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Topic Review
Molecular Mechanisms from Lung Fibrosis to Lung Cancer
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of diagnosis. Although IPF has unknown aetiology by definition, there have been identified several risks factors increasing the probability of the onset and progression of the disease in IPF patients such as cigarette smoking and environmental risk factors. Cigarette smoking together with concomitant emphysema might predispose IPF patients to lung cancer (LC), mostly to non-small cell lung cancer (NSCLC), increasing the risk of cancer development. 
  • 1.1K
  • 24 Nov 2021
Topic Review
COVID-19 Vaccine Tourism
Vaccine tourism is a novel health tourism concept, which provides an opportunity for countries with a vaccine surplus to offer medical tourism packages to entice international tourists from countries with vaccine shortages to visit for sightseeing and receive vaccine inoculations. 
  • 1.1K
  • 07 Dec 2021
Topic Review
Vascular Calcification in Chronic Kidney Disease
Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an active process regulated by various molecules that may act as inhibitors of vessel mineralization.
  • 1.1K
  • 09 Mar 2022
Topic Review
Update on Cyber Health Psychology
In recent years, there has been more and more talk of cyber health psychology and the implication that new technologies can have in the diagnosis, treatment, and rehabilitation of psychopathological issues in the field of mental health, ranging from post-traumatic stress disorder (PTSD) to addiction to substances of abuse.
  • 1.1K
  • 25 Mar 2022
Topic Review
A Threat to Food Price Stability in Turkey
The volatility of meat prices affects the accessibility and even food security of some consumers in Turkey. The prices of selected livestock and a major feed component, wheat, as well as the exchange rate of the domestic currency in Turkey because imports augmented the domestic live calf and sheep supply. The analysis applies 470 price observations from January 2005 to October 2019 for each of the following price series: live calf, live sheep, feed wheat, and exchange rate of Turkish lira to US dollar.
  • 1.1K
  • 07 May 2022
Topic Review
Neoantigen-Derived Cancer Vaccines
Cancers are driven by genetic instabilities that rapidly accumulate somatic mutations and eventually alter cell properties. Cancer immunotherapy has achieved multiple clinical benefits and has become an indispensable component of cancer treatment. Targeting tumor-specific antigens, also known as neoantigens, plays a crucial role in cancer immunotherapy. T cells of adaptive immunity that recognize neoantigens, but do not induce unwanted off-target effects, have demonstrated high efficacy and low side effects in cancer immunotherapy. 
  • 1.1K
  • 31 May 2022
Topic Review
Health Benefits of Dietary Fiber
Inflammatory bowel disease (IBD) is a severe and painful gastrointestinal tract disease that affects children and adults. IBD is a complex disease that has a detrimental effect on people’s quality of life. Due to the severe inflammation associated with IBD, the symptoms and associated morbidity are always prevalent. Despite substantial research, there is no permanent cure for IBD, and patients face an increased risk of colon cancer. Dietary fiber’s health advantages have been thoroughly investigated, and it is recommended for its enormous health benefits. 
  • 1.1K
  • 27 Jun 2022
Topic Review
Doxorubicin-Induced Mitochondrial Dysfunction
Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer cause of death in DOX-treated patients. 
  • 1.1K
  • 08 Jul 2022
Topic Review
E-Scaffolding and Virtual Learning Environments in Education
Educational institutions around the world were forced to suspend traditional classroom activities as part of the preventive actions taken to limit the spread of COVID-19. This has led to an increased interest in using e-learning, and the use of computers, mobile devices, and technology in general has become crucial across the curricula. Three-dimensional (3D) virtual environments are a good choice for this purpose. E-scaffolding is a way to provide temporary support and direction to learners during the learning process to help them to complete new learning tasks and to encourage them to build knowledge by themselves.
  • 1.1K
  • 02 Aug 2022
Topic Review
Advanced Glycation End Products in Diabetes Mellitus
Diabetes is well established as a chronic disease with a high health burden due to mortality or morbidity from the final outcomes of vascular complications. An increased duration of hyperglycemia is associated with abnormal metabolism. Advanced glycation end products (AGEs) are nonenzymatic glycated forms of free amino acids that lead to abnormal crosslinking of extra-cellular and intracellular proteins by disrupting the normal structure. Furthermore, the interaction of AGEs and their receptors induces several pathways by promoting oxidative stress and inflammation. 
  • 1.1K
  • 09 Aug 2022
Topic Review
The Role of the Microbiome in Pancreatic Cancer
The microbiome is now known to be associated with cancer development and progression in many types of cancer including pancreatic ductal adenocarcinoma (PDAC). Many observational studies have revealed the association of the oral, gut, and intratumor microbiome with human PDAC. The microbiome may affect the composition of tumor microenvironment via the immune response and generate an immunosuppressive environment. The microbiome could be a  biomarker for the prediction of an immunogenic tumor microenvironment and immune-targeted therapies.
  • 1.1K
  • 20 Oct 2022
Topic Review
Chloride Intracellular Channel Proteins and Malignant Tumor Progression
Chloride intracellular channel proteins (CLICs are the dimorphic protein present in both soluble and membrane fractions. As an integral membrane protein, CLICs potentially possess ion channel activity. In vertebrates, CLICs are classified into six classes: CLIC1, 2, 3, 4, 5, and 6. CLIC2 is expressed at higher levels in benign tumors than in malignant ones, most likely preventing tumor cell invasion into surrounding tissues. CLIC2 is also expressed in the vascular endothelial cells of normal tissues and maintains their intercellular adhesive junctions, presumably suppressing the hematogenous metastasis of malignant tumor cells. 
  • 1.1K
  • 11 Oct 2022
Topic Review
Climate Change and Children
Climate change has both a direct and indirect effect on children. Children are more vulnerable to the effects of climate change on humans than adults. The World Health Organization estimated that 88% of the existing global burden of disease is linked to climate change affecting children under 5 years of age. The Lancet review on health and climate change lists children as the worst-affected category by climate change. Children are physically more vulnerable to climate change in all its forms. Climate change affects the physical health of a child and his well-being. Prevailing inequalities, between and within countries, determines how climate change impacts children. Children have no voice or attention in terms of global responses to climate change. People living in low-income countries suffer from a higher burden of disease and are less capable of facing climate change threats.
  • 1.1K
  • 19 Oct 2022
Topic Review
Seifert–Van Kampen Theorem
In mathematics, the Seifert–van Kampen theorem of algebraic topology (named after Herbert Seifert and Egbert van Kampen), sometimes just called van Kampen's theorem, expresses the structure of the fundamental group of a topological space [math]\displaystyle{ X }[/math] in terms of the fundamental groups of two open, path-connected subspaces that cover [math]\displaystyle{ X }[/math]. It can therefore be used for computations of the fundamental group of spaces that are constructed out of simpler ones.
  • 1.1K
  • 27 Oct 2022
Topic Review
Metabolic Regulation of Mitochondrial Protein Biogenesis in neurons
Neurons critically depend on mitochondria for ATP production and Ca2+ buffering. They are highly compartmentalized cells and therefore a finely tuned mitochondrial network constantly adapting to the local requirements is necessary. For neuronal maintenance, old or damaged mitochondria need to be degraded, while the functional mitochondrial pool needs to be replenished with freshly synthesized components. Mitochondrial biogenesis is known to be primarily regulated via the PGC-1α-NRF1/2-TFAM pathway at the transcriptional level. However, while transcriptional regulation of mitochondrial genes can change the global mitochondrial content in neurons, it does not explain how a morphologically complex cell like a neuron adapts to local differences in mitochondrial demand. 
  • 1.1K
  • 07 Nov 2022
Topic Review
Pliohyracidae
Hyraxes (from grc ὕραξ (húrax) 'shrewmouse'), also called dassies, are small, thickset, herbivorous mammals in the order Hyracoidea. Hyraxes are well-furred, rotund animals with short tails. Typically, they measure between 30 and 70 cm (12 and 28 in) long and weigh between 2 and 5 kg (4 and 11 lb). They are superficially similar to pikas and marmots, but are more closely related to elephants and sea cows. Hyraxes have a life span from 9 to 14 years. Five extant species are recognised: the rock hyrax (Procavia capensis) and the yellow-spotted rock hyrax (Heterohyrax brucei), which both live on rock outcrops, including cliffs in Ethiopia and isolated granite outcrops called koppies in southern Africa; the western tree hyrax (Dendrohyrax dorsalis), southern tree hyrax (D. arboreus), and eastern tree hyrax (D. validus). Their distribution is limited to Africa, except for P. capensis, which is also found in the Middle East.
  • 1.1K
  • 21 Nov 2022
Topic Review
Pathophysiology of Fibromyalgia
Fibromyalgia syndrome (FMS) is one of the most prevalent disorders that affects the muscles and is characterized by pain, stiffness, and soreness in the muscles, tendons, and joints. Fibromyalgia is in a family of disorders termed the affective spectrum disorders (ASD). ASDs frequently co-occur in both individuals and families and share physiologic abnormalities along with genetic risk factors that may be central to their etiology. The most prevalent ASDs are attention-deficit/hyperactivity disorder, major depressive disorder [MDD], generalized anxiety disorder, obsessive compulsive disorder, bulimia nervosa, panic disorder, posttraumatic stress disorder, premenstrual dysphoric disorder, social phobia, and medical disorders such as irritable bowel syndrome [IBS], migraine, and cataplexy. FMS commonly manifests in young or middle-aged females as chronic widespread pain, stiffness, fatigue, disrupted unrefreshing sleep, and cognitive difficulties. FMS often coexists with a number of other unexplained symptoms, anxiety and/or depression, and functional impairment of daily living activities. Fibromyalgia typically causes broad pain that affects both sides of the body with numerous “tender points”. Despite having incapacitating physical pain, FMS is not accompanied by tissue inflammation, tissue damage, or deformity.
  • 1.1K
  • 26 Dec 2022
Topic Review
Biomarkers of Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct electrical cardioversion is a well-developed urgent treatment strategy for patients presenting with recent-onset AF.
  • 1.1K
  • 25 May 2023
Topic Review
Non-Aqueous Redox Flow Batteries
Redox flow batteries (RFBs) have been widely recognized in the domain of large-scale energy storage due to their simple structure, long lifetime, quick response, decoupling of capacity and power, and structural simplicity. Because of the limited open circuit voltage (OCV) by hydrogen and oxygen evolution reactions, together with the relatively low solubility of active species, RFBs with aqueous electrolytes are challenging to reach high energy densities. Researchers have been trying to develop new solvent systems without water to remove the electrochemical window limitation of water and pursue higher cell potential. However, non-aqueous solvents are also hindered by some key problems, such as high viscosity and poor safety.
  • 1.1K
  • 16 Jun 2023
Topic Review
Targeted Microbubbles for Immunotherapy Applications
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. In cancer immunotherapy, the microbubble shell can be engineered through the bioconjugation of molecular ligands to facilitate the delivery and uptake of drugs, genes, or cells. This approach allows for precise control of immune stimulation and improves the delivery and pharmacokinetics of immunomodulatory agents at the target site. It has emerged as an attractive strategy for treating various cancer immunotherapy modalities, including monoclonal antibodies, immune checkpoint inhibitors, adoptive cell transfer, cytokine therapy, and vaccines.
  • 1.1K
  • 20 Jun 2023
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