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Topic Review
Xylitol Biosynthesis in the Yeast Candida
Xylitol is an industrially important chemical due to its commercial applications. The use of xylitol as a sweetener as well as its utilization in biomedical applications has made it a high value specialty chemical.
  • 1.2K
  • 09 Nov 2021
Topic Review
Helminth Management
Understanding and managing the risk posed by helminth eggs (HE) is a key concern for wastewater engineers and public health regulators. The treatment processes that produce recycled water from sewage at wastewater treatment plants (WWTPs) rely on achieving a defined log10 reduction value (LRV) in HE concentration during the production of recycled water from sewage to achieve the guideline concentration of ≤1.0 HE/L.
  • 1.2K
  • 25 Nov 2021
Topic Review
Revisiting Hepatic Artery Infusion Chemotherapy
Hepatic artery infusion chemotherapy (HAIC) is a well-established and common treatment for advanced hepatocellular carcinoma (HCC), particularly in East Asia. However, HAIC is not recognized internationally. Although several trials have demonstrated the safety and efficacy of HAIC, evidence corroborating its overall survival (OS) benefits compared with standard treatments is insufficient. Nevertheless, HAIC may provide prominent benefits in selected patients such as patients with portal vein thrombosis or high intrahepatic tumor burden. Moreover, HAIC has been combined with several therapeutic agents and modalities, including interferon-alpha, multikinase inhibitors, radiation therapy, and immunotherapy, to augment its treatment efficacy. Most of these combinations appeared to increase overall response rates compared with HAIC alone, but results regarding OS are inconclusive. Two prospective randomized controlled trials comparing HAIC plus sorafenib with sorafenib alone have reported conflicting results, necessitating further research. As immunotherapy-based combinations became the mainstream treatments for advanced HCC, HAIC plus immunotherapy-based treatments also showed encouraging preliminary results. The trials of HAIC were heterogeneous in terms of patient selection, chemotherapy regimens and doses, HAIC combination agent selections, and HAIC technical protocols. These heterogeneities may contribute to differences in treatment efficacy, thus increasing the difficulty of interpreting trial results.
  • 1.2K
  • 29 Mar 2022
Topic Review
Slow City Concept in Cittaslow
The slow city concept is associated with great care for the protection of the natural environment and the use of renewable energy sources.
  • 1.2K
  • 04 Jan 2022
Topic Review
L-Arginine in Disturbed Carbohydrate Treatment
L-arginine, an endogenous amino acid, is a safe substance that can be found in food. The compound is involved in synthesis of various products responsible for regulatory functions in the body. Particularly noteworthy is, among others, nitric oxide, a signaling molecule regulating carbohydrate and lipid metabolism. The increasing experimental and clinical data indicate that L-arginine supplementation may be helpful in managing disturbed metabolism in obesity, regulate arterial blood pressure or alleviate type 2 diabetes symptoms, but the mechanisms underlying these effects have not been sufficiently elucidated.
  • 1.2K
  • 07 Mar 2022
Topic Review
Pulmonary Stem Cell Senescence and Differentiation Disorders
Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral infection induces acute pulmonary epithelial senescence followed by fibrosis. Notably, the TGF-β signalling pathway mediates alveolar epithelial stem cell senescence by mechanisms involving suppression of the telomerase reverse transcriptase gene in pulmonary fibrosis. Alternatively, telomere uncapping caused by stress-induced telomeric shelterin protein TPP1 degradation mediates DNA damage response, pulmonary senescence and fibrosis. However, targeted intervention of cellular senescence disrupts pulmonary remodelling and fibrosis by clearing senescent cells using senolytics or preventing senescence using telomere dysfunction inhibitor (TELODIN). Studies indicate that the development of senescence-associated differentiation disorders is reprogrammable and reversible by inhibiting stem cell replicative senescence in pulmonary fibrosis, providing a framework for targeted intervention of the molecular mechanisms of alveolar stem cell senescence and pulmonary fibrosis.
  • 1.2K
  • 18 Mar 2022
Topic Review
Bioactive Glasses in Periodontal Regeneration
Bioactive glasses (BGs) were discovered by Larry L. Hench in 1969; the original composition, named Bioglass® 45S5 (45S5 from here on), displayed outstanding properties such as bone regeneration capabilities and antibacterial activity. In fact, such BG is an amorphous and biocompatible silica oxide-based inorganic material able to induce surface property responses resulting in the formation of a bond between the bone and the glass itself. In general, the surface of BGs, when soaked in physiological fluids, undergoes a complex ion exchange mechanism with the medium, inducing the formation of precipitates and subsequently hydroxyapatite deposition. This mechanism could explain the effectiveness of these BGs to bind to bones and the wide number of studies on BGs as supporting materials for bone tissue engineering and tooth remineralization.
  • 1.2K
  • 01 Apr 2022
Topic Review
Blockchain in Revolutionizing the Agricultural Sector
Distributed Ledger Technology (DLT)/blockchain is an intriguing new technology that has the potential to be a game-changer, and, in general, DLT are tamper-resistant and time-stamped databases. They allow several parties to capture, validate, and distribute data over a network in a decentralized, synchronized, and transparent manner, with minimal human participation and intermediate processes. The application of blockchain agriculture is still in the early stage, although there are ongoing research, projects, and initiatives to gain the most benefits of introducing blockchain-based technology in agriculture. These ongoing processes are centered around topics such as traceability, transparency, creditability, and auditability of agricultural data via blockchain based technology. Moreover, they are developing useful models or applications that can be used to improve the performance of the agriculture sector.
  • 1.2K
  • 07 Apr 2022
Topic Review
Innate Lymphoid Cells in Pancreatic Disease
Innate lymphoid cells (ILCs) represent a heterogeneous population of non-B/non-T lymphocytes whose discovery has greatly expanded researchers understanding over the past 10 years. ILCs are defined mainly by three unique features: (1) their lymphoid morphology; (2) their lack of genetically rearranged antigen receptors; and (3) their deficiency of cell-surface markers expressed in other immune cell types, such as myeloid cells and dendritic cells. In recent years, emerging evidence has identified the existence of ILCs in the pancreas, and all ILC subsets have been identified. ILCs resident in the pancreas, as well as in other tissues, may play an important role in the occurrence and progression of pancreatic diseases and will therefore be expected to be applied in the prevention and treatment of these diseases.
  • 1.2K
  • 22 Apr 2022
Topic Review
Vaccinology in the COVID-19 Pandemic Era
Different approaches have been used in parallel to make COVID-19 vaccines, including the use of nucleic acid-based vectors, whole virus (live-attenuated and inactivated), viral vectors (replicating and nonreplicating), adjuvant recombinant protein nanoparticles, and virus-like particles (VLPs). Among the protective antigens of SARS-CoV-2, the attention has mainly focused on the native S protein, which is able to induce potent neutralizing antibodies, even if its presentation to the immune system differs substantially between the different categories of vaccines. However, new evidence is being raised about potential roles for other, more conserved non-spike viral antigens, such as nucleocapsid (N) proteins, which might represent an innovation in the fight against emerging SARS-CoV-2 variants and a source for universal vaccines providing long-lasting immunity.
  • 1.2K
  • 29 Apr 2022
Topic Review
Information Overload during the COVID-19
Research has revealed that people whose primary source of COVID-19 information was social media experienced information overload (IO), which subsequently impacted their information behaviors. By definition, IO is “a physical and psychological distress that from human’s physical adaptive systems and decision-making process”.
  • 1.2K
  • 22 Jul 2022
Topic Review
TP53 Mutations in Pancreatic Cancer Progression
The TP53 gene encodes a tumor suppressor protein. The TP53 gene is one of the most frequently mutated genes in humans. The TP53 protein is a transcription factor. TP53 can also influence the pancreatic ductal adenocarcinomas (PDAC) or colorectal cancer (CRC) microenvironment by influencing the expression of many genes. 
  • 1.2K
  • 08 Aug 2022
Topic Review
HMS Whiting (1812)
HMS Whiting, built in 1811 by Thomas Kemp as a Baltimore pilot schooner, was launched as Arrow. On 8 May 1812 a British navy vessel seized her under Orders in Council, for trading with the French. The Royal Navy re-fitted her and then took her into service under the name HMS Whiting. In 1816, after four years service, Whiting was sent to patrol the Irish Sea for smugglers. She grounded on the Doom Bar. When the tide rose, she was flooded and deemed impossible to refloat.
  • 1.2K
  • 30 Sep 2022
Topic Review
Leadership Institute at Harvard College
The Leadership Institute at Harvard College (LIHC) is the largest student-run leadership training and development organization at Harvard College, located in Cambridge, Massachusetts. Founded in 2005, the Leadership Institute hosts high-profile speakers, organizes skill development workshops and forums, and publishes the annual Harvard Undergraduate Leadership Magazine. LIHC is the umbrella organization for four integrated programs: the Leadership Development Initiative (LDI), the Presidents' Forum (TPF), the Harvard Undergraduate Leadership Magazine (HULM), and the LIHC-Citizen Schools Youth Outreach Initiative.
  • 1.2K
  • 31 Oct 2022
Topic Review
Venous Thromboembolism Prevention in Multiple Myeloma
Multiple myeloma (MM) is associated with an increased risk of thrombotic complications, which remains substantial despite the implementation of thromboprophylaxis. The procoagulant state that characterizes the disease is multifactorial, and a greater understanding of the underlying pathophysiology is required to inform appropriate thrombosis prevention. There is a shift towards using direct oral anticoagulants (DOACs) in this setting; head-to-head comparisons in the context of controlled clinical trials between class agents are still missing. MM-specific venous thromboembolism (VTE) risk assessment scores have been developed to optimize management and minimize the associated mortality/morbidity. Their clinical utility remains to be evaluated. 
  • 1.2K
  • 29 Dec 2022
Topic Review
Human SRC Homology 3 Domains
SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins. They are widely studied modular building blocks across all five kingdoms of life and viruses, mediating various biological processes. The SH3 domains are also implicated in the development of human diseases, such as cancer, leukemia, osteoporosis, Alzheimer’s disease, and various infections.
  • 1.2K
  • 16 Aug 2023
Topic Review
Biopolymers and Bioprinting for Dental Tissue Engineering
Dental tissues are composed of multiple tissues with complex organization, such as dentin, gingiva, periodontal ligament, and alveolar bone. These tissues have different mechanical and biological properties that are essential for their functions. Therefore, dental diseases and injuries pose significant challenges for restorative dentistry, as they require innovative strategies to regenerate damaged or missing dental tissues. Biomimetic bioconstructs that can effectively integrate with native tissues and restore their functionalities are desirable for dental tissue regeneration.
  • 1.2K
  • 23 Aug 2023
Topic Review
Codes of Conduct at Zoos
Zoos consistently implement codes of conduct in efforts to manage visitor behaviour. Zoos worldwide have implemented the use of codes of conduct to regulate and manage the activities and actions of visitors. Zoos have been an ethical ground for negotiating the relationship between people and animals. Codes of conduct in zoos are uniquely placed, manifesting this ethical dialogue between species.
  • 1.2K
  • 27 Feb 2024
Topic Review
Sustainable Water Infrastructure in Sub-Saharan Africa
Developing a sustainable water infrastructure entails the planning and management of water systems to ensure the availability, access, quality, and affordability of water resources in the face of social, environmental, and economic challenges. Sub-Saharan Africa (SSA) is currently in an era where it must make significant changes to improve the sustainability of its water infrastructure.
  • 1.2K
  • 11 Mar 2024
Topic Review
Inflation-Hedging Capabilities of Real Estate Investment Portfolios
Inflation is a term used to describe a purely monetary rate of upward movement in the prices of goods during a specific time frame. There has been a wide belief that real estate is a source of good investment portfolios because it has a hedge against inflation. 
  • 1.2K
  • 18 Jan 2024
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