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Topic Review
Organizational Health Literacy
The term organizational health literacy (OHL) is a new concept that emerged to address the challenge of predominantly in patients with limited health literacy (HL). 
  • 1.2K
  • 09 Feb 2021
Topic Review
Severe COVID-19 Lung Infection
Periodontal bacteria dissemination into the lower respiratory tract may create favorable conditions for severe COVID-19 lung infection. Once lung tissues are colonized, cells that survive persistent bacterial infection can undergo permanent damage and accelerated cellular senescence. Consequently, several morphological and functional features of senescent lung cells facilitate SARS-CoV-2 replication. The higher risk for severe SARS-CoV-2 infection, the virus that causes COVID-19, and death in older patients has generated the question whether basic aging mechanisms could be implicated in such susceptibility. Mounting evidence indicates that cellular senescence, a manifestation of aging at the cellular level, contributes to the development of age-related lung pathologies and facilitates respiratory infections. Apparently, a relationship between life-threatening COVID-19 lung infection and pre-existing periodontal disease seems improbable. However, periodontal pathogens can be inoculated during endotracheal intubation and/or aspirated into the lower respiratory tract.
  • 1.2K
  • 22 Feb 2021
Topic Review
Exosomes Derived from Tumor
Exosomes are lipid membrane-enclosed vesicles released by all cell types that act at the paracrine or endocrine level to favor cell differentiation, tissue homeostasis, organ remodeling, and immune regulation. Their biosynthesis begins with a cell membrane invagination which generates an early endosome that matures to a late endosome. By inward budding of the late endosome membrane, a multivesicular body (MVB) with intraluminal vesicles (ILVs) is generated. The fusion of MVBs with the plasma membrane releases ILVs into the extracellular space as exosomes, ranging in size from 30 to 100 nm in diameter. The bilipid exosome membrane is rich in cholesterol, ceramides, and phosphatidylserine and can be loaded with DNA, RNA, microRNAs, proteins, and lipids. It has been demonstrated that exosome secretion is a common mechanism used by the tumor to generate an immunosuppressive microenvironment that favors cancer development and progression, allowing tumor escape from immune control. 
  • 1.2K
  • 19 Mar 2021
Topic Review
The Alter Retina
Alternative splicing of mRNA is an essential mechanism to regulate and increase the diversity of the transcriptome and proteome. Alternative splicing frequently occurs in a tissue- or time-specific manner, contributing to differential gene expression between cell types during development. Neural tissues present extremely complex splicing programs and display the highest number of alternative splicing events. As an extension of the central nervous system, the retina constitutes an excellent system to illustrate the high diversity of neural transcripts. The retina expresses retinal specific splicing factors and produces a large number of alternative transcripts, including exclusive tissue-specific exons, which require an exquisite regulation. In fact, a current challenge in the genetic diagnosis of inherited retinal diseases stems from the lack of information regarding alternative splicing of retinal genes, as a considerable percentage of mutations alter splicing or the relative production of alternative transcripts. Modulation of alternative splicing in the retina is also instrumental in the design of novel therapeutic approaches for retinal dystrophies, since it enables precision medicine for specific mutations.
  • 1.2K
  • 22 Sep 2021
Topic Review
Biomaterials in 3D Cell Culture
The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. 
  • 1.2K
  • 16 Apr 2021
Topic Review
Precise Optical Modulation
Optoelectronic devices which play important roles in high-speed optical fiber networks can offer effective measurement methods for optoelectronic devices including optical modulators and photodetectors. Precise optical signal modulation is required for measurement applications.
  • 1.2K
  • 19 May 2021
Topic Review
Evolution of TFs and Enhancers
Adaptive immunity relies on the V(D)J DNA recombination of immunoglobulin (Ig) and T cell receptor (TCR) genes, which enables the recognition of highly diverse antigens and the elicitation of antigen-specific immune responses. This process is mediated by recombination-activating gene (Rag) 1 and Rag2 (Rag1/2), whose expression is strictly controlled in a cell type-specific manner; the expression of Rag1/2 genes represents a hallmark of lymphoid lineage commitment. Although Rag genes are known to be evolutionally conserved among jawed vertebrates, how Rag genes are regulated by lineage-specific transcription factors (TFs) and how their regulatory system evolved among vertebrates have not been fully elucidated. Here, we review the current body of knowledge concerning the cis-regulatory elements (CREs) of Rag genes and the evolution of the basic helix-loop-helix TF E protein regulating Rag gene CREs, as well as the evolution of the antagonist of this protein, the Id protein. This may help to understand how the adaptive immune system develops along with the evolution of responsible TFs and enhancers. 
  • 1.2K
  • 09 Jun 2021
Topic Review
Polymyxins
Polymyxins are non-ribosomal, cyclic oligopeptide antimicrobials, produced by the Gram-positive, spore-forming rod Bacillus aerosporus that were identified in 1946 from the soil of market gardens in England.
  • 1.2K
  • 11 Jun 2021
Topic Review
Silver lime (Tilia tomentosa)
Silver lime (Tilia tomentosa), a moderately drought-tolerant, thermophilous tree species of South-eastern Europe is considered suitable for the future.
  • 1.2K
  • 11 Aug 2021
Topic Review
Transcorneal Electrical Stimulation for Depression
The potential neuroprotective properties of Transcorneal Electrical Stimulation (TES) are possibly achieved through regulating neuroplasticity, neurotrophic expression, inflammatory responses, apoptosis, glutamate metabolism, and retinal blood flow. The putative neuroprotective effects of TES on mood control are supported by its shared mechanisms of action with current antidepressant treatments, including its neuroprotective effects against apoptosis and inflammation, as well as its ability to promote neurotrophic expression. This entry aims to discuss the neuromodulation potential of TES as a treatment for depressive disorders and the neuroprotective mechanisms of action that might contribute to the antidepressant-like responses.
  • 1.2K
  • 13 Oct 2021
Topic Review
Coronary Artery Disease
Coronary artery disease (CAD) is a significant cause of illness and death amongst women. The pathophysiology, manifestations, and outcomes of Cardiovascular disease (CVD) and CAD differ between sexes. These sex differences remain under-recognized.
  • 1.2K
  • 01 Nov 2021
Topic Review
Business Process Re-Engineering to Digitalise Quality Control Checks
Business process re-engineering allows optimising processes within businesses. One way to do so is to use lean thinking to maximise customer value whilst minimising waste. Just-in-time is one of the core elements of lean production and is the material flow design upon which the lean production model is founded. For such a production model to succeed and achieve high efficiency and productivity levels, it needs to have a robust quality management system to accomplish the notion of ‘right first time’ and have quality controls at the source to prevent defects from entering the production system altogether. Defects occur when products are produced outside of agreed tolerances of the approved specification. Defects are a significant contributor to product waste and waste of resources, including raw materials, energy, water, and human resources. A reduction in waste generation helps to boost business performance by lowering environmental, economic and social impacts, i.e., the three pillars of sustainability. Optimised process monitoring helps identify defects in advance or as they happen in real time. A key function of the quality control (QC) process is to provide evidence that customer requirements (tolerances) of the product are met; therefore, measuring and controlling the values of the different variables that regulate the manufacturing processes is critical. However, collecting these values and handling the data manually tends to be slow, tedious, and prone to human error, as data can be misread, misplaced, or misrecorded easily. Furthermore, human judgement may not be consistent due to various factors including fatigue, mental or physical stress, as well as variability in heuristic and cognitive capabilities. Data capturing and analysing technology can be used instead to acquire such data and use it to control processes within acceptable parameters, ensuring optimum product flow and quality. Furthermore, as computing devices get smaller and cheaper, it is increasingly possible to tailor them to meet more needs on the factory floor, enabling machines to gather data, measure key performance indicators, and track operational efficiency. Data archiving is also necessary so that results can be reviewed later for auditing purposes. As cloud storage becomes safer, more affordable and with connection speeds that provide quick access, companies are increasingly moving away from paper records. This change introduces the challenge of reviewing and re-writing internal procedures to capture these new ways of data collection and reporting. It is important to know and prove who does what, when, how, and why for the purposes of traceability, accuracy, and consistency.
  • 1.2K
  • 01 Dec 2021
Topic Review
Autophagy in Human Diseases
Autophagy, a process of cellular self-digestion, delivers intracellular components including superfluous and dysfunctional proteins and organelles to the lysosome for degradation and recycling and is important to maintain cellular homeostasis. In recent decades, autophagy has been found to help fight against a variety of human diseases, but, at the same time, autophagy can also promote the procession of certain pathologies, which makes the connection between autophagy and diseases complex but interesting.
  • 1.2K
  • 06 Dec 2021
Topic Review
A Structural Approach to Anti-Virulence
The anti-virulence strategy is designed to prevent bacterial virulence factors produced by pathogenic bacteria from initiating and sustaining an infection. 
  • 1.2K
  • 16 Dec 2021
Topic Review
Flavonoids Targeting CSC
Cancer stem cells (CSC) have been identified in several types of solid tumors. In some cases, CSC may be the source of all the tumor cells, the cause of the tumor’s resistance to chemotherapeutic agents, and the source of metastatic cells. Thus, a combination therapy targeting non-CSC tumor cells as well as specifically targeting CSCs holds the potential to be highly effective. Natural products (NPs) have been a historically rich source of biologically active compounds and are known for their ability to influence multiple signaling pathways simultaneously with negligible side effects. Natural flavonoids or potent derivatives are good candidates in exhibiting anti-CSC activity and targeting key functions required for CSC survival.
  • 1.2K
  • 29 Mar 2022
Topic Review
Chromophoric Dendrimer-Based Materials
Dendrimers (from the Greek dendros → tree; meros → part) are macromolecules with well-defined three-dimensional and tree-like structures. Remarkably, this hyperbranched architecture is one of the most ubiquitous, prolific, and recognizable natural patterns observed in nature. 
  • 1.2K
  • 16 Jan 2022
Topic Review
Garment Quality in a CE Context
The fashion industry is one of the most polluting industrial sectors in the world and its environmental impacts are huge. Garments are produced effectively at a low price, are of low quality, and are used for a very short time before ending up in increasing textile waste streams. One critical aspect in this context is the lifetime of a garment. Short garment lifetimes are the results of low quality and consumer dissatisfaction, or consumers’ constant search for newness, resulting in the early disposal of garments. 
  • 1.2K
  • 17 Jan 2022
Topic Review
Nerve Guidance Conduits
Nerve guidance conduits (NGCs) are tubular biostructures to bridge nerve injury sites via orienting axonal growth in an organized fashion as well as supplying a supportively appropriate microenvironment.
  • 1.2K
  • 09 Feb 2022
Topic Review
Data-Driven Learning Methods for Network Intrusion Detection Systems
An effective anomaly-based intelligent IDS (AN-Intel-IDS) must detect both known and unknown attacks. Hence, there is a need to train AN-Intel-IDS using dynamically generated, real-time data in an adversarial setting. Furthermore, the lack of real-time data produces potentially biased models that are less effective in predicting unknown attacks. Therefore, training AN-Intel-IDS using imbalanced and adversarial learning is instrumental to their efficacy and high performance. Unfortunately, the public datasets available to train AN-Intel-IDS are ineluctably static, unrealistic, and prone to obsolescence. Furthermore, the lack of real-time data produces potentially biased models that are less effective in predicting unknown attacks. Therefore, training AN-Intel-IDS using imbalanced and adversarial learning is instrumental to their efficacy and high performance. 
  • 1.2K
  • 28 Feb 2022
Topic Review
B-Cell Receptor Signaling Regulation and Aggressive B-Cell Lymphomas
The proliferation and survival signals emanating from the B-cell receptor (BCR) constitute a crucial aspect of mature lymphocyte’s life. Dysregulated BCR signaling is considered a potent contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B-NHLs). The emergence of BCR-associated kinases as rational therapeutic targets has led to the development and approval of several small molecule inhibitors targeting either Bruton’s tyrosine kinase (BTK), spleen tyrosine kinase (SYK), or phosphatidylinositol 3 kinase (PI3K), offering alternative treatment options to standard chemoimmunotherapy, and making some of these drugs valuable assets in the anti-lymphoma armamentarium. Despite their initial effectiveness, these precision medicine strategies are limited by primary resistance in aggressive B-cell lymphoma such as diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), especially in the case of first generation BTK inhibitors. In these patients, BCR-targeting drugs often fail to produce durable responses, and nearly all cases eventually progress with a dismal outcome, due to secondary resistance. 
  • 1.2K
  • 03 Mar 2022
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