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Topic Review
Avocado-Derived Biomass
The avocado (Persea americana Mill.) is a tree native to Mexico and Guatemala, and currently it is cultivated in more than 70 countries. Avocado consumption, fresh or in the form of processed products, is growing everywhere and it has caused a large number of countries to invest heavily in avocado production. The industrialization of avocado gives as a result a huge amount of waste: peel, stone, tree pruning, and oil extraction wastes. Although the industrial application of these biomasses is still limited, numerous studies suggest that they can serve as raw materials to obtain bioenergy and different types of bioproducts. To take full advantage of them, it would particularly interesting to develop biorefinery models.
  • 3.0K
  • 27 Dec 2020
Topic Review
Acidobacteria
Acidobacteria is a phylum of bacteria. Its members are physiologically diverse and ubiquitous, especially in soils, but are under-represented in culture.
  • 3.0K
  • 29 Nov 2022
Topic Review
Thread Block
A thread block is a programming abstraction that represents a group of threads that can be executed serially or in parallel. For better process and data mapping, threads are grouped into thread blocks. The number of threads varies with available shared memory. 'The number of threads in a thread block is also limited by the architecture to a total of 512 threads per block.' The threads in the same thread block run on the same stream processor. Threads in the same block can communicate with each other via shared memory, barrier synchronization or other synchronization primitives such as atomic operations. Multiple blocks are combined to form a grid. All the blocks in the same grid contain the same number of threads. Since the number of threads in a block is limited to 512, grids can be used for computations that require a large number of thread blocks to operate in parallel. CUDA is a parallel computing platform and programming model that higher level languages can use to exploit parallelism. In CUDA, the kernel is executed with the aid of threads. The thread is an abstract entity that represents the execution of the kernel. A kernel is a small program or a function. Multi threaded applications use many such threads that are running at the same time, to organize parallel computation. Every thread has an index, which is used for calculating memory address locations and also for taking control decisions.
  • 3.0K
  • 29 Nov 2022
Topic Review
Non-alcoholic Fraction of Beer
The present review focuses on the effects of non-alcoholic components of beer on abdominal fat, osteoporosis and body hydration in women, conditions selected for their relevance to health and aging. Although beer drinking is commonly believed to cause abdominal fat deposition, the available literature indicates this outcome is inconsistent in women. Additionally, the non-alcoholic beer fraction might improve bone health in postmenopausal women, and the effects of beer on body hydration, although still unconfirmed seem promising. Most of the health benefits of beer are due to its bioactive compounds, mainly polyphenols, which are the most studied. As alcohol-free beer also contains these compounds, it may well offer a healthy alternative to beer consumers.
  • 3.0K
  • 01 Nov 2020
Topic Review
Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral muscular dystrophy (FSHD)—the worldwide third most common inherited muscular dystrophy caused by the heterozygous contraction of a 3.3 kb tandem repeat (D4Z4) on a chromosome with a 4q35 haplotype—is a progressive genetic myopathy with variable onset of symptoms, distribution of muscle weakness, and clinical severity.  A rough correlation between the phenotypic severity of FSHD and the D4Z4 repeat size has been reported, and the majority of patients with infantile FSHD obtain a very short D4Z4 repeat length (one to three copies, EcoRI size 10–14 kb), in contrast to the classical, slowly progressive, form of FSHD (15–38 kb). With the increasing identifications of case reports and the advance in genetic diagnostics, recent studies have suggested that the variant of FSHD is not a genetically separate entity but a part of the FSHD spectrum. Nevertheless, many questions about the clinical phenotype and natural history of FSHD remain unanswered, limiting evidence-based clinical management.
  • 3.0K
  • 05 Nov 2020
Topic Review
Processing Properties of Starch
Starch is the second most abundantly available natural polymer in the world, after cellulose. If we add its biodegradability and non-toxicity to the natural environment, it becomes a raw material very attractive for the food and non-food industries. However, in the latter case, mainly due to the high hydrophilicity of starch, it is necessary to carry out many more or less complex operations and processes. One of the fastest growing industries in the last decade is the processing of biodegradable materials for packaging purposes. This is mainly due to awareness of producers and consumers about the dangers of unlimited production and the use of non-degradable petroleum polymers.
  • 3.0K
  • 05 Apr 2021
Topic Review
N,N-Dimethylacrylamide-Based Hydrogels
N,N-dimethylacrylamide produces hydrogel when polymerized with cross-linkers. Moreover, poly(N,N-dimethylacrylamide) has gotten a lot of attention as it is commonly used as the hydrophilic side of copolymers due to its unique properties and high water solubility. In addition, van der Waals interactions between N,N-dimethylacrylamide and dye molecules even more increase the applicability of DMAA hydrogels.
  • 3.0K
  • 03 Dec 2021
Topic Review
Buyeo Languages
The Buyeo languages, or Fuyu languages (Korean: 부여; Chinese: 扶餘, Fúyú), is a theoretical language family that consists of the Koreanic languages, the Japonic languages and of the ancient languages of the Korean Peninsula and Manchuria. According to ancient Chinese records, the languages of Buyeo, Goguryeo, Dongye, Okjeo, Baekje and Gojoseon were similar to one another but very different from Tungusic languages. The Ye-Maek language may have been ancestral.
  • 3.0K
  • 08 Oct 2022
Topic Review
Rational Vaccine Design
Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. 
  • 3.0K
  • 29 Apr 2021
Topic Review
Exploiting Proteotoxic Stress in Cancer
Cancer cells typically have elevated proteotoxic stress as a result of genomic instability. The disruption of protein homeostasis causes endoplasmic reticulum stress. If not promptly managed, it could lead to a global decline in cellular function and eventual cell death[1]. This summary of review explores different protein quality control pathways and the translation of drugs targeting proteotoxic stress in haematologic cancers (using multiple myeloma as an example) versus solid cancers (using Triple Negative Breast Cancer as an example).
  • 3.0K
  • 30 Oct 2020
Topic Review
Microcystins
Harmful cyanobacterial blooms pose an environmental health hazard due to the release of water-soluble cyanotoxins. One of the most prevalent cyanotoxins in nature is microcystins (MCs), a class of cyclic heptapeptide hepatotoxins, and they are produced by several common cyanobacteria in aquatic environments. Once released from cyanobacterial cells, MCs are subjected to physical chemical and biological transformations in natural environments. MCs can also be taken up and accumulated in aquatic organisms and their grazers/predators and induce toxic effects in several organisms, including humans.
  • 3.0K
  • 14 Sep 2021
Topic Review
Hyperspectral Remote Sensing and Plant
Hyperspectral remote sensing provides image data with very high spectral resolution. This high resolution allows subtle differences in plant health to be recognized. Such a multidimensional data space, generated by hyperspectral sensors, has given rise to new approaches and methods for analyzing hyperspectral data.
  • 3.0K
  • 31 Jan 2022
Topic Review
Associations between Population Density and Health Outcomes
Both density of population and proximity to man-made activities, as well as the natural environment, concentrate risk for humans. Population density is therefore a measure of “the degree of pressure on natural resources” as well as an indicator reflecting the level of human activity within a specific bounded landscape. Exposure to contaminants from soil, water or air coupled with social or economic vulnerability and population density may increase potential harm to health at a subclinical or clinical level.
  • 3.0K
  • 14 Mar 2022
Topic Review
Apostolic Administrator
An apostolic administrator in the Catholic Church is a prelate appointed by the Pope to serve as the ordinary for an apostolic administration. An apostolic administration can either be an area that is not yet a diocese (a stable 'pre-diocesan', usually missionary apostolic administration) or for a diocese, eparchy or similar permanent ordinariate (such a territorial prelature or a territorial abbacy) that either has no bishop (an apostolic administrator sede vacante, as after an episcopal death or resignation) or, in very rare cases, has an incapacitated bishop (apostolic administrator sede plena).
  • 3.0K
  • 31 Oct 2022
Topic Review
NK Cell Immunotherapy using Nanoparticles
Among various immunotherapies, natural killer (NK) cell cancer immunotherapy using adoptive transfer of NK cells takes a unique position by targeting tumor cells that evade the host immune surveillance. As the first-line innate effector cell, it has been revealed that NK cells have distinct mechanisms to both eliminate cancer cells directly and amplify the anticancer immune system. Over the last 40 years, NK cell cancer immunotherapy has shown encouraging reports in pre-clinic and clinic settings. In total, 288 clinical trials are investigating various NK cell immunotherapies to treat hematologic and solid malignancies in 2021. However, the clinical outcomes are unsatisfying, with remained challenges. The major limitation is attributed to the immune-suppressive tumor microenvironment (TME), low activity of NK cells, inadequate homing of NK cells, and limited contact frequency of NK cells with tumor cells. Innovative strategies to promote the cytolytic activity, durable persistence, activation, and tumor-infiltration of NK cells are required to advance NK cell cancer immunotherapy. As maturing nanotechnology and nanomedicine for clinical applications, there is a greater opportunity to augment NK cell therapeutic efficacy for the treatment of cancers. Active molecules/cytokine delivery, imaging, and physicochemical properties of nanoparticles are well equipped to overcome the challenges of NK cell cancer immunotherapy.
  • 3.0K
  • 26 Apr 2021
Topic Review
Staphylococcus pseudintermedius
Staphylococcus pseudintermedius is a pathogenic bacterium of concern within the veterinary sector and is involved in numerous infections in canines, including topical infections such as canine pyoderma and otitis externa, as well as systemic infections within the urinary, respiratory and reproductive tract. The high prevalence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) within such infections is a growing concern.
  • 3.0K
  • 14 May 2021
Topic Review
Smart City Industries
Smart city industries can be defined as construction businesses based on IT manufacturing (precision instruments, electrical and electronic equipment), IT services (communications and broadcasting) and knowledge services (six fields such as finance and insurance, real estate and lease, professional, scientific and technical services). 
  • 3.0K
  • 06 Sep 2021
Topic Review
Knowledge Graph
The Google Knowledge Graph is a knowledge base used by Google and its services to enhance its search engine's results with information gathered from a variety of sources. The information is presented to users in an infobox next to the search results. Knowledge Graph infoboxes were added to Google's search engine in May 2012, starting in the United States, with international expansion by the end of the year. The information covered by Google's Knowledge Graph grew quickly after launch, tripling its size within seven months (covering 570 million entities and 18 billion facts) and answering "roughly one-third" of the 100 billion monthly searches Google processed in May 2016. It has been criticized for providing answers without source attribution or citation. Information from the Knowledge Graph is presented as a box, which Google has referred to as the "knowledge panel", to the right (top on mobile) of search results. According to Google, this information is retrieved from many sources, including the CIA World Factbook, Wikidata, and Wikipedia. In October 2016, Google announced that the Knowledge Graph held over 70 billion facts; by May 2020, this had grown to 500 billion facts on 5 billion entities. There is no official documentation of how the Knowledge Graph is implemented. It is used to answer direct spoken questions in Google Assistant and Google Home voice queries.
  • 3.0K
  • 02 Dec 2022
Topic Review
Chinese Hamster Ovary-K1 Cells
CHO cells are epithelial-like cells isolated from Chinese hamster ovary. The original CHO cells are cultured adherently, but they can be cultured in suspension in serum-free medium after acclimation. CHO cells are widely used for the expression of recombinant proteins.
  • 3.0K
  • 18 Sep 2021
Topic Review
Licorice and the Cardiovascular System
Licorice is one of the oldest used herbs for medicinal purposes and consists of up to 300 active compounds. The main active constituent of licorice is the prodrug glycyrrhizin, which is successively converted to 3β-monoglucuronyl-18β-glycyrrhetinic acid (3MGA) and 18β-glycyrrhetinic acid (GA) in the intestines. Despite many reported health benefits, 3MGA and GA inhibit the 11-β-hydrogenase type II enzyme (11β-HSD2) oxidizing cortisol to cortisone. Through activation of mineralocorticoid receptors, high cortisol levels induce a mild form of apparent mineralocorticoid excess in the kidney and increase systemic vascular resistance. Continuous inhibition of 11β-HSD2 related to excess licorice consumption will create a state of hypernatremia, hypokalemia and increased fluid volume.
  • 3.0K
  • 21 May 2021
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