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Topic Review
Dental Implants in AUBB and ALBBs
The Implant survival rates were negatively affected in sub-entities linked to more extensive augmentation procedures such as bone donor site and dentition status. The inclusion and pooling of literature with a low level of evidence, the absence of randomized controlled clinical trials (RCTs) comparing AUBB and ALBB and the limited count of comparative studies with short follow-ups increases the risk of bias and complicates data interpretation.
  • 702
  • 08 Feb 2022
Topic Review
Artificial Intelligence-Assisted Discrimination of Oral Cancerous Lesions
Early detection of oral cancer is important to increase the survival rate and reduce morbidity. For the past few years, the early detection of oral cancer using artificial intelligence (AI) technology based on autofluorescence imaging, photographic imaging, and optical coherence tomography imaging has been an important research area. 
  • 701
  • 01 Aug 2022
Topic Review
Luteolin in Prevention and Treatment of Periodontal Disease
Polyphenols, a class of flavonoids, are secondary metabolites that play a crucial role in plant adaptation to both biotic and abiotic environments, including UV radiation, high light intensity, low/high temperatures, and attacks from pathogens, among others.
  • 697
  • 19 Dec 2023
Topic Review
Infraocclusion in the Primary and Permanent Dentition
The gradual movement of a tooth away from the occlusal plane is called infraocclusion or reinclusion. Reincluded teeth are most often deciduous molars, and permanent teeth are less frequently affected. Depending on the level of the infraocclusion, the severity of the disorder is classified as mild, moderate, or severe. The etiology of the phenomenon is not fully known. Tooth submerging can lead to serious complications, such as abnormal position of adjacent teeth, displacement of the bud of the permanent successor, shortening of the dental arch, or developmental disturbances of alveolar process. 
  • 695
  • 12 Mar 2024
Topic Review
Temporomandibular Joint Disorder Epidemiology
Temporomandibular disorders of all varieties affect people in every culture on every continent, affecting up to 11% of children and even as high as 31% of adults.
  • 694
  • 17 Aug 2023
Topic Review
Rotary Nickel-Titanium Instruments
Nickel–titanium alloy (Ni-Ti) rotary instruments must exert torque to cut and eradicate septic dentin during canal preparation; torsional stress, associated with friction between the instrument and dentin wall, accumulates in the instruments.
  • 691
  • 18 May 2021
Topic Review
Applications of 3D Printing in Dentistry
3D printing technologies include stereolithography, digital light processing, fused deposition modeling, selective laser sintering/melting, photopolymer jetting, powder binder, and 3D laser bioprinting. The main categories of 3D printing materials are polymers, metals, and ceramics. Despite limitations in printing accuracy and quality, 3D printing technology is now able to offer people a wide variety of potential applications in different fields of dentistry, including prosthodontics, implantology, oral and maxillofacial, orthodontics, endodontics, and periodontics. Understanding the existing spectrum of 3D printing applications in dentistry will serve to further expand its use in the dental field. Three-dimensional printing technology has brought about a paradigm shift in the delivery of clinical care in medicine and dentistry. 
  • 691
  • 08 Jan 2024
Topic Review
In Vivo Bone Tissue Engineering Advances
Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical translation of BTE requires overcoming a number of significant challenges.
  • 690
  • 24 Aug 2022
Topic Review
Full-Digital Customized Meshes in Guided Bone Regeneration
Meshes, especially titanium ones, are being widely applied in oral surgery. In guided bone regeneration (GBR) procedures, their use is often paired with membranes, being resorbable or non-resorbable. However, they present some limitations, such as difficulty in the treatment of severe bone defects, alongside frequent mesh exposure. Customized meshes, produced by a full-digital process, have been recently introduced in GBR procedures. The main findings in recent years of clinical trials regarding patient-specific mesh produced by CAD/CAM and 3D printing workflow, made in titanium or even PEEK, applied to GBR surgeries, are described. The purpose is to analyze their clinical management, advantages, and complications. 
  • 685
  • 26 May 2023
Topic Review
Novel Antibacterial Approaches for Eradicating Dental Biofilm
Periodontitis is a multifactorial chronic inflammatory disease that affects tooth-supporting soft/hard tissues of the dentition. The dental plaque biofilm is considered as a primary etiological factor in susceptible patients; however, other factors contribute to progression, such as diabetes and smoking. Current management utilizes mechanical biofilm removal as the gold standard of treatment. Antibacterial agents might be indicated in certain conditions as an adjunct to this mechanical approach. Studies suggest efficacy in the use of adjunctive antimicrobials in patients with grade C periodontitis of young age or where the associated risk factors are inconsistent with the amount of bone loss present. Meanwhile, alternative approaches such as photodynamic therapy and probiotics showed limited supportive evidence, and more studies are warranted to validate their efficiency.
  • 679
  • 20 Jan 2022
Topic Review
Matrix Metalloproteinases and Temporomandibular Joint Disorder
Temporomandibular disorders (TMD) are progressive degenerative disorders that affect the components of the temporomandibular joint (TMJ), characterized by pain and limitations in function. Matrix metalloproteinases (MMP) are enzymes involved in physiological breakdown of tissue that can have a pathological effect from an increase in activity during inflammation.
  • 677
  • 06 May 2023
Topic Review
Nystatin-Added Tissue Conditioners for DIS
Denture-induced stomatitis (DIS) represents a pathological condition caused by ill-fitting dentures trauma, manifested as inflammation of the palatal tissue beneath the denture. The fungal infec-tions are the principal contributory factors to DIS. Although the aetiology of DIS is multifactorial, the Candida albicans fungal infection remains the main cause.
  • 675
  • 25 Feb 2021
Topic Review
Home Oral Care of Children
Tooth decay remains one of the most common diseases in children. The oral health status of children can be influenced by many different factors related to their oral health practices, but also to parental factors.
  • 664
  • 26 Aug 2022
Topic Review
Obesity, Bone Loss, and Periodontitis
Obesity and periodontitis are both common health concerns that have given rise to considerable economic and societal burden worldwide. There are established negative relationships between bone metabolism and obesity, obesity and diabetes mellitus (DM), and DM and periodontitis, to name a few, with osteoporosis being considered a long-term complication of obesity. In the oral cavity, bone metabolic disorders primarily display as increased risks for periodontitis and alveolar bone loss. Obesity-driven alveolar bone loss and mandibular osteoporosis have been observed in animal models without inoculation of periodontopathogens. Clinical reports have also indicated a possible association between obesity and periodontitis.
  • 652
  • 08 Jul 2022
Topic Review
Scaffolds for Dentin–Pulp Complex Regeneration
Regenerative dentistry aims to regenerate the pulp–dentin complex and restore those of its functions that have become compromised by pulp injury and/or inflammation. Scaffold-based techniques are a regeneration strategy that replicate a biological environment by utilizing a suitable scaffold, which is considered crucial for the successful regeneration of dental pulp. 
  • 650
  • 08 Jan 2024
Topic Review
Tactile Sensibility Thresholds in Implant Prosthesis/Complete Dentures/Natural Dentition
The periodontium has important proprioceptive receptors that prevent teeth from using excessive occlusal forces during chewing. There are other receptors from adjacent tissues that replace periodontal ones when teeth are extracted and rehabilitated with prosthesis, although they seem to be less effective. Psychophysical studies investigate tactile sensibility thresholds, which are useful to measure this masticatory efficiency in different prosthetic rehabilitations. There are two types of sensibility depending on the receptors that are activated during these studies: active and passive tactile sensibility. The mean values of active tactile sensibility thresholds in complete dentures, implant prosthesis and natural dentition are 64 µ, 23.3 µ and 16.1 µ, respectively. The mean values of passive tactile sensibility thresholds in implant prosthesis and natural dentition are 6.7 N and 0.8 N, respectively. Implant prosthesis have lower thresholds, that are very close to those present in natural dentition, than complete dentures due to an increased tactile sensibility. Active tactile sensibility thresholds present fewer differences between values than passive tactile ones; as these are only influenced by receptors from periodontal or periimplant tissues.
  • 649
  • 11 May 2022
Topic Review
Photobiomodulation with Laser Technology in Fixed Orthodontic Treatment
Despite the growing demand for improving smile aesthetics and occlusal functionality, a significant percentage of patients still refuse or discontinue orthodontic treatment because of pain and discomfort related to this therapy. As consequence, controlling the pain experienced by patients during the same therapy represents a primary concern for both patients and clinicians. Pieces of evidence have suggested that photobiomodulation can reduce pain experienced by patients during the decrowding stage or during specific protocols, for example, rapid maxillary expansion. PBM can be performed with lasers and also with a light-emitting diode (LED) device. 
  • 649
  • 23 Apr 2023
Topic Review
Nano-Drug Delivery Systems in Oral Cancer Therapy
Oral cancer (OC), characterized by malignant tumors in the mouth, is one of the most prevalent malignancies worldwide. Chemotherapy is a commonly used treatment for OC; however, it often leads to severe side effects on human bodies. Nanotechnology has emerged as a promising solution for managing OC using nanomaterials and nanoparticles (NPs). Nano-drug delivery systems (nano-DDSs) that employ various NPs as nanocarriers have been extensively developed to enhance current OC therapies by achieving controlled drug release and targeted drug delivery.
  • 649
  • 04 Jan 2024
Topic Review
Antifungals in Preventing Oropharyngeal Candidiasis among HIV-Infected Adults
Oropharyngeal candidiasis (OPC) is attributed to the overgrowth of the commensal fungi, Candida spp., in the mouth and throat. Among HIV-infected adults, there is an increased risk of developing OPC due to the loss of cell-mediated immunity. Fluconazole can be considered as an effective agent with a better safety profile for the prevention of OPC in HIV-infected adults.
  • 646
  • 22 Jun 2022
Topic Review
Silver Diamine Fluoride in Arresting Caries
Dental caries is a painful condition that could lead to nutritional problems which affects the overall health of the child, as well it is expensive to treat. 
  • 645
  • 13 Sep 2022
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