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Topic Review
Negative Environmental Impact of Consumerization of Information Technology
The internet plays a pivotal role in Industry 4.0, where it provides the underlying infrastructure to support the substantial growth of digital platforms and systems to deliver a wealth of benefits. However, with the unprecedented growth of internet-based applications in recent history, the internet itself is harming the environment. The most effective strategy to reduce internet usage is to incorporate extrinsic strategies and allow individuals to pay a premium for green internet services.
  • 1.1K
  • 13 Sep 2023
Topic Review
Organic Agriculture affects Soil, Crop and Human Health
The underlying philosophy/hypothesis of organic farming—“healthy soils generate healthy crops which lead to healthy livestock and humans”—was first formulated by Sir Albert Howard and other organic farming pioneers. Organic crop production practices could increase the nutritional quality of food crops, the evidence now available suggests that there are nutritionally relevant composition differences between organic and conventional crops and that, overall, organic plant-foods contain higher concentrations of nutritionally desirable (phenolics, other antioxidants and/or mineral micronutrients) and lower concentrations of nutritionally undesirable chemicals (pesticide residues, cadmium, and/or Fusarium mycotoxins). However, agricultural intensification practices have reduced food quality and safety, the available evidence indicates that many “innovations” (monoculture/shorter rotations, mineral N and P fertilizers, pesticides, and short-straw cereal varieties) introduced as part of the agricultural intensification (or “green revolution”) have had negative effects on both crop health and the nutritional quality and/or safety of crops.
  • 1.1K
  • 23 Oct 2023
Topic Review
Disentangled Polymers and Composites
Macromolecule entanglements are common in polymers. The chains of macromolecules with carbon skeletons are flexible. The isolated chain easily takes the shape of a coil. When a macromolecule is surrounded by other macromolecules, its coils interpenetrate, and entanglements arise between these macromolecules. The condition of their occurrence is that their molecular weight exceeds a certain limit. The entanglements may be topological (these are common) or cohesive. Entanglement with another macromolecule limits the movement of the macromolecule's chain, so it is an obstacle to this movement.
  • 1.1K
  • 29 Dec 2023
Topic Review
Internal Migration
Migration and urbanization go hand-in-hand, and a country’s economic development is closely linked to its urbanization. There is a strong correlation between urbanization and income per capita, and developing countries are urbanizing much faster than developed countries, a process now occurring over a few decades instead of a century or more as it did in the past.
  • 1.1K
  • 22 Jan 2024
Topic Review
Dendritic Cells and Allergic Asthma
Here we describe the pathophysiology of type II allergic asthma and the role that dendritic cells (DCs) play in the instruction of allergen specific, T-cell mediated immune responses. Moreover, we provide an overview of our current understanding pertinent to DCs that acquire tolerogenic properties and thus represent essential regulators of aberrant Th2 asthmatic responses.
  • 1.1K
  • 17 Nov 2020
Topic Review
Encryption and Compression Schemes Based on JPEG
Due to the excellent compression performance of JPEG, many schemes based on JPEG have been developed for the encryption and compression of digital images. According to the positioning of the encryption within the compression process, they can be classified into three categories: encryption before compression, joint compression and encryption, and compression before encryption. Encryption before compression means that the image is encrypted before JPEG compression. Typical methods include permutation encryption and some chaos-based encryption schemes that directly operate on the original image
  • 1.1K
  • 15 Sep 2023
Topic Review
Adequate Chronic Pain Care in Italy
Appropriate pain care should be regarded as a right and effectively guaranteed to people with chronic pain (CP). Additionally, the World Health Organization (WHO) has recognized the importance of addressing CP as a global public health concern and has recommended that pain management be integrated into primary healthcare systems. Many individuals with CP continue to experience barriers to accessing appropriate and effective pain care, including a lack of education and training among healthcare providers, limited availability of specialized pain clinics, and misconceptions about the use of opioid medications for pain management. Furthermore, CP patients often encounter social stigmatization and discrimination, which can further complicate their access to care. There is a need for ongoing efforts to improve the recognition, assessment, and management of chronic pain, and to ensure that individuals with CP have access to appropriate and effective pain care that addresses their physical, psychological, and social needs. Law 38, enacted in Italy in 2010, establishes the citizen’s right not to suffer.
  • 1.1K
  • 12 Jan 2023
Topic Review
Dietetic Habits in Multiple Sclerosis
Multiple sclerosis (MS) is a disabling immune-mediated demyelinating neurodegenerative disease with an estimated prevalence of 1 in 1000 in populations of European descent. It primarily affects females (F:M = 2–3:1) mainly between the ages of 15 and 55 years. 
  • 1.1K
  • 27 Jun 2023
Topic Review
HIV-1 Latency and Viral Reservoirs
Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV cure. While antiretroviral therapy (ART) halts HIV replication by targeting multiple steps in the HIV life cycle, including viral entry, integration, replication, and production, it cannot get rid of the occult provirus incorporated into the host-cell genome. These latent proviruses are replication-competent and can rebound in cases of ART interruption or cessation. In general, a very small population of cells harbor provirus, serve as reservoirs in ART-controlled HIV subjects, and are capable of expressing little to no HIV RNA or proteins. Beyond the canonical resting memory CD4+ T cells, HIV reservoirs also exist within tissue macrophages, myeloid cells, brain microglial cells, gut epithelial cells, and hematopoietic stem cells (HSCs). Despite a lack of active viral production, latently HIV-infected subjects continue to exhibit aberrant cellular signaling and metabolic dysfunction, leading to minor to major cellular and systemic complications or comorbidities. These include genomic DNA damage; telomere attrition; mitochondrial dysfunction; premature aging; and lymphocytic, cardiac, renal, hepatic, or pulmonary dysfunctions. Therefore, the arcane machineries involved in HIV latency and its reversal warrant further studies to identify the cryptic mechanisms of HIV reservoir formation and clearance.
  • 1.1K
  • 10 Mar 2021
Topic Review
Otopalatodigital Syndrome Type 1
Otopalatodigital syndrome type 1 is a disorder primarily involving abnormalities in skeletal development.
  • 1.1K
  • 24 Dec 2020
Topic Review Peer Reviewed
Supplements for Smoking-Related Lung Diseases
Supplements for smoking-related lung diseases are considered as nonfood products and thought to improve health. Multivitamins and antioxidants are the most commonly dietary supplements used by cancer and asthma patients. There are currently no clear regulatory guidelines that include dietary supplements and their effect on lung cancer and asthma patients, particularly in smokers. Several countries have taken steps to overcome challenges in regulating dietary supplements in the marketplace. These challenges include inadequate assurance of safety/efficacy, inaccuracy of product labeling, misleading health claims, and lack of analytical techniques for dietary supplements. There is a need to establish standards and regulation of dietary supplement use in patients with lung cancer and asthma. The aim of this entry is to expand knowledge on dietary supplements use and smoking-related lung diseases (lung cancer and asthma). 
  • 1.1K
  • 13 Apr 2022
Topic Review
Regulatory RNAs in Communication
In eukaryotes, microRNAs (miRNAs) have roles in development, homeostasis, disease and the immune response. Recent work has shown that plant and mammalian miRNAs also mediate cross-kingdom and cross-domain communications, but these studies remain controversial and are lacking critical mechanistic explanations. However, there are several conserved features and homologous components in the distinct Regulatory RNA pathways in eukaryotes and bacteria that could explain how eukaryotic miRNAs could function in such cross-domain communications.
  • 1.1K
  • 09 Jan 2021
Topic Review
Epigenetic Regulation of Epidermal Differentiation
Epidermal differentiation relies on a highly coordinated program of gene expression. Epigenetic mechanisms, which commonly include DNA methylation, covalent histone modifications, and microRNA (miRNA) activity, modulate various stages of gene expression by altering chromatin accessibility and mRNA stability. Their involvement in epidermal differentiation is a matter ofintensive studies.
  • 1.1K
  • 18 Jan 2021
Topic Review
HIV-1 Entry
Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after infection, which poses a major challenge for drug treatment and curative strategies. Many efforts are therefore focused on blocking infection. To this end, both viral and host factors relevant to the onset of infection need to be considered. Given that HIV-1 is most often transmitted mucosally, strategies designed to protect against infection need to be effective at mucosal portals of entry. These strategies need to contend also with cell-free and cell-associated transmitted/founder (T/F) virus forms; both can initiate and establish infection.
  • 1.1K
  • 06 Mar 2021
Topic Review
Bone Marrow Aspirate Matrix
The rise in musculoskeletal disorders has prompted medical experts to devise novel effective alternatives to treat complicated orthopedic conditions. The ever-expanding field of regenerative medicine has allowed researchers to appreciate the therapeutic value of bone marrow-derived biological products, such as the bone marrow aspirate (BMA) clot, a potent orthobiologic which has often been dismissed and regarded as a technical complication. Numerous in vitro and in vivo studies have contributed to the expansion of medical knowledge, revealing optimistic results concerning the application of autologous bone marrow towards various impactful disorders. The bone marrow accommodates a diverse family of cell populations and a rich secretome; therefore, autologous BMA-derived products such as the “BMA Matrix”, may represent a safe and viable approach, able to reduce the costs and some drawbacks linked to the expansion of bone marrow. BMA eliminates many hurdles associated with its preparation, especially in regards to regulatory compliance. The BMA Matrix represents a suitable alternative, indicated for the enhancement of tissue repair mechanisms by modulating inflammation and acting as a natural biological scaffold as well as a reservoir of cytokines and growth factors that support cell activity. Although promising, more clinical studies are warranted in order to further clarify the efficacy of this strategy. 
  • 1.1K
  • 06 Apr 2021
Topic Review
Forest Grazing
Daegwallyeong is a mountain pass at an altitude of 832 m, which has been designated a conservation area because of its essential role in Korea’s forest ecosystem. Simultaneously, this area is considered a suitable place for forest grazing due to the cool temperature during the summer.
  • 1.1K
  • 22 Jul 2021
Topic Review
DNA Assembly
Assembly of DNA-grafted 3D superlattice is composed of two pivotal elements: nanoparticles (NPs) core and DNA shell. The progress of chemical synthesis technique enables the chemical composition of NP core unrestricted; it can be metals, oxides, polymers, even biological molecule, which also allow for the integration of multiple functions like luminescent, catalytic, magnetic properties, and so on.
  • 1.1K
  • 28 Jul 2021
Topic Review
Medical Uses of N-Acetylcysteine
N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings. There are numerous other uses or proposed uses in medicine that are still in preclinical and clinical investigations. NAC is also used in food supplements and cosmetics. Despite its abundant use, there are projections that the NAC global market will grow in the next five years; therefore, the purpose of this work is to provide a balanced view of further uses of NAC as a dietary supplement. Although NAC is considered a safe substance, the results among clinical trials are sometimes controversial or incomplete, like for many other antioxidants. More clinical trials are underway that will improve our understanding of NAC applicability.
  • 1.1K
  • 16 Aug 2021
Topic Review
Severity Indicator of Pesticide Poisoning
Pesticides are considered highly hazardous when presenting high acute toxicity according to internationally accepted classification systems such as the WHO Recommended Classification of Pesticides by Hazard. In addition, pesticides that cause severe or irreversible harm to health “… under conditions of use in a country” may be considered as highly hazardous.
  • 1.1K
  • 17 Aug 2021
Topic Review
Nanozyme-Based Glucose Biofuel Cells
The appearance and evolution of biofuel cells can be categorized into three groups: microbial biofuel cells (MBFCs), enzymatic biofuel cells (EBFCs), and enzyme-like nanomaterial (nanozyme)-based biofuel cells (NBFCs). MBFCs can produce electricity from waste; however, they have significantly low power output as well as difficulty in controlling electron transfer and microbial growth. EBFCs are more productive in generating electricity with the assistance of natural enzymes, but their vulnerability under diverse environmental conditions has critically hindered practical applications.
  • 1.1K
  • 26 Aug 2021
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