkable creations of classical antiquity; it was based on guidebooks popular among Ancient Greece sightseers and only includes works located around the Mediterranean rim and in Mesopotamia. The number seven was chosen because the Greeks believed it represented perfection and plenty, and because it was the number of the five planets known anciently, plus the sun and moon. Many similar lists have been made.
  • 2.9K
  • 23 Nov 2022
Topic Review
Cognitive Behavioural Therapy for Obesity
Personalized cognitive-behavioural therapy for obesity (CBT-OB) CBT-OB is an innovative treatment designed to help patients maintain long-term weight loss by addressing some limitations of traditional behavioural treatment of obesity (BT-OB), namely the poor personalization of the intervention and the prevalent focus on helping the patients to reach behavioural change (i.e., eating and exercise habits) rather than a cognitive change oriented to long-term weight control. As such, CBT-OB includes the main procedures of traditional BT-OB, but includes new strategies and procedures, introduced according to the individual patient’s needs, to address specific cognitive processes that previous research has found be associated with treatment discontinuation, weight loss and weight maintenance. Moreover, it can be delivered in a stepped-care approach, including three levels of care (i.e., outpatient, day-hospital, and residential) to treat patients with severe and disabling obesity.
  • 2.9K
  • 29 Oct 2020
Topic Review
Side Effects of Microbial Transglutaminase
Microbial transglutaminase (mTG) is a heavily used food additive and its industrial transamidated complexes usage is rising rapidly.  It was classified as a processing aid and was granted the GRAS (generally recognized as safe) definition, thus escaping full and thorough toxic and safety evaluations. Despite the manufacturers claims, mTG or its cross-linked compounds are immunogenic, pathogenic, proinflammatory, allergenic and toxic, and pose a risk to public health. 
  • 2.9K
  • 26 Oct 2021
Topic Review
Living Anionic Polymerization
Living anionic polymerization is a living polymerization technique involving an anionic propagating species. Living anionic polymerization was demonstrated by Szwarc and co workers in 1956. Their initial work was based on the polymerization of styrene and dienes. One of the remarkable features of living anionic polymerization is that the mechanism involves no formal termination step. In the absence of impurities, the carbanion would still be active and capable of adding another monomer. The chains will remain active indefinitely unless there is inadvertent or deliberate termination or chain transfer. This gave rise to two important consequences: The following experimental criteria have been proposed as a tool for identifying a system as living polymerization system. However, in practice, even in the absence of terminating agents, the concentration of the living anions will reduce with time due to a decay mechanism termed as spontaneous termination.
  • 2.9K
  • 31 Oct 2022
Biography
Claire Wineland
Claire Lucia Wineland (April 10, 1997 – September 2, 2018) was an American activist and author. Through her non-profit organization "Claire's Place Foundation," she supported people with terminal and chronic illnesses, as well as their families.[1][2] She died from a stroke one week after a lung transplant, at the age of 21. Wineland wrote the book Every Breath I Take, Surviving and Thriving
  • 2.9K
  • 22 Nov 2022
Topic Review Peer Reviewed
SARS-CoV-2 Associated Pulmonary Pathology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel entry in the betacoronaviridae group of coronaviruses. This is the second member of this group, and the third of the family overall to emerge in the last 20 years, which has caused significant health concerns due to the clinical severity and spread of the disease it causes—coronavirus disease identified in 2019 (COVID-19). While initially emerging as a respiratory disease, and while most cases experience symptoms predominantly from this system, SARS-CoV-2 has emerged as a multisystem pathogen. From a pathomorphological point of view, the severity of changes in the respiratory system can be summed up as diffuse alveolar damage—desquamation of the alveolar epithelium with exudative and proliferative changes—pulmonary hyaline membranes, Clara cell hyperplasia, squamous cell metaplasia, and fibrosis. The second most prominent way the disease affects the lung is through endotheliitis—damage to the endothelial cells of the pulmonary vasculature, predominantly affecting the medium and large caliber blood vessels that cause the well-established clinical phenomenon of thrombosis/thromboembolism of the pulmonary vasculature. As the spread of the disease continues with the emergence of new variants and the number of cases continues to grow, including a large percentage of recurrent cases, it is essential to remember that the viral effects are not only acute but, due to the proliferative phenomena, can produce chronic sequelae. Therefore, in the background of dwindling publication interest, it is critical to focus on the histopathological aspects of the pulmonary disease, with the goal of better understanding the effects of the virus on the organism and identifying probable future complications after infection.
  • 2.9K
  • 08 Oct 2022
Topic Review
Human Schistosomiasis in Nigeria
Schistosomiasis, also known as bilharzia, is a major parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma that live in fresh waterways in tropical and subtropical zones. Over 200 million people are infected globally, 90% of whom live in sub-Saharan Africa. Nigeria has the highest burden of schistosomiasis in this region. Elimination programmes have focused on human infections, with limited attention on infections in livestock that could be transmissible to humans, i.e. zoonotic schistosomiasis. This is now recognized as a risk factor for increased transmission and recrudescence of infection of more than one schistosome species, as well as of potential hybrid variants. Members of farming communities who herd grazing cattle, goats and sheep in proximity to rivers containing Bulinus freshwater snails that are the intermediate host of asexual lifecycle stages are particularly at risk of becoming infected through daily contact with contaminated water.
  • 2.9K
  • 21 Feb 2023
Topic Review
Lactic Acid Fermentation on Food
The microbial and biochemical changes in different fermented foods due to the fermenting microorganisms. It has been a matter of study because it contributes to the enhancement of nutritional content in fermented foods due to various fermenting microorganisms that results in the modifications of foods ecosystems like on flavour, rheology, and shelf-life, as well as on the functional/nutritional characteristics of the foods. Fermentation technique has been used for centuries to upgrade food materials and to formulate a more acceptable product. It helps in the successful degradation of anti-nutritive compounds present in the fermented foods thus making it safe and consumable. This entry will help to know more about the potential of fermented foods to increase substantially the nutritional value of the world's most abundant food resources. The fermentation process has converted the unpalatable food materials into attractive and nutritious foods to add variety and flavour to monotonous staple dishes. It also enhances the nutritional value of foods in terms of vitamins, antioxidants, volatile compounds and minerals, etc. This entry may promote microbial and biochemical changes in fermented foods in a broad manner that helps to understand the overall beneficial effect of microorganisms on fermented foods. 
  • 2.9K
  • 13 Dec 2020
Topic Review
Immunotherapy in Breast Cancer
Breast cancer is a cancer that develops from breast tissue. Symptoms of breast cancer may include a breast lump, a change in the shape of the breast, sunken skin, fluid leaking from the nipple, new sunken nipple, or red or scaly patches on the skin. Distant spread may present with bone pain, swollen lymph nodes, shortness of breath, or yellowing of the skin. Breast cancer is very complex and includes several subtypes with distinct pathological features. Most of the immunotherapy efforts have focused on the most immunogenic subtypes: triple-negative breast cancer and HER2-positive breast cancer.
  • 2.9K
  • 12 Apr 2022
Topic Review
Health Insurance Portability and Accountability Act
The Health Insurance Portability and Accountability Act of 1996 (HIPAA or the Kennedy–Kassebaum Act) is a United States federal statute enacted by the 104th United States Congress and signed into law by President Bill Clinton on August 21, 1996. It modernized the flow of healthcare information, stipulates how personally identifiable information maintained by the healthcare and healthcare insurance industries should be protected from fraud and theft, and addressed some limitations on healthcare insurance coverage. It generally prohibits healthcare providers and healthcare businesses, called covered entities, from disclosing protected information to anyone other than a patient and the patient's authorized representatives without their consent. With limited exceptions, it does not restrict patients from receiving information about themselves. It does not prohibit patients from voluntarily sharing their health information however they choose, nor does it require confidentiality where a patient discloses medical information to family members, friends, or other individuals not a part of a covered entity. The act consists of five titles. Title I of HIPAA protects health insurance coverage for workers and their families when they change or lose their jobs. Title II of HIPAA, known as the Administrative Simplification (AS) provisions, requires the establishment of national standards for electronic health care transactions and national identifiers for providers, health insurance plans, and employers. Title III sets guidelines for pre-tax medical spending accounts, Title IV sets guidelines for group health plans, and Title V governs company-owned life insurance policies.
  • 2.9K
  • 21 Oct 2022
Biography
Zera Yacob
Zera Yacob (/ˈzɪərə jæˈkoʊb/; Ge'ez: ዘርአ ፡ ያዕቆብ zar'ā yāʿiqōb "Seed of Jacob," modern Zer'a Yā'iqōb; also spelled Zärˀä Yaˁqob, Zar'a Ya'aqob, or Zar'a Ya'eqob; 31 August 1599 – 1692) was a seventeenth-century Ethiopian philosopher from the city Aksum. His 1667 treatise, developed around 1630 and known in the original Ge'ez language as the Hatata (Inquiry), has
  • 2.9K
  • 15 Nov 2022
Topic Review
Saman (Deity)
Saman (also called Sumana, Sumana Saman, Sinhala: සුමන සමන් දෙවි) is a deity, subject to local and indigenous belief and worship in Sri Lanka. The name Saman means "the rising morning sun". His character is of historical significance for the Sinhala people and veneration especially to all the Buddhists. God Maha Sumana Saman is depicted crowned, bejeweled, holding a lotus flower in his right or left hand and accompanied by a white elephant. According to Mahavamsa, the early chronicle of Sri Lanka, Saman is considered as one of the guardian deities of the island and Buddhism in the country. Natha, Upulvan, Vibhishana and Kataragama are the other guardian deities. Nayakkar dynasty from South India introduced the goddess Pattini replacing god Saman, during the period of Kandyan Kingdom. Saman is the guardian (patron deity) or the presiding deity of Sabaragamuwa and the Sri Pada mountain. Accordingly, his main shrine or devalaya is at Ratnapura, where an annual festival is held in his honor. Another major shrine dedicated to god Saman is situated at Mahiyangana in Uva Province of Sri Lanka. Saman is known as Samantabhadra in East Asia under the names, Pǔxián Púsà in Chinese, Fugen in Japanese, Bohyun Bosal in Korean, Kun-tu bzang-po in Tibetan and Phổ Hiền Bồ Tát in Vietnamese.
  • 2.9K
  • 21 Nov 2022
Topic Review
Mechanisms of Exosome Biogenesis
Exosomes are nanometer-sized vesicles released by different cells that are important in the normal functioning of the body. In cancer, exosomes have been found to promote tumor growth and metastasis by carrying functional biomolecules and acting on different target sites in the body. Understanding the mechanism by which cancers modulate exosome secretion is crucial to studying cancer biology and developing new therapeutic approaches.
  • 2.9K
  • 18 Apr 2023
Topic Review
Sonic Boom Prediction and Minimization
NASA describes the sonic boom as “thunder-like noise a person on the ground hears when an aircraft […] flies overhead faster than the speed of sound”. Sonic boom results from the coalescence of the shock waves generated by an aircraft flying supersonicly trough their propagation into the atmosphere to the ground.
  • 2.9K
  • 08 Nov 2023
Topic Review
Phenol
Phenol and its derivatives are hazardous, teratogenic and mutagenic, and have gained significant attention in recent years due to their high toxicity even at low concentrations. Phenolic compounds appear in petroleum refinery wastewater from several sources, such as the neutralized spent caustic waste streams, the tank water drain, the desalter effluent and the production unit. Therefore, effective treatments of such wastewaters are crucial. Conventional techniques used to treat these wastewaters pose several drawbacks, such as incomplete or low efficient removal of phenols.
  • 2.9K
  • 30 Aug 2021
Topic Review
Entropy and Banks' Income Diversification
We collected data pertaining to Chinese listed commercial banks from 2008 to 2016 and found that the competition between banks is becoming increasingly fierce. Commercial banks have actively carried out diversification strategies for greater returns, and the financial reports show that profits are increasingly coming from the non-interest income benefits of diversification strategies. However, diversification comes with risk. We built a panel threshold model and investigated the effect of income diversification on a bank’s profitability and risk. Diversification was first measured by the Herfindahl–Hirschman index (HHI), and the results show that there is a nonlinear relationship between diversification and profitability or risk does exist. We introduced an interesting index based on the entropy to test the robustness of our model and found that a threshold effect exists in both our models, which is statistically significant. We believe the combination of the entropy index (ENTI) and the HHI enables more efficient study of the relationship between diversification and profitability or risk more efficiently. Bankers and their customers have increasingly been interested in income diversification, and they value risk as well. We suggest that banks of different sizes should adopt the corresponding diversification strategy to achieve sustainable development.
  • 2.9K
  • 02 Nov 2020
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