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Topic Review Peer Reviewed
Cyclodextrin-Based Nanosponges and Proteins
Cyclodextrin-based nanosponges (CD-NSs) have gained importance in drug delivery in the last years due to their easy synthesis and versatility. However, their use as carriers for the delivery of macromolecules such as proteins is less known and sometimes difficult to consider. In this entry, the authors summarize and highlight the multiple possibilities of CD-NSs to deliver active proteins, improving their activity or stability. Starting with a brief description of CD-NSs and their characteristics, the entry will be focused on several proteins, such as (1) Lipase, (2) Insulin and (3) Nisin, for chemical or pharmaceutical applications. The revised results demonstrated that CD-NSs can generate different and interesting applications with proteins. These results could be added to their uses with small drugs, being an interesting alternative for protein delivery and applicability. 
  • 1.1K
  • 14 Apr 2022
Topic Review
Metabolic Vulnerabilities in Multiple Myeloma
Multiple myeloma (MM) remains an incurable malignancy with eventual emergence of refractory disease. Metabolic shifts, which ensure the availability of sufficient energy to support hyperproliferation of malignant cells, are a hallmark of cancer. Deregulated metabolic pathways have implications for the tumor microenvironment, immune cell function, prognostic significance in MM and anti-myeloma drug resistance.
  • 1.1K
  • 18 Apr 2022
Topic Review
Application of Metal Nanoparticles in Protective Edible Coatings
Metal nanoparticles (NPs) are increasingly being used in many areas, e.g., industry, pharmacy, and biomedical engineering. NPs can be obtained through chemical and biological synthesis or using physical methods. AgNPs, AuNPs, CuNPs, FeNPs, MgNPs, SnO2NPs, TiO2NPs, and ZnONPs are the most commonly synthesized metal nanoparticles. Many of them have anti-microbial properties and documented activity supported by many tests against some species of pathogenic bacteria, viruses, and fungi. AgNPs, which are used for the production of commercial self-sterilizing packages, are one of the best-explored nanoparticles. Moreover, the EFSA has approved the use of small doses of silver nanoparticles (0.05 mg Ag·kg−1) to food products. Recent studies have shown that metal NPs can be used for the production of coatings to prevent the spread of the SARS-CoV-2 virus, which has caused the global pandemic. Some nanoparticles (e.g., ZnONPs and MgONPs) have the Generally Recognized As Safe (GRAS) status, i.e., they are considered safe for consumption and can be used for the production of edible coatings, protecting food against spoilage. Promising results have been obtained in research on the use of more than one type of nanometals, which prevents the development of pathogen resistance through various mechanisms of inactivation thereof. 
  • 1.1K
  • 21 Apr 2022
Topic Review
Physiological Significance of Esophageal TRPV4 Channel
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of functional activities.
  • 1.1K
  • 27 Apr 2022
Topic Review
Biodegradable Film Materials for Packaging
In today’s world, the problem of “white pollution” is becoming more and more serious, and many countries have paid special attention to this problem, and it has become one of the most important tasks to reduce polymer waste and to protect the environment. Due to the degradability, safety, economy and practicality of biodegradable packaging film materials, biodegradable packaging film materials have become a major trend in the packaging industry to replace traditional packaging film materials, provided that the packaging performance requirements are met. Degraded plastics are plastics that have been subjected to defined environmental conditions for a period of time and contain one or more steps that result in significant changes in the chemical structure of the material resulting in loss of certain properties (such as integrity, molecular mass, structure or mechanical strength) and/or fragmentation.
  • 1.1K
  • 19 May 2022
Topic Review
Roles of Neuropeptides in Sleep–Wake Regulation
Sleep and wakefulness are basic behavioral states that require coordination between several brain regions, and they involve multiple neurochemical systems, including neuropeptides. Neuropeptides are a group of peptides produced by neurons and neuroendocrine cells of the central nervous system. Like traditional neurotransmitters, neuropeptides can bind to specific surface receptors and subsequently regulate neuronal activities. For example, orexin is a crucial component for the maintenance of wakefulness and the suppression of rapid eye movement (REM) sleep. In addition to orexin, melanin-concentrating hormone, and galanin may promote REM sleep. These results suggest that neuropeptides play an important role in sleep–wake regulation. These neuropeptides can be divided into three categories according to their effects on sleep–wake behaviors in rodents and humans. (i) Galanin, melanin-concentrating hormone, and vasoactive intestinal polypeptide are sleep-promoting peptides. It is also noticeable that vasoactive intestinal polypeptide particularly increases REM sleep. (ii) Orexin and neuropeptide S have been shown to induce wakefulness. (iii) Neuropeptide Y and substance P may have a bidirectional function as they can produce both arousal and sleep-inducing effects.
  • 1.1K
  • 23 Jun 2022
Topic Review
Aphthous Stomatitis
Aphthous stomatitis, or recurrent aphthous stomatitis (RAS), is a common condition characterized by the repeated formation of benign and non-contagious mouth ulcers (aphthae) in otherwise healthy individuals. The informal term canker sore is also used, mainly in North America, although it may also refer to other types of mouth ulcers. The cause is not completely understood but involves a T cell-mediated immune response triggered by a variety of factors which may include nutritional deficiencies, local trauma, stress, hormonal influences, allergies, genetic predisposition, certain foods, dehydration, or some food additives. These ulcers occur periodically and heal completely between attacks. In the majority of cases, the individual ulcers last about 7–10 days, and ulceration episodes occur 3–6 times per year. Most appear on the non-keratinizing epithelial surfaces in the mouth – i.e. anywhere except the attached gingiva, the hard palate and the dorsum of the tongue – although the more severe forms, which are less common, may also involve keratinizing epithelial surfaces. Symptoms range from a minor nuisance to interfering with eating and drinking. The severe forms may be debilitating, even causing weight loss due to malnutrition. The condition is very common, affecting about 20% of the general population to some degree. The onset is often during childhood or adolescence, and the condition usually lasts for several years before gradually disappearing. There is no cure, and treatments such as corticosteroids aim to manage pain, reduce healing time and reduce the frequency of episodes of ulceration.
  • 1.1K
  • 11 Oct 2022
Topic Review
Inflammation and Specialized Pro-Resolving Mediators in Atherosclerosis
Atherosclerosis, a disease of the arteries set off initially by fat deposition, is a major cause of life-threatening cardiovascular events. It was long thought to be a passive process caused by the accumulation of cholesterol within the lumen of arteries resulting in ischemia and an eventual complete blockage. Arteries are composed of endothelial cells (EC), elastin, collagen, and smooth muscle cells. ECs line the lumen of vessels and are subject to physical demands, such as shear stress, imposed by the flow of blood. Such stressors fluctuate and vary through the length of the artery, owing to the rheological properties of the blood and vulnerable areas of the arteries, such as branching points. Atherosclerosis is now known to be an active chronic inflammatory disease. Recently inflammation resolution has garnered great interest, as studies showed that it is active concerted effort by a class of specialized molecules termed SPMs, which led to look at treating that inflammation by enhancing its resolution.
  • 1.1K
  • 18 Nov 2022
Topic Review
Climate Audit
Climate Audit is a blog which was founded on 31 January 2005 by Steve McIntyre. In November 2009 journalist Andrew Revkin described it in The New York Times as "a popular skeptics’ blog" run by McIntyre, a retired Canadian mining consultant.
  • 1.1K
  • 21 Nov 2022
Topic Review
Radiation-Induced Intestinal Normal Tissue Toxicity Protein Signatures
Radiation-induced toxicity to healthy/normal intestinal tissues, especially during radiotherapy, limits the radiation dose necessary to effectively eradicate tumors of the abdomen and pelvis. Although the pathogenesis of intestinal radiation toxicity is highly complex, understanding post-irradiation alterations in protein profiles can provide crucial insights that make radiotherapy safer and more efficient and allow for increasing the radiation dose during cancer treatment.
  • 1.1K
  • 26 Dec 2022
Topic Review
T Cell Lipid Metabolism and Function by FABP5
To evade immune surveillance, tumors develop a hostile microenvironment that inhibits anti-tumor immunity. Recent immunotherapy breakthroughs that target the reinvigoration of tumor-infiltrating T lymphocytes (TIL) have led to unprecedented success in treating some cancers that are resistant to conventional therapy, suggesting that T cells play a pivotal role in anti-tumor immunity. In the hostile tumor microenvironment (TME), activated T cells are known to mainly rely on aerobic glycolysis to facilitate their proliferation and anti-tumor function. However, TILs usually exhibit an exhausted phenotype and impaired anti-tumor activity due to the limited availability of key nutrients (e.g., glucose) in the TME. Emerging evidence suggests that fatty acid binding protein 5 (FABP5) expression in T cells regulates T cell lipid metabolism and function. 
  • 1.1K
  • 31 Jan 2023
Topic Review
MHC-I Reduction and Immune Evasion
Cancer cells circumvent immune surveillance via diverse strategies. In accordance, a large number of complex studies of the immune system focusing on tumor cell recognition have revealed new insights and strategies developed, largely through major histocompatibility complexes (MHCs). MHC-I molecules are known as human leukocyte antigens (HLA) and HLA class-I molecules are composed of classical (class-Ia) and the non-classical (class-Ib) components.
  • 1.1K
  • 04 Aug 2023
Topic Review
Flavor Formation in Dry-Cured Fish
Dried salted fish is a traditional dry-cured fish that is sprinkled with salt before the curing process. With a unique flavor as well as diverse varieties, dry-cured fish is popular among consumers worldwide. The presence of various microbial communities during the curing process leads to numerous metabolic reactions, especially lipid oxidation and protein degradation, which influence the formation of flavor substances. 
  • 1.1K
  • 18 Aug 2023
Topic Review
Sustainable Approaches to Polymer-Modified Asphalt Binder
Due to periodic variations in temperature and heavy traffic loading, hot-mix asphalt (HMA) pavements undergo considerable distress during their service life. The rheological properties of asphalt binder, when subjected to complex physical and chemical processes, make it stiff and sometimes brittle, which ultimately plays a huge part in pavement deterioration. This phenomenon is commonly known as asphalt aging. Incorporating polymer modifiers with virgin asphalt can work as an effective means to change the binder properties and alleviate the issues related to asphalt aging. Different types of polymers, including elastomers, plastomers, and reactive polymers, can mixed in different combinations with the virgin asphalt to create polymer-modified binders (PMBs). In general, polymers are typically added to the virgin asphalt binder in PMB manufacturing at weight percentages ranging from 3% to 7%.
  • 1.1K
  • 28 Aug 2023
Topic Review
Recycled Waste Materials and Technologies in Asphalt Pavements
Given the prevailing concerns about greenhouse gas emissions, global warming, and the growing demand for renewable resources, the pavement industry, among others, is actively engaged in researching and exploring low-carbon materials and technologies. Despite the growing interest in low-carbon asphalt pavement, there is still a significant knowledge gap regarding the use of various waste materials and technologies to achieve this goal. 
  • 1.1K
  • 19 Oct 2023
Topic Review
Reducing Work Withdrawal Behaviors Facing Work Obstacles
Work withdrawal behavior is a type of negative reaction when employees face obstacles at work. Its negative impact on individuals and organizations has caught the attention of academic circles and managers.
  • 1.1K
  • 27 Nov 2023
Topic Review
Polyamines in Neurodegenerative Diseases
Polyamines (Pas) are short molecules that exhibit two or three amine groups that are positively charged at a physiological pH. These small molecules are present in high concentrations in a wide variety of organisms and tissues, suggesting that they play an important role in cellular physiology. Polyamines include spermine, spermidine, and putrescine, which play important roles in age-related diseases that have not been completely elucidated. Aging is a natural process, defined as the time-related deterioration of the physiological functions; it is considered a risk factor for degenerative diseases such as cardiovascular, neurodegenerative, and musculoskeletal diseases; arthritis; and even cancer.
  • 1.1K
  • 27 Nov 2023
Topic Review
Sudden Death Risk in Repaired Tetralogy of Fallot
Although substantial progress has been made to prevent sudden cardiac death in repaired tetralogy of Fallot patients, ventricular arrhythmia and sudden death continue to be major causes of morbidity and mortality in these patients. Greater survival in contemporary cohorts has been attributed to enhanced surgical techniques, more effective management of heart failure, and increased efforts in risk stratification and management of ventricular arrhythmias.
  • 1.1K
  • 05 Jan 2024
Topic Review
World Population Day
World Population Day is an annual observance held on July 11 to raise awareness about global population issues, including population growth, reproductive health, gender equality, and sustainable development. Established by the United Nations Development Programme (UNDP) in 1989, the day commemorates the approximate date when the world's population reached five billion in 1987.
  • 1.1K
  • 11 Jul 2025
Topic Review
Combined PARP inhibition Checkpoint Therapy
Genomic instability is a hallmark of cancer related to DNA damage response (DDR) deficiencies, offering vulnerabilities for targeted treatment. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) interfere with the efficient repair of DNA damage, particularly in tumors with existing defects in DNA repair, and induce synthetic lethality. PARPi are active across a range of tumor types harboring BRCA mutations and also BRCA-negative cancers, such as ovarian, breast or prostate cancers with homologous recombination deficiencies (HRD). Depending on immune contexture, immune checkpoint inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, elicit potent antitumor effects and have been approved in various cancers types. Although major breakthroughs have been performed with either PARPi or ICIs alone in multiple cancers, primary or acquired resistance often leads to tumor escape. PARPi-mediated unrepaired DNA damages modulate the tumor immune microenvironment by a range of molecular and cellular mechanisms, such as increasing genomic instability, immune pathway activation, and PD-L1 expression on cancer cells, which might promote responsiveness to ICIs. In this context, PARPi and ICIs represent a rational combination.
  • 1.1K
  • 10 Oct 2020
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