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Topic Review
Cyanine Derived Dyes
Cyanine dyes are compounds that typically absorb light in the visible to near-infrared-I (NIR-I) spectrum range (750–900 nm).
  • 3.0K
  • 09 Jul 2021
Topic Review
Monoculture
Monoculture is the agricultural practice of producing or growing a single crop, plant, or livestock species, variety, or breed in a field or farming system at a time. Polyculture, where more than one crop is grown in the same space at the same time, is the alternative to monoculture. Monoculture is widely used in both industrial farming and organic farming and has allowed increased efficiency in planting and harvest. Continuous monoculture, or monocropping, where the same species is grown year after year, can lead to the quicker buildup of pests and diseases, and then rapid spread where a uniform crop is susceptible to a pathogen. The practice has been criticized for its environmental effects and for putting the food supply chain at risk. Diversity can be added both in time, as with a crop rotation or sequence, or in space, with a polyculture. Oligoculture has been suggested to describe a crop rotation of just a few crops, as is practiced by several regions of the world. The term monoculture is frequently applied for other uses to describe any group dominated by a single variety, e.g. social monoculturalism, or in the field of musicology to describe the dominance of the American and British music-industries in Western pop music, or in the field of computer science to describe a group of computers all running identical software.
  • 3.0K
  • 28 Nov 2022
Topic Review
Methyl Benzoate as Insecticide
The methyl benzoate is an effective pesticide against a range of different agricultural, stored product, and urban insect pests. Methyl benzoate has several important modes of action, including as a contact toxicant, a fumigant, an ovicidal toxin, an oviposition deterrent, a repellent, and an attractant.
  • 3.0K
  • 31 Mar 2022
Topic Review
Near-Infrared Spectrum of Olive Oils
Olive oil is regarded as one of the healthiest food oils due to its high content in triglycerides with unsaturated acids, mainly oleic acid, and its phenolic composition. The analysis of the physico-chemical parameters of quality of olive oil is still carried out in laboratories using chemicals and generating waste, which is relatively costly and time-consuming. Among the various alternatives for the online or on-site measurement of these parameters, the available literature highlights the use of near-infrared spectroscopy (NIRS). 
  • 3.0K
  • 18 Apr 2022
Topic Review
P62
P62 is a versatile protein involved in the delicate balance between cell death and survival, which is fundamental for cell fate decision in the context of both cancer and neurodegenerative diseases. As an autophagy adaptor, p62 recognizes polyubiquitin chains and interacts with LC3, thereby targeting the selected cargo to the autophagosome with consequent autophagic degradation. Beside this function, p62 behaves as an interactive hub in multiple signalling including those mediated by Nrf2, NF-κB, caspase-8, and mTORC1. The protein is thus crucial for the control of oxidative stress, inflammation and cell survival, apoptosis, and metabolic reprogramming, respectively. As a multifunctional protein, p62 falls into the category of those factors that can exert opposite roles in the cells. Chronic p62 accumulation was found in many types of tumors as well as in stress granules present in different forms of neurodegenerative diseases. However, the protein seems to have a Janus behaviour since it may also serve protective functions against tumorigenesis or neurodegeneration. 
  • 3.0K
  • 04 Aug 2020
Topic Review
Consumer–Brand Congruence and Consumer-Celebrity Congruence
The consumer–celebrity congruence moderated the indirect effect of consumer–brand congruence on brand preference and boycott recommendations, but not purchase intention. When brands practice CSA, consumer–brand congruence rather than consumer–celebrity congruence could play a more important role in shaping consumer behaviors.
  • 3.0K
  • 28 Feb 2022
Topic Review
Mechanisms of CYP450 Inhibition
In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of adverse drug events, mainly from drug–drug interactions. The majority of currently available drugs are metabolized by CYP450 enzymes. Interactions due to shared CYP450-mediated metabolic pathways for two or more drugs are frequent, especially through reversible or irreversible CYP450 inhibition. The magnitude of these interactions depends on several factors, including varying affinity and concentration of substrates, time delay between the administration of the drugs, and mechanisms of CYP450 inhibition. Various types of CYP450 inhibition (competitive, non-competitive, mechanism-based) have been observed clinically, and interactions of these types require a distinct clinical management strategy.
  • 3.0K
  • 17 May 2021
Topic Review
Astaxanthin on Human Skin Ageing
Skin ageing is becoming a global challenge due to longer human longevity and intensive ultra-violet rays contributed to the ozone layer destruction, attracting greater scientific interests in developing nutricoesmetic products, especially from natural functional ingredients with lower side-effects. Astaxanthin, a carotenoid with high antioxidant and anti-inflammatory effects, which could be extracted from the byproduct of processed crustaceans, prevented skin photoaging and age-related skin diseases in the animal models. But these byproducts are generally discarded as marine waste, losing potentially valuable ingredients, and causing serious environmental problems by accumulating high amounts of organic materials. ASX may have cosmetical potential to prevent or reverse human skin ageing, which has been evaluated in several previous papers. Here, we conducted a systemic review and meta-analysis to help clarify its human skincare effects, which promote marine waste recycling, environmental protection, and sustainable development.   
  • 3.0K
  • 09 Sep 2021
Topic Review
Bump Fire
Bump fire is the act of using the recoil of a semi-automatic firearm to fire shots in rapid succession, which simulates the rate of fire of a fully automatic firearm. Bump fire gunstocks are of varying legality in the United States. The Department of Justice announced a plan on March 23, 2018 to classify bump stocks as "machine guns" and effectively ban them nationwide under existing federal law. If the rule becomes final, existing bump stocks would be required to be destroyed or surrendered by both manufacturers and individual owners. On April 17, 2018, Slide Fire Solutions, the sole holder of the bump stock patent, announced that it would cease production of bump stocks as of May 20, though they did not state whether this was a temporary or permanent measure. It has temporarily suspended production before.
  • 3.0K
  • 28 Oct 2022
Biography
Harold G. White
Harold G. "Sonny" White is a mechanical engineer, aerospace engineer and applied physicist who is the Advanced Propulsion Team Lead for the NASA Engineering Directorate and is known for proposing new Alcubierre drive concepts and promoting advanced propulsion projects, under development at the NASA Johnson Space Center, including the first practical experiment to test the existence of Alcubierre
  • 3.0K
  • 17 Nov 2022
Topic Review
Gearbox Technologies for Tidal Energy Harvesting
Gearboxes are widely used in automobile, aerospace, energy, and process industries and are considered indispensable. Tidal flows always have very low speeds that rarely exceed 5 m/s. Lower tidal speeds result in lower turbine rotation speeds. Therefore, if conventional generators are used to produce electricity, gearboxes are necessary to achieve higher rotor speeds. 
  • 3.0K
  • 26 Dec 2022
Topic Review
Equine Piroplasmosis
Equine piroplasmosis (EP), caused by the hemoparasites Theileria equi, Theileria haneyi, and Babesia caballi, is an important tick-borne disease of equines that is prevalent in most parts of the world. Infection may affect animal welfare and has economic impacts related to limitations in horse transport between endemic and non-endemic regions, reduced performance of sport horses and treatment costs.
  • 3.0K
  • 26 Nov 2020
Topic Review
HIV-1 Capsid Protein
The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors. Capsid shields the reverse transcription complex from restriction factors while it enables trafficking to the nucleus by hijacking various adaptor proteins, such as FEZ1 and BICD2. In addition, the capsid facilitates the import and localization of the viral complex in the nucleus through interaction with NUP153, NUP358, TNPO3, and CPSF-6. In the later stages of the HIV-1 life cycle, CA plays an essential role in the maturation step as a constituent of the Gag polyprotein. In the final phase of maturation, Gag is cleaved, and CA is released, allowing for the assembly of CA into a fullerene cone, known as the capsid core. The fullerene cone consists of ~250 CA hexamers and 12 CA pentamers and encloses the viral genome and other essential viral proteins for the next round of infection. As research continues to elucidate the role of CA in the HIV-1 life cycle and the importance of the capsid protein becomes more apparent, CA displays potential as a therapeutic target for the development of HIV-1 inhibitors.
  • 3.0K
  • 20 Feb 2021
Topic Review
Nucleotide Excision Repair
Nucleotide excision repair (NER) is the most versatile DNA repair pathway, which can remove diverse bulky DNA lesions destabilizing a DNA duplex. NER substrates are UV photoproducts, e.g., cyclobutane pyrimidine dimers (CPDs), pyrimidine-pyrimidone-(6-4)-photoproducts (6-4PPs), intrastrand crosslinks, and bulky adducts of DNA bases with reactive metabolites of some chemical carcinogens or chemotherapeutic agents. These kinds of lesions can be substrates for two NER sub-pathways—global genome NER (GG-NER) and transcription-coupled NER (TC-NER)—that overlap, except for the mode of DNA damage recognition. NER defects cause several autosomal recessive genetic disorders. Xeroderma pigmentosum (XP) is one of the NER-associated syndromes characterized by low efficiency of the removal of bulky DNA adducts generated by ultraviolet radiation. XP patients have extremely high ultraviolet-light sensitivity of sun-exposed tissues, often resulting in multiple skin and eye cancers.
  • 3.0K
  • 12 Oct 2021
Topic Review
Thermal Denaturation of Milk Whey Proteins: Rapid Quantification
Heat treatment of milk signifies a certain degree of protein denaturation, which modifies the functional properties of dairy products. Traditional methods for detecting and quantifying the denaturation of whey proteins are slow, complex and require sample preparation and qualified staff. The world’s current trend is to develop rapid, real-time analytical methods that do not destroy the sample and can be applied on/in-line during processing.
  • 3.0K
  • 03 Aug 2022
Topic Review
Solid Lipid Nanoparticle Preparation Techniques
Solid lipid nanoparticles (SLNs) are an alternate carrier system to liposomes, polymeric nanoparticles, and inorganic carriers. SLNs have attracted increasing attention for delivering drugs, nucleic acids, proteins, peptides, nutraceuticals, and cosmetics. These nanocarriers have attracted industrial attention due to their ease of preparation, physicochemical stability, and scalability. These characteristics make SLNs attractive for manufacture on a large scale. 
  • 3.0K
  • 23 Sep 2022
Topic Review
Aydın
Aydın (/ˈaɪdɪn/ EYE-din; Turkish: [ˈajdɯn]; formerly named Güzelhisar, Ancient and Modern Greek: Τράλλεις /Tralleis/) is a city in and the seat of Aydın Province in Turkey's Aegean Region. The city is located at the heart of the lower valley of Büyük Menderes River (ancient Meander River) at a commanding position for the region extending from the uplands of the valley down to the seacoast. Its population was 207,554 in 2014. Aydın city is located along a region which was famous for its fertility and productivity since ancient times. Figs remain the province's best-known crop, although other agricultural products are also grown intensively and the city has some light industry. At the crossroads of a busy transport network of several types, a six-lane motorway connects Aydın to İzmir, Turkey's second port, in less than an hour, and in still less time to the international Adnan Menderes Airport, located along the road between the two cities. A smaller airport, namely Aydın Airport, is located a few kilometers in the South-East of Aydın. The region of Aydın also pioneered the introduction of railways into Turkey in the 19th century and still has the densest railroad network. The province of Aydın is also where a number of internationally known historic sites and centers of tourism are concentrated.
  • 3.0K
  • 18 Nov 2022
Topic Review
Optical Sensors for Oil/Gas Applications
The sensing requirements of the Oil & Gas industry for improved sensing in deeper zones include increased transmission length, improved spatial coverage and integration of multiple sensors with multimodal sensing capability. This imposes problems like signal attenuation, crosstalks and cross sensitivities. Optical fibre-based sensors are expected to provide superior sensing capabilities compared to traditional electrical sensors. 
  • 3.0K
  • 26 Sep 2021
Topic Review
Internet Addiction Disorder
Internet addiction disorder (IAD), sometimes also called pathologic/problematic internet use (PIU), is widely defined in terms of an impulse control disorder characterized by uncontrolled Internet use. The disorder is associated with significant functional impairment and/or clinically measurable distress, anxiety, depression, and other psychopathological symptom.
  • 3.0K
  • 30 Oct 2020
Topic Review
Reversible Hydrogen Storage
In the field of energy storage, recently investigated nanocomposites show promise in terms of high hydrogen uptake and release with enhancement in the reaction kinetics. Among several, carbonaceous nanovariants like carbon nanotubes (CNTs), fullerenes, and graphitic nanofibers reveal reversible hydrogen sorption characteristics at 77 K, due to their van der Waals interaction. The spillover mechanism combining Pd nanoparticles on the host metal-organic framework (MOF) show at room temperature uptake of hydrogen. Metal or complex hydrides either in the nanocomposite form and its subset, nanocatalyst dispersed alloy phases illustrate the concept of nanoengineering and nanoconfinement of particles with tailor-made properties for reversible hydrogen storage. Another class of materials comprising polymeric nanostructures such as conducting polyaniline and their functionalized nanocomposites are versatile hydrogen storage materials because of their unique size, high specific surface-area, pore-volume, and bulk properties. The salient features of nanocomposite materials for reversible hydrogen storage are reviewed and discussed.
  • 3.0K
  • 22 Jul 2020
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