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Topic Review
Inflation-Hedging Capabilities of Real Estate Investment Portfolios
Inflation is a term used to describe a purely monetary rate of upward movement in the prices of goods during a specific time frame. There has been a wide belief that real estate is a source of good investment portfolios because it has a hedge against inflation. 
  • 1.2K
  • 18 Jan 2024
Topic Review
Thiazole-Based Peptides
Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide–peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.
  • 1.2K
  • 22 Sep 2020
Topic Review
Chaperone Sigma1R and Antidepressant Effect
The Sigma1R chaperone interacts with cellular mechanisms, which are associated with the formation of a depressive phenotype. Sigma1R is also involved in the pharmacodynamics of antidepressants with various pharmacological targets. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. Pharmacological activation of chaperone Sigma1R can be considered a promising strategy to improve and develop approaches for combined, adjuvant pharmacotherapy of depression.
  • 1.2K
  • 09 Oct 2020
Topic Review
Alumina Nanocomposite
Although pure titanium and titanium alloys are highly biosafe, there are many reports of patients with metal allergies caused by titanium. In addition, it was used as a prosthesis in the oral cavity, such as the black triangle in which the gingiva turns black due to the gradual elution and deposition of metal ions in the titanium alloy, and the black margin generated when the gingiva lowers and the metal part is exposed. In some cases, there are also aesthetic issues.Zirconia is attracting attention as an alternative material to such problems. Zirconia is excellent in aesthetics and biosafety, and with the progress of CAD / CAM technology, its application in various applications has begun, and yttria-stable zirconia has already been put into practical use as a dental implant.However, yttria-stabilized zirconia, which is generally used as dental ceramics, is more brittle than metals such as titanium and has less bending properties, so there is a risk of breakage. Although yttria-stable zirconia is harder than metal, it is brittle once it is distorted, and it is a technical issue that the strength decreases when low-temperature deterioration occurs due to phase transition due to long-term use in a wet state such as in the oral cavity.On the other hand, ceria-stable zirconia-alumina composite ceramics have the same hardness as yttria-stable zirconia, and also have extremely excellent toughness, eliminating the weaknesses of ceramics such as brittleness and low-temperature deterioration in wet conditions. It is attracting attention as a ceramic.This ceramic has a nano-composite structure in which nano-sized alumina particles are incorporated into ceria-stable zirconia particles, and nano-sized ceria-stable zirconia particles are inter-dispersed in the alumina particles. , Nano zirconia). Nano zirconia has a high bending strength equivalent to that of general zirconia, and has a very high fracture toughness of 3 to 5 times that of general zirconia. Due to its high toughness as well as its strength, it is expected to be used in implan.However, nanozirconia is inferior in bone formation after implant placement compared to titanium, so surface modification is required for application as a medical device. So far, surface modification of nanozirconia has been investigated by concentrated alkali treatment, etc., but it is equivalent to titanium or titanium alloy, although it has a certain effect on the initial attachment of bone marrow cells or the induction of differentiation into hard tissue. Biocompatibility has not been achieved.
  • 1.2K
  • 26 Oct 2020
Topic Review
Carboxylic Polyester-Degrading Enzymes
Esters are organic compounds widely represented in cellular structures and metabolism, originated by the condensation of organic acids and alcohols. Esterification reactions are also used by chemical industries for the production of synthetic plastic polymers. Polyester plastics are an increasing source of environmental pollution due to their intrinsic stability and limited recycling efforts. Bioremediation of polyesters based on the use of specific microbial enzymes is an interesting alternative to the current methods for the valorization of used plastics. Microbial esterases are promising catalysts for the biodegradation of polyesters that can be engineered to improve their biochemical properties.
  • 1.2K
  • 18 May 2021
Topic Review
Smart Distribution Networks Resilience Quantification
The introduction of pervasive telecommunication devices, in the scope of smart grids (SGs), has accentuated interest in the distribution network, which integrates a huge portion of new grid applications. High impact low probability (HILP) events, such as natural hazards, manmade errors, and cyber-attacks, as well as the inherent fragility of the distribution grid have propelled the development of effective resilience tools and methods for the power distribution network (PDN) to avoid catastrophic infrastructural and economical losses.
  • 1.2K
  • 03 Jun 2021
Topic Review
Nanomedicine for Stroke Diagnosis
Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in developed countries. Therapeutic methods such as recanalization approaches, neuroprotective drugs, or recovery strategies have been widely developed to improve the patient’s outcome; however, important limitations such as a narrow therapeutic window, the ability to reach brain targets, or drug side effects constitute some of the main aspects that limit the clinical applicability of the current treatments. Nanotechnology has emerged as a promising tool to overcome many of these drug limitations and improve the efficacy of treatments for neurological diseases such as stroke. 
  • 1.2K
  • 04 Jun 2021
Topic Review
Extracellular Vesicles(EVs)
Extracellular vesicles (EVs), comprising large microvesicles (MVs) and exosomes (EXs), play a key role in intercellular communication, both in physiological and in a wide variety of pathological conditions. However, the education of EV target cells has so far mainly been investigated as a function of EX cargo, while few studies have focused on the characterization of EV surface membrane molecules and the mechanisms that mediate the addressability of specific EVs to different cell types and tissues. Identifying these mechanisms will help fulfill the diagnostic, prognostic, and therapeutic promises fueled by our growing knowledge of EVs.
  • 1.2K
  • 13 Jul 2021
Topic Review
Cape Verde Tourism Online Reviews
Small Island Developing States (SIDS) depend on the tourism industry as an important source for their Gross Domestic Product (GDP). Indeed, tourism is seen as a viable and sometimes the only means of economic growth, job creation, and earnings. Lack of studies was found both in SIDS, including Cape Verde, in regard to analyzing customers perception and satisfaction, and even more so when considering online reviews as a proxy of tourism experience.
  • 1.2K
  • 28 Jul 2021
Topic Review
Colitis-Complex Diarrhea
Colitis-complex diarrhea (CCD) in pigs can be defined as a type of diarrhea, which is associated with colonic inflammation and disrupted colonic gut barrier functionality as well as infiltration of neutrophils at the inflamed colon in growing pigs (8–16 weeks of age) and can bear large costs on the pig farms. The exact etiology of CCD is still unclear; however, pathogens including Brachyspira (B.) hyodysenteriae, B. pilosicoli, and swine whipworms such as Trichuris (T.) suis have been involved in specific colitis (SC). In the absence of specific pathogens, dietary factors, such as high levels of protein, pelleted feedstuffs, and lack of sufficient antioxidants, can result in non-specific colitis (NSC). On the other hand, supplement of polyunsaturated fatty acids (PUFA) and polyphenols, sufficient supply of essential amino acids (e.g., threonine, cysteine, and proline), short-chain fatty acids (SCFA; especially butyrate), and resistant starch have shown to confer preventing/ameliorating effects on CCD.
  • 1.2K
  • 29 Jul 2021
Topic Review
Sustainability in a Matrix Approach
Considering that sustainability is a relative concept, but also that this limitation could be avoided through continuous adaptation of the evaluation tools by taking into account the directions of change (such as time, space, application domain), the goal of the present study is to elaborate a matrix for measuring the level of sustainability for small vegetable farms.
  • 1.2K
  • 22 Sep 2021
Topic Review
Pig Manure and Heavy Metals in Rice
Pig manure (PM) is often highly enriched in heavy metals, such as Cu and Zn, due to the wide use of feed additives. To study the potential risks of heavy metal accumulation in the soil and rice grains by the application of PM and other organic manure, a four-year field experiment was conducted in the suburb of Shanghai, southeast China. The contents of Cu, Zn, Pb, and Cd in the soils and rice plants by the treatments of PM and fungal culturing residues (FCR) show a trend of annual increase. Those in the soils and rice by the PM treatment are raised even more significantly. Cu and Zn contents in the soil and rice roots by the PM are significantly higher than those by the non-fertilizer control (CK) during the four years, and Pb and Cd also significantly higher than CK in the latter two years. 
  • 1.2K
  • 14 Jan 2022
Topic Review
Ultrasound Technologies in Giant Cell Arteritis Diagnosis
Giant cell arteritis (GCA) is a primary autoimmune vasculitis that specifically affects medium-sized extracranial arteries, like superficial temporal arteries (TAs). The most important data to be considered for the ultrasound (US) diagnosis of temporal arteritis are stenosis, acute occlusions and “dark halo” sign, which represent the edema of the vascular wall. The vessel wall thickening of large vessels in GCA can be recognized by the US, which has high sensitivity and is facile to use. Ocular complications of GCA are common and consist especially of anterior arterial ischemic optic neuropathies or central retinal artery occlusion with sudden, painless, and sharp loss of vision in the affected eye. Color Doppler imaging of the orbital vessels (showing low-end diastolic velocities and a high resistance index) is essential to quickly differentiate the mechanism of ocular involvement (arteritic versus non-arteritic), since the characteristics of TAs on US do not correspond with ocular involvement on GCA. GCA should be cured immediately with systemic corticosteroids to avoid further visual loss of the eyes. 
  • 1.2K
  • 30 Jan 2022
Topic Review
Narrow-Leaf (dnl2) Mutant in Maize
The dnl2 mutant is a recessive mutant caused by EMS mutagenesis that displays various developmental defects, with a short stature and narrowed leaves being the two most obvious features. Phenotypic and cytological observations revealed that narrow-leaf mutant, dnl2 showed inhibited cell growth, altered vascular bundle patterning, and disrupted secondary cell wall structure when compared with the wild-type, which could be the direct cause of the dwarf and narrow-leaf phenotype.
  • 1.2K
  • 21 Mar 2022
Topic Review
Yeast β-Glucan with Immune-Modulatory Properties
β-glucans are a large class of complex polysaccharides with bioactive properties, including immune modulation. Natural sources of these compounds include yeast, oats, barley, mushrooms, and algae. Yeast is abundant in various processes, including fermentation, and they are often discarded as waste products. The production of biomolecules from waste resources is a growing trend worldwide with novel waste resources being constantly identified. Yeast-derived β-glucans may assist the host’s defence against infections by influencing neutrophil and macrophage inflammatory and antibacterial activities. β-glucans were long regarded as an essential anti-cancer therapy and were licensed in Japan as immune-adjuvant therapy for cancer in 1980 and new mechanisms of action of these molecules are constantly emerging.
  • 1.2K
  • 01 Jun 2022
Topic Review
Celiac Disease in Children during COVID Pandemic
Celiac disease is a chronic inflammatory disease that primarily affects the small intestine following the ingestion of gluten and the related prolamins found in wheat, rye, oats, and barley. It has a prevalence in the general population worldwide of approximately 1%.
  • 1.2K
  • 25 Jul 2022
Topic Review
The Internet of Things in Poland
One definition of the Internet of Things refers to devices that can be directly connected to the internet or other devices using wireless networks or, less frequently, cables. This definition of the IoT includes contemporary telephones, cameras, movement sensors, weather stations, even dishwashers, vehicles, industrial machinery, and daily outfits. Almost any object can get connected to the internet even if it was not manufactured as intended for the IOT, because in the majority of cases its functionality can be extended. The IOT has been growing dynamically, offering smart technological solutions. IoT-based applications are client-server operable which requires a specific communication protocol that can be used to determine a client-server communication model, allowing all clients to perform specific tasks thanks to communications via the internet. Poland’s rural areas that are diversified in terms of economic development are poorly equipped with basic infrastructure, which is a barrier to the functioning of people with limited mobility. 
  • 1.2K
  • 03 Aug 2022
Topic Review
CANT Z.1007
The CANT Z.1007 Alcione (Kingfisher) was an Italian three-engined medium bomber, with wooden structure. Designed by Filippo Zappata, who also designed the CANT Z.506 it had "excellent flying characteristics and good stability" and was regarded by some as "the best Italian bomber of World War II" although its wooden structure was easily damaged by the climate, as experienced in North Africa and in Russia. It was used by the Italian Regia Aeronautica, Italian Co-Belligerent Air Force , Aeronautica Nazionale Repubblicana and Luftwaffe during World War II.
  • 1.2K
  • 03 Nov 2022
Topic Review
CloudBerry Backup
MSP360 Backup (former CloudBerry Backup) is an online backup app developed by MSP360. The software is integrated with 3rd-party cloud storage providers and supports data backup and restore for Windows (desktop and servers), macOS and Linux. Additionally, it offers support for Microsoft SQL Server, Microsoft Exchange, VMware, Hyper-V, Office 365 and G Suite (Google Apps). MSP360 Backup is available in several commercial editions as well as a free offering (MSP360 Backup Desktop Free). MSP360 Managed Backup is a SaaS solution and is designed to help manage backup and recovery across multiple computers or servers.
  • 1.2K
  • 10 Nov 2022
Topic Review
Induction Heater
An induction heater is a key piece of equipment used in all forms of induction heating. Typically an induction heater operates at either medium frequency (MF) or radio frequency (RF) ranges. Four main component systems form the basis of a modern induction heater
  • 1.2K
  • 28 Nov 2022
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