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Topic Review
Transfer-Appropriate Processing
Transfer-appropriate processing (TAP) is a type of state-dependent memory specifically showing that memory performance is not only determined by the depth of processing (where associating meaning with information strengthens the memory; see levels-of-processing effect), but by the relationship between how information is initially encoded and how it is later retrieved.
  • 1.1K
  • 03 Nov 2022
Topic Review
Kubity
Kubity is a cloud-based 3D communication tool that works on desktop computers, the web, smartphones, tablets, augmented reality gear, and virtual reality glasses. Kubity is powered by several proprietary 3D processing engines including "Paragone" and "Etna" that prepare the 3D file for transfer over mobile devices. Kubity has practical applications for architecture, interior design, engineering, product design, film, and video games among others. The majority of its users create 3D models using SketchUp or Autodesk Revit software. Kubity products include the Kubity web app and Kubity Go (a mobile application for iOS and Android). Kubity is compatible across many platforms, devices and operating systems including: iOS, Android, Firefox, Chrome, Windows, MacOS, and Linux.
  • 1.1K
  • 07 Nov 2022
Topic Review
Engineering Nicotinamide Cofactors for Continuous-Flow Biocatalysis
Nicotinamide cofactors represent the most common low-potential redox cofactor used in biocatalysis. Although a promising approach, cofactor immobilization depends on the chemical modification of the cofactor to enable the formation of a covalent bond between the cofactor and its flexible linker. The chemical modification of NAD(P)+/NAD(P)H remains challenging, and the major routes used to achieve it are reviewed herein.
  • 1.1K
  • 29 Nov 2022
Topic Review
Calcitonin Gene-Related Peptide and Gepants
Calcitonin gene-related peptide (CGRP) antagonists are a class of medications that act as antagonists of the CGRP receptor or ligand. They can be divided into monoclonal antibodies and non-peptide small molecules, also known as gepants. CGRP antagonists were the first oral agents specifically designed to prevent migraines. The second generation of gepants includes rimegepant (BHV-3000, BMS-927711), ubrogepant (MK-1602), and atogepant (AGN-241689, MK-8031). Zavegepant (BHV-3500, BMS-742413) belongs to the third generation of gepants characterized by different administration routes.
  • 1.1K
  • 29 Nov 2022
Topic Review
The Innate Immune System in Cardiovascular Diseases
Innate immune cells are the early responders to infection and tissue damage. They play a critical role in the initiation and resolution of inflammation in response to insult as well as tissue repair. Following ischemic or non-ischemic cardiac injury, a strong inflammatory response plays a critical role in the removal of cell debris and tissue remodeling. However, persistent inflammation could be detrimental to the heart. Studies suggest that cardiac inflammation and tissue repair needs to be tightly regulated such that the timely resolution of the inflammation may prevent adverse cardiac damage. This involves the recognition of damage; activation and release of soluble mediators such as cytokines, chemokines, and proteases; and immune cells such as monocytes, macrophages, and neutrophils. This is important in the context of doxorubicin-induced cardiotoxicity as well. Doxorubicin (Dox) is an effective chemotherapy against multiple cancers but at the cost of cardiotoxicity. The innate immune system has emerged as a contributor to exacerbate the disease.
  • 1.1K
  • 30 Nov 2022
Topic Review
Epidemiology of Lean/Normal-Weight Type 2 Diabetes
Several epidemiologic data have continued to support the existence of lean diabetes in populations living in low-income countries of Asia and Africa, and others studies pointed to a high prevalence of diabetes in normal-weight non-white populations, even in high-income settings such as the U.S.
  • 1.1K
  • 09 Jan 2023
Topic Review
The Influence of Specific Microbial Species on Diabetes
Diabetes mellitus (DM) is a metabolic disorder with an alarming incidence rate and a considerable burden on the patient’s life and health care providers. An increase in blood glucose level and insulin resistance characterizes it. Internal and external factors such as urbanization, obesity, and genetic mutations could increase the risk of DM. Microbes in the gut influence overall health through immunity and nutrition. More studies have been conducted to evaluate and estimate the role of the gut microbiome in diabetes development, progression, and management. 
  • 1.1K
  • 15 May 2023
Topic Review
Radial Artery Occlusion
The thrombotic occlusion of the radial artery has emerged as the most common complication of transradial coronary access, impeding its use in future interventions, and in the creation of arteriovenous fistulae for hemodialysis patients, or as a graft for coronary artery bypass grafting. In this entry, the researchers delve into the anatomy of the radial artery, the pathophysiology, and diagnosis of radial artery occlusion, the identification of potential risk factors, and finally prevention and treatment strategies. It is acknowledged that distal transradial access provides an effective alternative for coronary angiography and catheterization, with a reduced incidence of radial artery occlusion.
  • 1.1K
  • 14 Jul 2023
Topic Review
Gene Editing in Pluripotent Stem Cells
Gene editing in human pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), is highly relevant to clinical cell therapy and thus should be examined with particular caution. First, since all mutations in PSCs will be carried to all their progenies, off-target edits of editors will be amplified. Second, due to the hypersensitivity of PSCs to DNA damage, double-strand breaks (DSBs) made by gene editing could lead to low editing efficiency and the enrichment of cell populations with defective genomic safeguards. In this regard, DSB-independent gene editing tools, such as base editors and prime editors, are favored due to their nature to avoid these consequences. With more understanding of the microbial world, new systems, such as Cas-related nucleases, transposons, and recombinases, are also expanding the toolbox for gene editing.
  • 1.1K
  • 25 Aug 2023
Topic Review
Vision Systems for Fruit and Vegetable Classification
Citrus fruits are the second most important crop worldwide. One of the most important tasks is sorting, which involves manually separating the fruit based on its degree of maturity, and in many cases, involves a task carried out manually by human operators. A machine vision-based citrus sorting system can replace labor work for the inspection of fruit sorting.
  • 1.1K
  • 21 Sep 2023
Topic Review
Practical Aspects of Nuclear Magnetic Resonance Application
Nuclear magnetic resonance (NMR) is a primary method of measurement according to metrology standards. It has been proven to have good reproducibility. NMR spectra are evaluated numerically, including chemical shifts, coupling constants, and signal integrals, which lead to quantitative results.
  • 1.1K
  • 13 Dec 2023
Topic Review
Energy Recovery from Residual Municipal Solid Waste
Among the technologies for the recovery of energy from waste, in particular residual municipal solid waste (rMSW), combustion is the most widely used thermo-chemical treatment process associated with thermal and electric power production by a steam cycle, named, shortly, Waste to Energy (WtE). 
  • 1.1K
  • 26 Feb 2024
Topic Review
Electrocochleography in Auditory Neuropathy
Auditory Neuropathy (AN) is characterized by disruption of temporal coding of acoustic signals in auditory nerve fibers resulting in alterations of auditory perceptions. Mutations in several genes have been associated to the most forms of AN. Underlying mechanisms include both pre-synaptic and post-synaptic damage involving inner hair cell (IHC) depolarization, neurotransmitter release, spike initiation in auditory nerve terminals, loss of auditory fibers and impaired conduction. In contrast, outer hair cell (OHC) activities (otoacoustic emissions [OAEs] and cochlear microphonic [CM]) are normal. Disordered synchrony of auditory nerve activity has been suggested as the basis of both the alterations of auditory brainstem responses (ABRs) and reduction of speech perception. Authors will review how electrocochleography (ECochG) recordings provide detailed information to help objectively define the sites of auditory neural dysfunction and their effect on receptor summating potential (SP) and neural compound action potential (CAP), the latter reflecting disorders of ribbon synapses and auditory nerve fibers.
  • 1.1K
  • 30 Jan 2022
Topic Review
EUS and EUS-FNA
Endoscopic ultrasonography (EUS) has greater spatial resolution than other diagnostic imaging modalities. In addition, if gallbladder lesions are found and gallbladder cancer is suspected, EUS is an indispensable modality, enabling detailed tests for invasion depth evaluation using the Doppler mode and ultrasound agents. Furthermore, for gallbladder lesions, EUS fine-needle aspiration (EUS-FNA) can be used to differentiate benign and malignant forms of conditions, such as xanthogranulomatous cholecystitis, and collect evidence before chemotherapy.
  • 1.1K
  • 29 Mar 2022
Topic Review
Mesenchymal Stem Cell-Derived Exosomesas as a Therapeutic Tool
Exosomes are naturally occurring nanoscale vesicles that are released and received by almost all cells in the body. Exosomes can be transferred between cells and contain various molecular constitutes closely related to their origin and function, including proteins, lipids, and RNAs. The importance of exosomes in cellular communication makes them important vectors for delivering a variety of drugs throughout the body.
  • 1.1K
  • 23 Mar 2022
Topic Review
SIRT1 and SIRT2 Modulators
Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy. Recent evidence has indicated that neuroinflammation participates in the genesis and development of depression, and interacts with other factors involved in depression. Therefore, exploring effective anti-inflammatory medications could be beneficial for the development of new treatment options for depression. Sirtuins are a unique class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, which have seven members that can affect multiple downstream targets by deacetylation activity.
  • 1.1K
  • 05 Mar 2021
Topic Review
Fugitive Dust
Fugitive dust is a serious threat to unpaved road users from a safety and health point of view. Dust suppressing materials or dust suppressants are often employed to lower the fugitive dust. Currently, many dust suppressants are commercially available and are being developed for various applications. 
  • 1.1K
  • 09 Mar 2021
Topic Review
Postprandial Hyperglycemia
Postprandial hyperglycemia (PPHG) is strongly linked with the future development of cardiovascular complications in type 2 diabetes (T2D).
  • 1.1K
  • 17 May 2021
Topic Review
Electrode Materials in DESs
Deep Eutectic Solvents (DESs) are a new class of solvents characterized by a remarkable decrease in melting point compared to those of the starting components. The eutectic mixtures can be simply prepared by mixing a Hydrogen Bond Acceptor (HBA) with a Hydrogen Bond Donor (HBD) at a temperature of about 80 °C.
  • 1.1K
  • 01 Jul 2021
Topic Review
Microbial Conjugation Studies of Licochalcones&Xanthohumol
Microbial conjugation studies of licochalcones (1–4) and xanthohumol (5) were performed by using the fungi Mucor hiemalis and Absidia coerulea. As a result, one new glucosylated metabolite was produced by M. hiemalis whereas four new and three known sulfated metabolites were obtained by transformation with A. coerulea. Chemical structures of all the metabolites were elucidated on the basis of 1D-, 2D-NMR and mass spectroscopic data analyses. These results could contribute to a better understanding of the metabolic fates of licochalcones and xanthohumol in mammalian systems. Although licochalcone A 4′-sulfate (7) showed less cytotoxic activity against human cancer cell lines compared to its substrate licochalcone A, its activity was fairly retained with the IC50 values in the range of 27.35–43.07 μM.
  • 1.1K
  • 12 Jul 2021
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