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Topic Review
Coracle
A coracle is a small, rounded, lightweight boat of the sort traditionally used in Wales, and also in parts of the West Country and in Ireland, particularly the River Boyne, and in Scotland, particularly the River Spey. The word is also used of similar boats found in India , Vietnam, Iraq and Tibet. The word "coracle" is an English spelling of the original Welsh cwrwgl, cognate with Irish and Scottish Gaelic currach, and is recorded in English text as early as the sixteenth century. Other historical English spellings include corougle, corracle, curricle and coricle.
  • 3.4K
  • 05 Nov 2022
Topic Review
Summaries of Product Characteristics
The Summary of Product Characteristics (SmPC) is a legal document, is one of the obligatory elements of the registration dossier of a medication, and is necessary to issue a marketing authorization for a medicinal product. The obligation to draw up a Summary of Product Characteristics is laid down in several European Parliament laws. The first documents were Directive 2001/83/EC of the European Parliament and the Council relating to medicinal products for human use, and Regulation 726/2004. The document was amended several times and finally replaced in 2004 by Directive 2004/27/EC.
  • 3.4K
  • 07 Mar 2022
Topic Review
Energy Crops
Energy crops are dedicated cultures directed for biofuels, electricity, and heat production. Due to their tolerance to contaminated lands, they can alleviate and remediate land pollution by the disposal of toxic elements and polymetallic agents. Moreover, these crops are suitable to be exploited in marginal soils (e.g., saline), and, therefore, the risk of land-use conflicts due to competition for food, feed, and fuel is reduced, contributing positively to economic growth, and bringing additional revenue to landowners.
  • 3.4K
  • 29 Jun 2022
Topic Review
Permeation Enhancers of Hormones Penetration through the Skin
Hormones have attracted considerable interest in recent years due to their potential use in treatment of many diseases. Their ability to have a multidirectional effect leads to searching for new and increasingly effective drugs and therapies. Limitations in formulating drug forms containing hormones are mainly due to their low enzymatic stability, short half-life and limited bioavailability. One of the solutions may be to develop a hydrogel as a potential hormone carrier, for epidermal and transdermal application. 
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  • 01 Sep 2022
Topic Review
Ken Cuccinelli
Kenneth Thomas Cuccinelli II (/ˈkuːtʃɪˈnɛli/ KOO-chi-NEL-ee; born July 30, 1968) is an American politician and lawyer currently serving as Principal Deputy Director of the U.S. Citizenship and Immigration Services (USCIS) agency and Acting Deputy Secretary of Homeland Security. He previously served as the 46th attorney general of Virginia from 2010 until 2014, and acting Director of USCIS agency. Before this, he was in the Virginia Senate, representing the 37th district in Fairfax County from 2002 until he took office as attorney general in 2010. On May 18, 2013, Cuccinelli won the Republican Party's gubernatorial nomination at the state party convention. Cuccinelli was the Republican nominee for Governor of Virginia in the 2013 Virginia gubernatorial election, losing to the Democratic nominee, Terry McAuliffe, by 56,435 votes or 2.5% of the total votes cast. A self-described opponent of homosexuality, Cuccinelli in his position as Virginia Attorney General defended anti-sodomy laws and prohibitions on same-sex marriage. Cuccinelli rejects the scientific consensus on climate change, and in his position as Attorney General investigated climate scientists whom he accused of fraud. He filed lawsuits against the Obama administration’s Environmental Protection Agency. Characterized as an immigration hard-liner, Cuccinelli sought to prohibit undocumented immigrants from attending universities, repeal birthright citizenship, and force employees to speak English in the workplace. As CIS Director, he implemented and defended policies that would reject applications for visas or permanent residency for immigrants considered likely to utilize publicly funded benefits programs.
  • 3.4K
  • 12 Oct 2022
Topic Review
The Hazards of Skin Glycation and Related Inhibitors
Skin saccharification, a non-enzymatic reaction between proteins, e.g., dermal collagen and naturally occurring reducing sugars, is one of the basic root causes of endogenous skin aging. During the reaction, a series of complicated glycation products produced at different reaction stages and pathways are usually collectively referred to as advanced glycation end products (AGEs). AGEs cause cellular dysfunction through the modification of intracellular molecules and accumulate in tissues with aging. AGEs are also associated with a variety of age-related diseases, such as diabetes, cardiovascular disease, renal failure (uremia), and Alzheimer’s disease. AGEs accumulate in the skin with age and are amplified through exogenous factors, e.g., ultraviolet radiation, resulting in wrinkles, loss of elasticity, dull yellowing, and other skin problems. 
  • 3.4K
  • 24 Nov 2022
Topic Review
Additive Manufacturing Technology in Railway Infrastructure Systems
Additive manufacturing technologies, well known as three-dimensional printing (3DP) technologies, have been applied in many industrial fields, including aerospace, automobiles, shipbuilding, civil engineering and nuclear power. However, despite the high material utilization and the ability to rapidly construct complex shaped structures of 3D printing technologies, the application of additive manufacturing technologies in railway track infrastructure is still at the exploratory stage. 
  • 3.4K
  • 07 Jan 2022
Topic Review
Universal Reconciliation
In Christian theology, universal reconciliation (also called universal salvation, Christian universalism, or in context simply universalism) is the doctrine that all sinful and alienated human souls—because of divine love and mercy—will ultimately be reconciled to God. The doctrine has often been rejected by mainstream Christian religion, which holds to the doctrine of special salvation that only some members of humanity will eventually enter heaven, but it has received support from many prestigious Christian thinkers as well as many groups of Christians. The Bible itself has a variety of verses that, on the surface, seem to support a plurality of views. Universal salvation may be related to the perception of a problem of Hell, standing opposed to ideas such as endless conscious torment in Hell, but may also include a period of finite punishment similar to a state of purgatory. Believers in universal reconciliation may support the view that while there may be a real "Hell" of some kind, it is neither a place of endless suffering nor a place where the spirits of human beings are ultimately 'annihilated' after enduring the just amount of divine retribution. The concept of reconciliation is related to the concept of salvation—i.e., salvation from spiritual and eventually physical death—such that the term "universal salvation" is functionally equivalent. Universalists espouse various theological beliefs concerning the process or state of salvation, but all adhere to the view that salvation history concludes with the reconciliation of the entire human race to God. Many adherents assert that the suffering and crucifixion of Jesus Christ constitute the mechanism that provides redemption for all humanity and atonement for all sins. Unitarian Universalism is a religious movement which emerged in part from the Universalist Church, but it no longer holds any official doctrinal positions, being a non-creedal faith. Universal reconciliation, however, remains a popular viewpoint among many congregations and individual believers including many that have not at all associated with said church. An alternative to universal reconciliation is the doctrine of annihilationism, often in combination with Christian conditionalism. Some Christian leaders, such as influential theologian Martin Luther, have hypothesized other concepts such as 'soul death'.
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  • 14 Nov 2022
Topic Review
Skeletal Muscle Myokines
The skeletal muscle is the largest organ in the body and secretes circulating factors, including myokines, which are involved in various cellular signaling processes. Skeletal muscle is vital for metabolism and physiology and plays a crucial role in insulin-mediated glucose disposal. Myokines have autocrine, paracrine, and endocrine functions, serving as critical regulators of myogenic differentiation, fiber-type switching, and maintaining muscle mass. Myokines have profound effects on energy metabolism and inflammation, contributing to the pathophysiology of type 2 diabetes (T2D) and other metabolic diseases. Myokines have been shown to increase insulin sensitivity, thereby improving glucose disposal and regulating glucose and lipid metabolism. 
  • 3.4K
  • 05 May 2022
Topic Review
Zero-Waste Manufacturing
At first glance, zero waste (ZW) means complete and total elimination or absence of waste. However, much more than that, ZW entails waste prevention and where all materials are reused. It is a philosophy that forbids sending any unused material to landfills, dumpsites, or incinerators.
  • 3.4K
  • 16 May 2022
Topic Review
Flashline Mars Arctic Research Station
The Flashline Mars Arctic Research Station (FMARS) is the first of two simulated Mars habitats (or Mars Analog Research Stations) established and maintained by the Mars Society.
  • 3.4K
  • 10 Oct 2022
Topic Review
Biblical Apocrypha
The biblical apocrypha (from the Greek ἀπόκρυφος, apókruphos, meaning "hidden") denotes the collection of apocryphal ancient books found in some editions of Christian Bibles in a separate section between the Old and New Testaments or as an appendix after the New Testament. Some Christian Churches include some or all of the same texts within the body of their version of the Old Testament. Although the term apocrypha had been in use since the 5th century, it was in Luther's Bible of 1534 that the Apocrypha was first published as a separate intertestamental section. To this date, the Apocrypha is "included in the lectionaries of Anglican and Lutheran Churches." Moreover, the Revised Common Lectionary, in use by most mainline Protestants including Methodists and Moravians, lists readings from the Apocrypha in the liturgical kalendar, although alternate Old Testament scripture lessons are provided. The preface to the Apocrypha in the Geneva Bible explained that while these books "were not received by a common consent to be read and expounded publicly in the Church," and did not serve "to prove any point of Christian religion save in so much as they had the consent of the other scriptures called canonical to confirm the same," nonetheless, "as books proceeding from godly men they were received to be read for the advancement and furtherance of the knowledge of history and for the instruction of godly manners." Later, during the English Civil War, the Westminster Confession of 1647 excluded the Apocrypha from the canon and made no recommendation of the Apocrypha above "other human writings", and this attitude towards the Apocrypha is represented by the decision of the British and Foreign Bible Society in the early 19th century not to print it (see below). Today, "English Bibles with the Apocrypha are becoming more popular again" and they are often printed as intertestamental books. Most of the books of the Protestant Apocrypha are called deuterocanonical by Catholics per the Council of Trent and all of them are called anagignoskomena by the Eastern Orthodox per the Synod of Jerusalem. The Anglican Communion accepts "the Apocrypha for instruction in life and manners, but not for the establishment of doctrine (Article VI in the Thirty-Nine Articles)", and many "lectionary readings in The Book of Common Prayer are taken from the Apocrypha", with these lessons being "read in the same ways as those from the Old Testament". The first Methodist liturgical book, The Sunday Service of the Methodists, employs verses from the Apocrypha, such as in the Eucharistic liturgy. The Protestant Apocrypha contains three books (3 Esdras, 4 Esdras and the Prayer of Manasseh) that are accepted by many Eastern Orthodox Churches and Oriental Orthodox Churches as canonical, but are regarded as non-canonical by the Catholic Church and are therefore not included in modern Catholic Bibles.
  • 3.4K
  • 21 Oct 2022
Topic Review Peer Reviewed
COVID-19 and Dentistry
Dentistry is a healthcare profession requiring close contacts between the dental practitioner and the patient. In particular, many dental procedures generate aerosols and droplets which are proved to be the major transmission route for COVID-19.
  • 3.4K
  • 13 Apr 2022
Topic Review
Redox Flow Batteries
Redox Flow Batteries (RFB) are electrochemical energy storage devices that converts chemical energy into electrical energy through reversible oxidation and reduction of the working fluids. Redox flow batteries are considered by many to be a promising technology for the storage of energy for days or even weeks. Other advantages of RFBs are modularly and the ability to change the output power and energy capacity independently, by changing the size and number of cells in a stack and by adjusting the volume of electrolyte. Also, RFBs show a long lifecycle compared to lithium-ion batteries.
  • 3.4K
  • 14 Oct 2021
Topic Review
Sustainable Leadership Practices and Competencies of SMEs
Sustainability leadership has gained much popularity as an emergent multidisciplinary area in the recent literature. Worldwide scholars call for more sustainability studies as an important leadership agenda . Modern leaders need to strategically lead their businesses beyond profit-maximization or economic performance and maneuver their vision and strategy toward environmental protection and social responsibility. The literature urges future leaders and managers to purposefully develop value-oriented sustainable leadership and sustainability competencies in their business practices as well as to balance the economic performance and socio-environmental responsibility to thrive for long-term success. The latest empirical research also indicates that sustainability leadership is a key determinant of long-term success and sustainability performance outcomes. The topic strategically becomes critical to achieve corporate resilience, longevity and sustainable futures.
  • 3.4K
  • 15 Jun 2022
Topic Review
The Bioactivity and Health Benefits of Alpha-Phellandrene
Aromatic essential oils play a significant role in pharmaceuticals, food additives, cosmetics, and perfumery. Essential oils mostly comprise aliphatic hydrocarbons, monoterpenoids, sesquiterpenoids and diterpenes. Plant extracts comprise a complex mixture of terpenes, terpenoids, aliphatic and phenol-derived aromatic components. Terpenes are a significant class of hydrocarbons with numerous health benefits. Monoterpenes are the most important constituents of essential oils. α-phellandrene (α-PHE) is a cyclic monoterpene with two double bonds in a heterocyclic ring (endocyclic).
  • 3.4K
  • 20 Oct 2022
Topic Review
Cairn
A cairn is a man-made pile (or stack) of stones. The word cairn comes from the Scottish Gaelic: càrn [ˈkʰaːrˠn̪ˠ] (plural càirn [ˈkʰaːrˠɲ]). Cairns have been and are used for a broad variety of purposes, from prehistoric times to the present. In modern times, cairns are often erected as landmarks, a use they have had since ancient times. However, since prehistory, they have also been built and used as burial monuments; for defense and hunting; for ceremonial purposes, sometimes relating to astronomy; to locate buried items, such as caches of food or objects; and to mark trails, among other purposes. Cairns are used as trail markers in many parts of the world, in uplands, on moorland, on mountaintops, near waterways and on sea cliffs, as well as in barren deserts and tundras. They vary in size from small stone markers to entire artificial hills, and in complexity from loose conical rock piles to delicately balanced sculptures and elaborate feats of megalithic engineering. Cairns may be painted or otherwise decorated, whether for increased visibility or for religious reasons. An ancient example is the inuksuk (plural inuksuit), used by the Inuit, Inupiat, Kalaallit, Yupik, and other peoples of the Arctic region of North America. Inuksuit are found from Alaska to Greenland. This region, above the Arctic Circle, is dominated by the tundra biome and has areas with few natural landmarks.
  • 3.4K
  • 30 Nov 2022
Topic Review
Ideal Type
The concept of "ideal type" was introduced by the sociologist Max Weber as a methodological tool to analyze and understand complex social phenomena. An ideal type is an abstract, simplified model constructed by the researcher to highlight essential characteristics of a social phenomenon, allowing for clearer analysis and comparison, despite recognizing that real-world instances may not perfectly align with the constructed model. It serves as an analytical device rather than a precise representation of empirical reality, aiding in the systematic examination of social phenomena.
  • 3.4K
  • 25 Jan 2024
Topic Review
Topologies of T-Type Multilevel Inverters
Multilevel inverters (MLI) consist of a wide range of power converters. They have many designs and have been introduced with different circuit topologies such as neutral point clamped, diode clamped, cascaded H-bridges, and flying capacitors. Some of these MLIs have disadvantages, including design complexity, size, and losses due to the large number of switching devices required when they produce many output voltage levels. They are also bulky in size and may require several DC power sources. 
  • 3.4K
  • 24 May 2023
Topic Review
Immune Engineering Approaches to Improve Wound Healing
Recently, targeted modulation of the immune response via biotechnological approaches and biomaterials has gained attention as a means to restore the pro-healing phenotype and promote tissue regeneration. In order to fully realize the potential of these approaches in traumatic wounds, a critical and nuanced understanding of the relationships between immune dysregulation and healing outcomes is needed. 
  • 3.4K
  • 27 Apr 2022
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