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Topic Review
Nuclear Pore Complex
The import and export of proteins requires interaction with the components of the nuclear envelope (NE), which is formed by a double membrane that harbor protein channels called nuclear pore complexes (NPCs). NPCs are formed by multiple copies of Nups that participate in the bi-directional nucleus–cytoplasmic transport of macromolecules, ribosomal subunits, viral proteins and RNAs (mRNAs, rRNAs, tRNAs, miRNAs) from both cellular and viral origin.
  • 3.5K
  • 28 Apr 2021
Topic Review
Euphorbia neriifolia Linn.
Medicinal plants have considerable potential as antimicrobial agents due to the presence of secondary metabolites. Researchers aim to summarize the classification, morphology, and ethnobotanical uses of Euphorbia neriifolia L. and its derived phytochemicals with the recent updates on the pharmacological properties against emerging infectious diseases, mainly focusing on bacterial, viral, fungal, and parasitic infections. 
  • 3.5K
  • 14 Jul 2022
Topic Review
Internet of Everything (IoE) Taxonomies
The paradigm of the Internet of everything (IoE) is advancing toward enriching people’s lives by adding value to the Internet of things (IoT), with connections among people, processes, data, and things. This paper provides a survey of the literature on IoE research, highlighting concerns in terms of intelligence services and knowledge creation. The significant contributions of this study are as follows: (1) a systematic literature review of IoE taxonomies (including IoT); (2) development of a taxonomy to guide the identification of critical knowledge in IoE applications, an in-depth classification of IoE enablers (sensors and actuators); (3) validation of the defined taxonomy with 50 IoE applications; and (4) identification of issues and challenges in existing IoE applications (using the defined taxonomy) with regard to insights about knowledge processes.
  • 3.5K
  • 27 Jan 2021
Topic Review
Synthesis of MoS2
Molybdenum disulfide (MoS2), with a two-dimensional (2D) structure, has attracted huge research interest due to its unique electrical, optical, and physicochemical properties. MoS2 has been used as a co-catalyst for the synthesis of novel heterojunction composites with enhanced photocatalytic hydrogen production under solar light irradiation. Nanostructured MoS2 can be fabricated via both top-down and bottom-up approaches.
  • 3.5K
  • 10 Jun 2022
Topic Review
Marsupial Lion
The marsupial lion (Thylacoleo carnifex) is an extinct species of carnivorous marsupial mammal that lived in Australia from the early to the late Pleistocene (1,600,000–46,000 years ago). Despite its name, it is not closely related to the lion, but is a member of the order Diprotodontia, one of the taxonomic groups of Australian marsupials.
  • 3.5K
  • 20 Oct 2022
Topic Review
μ-Recursive Function
In mathematical logic and computer science, the general recursive functions (often shortened to recursive functions) or μ-recursive functions are a class of partial functions from natural numbers to natural numbers that are "computable" in an intuitive sense. In computability theory, it is shown that the μ-recursive functions are precisely the functions that can be computed by Turing machines(this is one of the theorems that supports the Church–Turing thesis). The μ-recursive functions are closely related to primitive recursive functions, and their inductive definition (below) builds upon that of the primitive recursive functions. However, not every μ-recursive function is a primitive recursive function—the most famous example is the Ackermann function. Other equivalent classes of functions are the λ-recursive functions and the functions that can be computed by Markov algorithms. The subset of all total recursive functions with values in {0,1} is known in computational complexity theory as the complexity class R.
  • 3.5K
  • 01 Dec 2022
Topic Review Peer Reviewed
Urine Organic Acid Testing in the Clinical Laboratory: The Past, Current, and Future
Organic acidurias, a subgroup of inborn errors of metabolism (IEMs), are characterized by the accumulation of non-amine-containing, low-molecular-weight organic acids (OAs) in urine and/or plasma due to defects in specific metabolic pathways. Early diagnosis can be critical to enable timely intervention to prevent irreversible neurological injury or death. Therefore, urine organic acid (UOA) testing plays an indispensable role in the differential diagnosis of symptomatic individuals and the follow-up of abnormal newborn screen results. Historically, gas chromatography-mass spectrometry (GC-MS) has been the gold standard method, with well-established protocols for sample preparation and result interpretation. Recent advances in liquid chromatography-mass spectrometry (LC-MS), including both triple quadrupole and high-resolution Quadrupole Time-of-Flight (QTOF) platforms, have enabled UOA analysis with simplified workflows and improved coverage to diagnose a broader array of IEMs. This review summarizes the evolution of UOA testing from manual colorimetric assays to mass spectrometry-based platforms, highlights the analytical and interpretative considerations of GC-MS, and explores emerging LC-MS technologies and bioinformatics tools that offer enhanced diagnostic capabilities and efficiency for the future of IEM testing.
  • 3.5K
  • 25 Sep 2025
Topic Review
Level of Consciousness (Esotericism)
Consciousness is a loosely defined concept that addresses the human awareness of both internal and external stimuli. This can refer to spiritual recognition, psychological understanding, medically altered states, or more modern-day concepts of life purpose, satisfaction, and self-actualization. Levels of Consciousness can be presented in a map. Some levels are more continuous or complex than others. Movement between levels or stages is often bidirectional depending on internal and external conditions, with each mental ascension precipitating a change in reactivity. In the most basic sense, this alteration might lead to a reduced responsiveness as seen in anesthesiology; more abstract facets of tiered consciousness describe characteristics of profoundness, insight, perception, or understanding. First appearing in the historical records of the ancient Mayan and Incan civilizations, proposals of multiple levels of consciousness have pervaded spiritual, psychological, medical, and moral speculations in both Eastern and Western cultures. Because of occasional and sometimes substantial overlap between hypotheses, there have recently been attempts to combine perspectives to form new models that integrate components of separate viewpoints. Any of these proposals, models or viewpoints can be verified or falsified, and are open to question.
  • 3.5K
  • 24 Nov 2022
Topic Review
Innovation-Driven Strategy on High-Quality Economic Development
The positive role of innovation-driven strategy is mainly realized through high-tech markets in China. Therefore, R&D investment should focus on high-tech industries or fields related to the national economic lifeline or strategic industries, such as environmental protection, microchips, and high-end instruments industries in China. 
  • 3.5K
  • 26 Apr 2022
Biography
Michael Green (Physicist)
Michael Boris Green FRS[1] (born 22 May 1946) is a British physicist and one of the pioneers of string theory. Currently a Professor of Theoretical Physics in the School of Physics and Astronomy at Queen Mary University of London, and emeritus professor in the Department of Applied Mathematics and Theoretical Physics and a Fellow in Clare Hall, Cambridge in England, he was Lucasian Professor of
  • 3.5K
  • 04 Jan 2023
Topic Review
Logistics Sprawl
The concentration of warehouses in peripheral regions of metropolitan areas in a time period is called logistics sprawl (LS).
  • 3.5K
  • 27 Nov 2020
Topic Review
Yarrowia lipolytica
After having drawn some industrialists’ attention as early as the 1950s, the non-conventional oleaginous yeast Yarrowia lipolytica has been recognized since several decades, as a powerful host for heterologous protein expression, secretion and surface display. The development of sequencing and genetic engineering tools, combined with an increasing knowledge of its metabolism, have then facilitated the complex engineering of the metabolic pathways of this yeast for various applications. Since nearly two decades, numerous laboratories throughout the world have chosen Y. lipolytica as a chassis for designing microbial cell factories. White biotechnology applications of this yeast include notably single cell oil production, whole cell bioconversion and upgrading of industrial wastes. 
  • 3.5K
  • 19 Jul 2021
Topic Review
Carbon Capture Utilization and Storage in Korea
In 2008, the Republic of Korea announced the Low Carbon Green Growth vision as the national growth engine. This Green Growth vision invested in developing state-of-the-art green technologies to minimize greenhouse gas and pollutant emissions. Following a change in administration, Korean green technologies were re-categorized into six core technologies for climate change response in 2014, and ten core technologies for carbon-neutrality in 2021. The government proposed the realization of an inclusive green state in the 3rd Five-Year Green Growth Plan announced in 2019. Following the Green New Deal announced in 2020, green technology policies and investments continue, with the declaration of 2050 carbon neutrality. In the past two years, government policies from the 2050 Carbon Neutrality Strategy to the 2050 Carbon-Neutral Scenario consider Carbon Capture Utilization and Storage (CCUS) as an important technology to reduce CO2 and meet carbon-neutral goals.
  • 3.5K
  • 17 Mar 2022
Topic Review
GeoAI in Integrated Hydrological and Fluvial Systems Modeling
Geospatial artificial intelligence (GeoAI) allows the harnessing of big and high-dimensional data to better understand the hydrological processes in a particular system. Specifically, GeoAI provides new data analytic tools to the entire data processing cycle, such as sensor data fusion, hydrological modeling, data assimilation, multi-objective scenario optimization, smart decision support, evaluation of climate change impact, construction of early warning systems, and geo-visualization. 
  • 3.5K
  • 22 Jul 2022
Topic Review
History of the Portable Document Format (PDF)
The Portable Document Format was created in the early 1990s by Adobe Systems, introduced at the Windows and OS|2 Conference in January 1993 and remained a proprietary format until it was released as an open standard in 2008. Since then, it is under control of International Organization for Standardization Committee of volunteer industry experts. PDF was developed to share documents, including text formatting and inline images, among computer users of disparate platforms who may not have access to mutually-compatible application software.It was created by a research and developement team called Camelot, led by Adobe's co-founder John Warnock. PDF was one among a number of competing formats such as DjVu, Envoy, Common Ground Digital Paper, Farallon Replica and even Adobe's own PostScript format. In those early years before the rise of the World Wide Web and HTML documents, PDF was popular mainly in desktop publishing workflows. PDF's adoption in the early days of the format's history was slow. Adobe Acrobat, Adobe's suite for reading and creating PDF files, was not freely available; early versions of PDF had no support for external hyperlinks, reducing its usefulness on the Internet; the larger size of a PDF document compared to plain text required longer download times over the slower modems common at the time; and rendering PDF files was slow on the less powerful machines of the day. Adobe distributed its Adobe Reader (now Acrobat Reader) program free of charge from version 2.0 onwards, and continued supporting the original PDF, which eventually became the de facto standard for fixed-format electronic documents. In 2008 Adobe Systems' PDF Reference 1.7 became ISO 32000:1:2008. Thereafter, further development of PDF (including PDF 2.0) is conducted by ISO's TC 171 SC 2 WG 8 with the participation of Adobe Systems and other subject matter experts.
  • 3.5K
  • 14 Oct 2022
Topic Review
Jáchymov
Jáchymov (Czech pronunciation: [ˈjaːxɪmof]); German: Sankt Joachimsthal or Joachimsthal) is a spa town in Karlovy Vary District in the Karlovy Vary Region of the Czech Republic. It has about 2,300 inhabitants. The historical core of the town from the 16th century is well preserved and protected by law as urban monument zone. It is a comprehensive set of Gothic–Renaissance patrician houses. Jáchymov has a long mining tradition, thanks to which it used to be the second most populous town in the Kingdom of Bohemia in 1534. At first silver was mined here. The silver Joachimsthaler coins minted here since the 16th century gave their name to the Thaler and the dollar. After the Wieliczka Salt Mine ceased industrial exploitation in 2007, the Svornost mine (1525) became the oldest mine still in use in Europe. It is also the first and for a long time the only mine in the world, where radium was mined. The mining cultural landscape of Jáchymov is a UNESCO World Heritage Site as a part of the Ore Mountain Mining Region.
  • 3.5K
  • 04 Nov 2022
Topic Review
Pseudomyxoma Peritonei
Pseudomyxoma Peritonei (PMP) is a unique clinical condition characterized by massive intraperitoneal growth of mucinous ascites that may be accompanied by peritoneal implants of mucinous tumors. 
  • 3.5K
  • 28 Dec 2020
Topic Review
Fruit Development in Sweet Cherry
Fruits are an important source of vitamins, minerals and nutrients in the human diet. They also contain several compounds of nutraceutical importance that have significant antioxidant and anti-inflammatory roles. Cherries contain high concentrations of bioactive compounds and minerals, including calcium, phosphorous, potassium and magnesium, and it is, therefore, unsurprising that cherry consumption has a positive impact on health. The sweet cherry fruit is a drupe—an indehiscent fruit of 1–2 cm in diameter (in some cultivars the diameter can be larger) that has an attractive appearance due to its color (bright red to dark purple depending on the cultivar) and desirable, intense flavor.
  • 3.5K
  • 16 Jun 2022
Topic Review
Factors Affecting Success of Entrepreneurship in Agribusinesses
Entrepreneurship and innovation are the fuel of economic growth. Understanding the motivational factors that lead to the success of entrepreneurs in agribusiness can be useful in affecting the degree of successful investment that accelerates development and economic growth in the agriculture sector. Entrepreneurship experience, risk-taking behavior, interest rates, and initial capital have a significant impact on the probability of entrepreneurship success and entrepreneur’s profits. Policies that could improve the skills of entrepreneurs, provision of initial capital requirements, and financial market efficiency had an effective role in increasing entrepreneurship and innovation in the agribusiness sector. Entrepreneurs in the field of agriculture could consider these factors to have better choices while entering or continuing with their agribusinesses.
  • 3.5K
  • 30 Jun 2022
Topic Review
Gambling Mathematics
The mathematics of gambling are a collection of probability applications encountered in games of chance and can be included in game theory. From a mathematical point of view, the games of chance are experiments generating various types of aleatory events, the probability of which can be calculated by using the properties of probability on a finite space of events.
  • 3.5K
  • 25 Oct 2022
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