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Topic Review
N,N-Dimethylacrylamide-Based Hydrogels
N,N-dimethylacrylamide produces hydrogel when polymerized with cross-linkers. Moreover, poly(N,N-dimethylacrylamide) has gotten a lot of attention as it is commonly used as the hydrophilic side of copolymers due to its unique properties and high water solubility. In addition, van der Waals interactions between N,N-dimethylacrylamide and dye molecules even more increase the applicability of DMAA hydrogels.
  • 3.0K
  • 03 Dec 2021
Topic Review
Thia-Michael Reaction
While the Michael addition has been employed for more than 130 years for the synthesis of a vast diversity of compounds, the reversibility of this reaction when heteronucleophiles are involved has been generally less considered. First applied to medicinal chemistry, the reversible character of the hetero-Michael reactions has been explored for the synthesis of Covalent Adaptable Networks (CANs), in particular the thia-Michael reaction and more recently the aza-Michael reaction. In these cross-linked networks, exchange reactions take place between two Michael adducts by successive dissociation and association steps. In order to understand and precisely control the exchange in these CANs, it is necessary to get an insight into the critical parameters influencing the Michael addition and the dissociation rates of Michael adducts by reconsidering previous studies on these matters. 
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  • 28 Nov 2022
Topic Review
Implications of Sphingolipid Metabolites in Kidney Diseases
Sphingolipids (SLs) are lipids with complex structures which were named after their sphinx-like structure by Thudichium in 1870. Lipids are major components of membranes in all eukaryotic cells determining the structural and functional integrity of cells. SLs are one of the important structural components of plasma membranes in all eukaryotes, but they also act as bioactive signaling molecules with numerous cellular physiological functions that include cell adhesion, cell proliferation, cell migration, inflammatory response and apoptosis. Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can be lethal to cells. Abnormalities in the levels of sphingolipids are associated with several human diseases including kidney diseases. Several studies demonstrate that sphingolipids play an important role in maintaining proper renal function. Sphingolipids can alter the glomerular filtration barrier by affecting the functioning of podocytes, which are key cellular components of the glomerular filtration barrier. 
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  • 29 Apr 2022
Topic Review
Online Hate Speech
Online hate speech is a type of speech that takes place online with the purpose of attacking a person or a group based on their race, religion, ethnic origin, sexual orientation, disability, or gender. Online hate speech is the expression of conflicts between different groups within and across societies. Online hate speech is a vivid example of how the Internet brings both opportunities and challenges regarding the freedom of expression and speech while also defending human dignity. Multilateral treaties such as the International Covenant on Civil and Political Rights (ICCPR) have sought to define its contours. Multi-stakeholders processes (e.g. the Rabat Plan of Action) have tried to bring greater clarity and suggested mechanisms to identify hateful messages. Yet, hate speech is still a generic term in everyday discourse, mixing concrete threats to individuals and/or groups with cases in which people may be simply venting their anger against authority. Internet intermediaries—organizations that mediate online communication such as Facebook, Twitter, and Google—have advanced their own definitions of hate speech that bind users to a set of rules and allow companies to limit certain forms of expression. National and regional bodies have sought to promote understandings of the term that are more rooted in local traditions. The Internet's speed and reach makes it difficult for governments to enforce national legislation in the virtual world. Social media is a private space for public expression, which makes it difficult for regulators. Some of the companies owning these spaces have become more responsive towards tackling the problem of hate speech online. Politicians, activists, and academics discuss the character of online hate speech and its relation to offline speech and action, but the debates tend to be removed from systematic empirical evidence. The character of perceived hate speech and its possible consequences has led to placing much emphasis on the solutions to the problem and on how they should be grounded in international human rights norms. Yet this very focus has also limited deeper attempts to understand the causes underlying the phenomenon and the dynamics through which certain types of content emerge, diffuse and lead—or not—to actual discrimination, hostility or violence. Online hate speech has been on the rise since the start of 2020, with COVID-19 tensions, Anti-Asian rhetoric, ongoing racial injustice, mass civil unrest, violence, and the 2020 Presidential Election. Yet, many instances of hate speech have been refuted with the First Amendment, which allows online hate speech to continue.
  • 3.0K
  • 31 Oct 2022
Topic Review
Bayonetta
Bayonetta is an action hack and slash video game developed by PlatinumGames and published by Sega. The game was originally released for Xbox 360 and PlayStation 3 in Japan in October 2009, and in North America and Europe in January 2010. The game was later released on the Wii U alongside its sequel, Bayonetta 2, releasing in September 2014 in Japan and worldwide the following month - the two games were later released worldwide on the Nintendo Switch in February 2018. An enhanced port for Windows was released in April 2017 with 4K support. A remastered version of Bayonetta as well as another PlatinumGames title, Vanquish, was released for PlayStation 4 and Xbox One on February 18, 2020, as part of a compilation to celebrate the 10th anniversary of the game. Bayonetta takes place in Vigrid, a fictional city in Europe. The game stars the eponymous character, a witch who is capable of shapeshifting and using various firearms. She possesses magical attacks, and she can use her hair to summon demons to dispatch her foes. It features a rating system, which gives players a grade based on their performance, and a combat system that is similar to the Devil May Cry series. Development of the game was started in January 2007, with Hideki Kamiya being the game's director. According to Kamiya, the game was completely original, though he drew some inspirations from Scandinavian mythology, and played Devil May Cry 4 for reference. The game's theme is "sexiness" and "partial nudity", and that the characters were designed to be "fashionable". Kamiya and artist Mari Shimazaki spent more than a year to create Bayonetta's design. Several demos were released for the game prior to its launch. Bayonetta was the third project released by PlatinumGames, which was founded by former Clover Studio employees. Upon release, the game received generally positive reviews. The game was praised for its combat, presentation and soundtrack, but drew criticism for its story and quick time events. Bayonetta was nominated for and won several end-of-the-year accolades, and had sold over a million units worldwide by 2010. An anime film adaptation of the game by Gonzo, titled Bayonetta: Bloody Fate, was released in Japan in November 2013. A third game, Bayonetta 3, is in development for the Switch.
  • 3.0K
  • 22 Nov 2022
Biography
Brian Krzanich
Brian Matthew Krzanich (born May 9, 1960) is the former chief executive officer (CEO) of Intel. He joined the company as an engineer in 1982, and served as chief operating officer before being promoted to CEO. As CEO, Krzanich was credited for diversifying Intel's product offerings and workforce. Krzanich has served on the Deere & Co. and Semiconductor Industry Association boards, as well as the
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  • 05 Dec 2022
Topic Review
Cyanine Derived Dyes
Cyanine dyes are compounds that typically absorb light in the visible to near-infrared-I (NIR-I) spectrum range (750–900 nm).
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  • 09 Jul 2021
Topic Review
Culture in Maintenance Management of Public Buildings
Culture is one of the significant elements that influence the behavior of doing things the right way, without which there is a hindrance to the attainment of set goals. It has also been stated that culture is essential to maintaining public buildings, which is significant to national development. However, the level of abandonment and deterioration of public buildings is high due to a lack of culture among stakeholders in the maintenance process.
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  • 08 Jun 2022
Topic Review
Honey for Antimicrobial and Wound Healing Applications
Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey’s antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey’s active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). 
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  • 29 Aug 2022
Topic Review
Allium sativum (Garlic)
Garlic (Allium sativum) is an ancient civilised plant, originated from the Asian continent between the Mediterranean and China over 600 years ago. Humans use garlic as a medicinal herb in food as well as to relieve from pain and physical and emotional stress. Currently, people are looking for alternative natural medicine.
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  • 08 Feb 2021
Topic Review
Equine Piroplasmosis
Equine piroplasmosis (EP), caused by the hemoparasites Theileria equi, Theileria haneyi, and Babesia caballi, is an important tick-borne disease of equines that is prevalent in most parts of the world. Infection may affect animal welfare and has economic impacts related to limitations in horse transport between endemic and non-endemic regions, reduced performance of sport horses and treatment costs.
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  • 26 Nov 2020
Topic Review
Brain Lymphatic Drainage System
In 2012, Iliff et al., for the first time, identified a novel structure in the brain called the glymphatic system. This system is considered as a crucial fluid-clearance system in the brain.
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  • 07 Apr 2022
Topic Review
Microencapsulation
Microencapsulation is a well-known technology for the lipid delivery system. It prevents the oxidation of fatty acids and maintains the quality of lipid after extraction from oil seed and processing. In flaxseed oil, the amount of ω-3 and ω-6 polyunsaturated fatty acids are 39.90–60.42% and 12.25–17.44%, respectively.
  • 3.0K
  • 18 Feb 2021
Topic Review
King Cherry
King cherry (Cerasus × nudiflora, 왕벚 wangbeoj, 왕벚나무 wangbeojnamu or 왕벚꽃 wangbeojkkoch) is a Korean native cherry tree originated from Jeju Island. It is a distinct species from Japanese native Yoshino cherry. King cherry is a rare plant and listed as an endangered species. As of April 2017, 194 King cherry trees were growing around Mt. Halla in Jeju Island. According to Gen-ichi Koidzumi, King cherry is erroneously believed to be discovered by a French missionary Emile Taquet although what he discovered was a different species. There have been disputes over the origin of king cherry and Yoshino cherry. In 2007, a study conducted on the comparison of king cherry and Yoshino cherry concluded that these trees were categorized as distinct species. However, South Korean media assert that King cherry is the same species as Yoshino cherry. In Korea most of the places for cherry blossom festivals, including Yeouido and Jinhae, are still planted with Japanese Yoshino cherry trees.
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  • 01 Nov 2022
Topic Review
Abiraterone
Abiraterone, also known as abiraterone acetate and sold under the brand name Zytiga among others, is a medication used to treat prostate cancer. Specifically it is used together with corticosteroid for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC). It should either be used following removal of the testicles or along with a gonadotropin-releasing hormone (GnRH) analog. It is taken by mouth. Common side effects include tiredness, vomiting, headache, joint pain, high blood pressure, swelling, low blood potassium, high blood sugar, hot flashes, diarrhea, and cough. Other severe side effects may include liver failure and adrenocortical insufficiency. In males who partners can become pregnant, birth control is recommended. Supplied as abiraterone acetate it is converted in the body to abiraterone. Abiraterone works by suppressing the production of androgens – specifically it inhibits CYP17A1 – and thereby decreases the production of testosterone. In doing so, it prevents the effects of these hormones in prostate cancer. Abiraterone was described in 1995, and approved for medical use in the United States and Europe in 2011. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. In the United Kingdom it costs the NHS £2,735 a month as of 2018. In the United States this amount costs US$3,276 as of 2019. The medication is marketed widely throughout the world.
  • 3.0K
  • 14 Nov 2022
Topic Review
Bioglass
Bioglass 45S5, commonly referred to by its commercial name Bioglass, is a glass specifically composed of 45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O, and 6.0 wt% P2O5.  Glasses are non-crystalline amorphous solids that are commonly composed of silica-based materials with other minor additives.  Compared to soda-lime glass (commonly used, as in windows or bottles), Bioglass 45S5 contains less silica and higher amounts of calcium and phosphorus.  The 45S5 name signifies glass with 45 weight % of SiO2 and 5:1 molar ratio of calcium to phosphorus.  This high ratio of calcium to phosphorus promotes formation of apatite crystals; calcium and silica ions can act as crystallization nuclei.  Lower Ca:P ratios do not bond to bone.  Bioglass 45S5's specific composition is optimal in biomedical applications because of its similar composition to that of hydroxyapatite, the mineral component of bone. This similarity provides Bioglass' ability to be integrated with living bone. This composition of bioactive glass is comparatively soft in comparison to other glasses. It can be machined, preferably with diamond tools, or ground to powder. Bioglass has to be stored in a dry environment, as it readily absorbs moisture and reacts with it. Bioglass 45S5 is the first formulation of an artificial material that was found to chemically bond with bone. One of its main medical advantages is its biocompatibility, seen in its ability to avoid an immune reaction and fibrous encapsulation. Its primary application is the repair of bone injuries or defects too large to be regenerated by the natural process. The first successful surgical use of Bioglass 45S5 was in replacement of ossicles in the middle ear, as a treatment of conductive hearing loss. Other uses include cones for implantation into the jaw following a tooth extraction. Composite materials made of Bioglass 45S5 and patient's own bone can be used for bone reconstruction. Further research is being conducted for the development of new processing techniques to allow for more applications of Bioglass.
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  • 01 Nov 2022
Topic Review
Control Strategy for High Speed On/off Valves
Digital hydraulic technology is considered to be a potential solution to replace traditional hydraulic servo control technology in the “Industry 4.0” era. Digital valves mainly consist of incremental digital valves and high speed on/off valves (HSV), of which the former have been abandoned by academia and industry due to its low-frequency and tendency to become out-of-step. 
  • 3.0K
  • 28 Jan 2023
Topic Review
Health Benefits of Chlorophylls and Chlorophyll-Rich Agro-Food
Chlorophylls play a crucial role in photosynthesis and are abundantly found in green fruits and vegetables that form an integral part of our diet. Although limited, existing studies suggest that these photosynthetic pigments and their derivatives possess therapeutic properties. These bioactive molecules exhibit a wide range of beneficial effects, including antioxidant, antimutagenic, antigenotoxic, anti-cancer, and anti-obesogenic activities.
  • 3.0K
  • 10 Aug 2023
Topic Review
Cyclic AMP in Plants
The cyclic nucleotide cAMP (3′,5′-cyclic adenosine monophosphate) is nowadays recognised as an important signalling molecule in plants, involved in many molecular processes, including sensing and response to biotic and abiotic environmental stresses. The validation of a functional cAMP-dependent signalling system in higher plants has spurred a great scientific interest on the polyhedral role of cAMP, as it actively participates in plant adaptation to external stimuli, in addition to the regulation of physiological processes. The complex architecture of cAMP-dependent pathways is far from being fully understood, because the actors of these pathways and their downstream target proteins remain largely unidentified. Recently, a genetic strategy was effectively used to lower cAMP cytosolic levels and hence shed light on the consequences of cAMP deficiency in plant cells. This review aims to provide an integrated overview of the current state of knowledge on cAMP’s role in plant growth and response to environmental stress. Current knowledge of the molecular components and the mechanisms of cAMP signalling events is summarised.
  • 3.0K
  • 23 May 2021
Topic Review
Sludge Treatment Reed Beds
Sludge Treatment Reed Beds (STRB) represent a state-of-the-art nature-based solution to sludge treatment and management. It is an effective, economical (i.e., of low investment, operation and maintenance cost, and low energy consumption), environmentally friendly, and technically efficient technology. In STRBs, the sludge is applied to a growing stand of reeds under controlled conditions. The method relies on the exploitation of the transpiring and aerating capabilities of the reeds, which absorb moisture and nutrients from the sludge for their growth. Additionally, the sludge is dewatered by drainage through the underlying gravel layers, and evaporation from the sludge surface. In the long run, the sludge is oxidized and its organic matter content decreases. The final solids content of the dewatered sludge can build up to and exceed 40%, depending on the sludge loading rate and the climate. STRB operational life is usually at least 30 years and is divided into two or three operational phases of 8-12 years. At the end of each operational phase, the accumulated residual sludge is removed and recycled typically in agriculture and the STRB is emptied.
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  • 01 Apr 2021
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