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Topic Review
Pathophysiology of Drug-Induced Hyponatremia
Drug-induced hyponatremia caused by renal water retention is mainly due to syndrome of inappropriate antidiuresis (SIAD). SIAD can be grouped into syndrome of inappropriate antidiuretic hormone secretion (SIADH) and nephrogenic syndrome of inappropriate antidiuresis (NSIAD). The former is characterized by uncontrolled hypersecretion of arginine vasopressin (AVP), and the latter is produced by intrarenal activation for water reabsorption and characterized by suppressed plasma AVP levels. Desmopressin is useful for the treatment of diabetes insipidus because of its selective binding to vasopressin V2 receptor (V2R), but it can induce hyponatremia when prescribed for nocturnal polyuria in older patients. Oxytocin also acts as a V2R agonist and can produce hyponatremia when used to induce labor or abortion. 
  • 1.1K
  • 25 Oct 2022
Topic Review
Deformable Mirror
Deformable mirrors (DM) are mirrors whose surface can be deformed, in order to achieve wavefront control and correction of optical aberrations. Deformable mirrors are used in combination with wavefront sensors and real-time control systems in adaptive optics. In 2006 they found a new use in femtosecond pulse shaping. The shape of a DM can be controlled with a speed that is appropriate for compensation of dynamic aberrations present in the optical system. In practice the DM shape should be changed much faster than the process to be corrected, as the correction process, even for a static aberration, may take several iterations. A DM usually has many degrees of freedom. Typically, these degrees of freedom are associated with the mechanical actuators and it can be roughly taken that one actuator corresponds to one degree of freedom.
  • 1.1K
  • 03 Nov 2022
Topic Review
Overview of Nonalcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is defined by the presence of >5% of hepatic steatosis demonstrated, either radiographically or histologically, in the absence of significant alcohol consumption. NAFLD is the most common liver disease worldwide, with a continuously growing prevalence. The pathophysiology of the disease is complex and includes several mechanisms, with metabolic syndrome and insulin resistance playing a major role. It is crucial to diagnose NAFLD before it advances to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis, presented by its complications which include ascites, portal hypertension, bleeding varices and encephalopathy. Another important complication of NAFLD and cirrhosis is hepatocellular carcinoma (HCC), a cancer with increasing incidence and poor prognosis. Even with the growing prevalence of NAFLD, diagnosis via liver biopsies is unrealistic, considering the costs and complications. Noninvasive tests, including serum biomarkers and elastography, are cost-effective and convenient, thereby replacing liver biopsies in diagnosing and excluding liver fibrosis
  • 1.1K
  • 23 Nov 2022
Topic Review
Positive Welfare Indicators in Dairy Animals
Nowadays, there is growing interest in positive animal welfare not only from the view of scientists but also from that of society. The consumer demands more sustainable livestock production, and animal welfare is an essential part of sustainability, so there is interest in incorporating positive welfare indicators into welfare assessment schemes and legislation.
  • 1.1K
  • 28 Nov 2022
Topic Review
Etiquette in Technology
Social etiquette in real life is ingrained into our social life, although etiquette in technology, colloquially referred to as netiquette, is a fairly recent concept. It is a term used to refer to the unofficial code of policies that encourage good behavior on the Internet which is used to regulate respect and polite behavior on social media platforms, online chatting sites, web forums, and other online engagement websites. The rules of etiquette that apply when communicating over the Internet are different from those applied when communicating in person or by audio (such as telephone) or videophone. It is a social code that is used in all places where one can interact with other human beings via the Internet, including text messaging, email, online games, Internet forums, chat rooms, and many more. It can be a challenge to communicate on the Internet without misunderstandings mainly because input from facial expressions and body language is absent in cyberspace. Therefore, several rules, in an attempt to safeguard against these misunderstandings and to discourage unfriendly behavior, are regularly put in place at many websites, and often enforced by moderation by the website's users or administrators.
  • 1.1K
  • 01 Dec 2022
Topic Review
Factors That Affect Secondary School Mathematics Achievement in Indonesia
Students’ achievement is defined by the extent to which predetermined learning goals are obtained, and it is usually measured through test scores and ongoing assessments.
  • 1.1K
  • 29 Dec 2022
Topic Review
Anti-Aggregation-Enabled Colorimetric Sensing Applications of Nanoparticles
Gold- and silver nanoparticles (Au NPs and Ag NPs)-based colorimetric detection of specific analytes has attracted intense research interest and is still in great demand. The majority of Au NPs- and Ag NPs-based sensory reports have revealed that, during the analyte recognition, dispersed NPs typically aggregated and displayed color changes from wine-red to blue/purple and yellow to orange/brown, respectively. On the other hand, only a few reports demonstrated that the aggregated Au NPs and Ag NPs underwent anti-aggregation in the presence of certain analytes, which displayed reversed color changes from blue/purple to wine-red and orange/brown to yellow, correspondingly. There are some examples of anti-aggregation phenomena mentioned in a vast number of studies on Au NPs- and Ag NPs-based colorimetric sensors via NP aggregation.
  • 1.1K
  • 29 Dec 2022
Topic Review
Leptomeningeal Disease Treatment
Leptomeningeal disease (LMD) is a devastating complication caused by seeding malignant cells to the cerebrospinal fluid (CSF) and the leptomeningeal membrane. LMD is diagnosed in 5–15% of patients with systemic malignancy. Management of LMD is challenging due to the biological and metabolic tumor microenvironment of LMD being largely unknown. Patients with LMD can present with a wide variety of signs and/or symptoms that could be multifocal and include headache, nausea, vomiting, diplopia, and weakness, among others. The median survival time for patients with LMD is measured in weeks and up to 3–6 months with aggressive management, and death usually occurs due to progressive neurologic dysfunction. In melanoma, LMD is associated with a suppressive immune microenvironment characterized by a high number of apoptotic and exhausted CD4+ T-cells, myeloid-derived suppressor cells, and a low number of CD8+ T-cells. Proteomics analysis revealed enrichment of complement cascade, which may disrupt the blood–CSF barrier. Clinical management of melanoma LMD consists primarily of radiation therapy, BRAF/MEK inhibitors as targeted therapy, and immunotherapy with anti-PD-1, anti-CTLA-4, and anti-LAG-3 immune checkpoint inhibitors.
  • 1.1K
  • 31 Mar 2023
Topic Review
Intelligent Physical Exercise Training
The background for this research concerns a high frequency of work-related disorders that may result from physical exposure at work being highly sedentary, repetitive–monotonous, or physically demanding. This may result in levels of physical inactivity or strenuous activity impairing health.
  • 1.1K
  • 08 Jun 2023
Topic Review
Gall Formation Induced by Mites and Insects
Publications on gall formation induced on the leaves of dicotyledonous flowering plants by eriophyoid mites (Eriophyoidea) and representatives of four insect orders (Diptera, Hemiptera, Hymenoptera, Lepidoptera) are analyzed. Cellular and molecular level data on the stimuli that induce and sustain the development of both mite and insect galls, the expression of host plant genes during gallogenesis, and the effects of these galling arthropods on photosynthesis are considered. A hypothesis is proposed for the relationship between the size of galls and the volume of secretions injected by a parasite. Multistep, varying patterns of plant gene expression and accompanying histo-morphological changes in the transformed gall tissues are apparent. The main obstacle to better elucidating the nature of the induction of gallogenesis is the impossibility of collecting a sufficient amount of saliva for analysis, which is especially important in the case of microscopic eriophyoids. The use of modern omics technologies at the organismal level has revealed a spectrum of genetic mechanisms of gall formation at the molecular level but has not yet answered the questions regarding the nature of gall-inducing agents and the features of events occurring in plant cells at the very beginning of gall growth.
  • 1.1K
  • 15 Jun 2023
Topic Review
Milk Exosomes as Drug Delivery Agents
Milk is a unique natural source of exosomes available in semi-preparative and preparative quantities. Milk exosomes are highly resistant to the harsh conditions of the gastrointestinal tract. In vitro studies have demonstrated that milk exosomes have an affinity to epithelial cells, are digested by cells by endocytosis mechanism, and can be used for oral delivery. With milk exosome membranes containing hydrophilic and hydrophobic components, exosomes can be loaded with hydrophilic and lipophilic drugs.
  • 1.1K
  • 21 Jun 2023
Topic Review
Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions
To circumvent these constraints, the development of biodegradable nano-based drug delivery systems (DDS) has gained prominence. These systems promise extended residence time in ocular tissues, improved penetration through ocular barriers, and are composed of nanosized, biodegradable polymers, thereby diminishing the risk of toxicity and adverse reactions.
  • 1.1K
  • 24 Jul 2023
Topic Review
Strategies for Entomopathogenic Fungi in Mosquito Biocontrol
Fungal diseases are widespread among insects and play a crucial role in naturally regulating insect populations. Mosquitoes, known as vectors for numerous infectious diseases, pose a significant threat to human health. Entomopathogenic fungi (EPF) have emerged as highly promising alternative agents to chemical mosquitocides for controlling mosquitoes at all stages of their life cycle due to their unique infection pathway through direct contact with the insect’s cuticle.
  • 1.1K
  • 04 Aug 2023
Topic Review
Zinc Functions
Zinc is a structural component of proteins, functions as a catalytic co-factor in DNA synthesis and transcription of hundreds of enzymes, and has a regulatory role in protein–DNA interactions of zinc-finger proteins.
  • 1.1K
  • 15 Nov 2023
Topic Review Peer Reviewed
Overview of Triticale Use for Poultry Feeding
Triticale, a hybrid of wheat and rye, is one of the most promising grain crops. In terms of productivity, the level of metabolizable energy, and the composition of essential amino acids, triticale surpasses rye and is not inferior to wheat. It is resistant to the most dangerous diseases and pests. In terms of nutritional value, triticale can compete with wheat, corn, sorghum, and barley. The presence, however, of antinutrients in triticale such as non-starch polysaccharides, alkylresorcinols, and trypsin inhibitors significantly reduces the biological value of this crop. In the global practice of compound feed production, there are many methods and technologies for processing grain raw materials to increase their nutritional value. Enzymatic treatment and extrusion technologies are worthy of special attention. The high content of triticale in the compound feed of poultry breeder flocks should be used effectively, taking into account the characteristics of triticale varieties and climatic conditions. An optimal triticale level in feed (15% for layer and broiler chicks) may improve body weight gain and reduce feed costs when raising replacement young stock. Layer breeder flocks fed a 20% triticale-based diet may have increased egg production, high viability, and flock uniformity. Producing triticale–soy and triticale–sunflower extrudates and supplementing the diet of poultry flocks with essential amino acids represent promising avenues for maximizing the benefits of triticale. Innovative methods of achieving this goal should be further developed and put into practice, particularly given the expansion of triticale’s cultivation areas.
  • 1.1K
  • 02 Jul 2026
Topic Review
One Spatial Planning Policy
Indonesia, which predominantly consists of maritime areas, faces complexities in implementing spatial planning.  The RZWP3K (Coastal Zone and Small Islands Zoning Plan), a component of the marine spatial planning document, has not been adopted as a reference in the marine spatial plan. To address this, the government has achieved a policy breakthrough concerning spatial planning— integrating land and marine spatial planning into a singular spatial planning product. Even so, it will be hard to implement one spatial planning policy because Indonesia's regional development plans have mostly ignored the marine environment, seeing the sea as a barrier to regional development rather than an asset. Therefore, it is essential to examine the elements that will influence the successful execution of the policy in the Rebana Metropolitan Area.
  • 1.1K
  • 05 Feb 2025
Topic Review
Anatomy and Barriers of Ocular Drug Delivery
Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology and biomaterial science, primarily due to the intricate anatomical and physiological barriers unique to the eye.
  • 1.1K
  • 13 Nov 2023
Topic Review
Probiotics in Milk and Milk-Derived Products
Milk is a source of many valuable nutrients, including minerals, vitamins and proteins, with an important role in adult health. Milk and dairy products naturally containing or with added probiotics have healthy functional food properties. Indeed, probiotic microorganisms, which beneficially affect the host by improving the intestinal microbial balance, are recognized to affect the immune response and other important biological functions.
  • 1.1K
  • 05 Mar 2024
Topic Review
Chemotherapeutic Targeting of Tumors with Imidazole-Enriched Nanoparticles
Accumulating chemotherapeutic drugs such as doxorubicin within a tumor while limiting the drug dose to normal tissues is a central goal of drug delivery with nanoparticles. Liposomal products such as Doxil® represent one of the marked successes of nanoparticle-based strategies. To replicate this success for cancer treatment, many approaches with nanoparticles are being explored in order to direct and release chemotherapeutic agents to achieve higher accumulation in tumors. 
  • 1.1K
  • 28 Nov 2022
Topic Review
Artificial Intelligence for Alzheimer’s Disease
The recent growth of open data-sharing initiatives collecting lifestyle, clinical, and biological data from Alzheimer's disease (AD) patients has provided a potentially unlimited amount of information about the disease, far exceeding the human ability to make sense of it. Integrating Big Data from multi-omics studies provides the potential to explore the pathophysiological mechanisms of the entire biological continuum of AD. In this context, Artificial Intelligence (AI) offers a wide variety of methods to analyze large and complex data in order to improve knowledge in the AD field.
  • 1.1K
  • 03 Sep 2021
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