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Topic Review
Pioglitazone-Loaded PLGA Nanoparticles
Albeit, the relationship between diabetes drugs and the progression of atherosclerosis is still elusive, Pioglitazone (PGZ; 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]–1,3- thiazolidine-2,4-diona), one of the most frequently prescribed anti-diabetic medication in the United States, slows the progression of atherosclerosis.
  • 1.1K
  • 14 Mar 2022
Topic Review
Deciphering Tumour Heterogeneity
Decoding tumour heterogeneity is a major clinical challenge, considering that it immensely contributes to cancer progression, treatment failure and emergence of drug resistance. Emerging technical and sampling strategies have been developed in order to deeply characterise tumour complexity and clonal architecture, including single-cell profiling, multi-region sampling, representative sampling and longitudinal analysis of liquid biopsy samples.
  • 1.1K
  • 25 Mar 2022
Topic Review
Omics Strategies in Infectious Fish Disease Management
Aquaculture is an important industry globally as it remains one of the significant alternatives of animal protein source supplies for humankind. Yet, the progression of this industry is being dampened by the increasing rate of fish mortality, mainly the outbreak of infectious diseases. Consequently, the regress in aquaculture ultimately results in the economy of multiple countries being affected due to the decline of product yields and marketability. By 2025, aquaculture is expected to contribute approximately 57% of fish consumption worldwide. Without a strategic approach to curb infectious diseases, the increasing demands of the aquaculture industry may not be sustainable and hence contributing to the over-fishing of wild fish. A new holistic approach that utilizes multi-omics platforms including transcriptomics, proteomics, and metabolomics is unraveling the intricate molecular mechanisms of host-pathogen interaction. 
  • 1.1K
  • 23 May 2022
Topic Review
Use of Bio-Inspired Design Tools by Industry Professionals
Bio-inspired design (BID) has the potential to evolve the way engineers and designers solve problems. Several tools have been developed to assist one or multiple phases of the BID process. These tools, typically studied individually and through the performance of college students, have yielded interesting results for increasing the novelty of solutions. Human-centered design (HCD) and “design thinking” have become standard practice in consumer-product design and development. Now, it is common for industrial designers, engineers, and product managers to be conversant in the process and methodologies of HCD.
  • 1.1K
  • 01 Jun 2022
Topic Review
Catatonia
Catatonia is a complex syndrome that includes psychomotor disorders (negativity, catalepsy, wax flexibility, mutism, automatism, mannerisms, or echolalia) and volitional processes affect modulation and action planning, which leads to hypofunctional, hyperfunctional, or parafunctional motor action. This is a very important clue that this state can be associated with both mental and somatic diseases. The treatment of catatonia is not standardized. It is based on the use of benzodiazepines, GABAa receptor antagonists, NMDA receptor antagonists, D2 receptor antagonist, and electroconvulsive therapy (ECT). The topic of catatonia should be of interest not only to psychiatrists, but also to doctors of other specialties, who may encounter cases of catatonia complicating somatic states in hospital wards.
  • 1.1K
  • 16 Sep 2022
Topic Review
Machine Learning Used to Combat COVID-19
Coronavirus disease (COVID-19) has had a significant impact on global health since the start of the pandemic in 2019. As of June 2022, over 539 million cases have been confirmed worldwide with over 6.3 million deaths as a result. Artificial Intelligence (AI) solutions such as machine learning and deep learning have played a major part in this pandemic for the diagnosis and treatment of COVID-19.
  • 1.1K
  • 20 Sep 2022
Topic Review
Radial Basis Functions Theory Background
Radial Basis Functions were born as interpolation methods for scattered data. They provide a tool to interpolate everywhere in a generic n-dimensional space, a scalar function defined at discrete points providing the exact values at the original points.
  • 1.1K
  • 14 Oct 2022
Topic Review
Timeline of Computing 1980–89
This article presents a detailed timeline of events in the history of computing from 1980 to 1989. For narratives explaining the overall developments, see the History of computing.
  • 1.1K
  • 17 Oct 2022
Topic Review
Permeable Pavement Systems for Stormwater Management
There has been growing interest in the field of permeable pavement systems (PPS), especially in the scope of stormwater management as a sustainable urban drainage system (SUDS). Slight modifications within the PPS layers or incorporation of innovative filters could result in improved contaminant removal efficiency. In addition maintenance procedures were proven effective in mitigating clogging effects, mostly occurring at the upper 1.5–2.5 cm of the PPS. Although partial replacement of the PPS mix design with recycled aggregates improved the overall permeability, the compressive strength was slightly compromised. 
  • 1.1K
  • 21 Oct 2022
Topic Review
Agrippa (A Book of the Dead)
Agrippa (A Book of the Dead) is a work of art created by science fiction novelist William Gibson, artist Dennis Ashbaugh and publisher Kevin Begos Jr. in 1992. The work consists of a 300-line semi-autobiographical electronic poem by Gibson, embedded in an artist's book by Ashbaugh. Gibson's text focused on the ethereal, human-owed nature of memories retained over the passage of time (the title referred to a Kodak photo album from which the text's memories are taken). Its principal notoriety arose from the fact that the poem, stored on a 3.5" floppy disk, was programmed to encrypt itself after a single use; similarly, the pages of the artist's book were treated with photosensitive chemicals, effecting the gradual fading of the words and images from the book's first exposure to light.
  • 1.1K
  • 24 Oct 2022
Topic Review
The Gut Microbiota and Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a malignant pulmonary vascular disease characterized by increased pulmonary vascular resistance, pulmonary vasoconstriction, and right ventricular hypertrophy. Developments in genomics and metabolomics have gradually revealed the roles of the gut microbiota (GM) and its metabolites in cardiovascular diseases. Accumulating evidence reveals that the GM plays important roles in the occurrence and development of PAH. Gut microbiota dysbiosis directly increases the gut permeability, thereby facilitating pathological bacterial translocation and allowing translocation of bacterial products such as lipopolysaccharides from the gut into circulation. This process aggravates pulmonary perivascular inflammation and exacerbates PAH development through the endothelial–mesenchymal transition. Additionally, a shift in the composition of PAH also affects the gut metabolites. Changes in gut metabolites, such as decreased short-chain fatty acids, increased trimethylamine N-oxide, and elevated serotonin, contribute to pulmonary perivascular inflammation and pulmonary vascular remodeling by activating several signaling pathways. Studies of the intestinal microbiota in treating pulmonary hypertension have strengthened linkages between the GM and PAH. Probiotic therapy and fecal microbiota transplantation may supplement existing PAH treatments.
  • 1.1K
  • 04 Nov 2022
Topic Review
Picture Exchange Communication System
The Picture Exchange Communication System (PECS) is an augmentative and alternative communication system developed and produced by Pyramid Educational Consultants, Inc. PECS was developed in 1985 at the Delaware Autism Program by Andy Bondy, PhD, and Lori Frost, MS, CCC-SLP. The developers of PECS noticed that traditional communication techniques, including speech imitation, sign language, and picture point systems, relied on the teacher to initiate social interactions and none focused on teaching students to initiate interactions. Based on these observations, Bondy and Frost created a functional means of communication for individuals with a variety of communication challenges. Although PECS was originally developed for young children with autism spectrum disorder (ASD), its use has become much more widespread. Through the years, PECS has been successfully implemented with individuals with varying diagnoses across the aged span. PECS is an evidence-based practice that has been highly successful with regard to the development of functional communication skills.
  • 1.1K
  • 02 Nov 2022
Topic Review
European Air Pollution Restrictions on Internal Combustion Engines
European Union (EU) legislators have laid out limits for emissions to air, grouping combustion engines by application, and then by power, displacement, engine type (spark ignited (SI) or compression-ignition (CI)), operating conditions and site, as well as the type of fuel used. The basic groups are cars and light trucks, heavy-duty truck and bus engines, and non-road engines. The regulations concerning road vehicles are more stringent than those for engines used in non-road machinery. EU law is considerably more liberal for small engine non-road equipment, which is defined as featuring engines below 56 kW. Some of the main reasons for this include the size and weight of those engines.
  • 1.1K
  • 14 Nov 2022
Topic Review
Remote Keyless Using Pre-Trained Deep Neural Network
Keyless systems have replaced the old-fashioned methods of inserting physical keys into keyholes to unlock the door, which are inconvenient and easily exploited by threat actors. Keyless systems use the technology of radio frequency (RF) as an interface to transmit signals from the key fob to the vehicle.
  • 1.1K
  • 10 Nov 2022
Topic Review
Markers in Diagnostics and Classification of Breast Cancer
Breast cancer (BC)is etiologically, histopathologically and genetically a heterogeneous disease with both hereditary predispositions and non-hereditary factors. This is certainly true for BC as it refers to mammary carcinoma from ductal or lobular cells in the mammary epithelial tissue. Only a minor portion are sarcomas transformed from connective tissue and vessels. Malignant transformation in BC is the product of accumulations of consecutive mutations in critical regions of the genome that are normally involved in control of cell growth and division, DNA repair and programmed cell death. These mutations are partly inherited but mostly spontaneous. Contribution of genetic factors in BC has been indicated by familial occurrence which is estimated as 5–10% of all cases. High-penetrance genes which are linked with inherited BC susceptibility include BRCA1 and BRCA2, and more rarely TP53, PTEN, CDH1 and SKT11. Heterozygotic mutations in DNA repair genes BRCA1 (locus Ch17q21.31) or BRCA2 (Ch13q13.1) are the most common inherited conditions associated with BC. Absolute risk of BC for BRCA1 mutations reads ~50–65% in females and ~1% in males, while in BRCA2 mutations female risk ranges from 40% to 55% and reaches up to 9% in males. Familiar susceptibility to BC is also associated with mutations of lower penetrance genes as ATM (Ch11q22.3), PALB2 (Ch16p12.2) and CHEK2 (Ch22q12.1). Mutation in the androgen receptor gene (AR) has been found in cases of male BC. Susceptibility to sporadic BC cases can be linked with many more genes: e.g., sporadic invasive ductal variant of BC and lobular BC are associated with somatic mutation of genes RAD54L (Ch1p34.1) and CDH1 (Ch16q22.1), respectively. Other genes candidates associated with sporadic BC include: TP53 (Ch17p13.1), SLC22A1 (Ch11p15.4), PIK3CA (Ch3q26.32), ESR1 (Ch6q25.1-q25.2), RB1CC1 (Ch8q11.23), KRAS (12p12.1), AKT1 (14q32.33), RB1 (Ch13q14.2), PPM1D (Ch17q23.2), MYC (Ch8q24.21), FGFR1 and eventually ERBB2 (Ch17q12), CCND1 (Ch11q13.3), GATA3 (Ch10p14), MAP3K1 (Ch5q11.2) in certain lineages.
  • 1.1K
  • 22 Nov 2022
Topic Review
Proinsulin
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene. The islets of Langerhans only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood. There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induced by insulin. Proinsulin is the final single chain protein structure secreted by cells before cleavage into mature insulin. Proinsulin was discovered by Professor Donald F. Steiner of the University of Chicago in 1967.
  • 1.1K
  • 24 Nov 2022
Topic Review
Mid-Infrared External Cavity Quantum Cascade Lasers
External cavity quantum cascade lasers (ECQCLs) in the mid-infrared band have a series of unique spectral properties, which can be widely used in spectroscopy, gas detection, protein detection, medical diagnosis, free space optical communication, and so on, especially wide tuning range, the tuning range up to hundreds of wavenumbers; therefore, ECQCLs show great applications potential in many fields. 
  • 1.1K
  • 29 Nov 2022
Topic Review
Wall Materials of Peptide Microcapsules
Microencapsulation technology can improve the utilization rate of the active peptides. Microencapsulation technology is a kind of encapsulation technology based on nanocarriers. The microencapsulation of peptides refers to the selection of appropriate wall materials and the use of physical, chemical, or physicochemical methods to embed the active peptides, in order to give play to the advantages of isolating the interaction between the active peptide and the external environment.
  • 1.1K
  • 15 Mar 2023
Topic Review
Microplastics and Nanoplastics on Livestock Health
Pollution due to microplastics and nanoplastics is one of the major environmental issues and represents a growing threat to human and animal health. In aquatic species, there is a large amount of information regarding the perturbation of marine organisms; only few studies focused on the pathophysiological consequences of an acute and chronic exposure to micro- and nanoplastics in mammalian systems, especially on the reproductive system.
  • 1.1K
  • 04 Apr 2023
Topic Review
Role of Barbed Sutures in Reconstructive Surgery
Surgical ligatures are a critical component of any surgical procedure since they are the device that provides immediate post-surgical tissue apposition. There have been several studies to improve the design and use of these wound closure devices for different surgical procedures. Yet, there is no standardized technique or device that can be used for any specific application. Over the last two decades, there has been an increased focus on the innovative surgical sutures known as knotless or barbed sutures, along with studies focusing on their advantages and disadvantages in clinical environments. Barbed sutures were invented to reduce the localized stress on the approximated tissues as well as facilitating the surgical technique and improving the clinical outcome for the patient. Barbed sutures can be used in several surgical situations, such as emergency room procedures, general and thoracic applications, urological surgery, orthopedic and hand applications, obstetric and gynecological procedures, hair restoration and in the majority of plastic, reconstructive and cosmetic applications.
  • 1.1K
  • 11 Apr 2023
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