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Topic Review
Interventions for Preventing the Development of Psychopathic Traits
Individuals with the combination of psychopathy and severe conduct disorder often get in a lot of trouble from their early childhood, and can cause great suffering and problems for other people and their immediate environment. Their antisocial behaviour has a tendency to develop into a chronic pattern early in life, and the treatment prognosis in adulthood is poor. A large proportion of serious violent crimes in society can be attributed to this group of perpetrators. Until recently, it has been unclear whether traits of this type can be prevented or changed, so that these individuals and their surroundings can benefit from targeted treatments at an early stage. To reduce serious crime in a society, it is very important to develop effective measures for this particular group. 
  • 1.2K
  • 07 Mar 2022
Topic Review
Aloperine
Aloperine is an alkaloid found in the seeds and leaves of the medicinal plant Sophora alopecuroides L. It has been used as herbal medicine in China for centuries due to its potent anti-inflammatory, antioxidant, antibacterial, and antiviral properties. Recently, aloperine has been widely investigated for its therapeutic activities. Aloperine is proven to be an effective therapeutic agent against many human pathological conditions, including cancer, viral diseases, and cardiovascular and inflammatory disorders. Aloperine is reported to exert therapeutic effects through triggering various biological processes, including cell cycle arrest, apoptosis, autophagy, suppressing cell migration, and invasion. It has also been found to be associated with the modulation of various signaling pathways in different diseases.
  • 1.2K
  • 05 May 2022
Topic Review
Autopsy by Imaging
Virtual autopsies (VAs) are non-invasive, bypassing many of the challenges posed by traditional autopsies (TAs). One of the main methods for post mortem (PM) imaging is the use of X-ray images, a technique that has been used for a relatively long time now. PM X-ray images allow clear visualisation of fractures and radio-opaque foreign bodies within the deceased, and in this way are useful in guiding TAs in certain circumstances, for example in traumatic deaths. This imaging can also limit the TA, perhaps by providing information that would be difficult to access during the invasive examination, such as fractures in areas like the base of the skull which would require extensive, time-consuming, and delicate dissection. 
  • 1.2K
  • 09 Nov 2022
Topic Review
Quasi-Constitutionality
In Canada, the term quasi-constitutional is used for laws which remain paramount even when subsequent statutes, which contradict them, are enacted by the same legislature. This is the reverse of the normal practice, under which newer laws trump any contradictory provisions in any older statute.
  • 1.2K
  • 16 Nov 2022
Topic Review
Τhe “GPS/GNSS on Boat” Technique
The opening up of the global positioning system (GPS) for non-military uses provided a new impetus for the study of the sea surface topography (SST) and geoid, especially in coastal areas which are important from the viewpoint of the climate crisis. The application of the “GPS/GNSS on boat” method, as an alternative to traditional (indirect and direct) methods, has provided detailed SST maps in coastal and oceanic areas with an accuracy of up to few centimeters.
  • 1.2K
  • 06 Jan 2023
Topic Review
Functionalities of Solid State Transformers
The ongoing energy transition has changed the architecture of electricity networks in ways that conventional power transformers are not able to cope with the new required functionalities. The solid state transformer (SST), which comprises state-of-the-art power electronics with galvanic isolation to interconnect two separate alternating current (AC) or direct current (DC) power grids, is considered to be the dominant solution. 
  • 1.2K
  • 19 Apr 2023
Topic Review
Hyperbaric Oxygen Therapy in Treating Surgical Site Infections
Hyperbaric oxygen therapy (HBOT) can result in rapid healing and epithelialization of various wounds and has potential beneficial effects in the treatment of surgical site infections (SSIs) or other similar infections following cardiac, neuromuscular scoliosis, coronary artery bypass, and urogenital surgeries. Moreover, it was a safe therapeutic procedure in most cases. The mechanisms related to the antimicrobial activity of HBOT include direct bactericidal effects through the formation of reactive oxygen species (ROS), the immunomodulatory effect of HBOT that increase the antimicrobial effects of the immune system, and the synergistic effects of HBOT with antibiotics. 
  • 1.2K
  • 08 May 2023
Topic Review
CAES Systems Coupled with Wind Energy
With the strong advancement of the global carbon reduction strategy and the rapid development of renewable energy, compressed air energy storage (CAES) technology has received more and more attention for its key role in large-scale renewable energy access. It is shown that the coupling of wind energy and CAES is mainly combined in series and in parallel, and sometimes part of the wind power can be converted into thermal energy when coupled to CAES.
  • 1.2K
  • 29 Jun 2023
Topic Review
Photobiostimulation in Neurodegenerative Diseases
Photobiomodulation (PBM), also known as Low-level Laser Therapy (LLLT), involves the use of light from a laser or light-emitting diode (LED) in the treatment of various disorders and it has recently gained increasing interest. Progressive neuronal loss with attendant consequences such as cognitive and/or motor decline characterize neurodegenerative diseases. The available therapeutic drugs have only been able to provide symptomatic relief and may also present with some side effects, thus precluding their use in treatment. There has been an exponential increase in interest and attention in the use of PBM as a therapy in various neurodegenerative diseases in animal studies. Because of the financial and social burden of neurodegenerative diseases on the sufferers and the need for the discovery of potential therapeutic inventions in their management, it is pertinent to examine the beneficial effects of PBM and the various cellular mechanisms by which it modulates neural activity.
  • 1.2K
  • 31 Jul 2023
Topic Review
Mobile Energy Storage for Enhancing Power Grid Resilience
Natural disasters can lead to large-scale power outages, affecting critical infrastructure and causing social and economic damages. These events are exacerbated by climate change, which increases their frequency and magnitude. Improving power grid resilience can help mitigate the damages caused by these events. Mobile energy storage systems, classified as truck-mounted or towable battery storage systems, have been considered to enhance distribution grid resilience by providing localized support to critical loads during an outage. 
  • 1.2K
  • 02 Nov 2023
Topic Review
Smartphone Lidar Technology for Low-Cost 3D Building Documentation
Laser scanning technology has long been the preferred method for capturing interior scenes in various industries. With a growing market, smaller and more affordable scanners have emerged, offering end products with sufficient accuracy. While not on par with professional scanners, Apple has made laser scanning technology accessible to users with the introduction of the new iPhone Pro models, democratizing 3D scanning.
  • 1.2K
  • 02 Jan 2024
Topic Review
Resveratrol and TGF-β Signaling Pathway
Resveratrol (Res) is a well-known natural product that can exhibit important pharmacological activities such as antioxidant, anti-diabetes, anti-tumor, and anti-inflammatory. An evaluation of its therapeutic effects demonstrates that this naturally occurring bioactive compound can target different molecular pathways to exert its pharmacological actions. Transforming growth factor-beta (TGF-β) is an important molecular pathway that is capable of regulating different cellular mechanisms such as proliferation, migration, and angiogenesis. TGF-β has been reported to be involved in the development of disorders such as diabetes, cancer, inflammatory disorders, fibrosis, cardiovascular disorders, etc. 
  • 1.2K
  • 06 Jul 2021
Topic Review
Biological Properties of Essential Oils
Essential oils (EOs) are a mixture of natural, volatile, and aromatic compounds obtained from plants. In recent years, several studies have shown that some of their benefits can be attributed to their antimicrobial, antioxidant, anti-inflammatory, and also immunomodulatory properties. Therefore, EOs have been proposed as a natural alternative to antibiotics or for use in combination with antibiotics against multidrug-resistant bacteria in animal feed and food preservation. 
  • 1.2K
  • 29 Jul 2021
Topic Review
Urban Village Redevelopment Projects in China
The dual land system that resulted from the 1982 land reform makes the Chinese land situation unique. A dichotomy has existed between the state ownership of urban land and public ownership of rural land ever since. Urbanization in China often takes place by penetrating spatially into rural villages, where land is collectively owned. Urban villages are often regarded as temporary entities with undesirable urban planning and governance. Combined with the negative social externalities that urban villages emit, the Chinese government has implemented large-scale urban village redevelopment projects (UVRPs) in recent years to replace shabby entities with formal urban neighbourhoods. This phenomenon is in line with Kochan’s argument that urban planners will ultimately eradicate urban villages in urbanization. UVRPs have stimulated rapid urban development, which plays a great role in economic growth and modernization.
  • 1.2K
  • 02 Jun 2022
Topic Review
Dent Disease
Dent disease is a chronic kidney disorder that occurs almost exclusively in males. In affected individuals, kidney problems result from damage to structures called proximal tubules. Signs and symptoms of this condition appear in early childhood and worsen over time.
  • 1.2K
  • 24 Dec 2020
Topic Review
CTNNB1 Gene
catenin beta 1
  • 1.2K
  • 24 Dec 2020
Topic Review
Engineering Microbial Phenotypes
Microbial strains are being engineered for an increasingly diverse array of applications, from chemical production to human health. While traditional engineering disciplines are driven by predictive design tools, these tools have been difficult to build for biological design due to the complexity of biological systems and many unknowns of their quantitative behavior. However, due to many recent advances, the gap between design in biology and other engineering fields is closing.
  • 1.2K
  • 15 Jan 2021
Topic Review
Nanoparticles prevent arbovirus infection
Nanomedicine is a new and emerging research subject that aims to use nanotechnology with the pharmaceutical and biomedical sciences. The use of nanoparticles to develop new vaccines, diagnostic tests, and treatments for infectious diseases is a new alternative to solve important problems in some diseases caused by viruses. Arthropod-borne viruses (arboviruses) are a significant public health problem worldwide. Nanoparticles have been widely explored as new vaccine platforms, and vaccination is considered one of the most effective ways to control arbovirus diseases in the human population.  
  • 1.2K
  • 25 Jan 2021
Topic Review
Microbiota Modulation in Cancer Survivors
Chemotherapy, targeting not only malignant but also healthy cells, causes many undesirable side effects in cancer patients. Interventions and supportive care for treatment-induced late effects remain an emerging area of research in long-term cancer survivors. Due to the lack of preventive measures and approved pharmacological agents, different possibilities in preventing or mitigating the late toxicities need to be assessed. Targeting the gut microbiome in cancer survivors might represent a new potential trend being in its infancy to date. Gut microbiota disruption after chemo- and radiotherapy can be recovered by several mechanisms including administration of probiotics and/or prebiotics and FMT. Interestingly, the relationship between diet, physical activity, and gut microbiome appears to be another potential tool in cancer survivors. However, most of the data dealing with neuro- and cardioprotective effects of microbiota modulation came from preclinical and non-cancer patients´ clinical studies, and further evaluations in cancer patients are highly warranted.
  • 1.2K
  • 08 Mar 2021
Topic Review
Challenge of Antimicrobial Drug Resistance
Antimicrobial resistance is mushrooming as a silent pandemic. It is considered among the most common priority areas identified by both national and international agencies. The global development of multidrug-resistant strains now threatens public health care improvement by introducing antibiotics against infectious agents. 
  • 1.2K
  • 31 May 2021
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