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Topic Review
Definitions and the Basics of Knot Tying
Surgical knots are sequences of half-knots (H) or half-hitches (S), defined by their number of throws, by an opposite or similar rotation compared with the previous one, and for half-hitches whether they are sliding (s) or blocking (b). Opposite rotation results in (more secure) symmetric (s) knots, similar rotation in asymmetric (a) knots, and changing the active and passive ends has the same effect as changing the rotation. Loop security is the force to keep tissue together after a first half-knot or sliding half-hitches. With polyfilament sutures, H2, H3, SSs, and SSsSsSs have a loop security of 10, 18, 28, and 48 Newton (N), respectively. With monofilament sutures, they are only 7, 16, 18, and 25 N. For knot security, half hitch sequences such as 2 sliding and 2 blocking half hitches are the future: the risk of destabilisation is less, and for monofilament sutures, they are mandatory.   
  • 4.2K
  • 05 Dec 2023
Topic Review
Musical Instruments Made of Composites and Alternative Materials
The evolution of musical instrument manufacturing has been a dynamic process, with traditional materials such as wood playing a predominant role for centuries. However, the need for innovation in the musical industry has driven researchers and manufacturers to explore alternative materials that offer enhanced performance, sustainability, and versatility. The demand for different materials arises from various challenges faced by the musical instruments industry, including the lack of high-quality tonewoods, the significant variations in both mechanical and acoustical properties of wood internally within a single piece or across the same species, environmental concerns, and the quest for achieving specific acoustic properties. Composite materials, such as carbon- and graphite fiber-reinforced plastics (CFRPs and GFRPs), ceramic polymers, and nanocomposites, constitute promising alternatives that not only address these challenges, but also offer unique advantages in terms of durability, weight reduction, and customizable acoustic characteristics. 
  • 4.2K
  • 14 Mar 2024
Topic Review Peer Reviewed
Machine Learning for Additive Manufacturing
Additive manufacturing (AM) is the name given to a family of manufacturing processes where materials are joined to make parts from 3D modelling data, generally in a layer-upon-layer manner. AM is rapidly increasing in industrial adoption for the manufacture of end-use parts, which is therefore pushing for the maturation of design, process, and production techniques. Machine learning (ML) is a branch of artificial intelligence concerned with training programs to self-improve and has applications in a wide range of areas, such as computer vision, prediction, and information retrieval. Many of the problems facing AM can be categorised into one or more of these application areas. Studies have shown ML techniques to be effective in improving AM design, process, and production but there are limited industrial case studies to support further development of these techniques.
  • 4.2K
  • 13 Apr 2022
Topic Review
History of Intersex Surgery
The history of intersex surgery is intertwined with the development of the specialities of pediatric surgery, pediatric urology, and pediatric endocrinology, with our increasingly refined understanding of sexual differentiation, with the development of political advocacy groups united by a human qualified analysis, and in the last decade by doubts as to efficacy, and controversy over when and even whether some procedures should be performed. Prior to the medicalization of intersex, Canon and common law referred to a person's sex as male, female or hermaphrodite, with legal rights as male or female depending on the characteristics that appeared most dominant. The foundation of common law, the Institutes of the Lawes of England described how a hermaphrodite could inherit "either as male or female, according to that kind of sexe which doth prevaile." Single cases have been described by legal cases sporadically over the centuries. Modern ideas of medicalization of intersex and birth defects can be traced to French anatomist Isidore Geoffroy Saint-Hilaire (1805–1861), who pioneered the field of teratology. Since the 1920s surgeons have attempted to "fix" an increasing variety of conditions. Success has often been partial and surgery is often associated with minor or major, transient or permanent complications. Techniques in all fields of surgery are frequently revised in a quest for higher success rates and lower complication rates. Some surgeons, well aware of the immediate limitations and risks of surgery, feel that significant rates of imperfect outcomes are no scandal (especially for the more severe and disabling conditions). Instead they see these negative outcomes as a challenge to be overcome by improving the techniques. Genital reconstruction evolved within this tradition. In recent decades, nearly every aspect of this perspective has been called into question, with increasing concern regarding the human rights implications of medical interventions.
  • 4.2K
  • 01 Nov 2022
Topic Review
Promoting Traditional Craftsmanship Through Digital Technology
Τhe success of assisting Cultural Heritage (CH) valorization through digital technologies (availability, accessibility, and engaging and interactive presentations) is due to the captivating content of stories, memories, and meaning that CH offers. Traditional Crafts (TCs) have a paramount cultural value and offer a thematic thesaurus of stories and narratives related to the origins of modern societies, history, and culture, the origins of industrial development and design, economic factors and societal outcomes, as well as, personal and family memories, all of which general audiences can relate to.
  • 4.2K
  • 30 Mar 2022
Topic Review
Ochlocracy
Ochlocracy (Greek: ὀχλοκρατία, romanized: okhlokratía; Latin: ochlocratia) or mob rule is the rule of government by a mob or mass of people and the intimidation of legitimate authorities. Insofar as it represents a pejorative for majoritarianism, it is akin to the Latin phrase mobile vulgus, meaning "the fickle crowd", from which the English term "mob" originally was derived in the 1680s. Ochlocracy is synonymous in meaning and usage to the modern, informal term "mobocracy", which arose in the 18th century as a colloquial neologism. Likewise, whilst the ruling mobs in ochlocracies may sometimes genuinely reflect the will of the majority in a manner approximating democracy, ochlocracy is characterized by the absence or impairment of a procedurally civil and democratic process.
  • 4.2K
  • 01 Nov 2022
Topic Review
Goose Bumps
Goose bumps, goosebumps or goose-pimples are the bumps on a person's skin at the base of body hairs which may involuntarily develop when a person is tickled, cold or experiencing strong emotions such as fear, euphoria or sexual arousal. The formation of goose bumps in humans under stress is considered to be a vestigial reflex. Its function in other apes is to raise the body's hair, and would have made human ancestors appear larger to scare off predators or to increase the amount of air trapped in the fur to make it more insulating. The reflex of producing goose bumps is known as piloerection or the pilomotor reflex, or, more traditionally, horripilation. It occurs in many mammals; a prominent example is porcupines, which raise their quills when threatened, or sea otters when they encounter sharks or other predators.
  • 4.2K
  • 29 Nov 2022
Topic Review
Social Trap
In psychology, a social trap is a conflict of interest or perverse incentive where individuals or a group of people act to obtain short-term individual gains, which in the long run leads to a loss for the group as a whole. Social traps are the cause of countless environmental issues, including overfishing, energy "brownout" and "blackout" power outages during periods of extreme temperatures, the overgrazing of cattle on the Sahelian Desert, the destruction of the rainforest by logging interests and agriculture, and, most importantly, climate change.
  • 4.2K
  • 01 Dec 2022
Topic Review
Misnagdim
Misnagdim (מתנגדים; also Mitnagdim; singular misnaged/mitnaged) is a Hebrew word meaning "opponents". The term "Misnagdim" commonly refers to opponents of Hasidism. The term "Misnagdim" gained a common usage among Jews living in Europe as the term that referred to Ashkenazi Jews who opposed the rise and spread of early Hasidic Judaism.
  • 4.1K
  • 18 Nov 2022
Topic Review
Polyphenols against Skin Aging
Polyphenols représente a superfamily of diverse naturally occurring phytochemicals, which exert a particularly potent antioxidant activity, thereby contributing to delay skin aging.
  • 4.1K
  • 19 Nov 2020
Topic Review
Rhinovirus
Rhinoviruses (RVs) are non-enveloped positive sense RNA viruses with a lifecycle fully contained within the cytoplasm. Despite decades of study, the details of how RVs exit the infected cell are still unclear. Current literature strongly suggests a role for necroptosis and/or autophagy in RV release, with the caveat that all the literature is based on RV-A and RV-B strains, with no studies to date examining the interaction of RV-C strains with cell death pathways.
  • 4.1K
  • 15 Jun 2021
Topic Review
Marketing Information System
A marketing information system (MKIS) is a management information system (MIS) designed to support marketing decision making. Jobber (2007) defines it as a "system in which marketing data is formally gathered, stored, analysed and distributed to managers in accordance with their informational needs on a regular basis." In addition, the online business dictionary defines Marketing Information System (MKIS) as "a system that analyzes and assesses marketing information, gathered continuously from sources inside and outside an organization or a store." Furthermore, "an overall Marketing Information System can be defined as a set structure of procedures and methods for the regular, planned collection, analysis and presentation of information for use in making marketing decisions." (Kotler, at al, 2006)
  • 4.1K
  • 17 Oct 2022
Topic Review
Ethics in Religion
Ethics involves systematizing, defending, and recommending concepts of right and wrong behavior. A central aspect of ethics is "the good life", the life worth living or life that is simply satisfying, which is held by many philosophers to be more important than traditional moral conduct. Most religions have an ethical component, often derived from purported supernatural revelation or guidance. Some assert that religion is necessary to live ethically. Simon Blackburn states that there are those who "would say that we can only flourish under the umbrella of a strong social order, cemented by common adherence to a particular religious tradition".
  • 4.1K
  • 17 Oct 2022
Topic Review
Methotrexate
Methotrexate (MTX), a structural analogue of folic acid, that inhibits cell division (mainly in the S phase of the cell cycle) is commonly used for the treatment of many cancers as well for severe and resistant forms of autoimmune pathologies and inflammatory disorders. This paragraph of clinical overview presents state of knowledge with regards to different pathways of MTX active transport system, mechanisms of action and its applications as immunosuppressive drug and anticancer agent.  
  • 4.1K
  • 28 Oct 2020
Topic Review Peer Reviewed
Joanna I of Anjou (1343–1382)
Joanna I of Anjou (1325–1382), countess of Provence and the fourth sovereign of the Angevin dynasty in south Italy (since 1343), became the heir to the throne of the Kingdom of Sicily, succeeding her grandfather King Robert “the Wise” (1277–1343). The public and official images of the queen and the “symbolic” representations of her power, commissioned by her or by her entourage, contributed to create a new standard in the cultural references of the Angevin iconographic tradition aiming to assimilate models shared by the European ruling class. In particular, the following works of art and architecture will be analyzed: the queen’s portraits carved on the front slabs of royal sepulchers (namely those of her mother Mary of Valois and of Robert of Anjou) and on the liturgical furnishings in the church of Santa Chiara in Naples; the images painted in numerous illuminated manuscripts, in the chapter house of the friars in the Franciscan convent of Santa Chiara in Naples, in the lunette of the church in the Charterhouse of Capri. The church of the Incoronata in Naples does not show, at the present time, any portrait of the queen or explicit reference to Joanna as a patron. However, it is considered the highest symbolic image of her queenship. 
  • 4.1K
  • 13 Apr 2022
Topic Review
Stuttering
Stuttering, also known as stammering, is a speech disorder in which the flow of speech is disrupted by involuntary repetitions and prolongations of sounds, syllables, words, or phrases as well as involuntary silent pauses or blocks in which the person who stutters is unable to produce sounds. The term stuttering is most commonly associated with involuntary sound repetition, but it also encompasses the abnormal hesitation or pausing before speech, referred to by people who stutter as blocks, and the prolongation of certain sounds, usually vowels or semivowels. According to Watkins et al., stuttering is a disorder of "selection, initiation, and execution of motor sequences necessary for fluent speech production". For many people who stutter, repetition is the main concern. The term "stuttering" covers a wide range of severity, from barely perceptible impediments that are largely cosmetic to severe symptoms that effectively prevent oral communication. Almost 70 million people worldwide stutter, about 1% of the world's population. The impact of stuttering on a person's functioning and emotional state can be severe. This may include fears of having to enunciate specific vowels or consonants, fears of being caught stuttering in social situations, self-imposed isolation, anxiety, stress, shame, low self-esteem, being a possible target of bullying (especially in children), having to use word substitution and rearrange words in a sentence to hide stuttering, or a feeling of "loss of control" during speech. Stuttering is sometimes popularly seen as a symptom of anxiety, but there is no direct correlation in that direction. Stuttering is generally not a problem with the physical production of speech sounds or putting thoughts into words. Acute nervousness and stress are not thought to cause stuttering, but they can trigger stuttering in people who have the speech disorder, and living with a stigmatized disability can result in anxiety and high allostatic stress load (chronic nervousness and stress) that reduce the amount of acute stress necessary to trigger stuttering in any given person who stutters, worsening the situation in the manner of a positive feedback system; the name 'stuttered speech syndrome' has been proposed for this condition. Neither acute nor chronic stress, however, itself creates any predisposition to stuttering. The disorder is also variable, which means that in certain situations, such as talking on the telephone or in a large group, the stuttering might be more severe or less, depending on whether or not the person who stutters is self-conscious about their stuttering. People who stutter often find that their stuttering fluctuates and that they have "good" days, "bad" days and "stutter-free" days. The times in which their stuttering fluctuates can be random. Although the exact etiology, or cause, of stuttering is unknown, both genetics and neurophysiology are thought to contribute. There are many treatments and speech therapy techniques available that may help decrease speech disfluency in some people who stutter to the point where an untrained ear cannot identify a problem; however, there is essentially no cure for the disorder at present. The severity of the person's stuttering would correspond to the amount of speech therapy needed to decrease disfluency. For severe stuttering, long-term therapy and hard work is required to decrease disfluency.
  • 4.1K
  • 23 Nov 2022
Topic Review
Classification of Electric Vehicles
EVs have the ability to run solely on electric propulsion or in conjunction with an internal combustion engine (ICE). The simplest sort of EV relies just on batteries as its source of energy; however, there are many variants that make use of a variety of other types of energy sources. These automobiles are hybrid electric models (HEVs). The Technical Committee 69 Electric Road Vehicles (ERV) of the International Electrical Technical Commission proposes that vehicles with two or more forms of energy source, storage, or converters can be classified as HEVs as long as at least one of them provides electrical energy.
  • 4.1K
  • 19 Jun 2023
Topic Review
NRF2
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges. In addition to antioxidant responses, NRF2 is involved in other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cell’s response and adaptation to various pathological stressors for the homeostasis maintenance. Elevated or decreased NRF2 activity by pharmacological and genetic manipulations of NRF2 activation is associated with many metabolism- or inflammation-related diseases. Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and establishes NRF2 as a truly pleiotropic transcription factor. Here we summarize the complex regulatory network of NRF2 activity and its roles in metabolic reprogramming, unfolded protein response, proteostatsis, autophagy, mitochondrial biogenesis, inflammation, and immunity.
  • 4.1K
  • 17 Jul 2020
Topic Review
Values in Action Inventory of Strengths
The VIA Inventory of Strengths (VIA-IS), formerly known as the "Values in Action Inventory," is a proprietary psychological assessment measure designed to identify an individual's profile of character strengths. It was created by Christopher Peterson and Martin Seligman, well-known researchers in the field of positive psychology, in order to operationalize their Character Strengths and Virtues Handbook (CSV). The CSV is the positive psychology counterpart to the Diagnostic and Statistical Manual of Mental Disorders (DSM) used in traditional psychology. Unlike the DSM, which scientifically categorizes human deficits and disorders, the CSV classifies positive human strengths. Moreover, the CSV is centered on helping people recognize and build upon their strengths. This aligned with the overall goal of the positive psychology movement, which aims to make people's lives more fulfilling, rather than simply treating mental illness. Notably, the VIA-IS is the tool by which people can identify their own positive strengths and learn how to capitalize on them.
  • 4.1K
  • 01 Dec 2022
Topic Review
Integrated Watershed Management
Human activities mostly impact the trend and direction of rainwater, groundwater, and other river basin resources in the watershed in Africa. These activities alter river flows and the quality of usable water supplies at both highlands and lowlands. A watershed is indeed a conserved area of land that collects rain, sleet and snow, and empties or penetrates groundwater sources.
  • 4.1K
  • 26 Jan 2022
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