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Topic Review
The Perry High/Scope Preschool Program: A Critique
Early Childhood Education programs aim at preventing educational delays associated with socio-ethnic disadvantage in the home environment of young children. Advocates claim that such programs can be effective, provided they are of high quality. Despite the investment of enormous budgets, the educational gap between socio-economically deprived families and their wealthier counterparts is still widening. The question therefore is justified whether these claims are warranted. This article focuses on the internal and external validity of the most cited preschool program, the High/Scope Perry Preschool Project, which was carried out between 1962 and 1967 in one school in Ypsilant, MI. Are the program's effects as reported by, e.g. Lawrence Schweinhart and James Heckman, reliable and valid? And is it really possible to generalize the findings of this so-called model program to other programs, target groups, settings and conditions, as is being claimed?
  • 4.2K
  • 21 Aug 2023
Topic Review
Power Grid
One of the most critical infrastructures in the world is electrical power grids (EPGs). New threats affecting EPGs, and their different consequences, are analyzed in this survey along with different approaches that can be taken to prevent or minimize those consequences, thus improving EPG resilience. The necessity for electrical power systems to become resilient to such events is becoming compelling; indeed, it is important to understand the origins and consequences of faults. This survey provides an analysis of different types of faults and their respective causes, showing which ones are more reported in the literature. As a result of the analysis performed, it was possible to identify four clusters concerning mitigation approaches, as well as to correlate them with the four different states of the electrical power system resilience curve.
  • 4.2K
  • 23 Oct 2020
Topic Review
PCR and NGS in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a clonal disorder that affects myeloid progenitor cells residing in the bone marrow (BM). This implies altered differentiation with subsequent abnormal proliferation and accumulation of inadequately matured myeloid cells. The detection of leukemic cells moved in the last two decades from immune-phenotyping to polymerase chain reaction (PCR) and real-time quantitative PCR (RT-qPCR). This technique was shown to be reproducible, accurate and highly sensitive for MRD monitoring, with a significant capacity in predicting prognosis, treatment effectiveness and relapse risk. NGS or massively parallel sequencing is a revolutionary method of DNA and RNA sequencing. It is called parallel because it sequences millions of DNA fragments simultaneously. In the early years of its appearance, Next Generation Sequencing (NGS) platforms were used primarily for cancer research purposes. Recently, they are increasingly emerging as irreplaceable diagnostic tools in clinical settings.
  • 4.2K
  • 10 Feb 2022
Topic Review
Types of Snow
Types of snow can be designated by the shape of its flakes, description of how it is falling, and by how it collects on the ground. A blizzard and snow storm indicate heavy snowfalls over a large area, snow squalls give heavy snowfalls over narrow bands, while flurries are used for the lightest snowfall. Types which fall in the form of a ball, rather than a flake, are known as graupel, with sleet and snow grains as types of graupel. Once on the ground, snow can be categorized as powdery when fluffy, granular when it begins the cycle of melting and refreezing, and crud or eventually ice once it packs down into a dense drift after multiple melting and refreezing cycles. When powdering, snow drifts with the wind or ground blizzard, sometimes to the depth of several metres. After attaching to hillsides, blown snow can evolve into a snow slab, which is an avalanche hazard on steep slopes.
  • 4.2K
  • 04 Nov 2022
Topic Review
Parity
In quantum mechanics, a parity transformation (also called parity inversion) is the flip in the sign of one spatial coordinate. In three dimensions, it can also refer to the simultaneous flip in the sign of all three spatial coordinates (a point reflection): It can also be thought of as a test for chirality of a physical phenomenon, in that a parity inversion transforms a phenomenon into its mirror image. All fundamental interactions of elementary particles, with the exception of the weak interaction, are symmetric under parity. The weak interaction is chiral and thus provides a means for probing chirality in physics. In interactions that are symmetric under parity, such as electromagnetism in atomic and molecular physics, parity serves as a powerful controlling principle underlying quantum transitions. A matrix representation of P (in any number of dimensions) has determinant equal to −1, and hence is distinct from a rotation, which has a determinant equal to 1. In a two-dimensional plane, a simultaneous flip of all coordinates in sign is not a parity transformation; it is the same as a 180° rotation. In quantum mechanics, wave functions that are unchanged by a parity transformation are described as even functions, while those that change sign under a parity transformation are odd functions.
  • 4.2K
  • 10 Nov 2022
Topic Review
Causes and Risk Factors of Alzheimer’s Disease
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities. AD is considered a multifactorial disease: two main hypotheses were proposed as a cause for AD, cholinergic and amyloid hypotheses. Additionally, several risk factors such as increasing age, genetic factors, head injuries, vascular diseases, infections, and environmental factors play a role in the disease.
  • 4.2K
  • 29 Feb 2024
Topic Review
Applications of Chitin in Agricultural Industries
Chitin can play a key role in the agricultural industry due to its water-soluble nature. The different applications of chitin in the agricultural industry have been well documented with even more novel processes still in development. Some of those would include, but are not limited to, being used as fertilizers, soil conditioning agents, plant disease control agents, antitranspirants, fruit retardants, and seed coatings. Furthermore, chitin can increase the natural defense mechanisms in plants by upregulating plant growth regulators, growth stimulants, anti-stress agents, and elicitors for the production of secondary metabolites.
  • 4.2K
  • 24 Dec 2021
Topic Review Video
Classification of Energy Storage Technologies
The intensive exploitation and usage of fossil fuels has led to serious environmental consequences, including soil, water, and air pollution and climate changes, and it has compromised the natural resources available for future generations. In this context, identifying new energy storage technologies can be considered a sustainable solution to these problems, with potential long-term effects.
  • 4.2K
  • 19 Jan 2024
Biography
Ashoke Sen
Ashoke Sen, FRS (/əˈʃoʊk sɛn/; born 1956) is an Indian theoretical physicist and distinguished professor at the Harish-Chandra Research Institute, Allahabad.[1] He is also an honorary fellow in National Institute of Science Education and Research (NISER), Bhubaneswar, India [2] and also a Morningstar Visiting professor at MIT and a distinguished professor at the Korea Institute for Advanced
  • 4.2K
  • 16 Nov 2022
Topic Review
Applications of Liquid Crystals-Based Sensors
Liquid crystals are a class of chemical substances that exist in intermediate states between crystalline solids and liquids. They thus share the anisotropic properties of crystalline solids as well as fluid properties of isotropic liquids. 
  • 4.2K
  • 23 Mar 2022
Topic Review
Mie–Gruneisen Equation of State
The Mie–Grüneisen equation of state is a relation between the pressure and the volume of a solid at a given temperature. It is used to determine the pressure in a shock-compressed solid. The Mie–Grüneisen relation is a special form of the Grüneisen model which describes the effect that changing the volume of a crystal lattice has on its vibrational properties. Several variations of the Mie–Grüneisen equation of state are in use. The Grüneisen model can be expressed in the form where V is the volume, p is the pressure, e is the internal energy, and Γ is the Grüneisen parameter which represents the thermal pressure from a set of vibrating atoms. If we assume that Γ is independent of p and e, we can integrate Grüneisen's model to get where p0 and e0 are the pressure and internal energy at a reference state usually assumed to be the state at which the temperature is 0K. In that case p0 and e0 are independent of temperature and the values of these quantities can be estimated from the Hugoniot equations. The Mie–Grüneisen equation of state is a special form of the above equation.
  • 4.2K
  • 22 Nov 2022
Topic Review
Closed-Loop Supply Chain
A CLSC can be defined as “a supply chain system entailing design and implementation for enhancing the useful value throughout the product life cycle while dynamically extracting value from different returned products”[1].
  • 4.2K
  • 23 Oct 2020
Topic Review
Fat-tailed Gerbil
The fat-tailed gerbil (Pachyuromys duprasi), also called the duprasi gerbil, is a rodent belonging to subfamily Gerbillinae. It is the only member of the genus Pachyuromys. These rodents are the most docile species of the gerbil subfamily. They have fluffy and soft fur. Fat-tailed gerbils have been available on the pet market for decades, but in the 21st century breeders can be hard to find. They are sometimes considered as pocket pets. Other common English names are: fat-tailed jird, fat-tailed rat, and beer mat gerbil. Names in other languages are: abu lya (أبو ليه) in Egyptian Arabic, and adhal alyan (عضل أليان) in Standard Arabic, souris à grosse queue (French), Fettschwanzrennmaus (German), fedthale mus (Danish), rasvahäntägerbiili (Finnish), and dikstaartgerbil (Dutch).
  • 4.2K
  • 08 Oct 2022
Topic Review Peer Reviewed
Financial Interdependence: A Social Perspective
Financial interdependence refers to the practice of sharing money as an expression of mutuality. Forms of financial interdependence are often rooted in cultural norms and values and may be carried out as a commitment to the well-being of the family through financial transfers, practiced as informal savings groups, or even established as legally constructed agreements. Financial interdependence can result in either beneficial or harmful outcomes, depending upon the nature of the relationships and the available resources. As a social and cultural concept, it has been generally neglected in the discourse on financial independence, yet it has important implications for society as a basis for collective prosperity.
  • 4.2K
  • 28 Aug 2023
Topic Review
Targeted Therapeutic Sites for Non-Small Cell Lung Cancer
The advent of precision medicine has brought light to the treatment of non-small cell lung cancer (NSCLC), expanding the options for patients with advanced NSCLC by targeting therapy through genetic and epigenetic cues. Tumor driver genes in NSCLC patients have been uncovered one by one, including epidermal growth factor receptor (EGFR), mesenchymal lymphoma kinase (ALK), and receptor tyrosine kinase ROS proto-oncogene 1 (ROS1) mutants. Antibodies and inhibitors that target the critical gene-mediated signaling pathways that regulate tumor growth and development are anticipated to increase patient survival and quality of life. Targeted drugs continue to emerge, with as many as two dozen approved by the Food and Drug Administration (FDA), and chemotherapy and targeted therapy have significantly improved patient prognosis.
  • 4.2K
  • 06 Dec 2022
Topic Review
Pharmacological Update Properties of Aloe Vera Active Constituents
Aloe vera (Aloe barbadensis Miller, family Xanthorrhoeaceae) is a perennial green herb with bright yellow tubular flowers that is extensively distributed in hot and dry areas of North Africa, the Middle East of Asia, the Southern Mediterranean, and the Canary Islands.  Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. 
  • 4.2K
  • 27 Jul 2022
Topic Review
Raccoon Dog
The Raccoon dog (Nyctereutes procyonoides) is a canid species native to East Asia, known for its distinctive appearance resembling both raccoons and dogs. Despite its name, it is not closely related to raccoons but belongs to the Canidae family. Raccoon dogs are highly adaptable omnivores, inhabiting a variety of habitats from forests to urban areas, and are recognized for their unique behaviors such as hibernation-like torpor during harsh winters.
  • 4.2K
  • 08 Mar 2024
Topic Review
2014 Taiwan Food Scandal
The 2014 Taiwan food scandal refers to a series of food safety incidents in Taiwan that came to light in 2014. Adulteration of cooking oil with recycled waste oil and animal feed oil was discovered in September 2014. Despite coming to light only in 2014, mass food adulteration by Taiwanese food conglomerates, however, has been suppressed for decades, and the food safety crisis has been among the reasons for the electoral defeat of the Kuomintang in late 2014. At least 1,256 businesses were affected in the gutter oil scandal. In November 2014, it was found that dried tofu products (a.k.a. dougan 豆乾) have been adulterated with an industrial dye, methyl yellow (a.k.a. dimethyl), for some 20 years. In December 2014, it was furthermore found that even regular non-dyed tofu has been found contaminated with carcinogens, resulting in over 25,000 kg recalled.
  • 4.2K
  • 28 Nov 2022
Topic Review
Importance of Mud Crab in Saline Water Ecosystems
Mud crabs genus Scylla (S. serrata, S. tranquebarica, S. olivacea, and S. paramamosain) is an important member of mangrove/estuarine saline water ecosystems than other crustaceans due to its major activities (biological burrowing and bioturbation creation) in protecting and spreading mangrove forests. Mud crabs are generally found in estuaries, especially in mangrove forests of India, Taiwan, Japan, China, South Africa, Indonesia, and the Philippines of Indo-Pacific places. Similarly, Malaysia, Singapore, Western Samoa, Salmon Island, Fiji, and New Caledonia are big mud crabs habitats.
  • 4.2K
  • 08 Jun 2023
Topic Review
Principles of Aboveground Biomass Estimation via Remote Sensing
Quantifying forest aboveground biomass (AGB) is essential for elucidating the global carbon cycle and the response of forest ecosystems to climate change.  Remote-sensing techniques have played a vital role in forest AGB estimation at different scales.
  • 4.2K
  • 15 Aug 2023
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