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Topic Review
Women's Studies
Women's studies is an academic field that draws on feminist and interdisciplinary methods in order to place women’s lives and experiences at the center of study, while examining social and cultural constructs of gender; systems of privilege and oppression; and the relationships between power and gender as they intersect with other identities and social locations such as race, sexual orientation, socio-economic class, and disability. Popular theories within the field of women's studies include feminist theory, standpoint theory, intersectionality, multiculturalism, transnational feminism, social justice, affect studies, agency, biopolitics, materialisms, and embodiment. Research practices and methodologies associated with women's studies include ethnography, autoethnography, focus groups, surveys, community-based research, discourse analysis, and reading practices associated with critical theory, post-structuralism, and queer theory. The field researches and critiques societal norms of gender, race, class, sexuality, and other social inequalities. Women's studies is closely related to the fields of gender studies, feminist studies, and sexuality studies, and more broadly related to the fields of cultural studies, ethnic studies, and African-American studies. Women's studies courses are offered in over seven hundred institutions in the United States, and globally in more than forty countries.
  • 3.0K
  • 05 Nov 2022
Topic Review Peer Reviewed
Integrating Positive Psychology into Substance Use Treatments
Positive psychology is a rapidly expanding and recent empirical. interdisciplinary research topic (i.e., within the last 25 years). Early evidence supported that targeting positive variables (i.e., empathy or kindness) has numerous benefits, including improving health outcomes, vocational success, psychological well-being, and interpersonal connectedness. Positive Psychological Interventions (PPIs) are activities and behavioral interventions that target positive variables to promote adaptive functioning (e.g., reducing depression or promoting psychological well-being). PPIs may make excellent contributions to treating substance use, substance use disorders (SUDs), and substance use problems because the interventions can partially shift the notable negative treatment focus (e.g., avoiding the consequences of using) onto positive aspects (e.g., pursuing an ideal future). Current substance use treatment outcomes demonstrate a need for improvements (e.g., low abstinence rates and lifetime symptom remission of SUDs), and positive psychology may provide a framework for improving existing treatments. In the current paper, the author reviewed research supporting the use of PPIs in substance use treatments, provide suggestions for PPI applications, examine advantages and practical issues, outline the current limitations, and provide future directions for continuing this line of work. The author aimed to encourage researchers to advance substance use treatment improvements with positive psychology because the growing consequences from substance use (e.g., the growing frequency of accidental fatal overdose) and the variable, limited treatment outcomes, placing those who use substances in a uniquely vulnerable position.
  • 3.0K
  • 14 Sep 2023
Topic Review
Synthesis of nucleobase-modified RNA oligonucleotides
The review summarizes the methods of site-specific incorporation of nucleobase-modified units into RNA oligomers via the post-synthetic strategy including recently discovered native hypermodified functional groups, fluorescent dyes, photoreactive groups, disulfide crosslinks, and nitroxide spin labels.
  • 3.0K
  • 06 Aug 2020
Topic Review
Polylactic Acid for Single-Use Laboratory Components
Sustainability needs have driven interest in polymers which are degradable, recyclable, and/or derived from eco-friendly input materials. Biomass-based polymers are one option with many benefits to sustainability: reducing dependence on fossil fuel extraction; produced from renewable resources; may make use of waste materials; and better biodegradability. Polylactic Acid (PLA) is one of the most commonly used bioplastics, in 2021 it was reported to hold the largest market share worldwidefor biodegradable bioplastics manufacturing capacity.
  • 3.0K
  • 06 May 2022
Topic Review
Winkler Index
The Winkler Index, sometimes known as the Winkler Scale or Winkler Regions, is a technique for classifying the climate of wine growing regions based on heat summation or growing degree-days. In the system, geographical areas are divided into five climate regions based on temperature converted to growing degree-days, and is commonly known as Regions I–V (see below). The system was developed at the University of California, Davis by A. J. Winkler and Maynard Amerine.
  • 3.0K
  • 27 Sep 2022
Topic Review
Computer Reservation System
A computer reservation system or central reservation system (CRS) is a computerized system used to store and retrieve information and conduct transactions related to air travel, hotels, car rental, or other activities. Originally designed and operated by airlines, CRSs were later extended for the use of travel agencies. Global distribution systems (GDS) book and sell tickets for multiple airlines. Most airlines have outsourced their CRSs to GDS companies, which also enable consumer access through Internet gateways. Modern GDS's typically allow users to book hotel rooms, rental cars, airline tickets as well as other activities and tours. They also provide access to railway reservations and bus reservations in some markets, although these are not always integrated with the main system. These are also used to relay computerized information for users in the hotel industry, making reservation and ensuring that the hotel is not overbooked. Airline reservations systems may be integrated into a larger passenger service system, which also includes an airline inventory system and a departure control system.
  • 3.0K
  • 17 Nov 2022
Topic Review
Dragon 2
Dragon 2 is a class of reusable spacecraft developed and manufactured by U.S. aerospace manufacturer SpaceX, intended as the successor to the Dragon cargo spacecraft. The spacecraft launches atop a Falcon 9 Block 5 rocket and returns via ocean splashdown. When compared to Dragon, Crew Dragon has larger windows, new flight computers and avionics, redesigned solar arrays, and a modified outer mold line. The spacecraft has two planned variants – Crew Dragon, a human-rated capsule capable of carrying up to seven astronauts, and Cargo Dragon, an updated replacement for the original Dragon. Crew Dragon is equipped with an integrated launch escape system in a set of four side-mounted thruster pods with two SuperDraco engines each. Crew Dragon has been contracted to supply the International Space Station (ISS) with crew under the Commercial Crew Program, with the initial award occurring in October 2014 alongside Boeing CST-100 Starliner. Crew Dragon's first non-piloted test flight to the ISS launched in March 2019. Cargo Dragon will supply the ISS with cargo under the Commercial Resupply Services-2 (CRS-2) after a January 2016 selection alongside Northrop Grumman Innovation Systems' Cygnus and Sierra Nevada Corporation's Dream Chaser. SpaceX's first CRS-2 mission with the Cargo Dragon is slated to occur in August 2020 after SpaceX's final CRS-20 mission with the original Dragon spacecraft. The Crew Dragon capsule that flew in the first test flight was scheduled to be used in a flight abort test before it unexpectedly exploded during a test of its SuperDraco engines on 20 April 2019. An investigation into the explosion was completed on 15 July 2019 and resulted in changes to vehicle plumbing. The in-flight abort test was conducted on 19 January 2020 at 15:30 UTC. The first crewed launch is scheduled for April 2020.
  • 3.0K
  • 29 Nov 2022
Topic Review
Chrysin
Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.
  • 3.0K
  • 13 Oct 2020
Topic Review
Theranostics
“Theranostics,” a new concept of medical advances featuring a fusion of therapeutic and diagnostic systems, provides promising prospects in personalized medicine, especially cancer. 
  • 3.0K
  • 27 Apr 2021
Topic Review
Breakdown Voltages in Different Types of Gases
The idea of using a vacuum as an insulating medium is to take advantage of the fact that when the gas pressure is reduced to a value at which the average free paths of molecules and electrons are greater than the contact gap in the insulating system, the development of electron avalanches that initiate discharges in gases is impossible.
  • 3.0K
  • 07 Sep 2022
Biography
Martin Lings
Martin Lings (24 January 1909 – 12 May 2005), also known as Abū Bakr Sirāj ad-Dīn, was an England writer, scholar, and philosopher. A student of the Swiss metaphysician Frithjof Schuon[1] and an authority on the work of William Shakespeare, he is best known as the author of Muhammad: His Life Based on the Earliest Sources, first published in 1983 and still in print. Lings was born in Bur
  • 3.0K
  • 09 Dec 2022
Topic Review
Premna odorata Blanco
In-depth botanical characterization was performed on Premna odorata Blanco (Lamiaceae) different organs for the first time. The leaves are opposite, hairy and green in color. Flowers possess fragrant aromatic odors and exist in inflorescences of 4–15 cm long corymbose cyme-type. In-depth morphological and anatomical characterization revealed the great resemblance to plants of the genus Premna and of the family Lamiaceae, such as the presence of glandular peltate trichomes and diacytic stomata. Additionally, most examined organs are characterized by non-glandular multicellular covering trichomes, acicular, and rhombic calcium oxalate crystals. P. odorata leaves n-hexane fraction revealed substantial anti-tuberculous potential versus Mycobacterium tuberculosis, showing a minimum inhibition concentration (MIC) of 100 μg/mL. Metabolic profiling of the n-hexane fraction using gas-chromatography coupled to mass spectrometry (GC/MS) analysis revealed 10 major compounds accounting for 93.01%, with trans-phytol constituting the major compound (24.06%). The virtual screening revealed that trans-phytol highly inhibited MTB C171Q receptor as M. tuberculosis KasA (β-ketoacyl synthases) with a high fitting score (∆G = −15.57 kcal/mol) approaching that of isoniazid and exceeding that of thiolactomycin, the co-crystallized ligand. Absorption, distribution, metabolism, excretion and toxicity predictions (ADME/TOPKAT) revealed that trans-phytol shows lower solubility and absorption levels when compared to thiolactomycin and isoniazid. Still, it is safer, causing no mutagenic or carcinogenic effects with higher lethal dose, which causes the death of 50% (LD50). Thus, it can be concluded that P. odorata can act as a source of lead entities to treat tuberculosis.
  • 3.0K
  • 12 Oct 2021
Topic Review
Viroids
Viroids are a group of infectious plant lncRNAs that are composed of RNA genomes and replicate by using the host enzymatic activities.
  • 3.0K
  • 30 Oct 2020
Topic Review
Trust (Emotion)
In a social context, trust has several connotations. Definitions of trust typically refer to a situation characterized by the following aspects: One party (trustor) is willing to rely on the actions of another party (trustee); the situation is directed to the future. In addition, the trustor (voluntarily or forcedly) abandons control over the actions performed by the trustee. As a consequence, the trustor is uncertain about the outcome of the other's actions; they can only develop and evaluate expectations. The uncertainty involves the risk of failure or harm to the trustor if the trustee will not behave as desired. Trust can be attributed to relationships between people. It can be demonstrated that humans have a natural disposition to trust and to judge trustworthiness that can be traced to the neurobiological structure and activity of a human brain. Some studies indicate that trust can be altered e.g. by the application of oxytocin. When it comes to the relationship between people and technology, the attribution of trust is a matter of dispute. The intentional stance demonstrates that trust can be validly attributed to human relationships with complex technologies. However, rational reflection leads to the rejection of an ability to trust technological artefacts. One of the key current challenges in the social sciences is to re-think how the rapid progress of technology has impacted constructs such as trust. This is specifically true for information technology that dramatically alters causation in social systems. In the social sciences, the subtleties of trust are a subject of ongoing research. In sociology and psychology the degree to which one party trusts another is a measure of belief in the honesty, fairness, or benevolence of another party. The term "confidence" is more appropriate for a belief in the competence of the other party. A failure in trust may be forgiven more easily if it is interpreted as a failure of competence rather than a lack of benevolence or honesty. In economics, trust is often conceptualized as reliability in transactions. In all cases trust is a heuristic decision rule, allowing the human to deal with complexities that would require unrealistic effort in rational reasoning. In religion, trust is the faith and hope in good God who forgives everything and gives everlasting happiness.
  • 3.0K
  • 08 Nov 2022
Topic Review
Structure and Formation of Chitin
Due to the properties such as biodegradability, biocompatibility, non-toxicity, physiological inertness, and gel-forming properties, chitin has been found to have countless applications in different industries, e.g., food, cosmetic, pharmaceutical, manufacturing of synthetic materials, agriculture, and even electronics for the production of biosensors. It's important to understand the structure and formation of chitin.
  • 3.0K
  • 22 Nov 2022
Topic Review
Tayra
The Tayra (Eira barbara) is a sleek and agile carnivorous mammal native to the forests of Central and South America. Also known as the "tolomuco" or "tolomuco real," this elusive mustelid is characterized by its slender body, dark fur, and a distinctive, bushy tail.
  • 3.0K
  • 08 Feb 2024
Topic Review
IBD
Inflammatory bowel disease (IBD) continue to cause substantial morbidity and massive productivity loss globally. IBD is more common among the productive generation (age group of <30yrs) and affects their quality of life. A single mechanism responsible for IBD is difficult to determine due to the complex interplay of multiple factors including host’s genetic predisposition and environmental factors. The relapsing nature of IBD demands repeated treatment implicating a substantial financial burden to individual patients and the concerned healthcare system, especially in developing nations. This review focuses on the causes of IBD,risk factors, current treatment options and challenges, the role played by the natural products in IBD health care; and situate these natural products within the current biodiscovery research agenda, including the applications of drug discovery techniques and the search for next generation drugs to treat IBD.
  • 3.0K
  • 29 Oct 2020
Topic Review
Cadmium and Lead Exposure
This entry provides information relevant to public health policy regarding advisable exposure limits for cadmium (Cd) and lead (Pb) that have no biologic role in humans. All of their perceptible effects are toxic. These metals exist in virtually all foodstuffs. Foods which are frequently consumed in large quantities such as cereals, rice, potatoes and vegetables contribute the most to total intake of these metals. Because Cd and Pb exposure are highly prevalent, even a small increase in disease risk can result in a large number of people affected by a disease that is preventable. Public measures to minimize environmental pollution and the food-chain transfer of Cd and Pb are required to prevent Cd- and Pb- related ailments and mortality as are risk reduction measures that set a maximally permissible concentration of Cd and Pb in staple food to the lowest achievable levels.
  • 3.0K
  • 29 Oct 2020
Topic Review
AKG
AKG Acoustics (originally Akustische und Kino-Geräte Gesellschaft m.b.H., English: Acoustic and Cinema Equipment L.L.C.) is an acoustics engineering and manufacturing company. It was founded in 1947 by Dr. Rudolf Görike and Ernest Plass in Vienna, Austria. It is a part of Harman International Industries, a subsidiary of Samsung Electronics. The products currently marketed under the AKG brand mostly consist of microphones, headphones, wireless audio systems and related accessories for professional and consumer markets.
  • 3.0K
  • 20 Oct 2022
Topic Review
Hadrosauridae
Hadrosaurids (from grc ἁδρός (hadrós) 'stout, thick', and σαύρα (saúra) 'lizard'), or duck-billed dinosaurs, are members of the ornithischian family Hadrosauridae. This group is known as the duck-billed dinosaurs for the flat duck-bill appearance of the bones in their snouts. The ornithopod family, which includes genera such as Edmontosaurus and Parasaurolophus, was a common group of herbivores during the Late Cretaceous Period. Hadrosaurids are descendants of the Upper Jurassic/Lower Cretaceous iguanodontian dinosaurs and had a similar body layout. Hadrosaurs were among the most dominant herbivores during the Late Cretaceous in Asia and North America, and during the close of the Cretaceous several lineages dispersed into Europe, Africa, South America and Antarctica. Like other ornithischians, hadrosaurids had a predentary bone and a pubic bone which was positioned backwards in the pelvis. Unlike more primitive iguanodonts, the teeth of hadrosaurids are stacked into complex structures known as dental batteries, which acted as effective grinding surfaces. Hadrosauridae is divided into two principal subfamilies: the lambeosaurines (Lambeosaurinae), which had hollow cranial crests or tubes; and the saurolophines (Saurolophinae), identified as hadrosaurines (Hadrosaurinae) in most pre-2010 works, which lacked hollow cranial crests (solid crests were present in some forms). Saurolophines tended to be bulkier than lambeosaurines. Lambeosaurines included the aralosaurins, tsintaosaurins, lambeosaurins and parasaurolophins, while saurolophines included the brachylophosaurins, kritosaurins, saurolophins and edmontosaurins. Hadrosaurids were facultative bipeds, with the young of some species walking mostly on two legs and the adults walking mostly on four.
  • 3.0K
  • 02 Dec 2022
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