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Topic Review
Viral Enteritis in Cattle
Livestock products supply about 13 percent of energy and 28 percent of protein in diets consumed worldwide. Diarrhea is a leading cause of sickness and death of beef and dairy calves in their first month of life and also affecting adult cattle, resulting in large economic losses and a negative impact on animal welfare. Despite the usual multifactorial origin, viruses are generally involved, being among the most important causes of diarrhea. There are several viruses that have been confirmed as etiological agents (i.e., rotavirus and coronavirus), and some viruses that are not yet confirmed as etiological agents. 
  • 1.2K
  • 03 Sep 2021
Topic Review
The Application of Zeolites and Mesoporous Silica Materials
Zeolites and mesoporous silica materials are effective adsorbents that can be useful for the removal of various pharmaceuticals including non-steroidal anti-inflammatory drugs and antibiotics from low-quality water. This paper summarizes the properties and basic characteristics of zeolites and mesoporous silica materials and reviews the recent studies on the efficacy of the adsorption of selected non-steroidal medicinal products and antibiotics by these adsorbents to assess the potential opportunities and challenges of using them in water treatment. It was found that the adsorption capacity of sorbents with high silica content is related to their surface hydrophobicity (hydrophilicity) and structural features, such as micropore volume and pore size, as well as the properties of the studied medicinal products. 
  • 1.2K
  • 20 Oct 2021
Topic Review
Ribosomal Protein S6 as A Therapeutic Target
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been recognized as a surrogate marker for the activated PI3K/AKT/mTORC1 pathway, which occurs in many cancer types. However, downstream mechanisms regulated by RPS6 or p-RPS remains elusive, and the therapeutic implication of RPS6 is underappreciated despite an approximately half a century history of research on this protein. In addition, substantial evidence from RPS6 knockdown experiments suggests the potential role of RPS6 in maintaining cancer cell proliferation. This motivates us to investigate the current knowledge of RPS6 functions in cancer. 
  • 1.2K
  • 11 Jan 2022
Topic Review
Spanish Spelt Wheat
Spelt wheat (Triticum aestivum L. ssp. spelta Thell.) is an ancient wheat that was widely cultivated in the past. This species derived from a cross between emmer wheat (T. turgidum spp. dicoccum Schrank em. Thell.) and Aegilops tauschii Coss. Its main origin was in the Fertile Crescent (Near East), with a secondary center of origin in Europe due to a second hybridization event between emmer and hexaploid wheat. This species has been neglected in most of Europe; however, the desire for more natural foods has driven a revival in interest. Iberian spelt is classified as a geographical group differing to the rest of European spelt.
  • 1.2K
  • 07 Feb 2022
Topic Review
ATT Triplex and DNA
Due to the involvement of DNA:RNA hybrids and triplex helices in many essential functions in cells, this entry’s main aim is to detect benzothiazole based moieties with selective binding or spectroscopic response to these nucleic structures compared to regular (non-hybrid) DNA and RNA duplexes and single-stranded forms.
  • 1.2K
  • 29 Mar 2022
Topic Review
Smart Textile
The integration of electronic components in/onto conductive textile yarns without compromising textile qualities such as flexibility, conformability, heat and moisture transfer, and wash resistance is essential to ensuring acceptance of electronic textiles. One solution is creating flexible and stretchable conductive yarns that contain tiny surface-mounted electronic elements embedded at the fiber level.
  • 1.2K
  • 06 May 2022
Topic Review
Atypical Ubiquitination and Parkinson’s Disease
Ubiquitination (the covalent attachment of ubiquitin molecules to target proteins) is one of the main post-translational modifications of proteins. Historically, the type of polyubiquitination, which involves K48 lysine residues of the monomeric ubiquitin, was the first studied type of ubiquitination. It usually targets proteins for their subsequent proteasomal degradation. All the other types of ubiquitination, including monoubiquitination; multi-monoubiquitination; and polyubiquitination involving lysine residues K6, K11, K27, K29, K33, and K63 and N-terminal methionine, were defined as atypical ubiquitination (AU). Good evidence now exists that AUs, participating in the regulation of various cellular processes, are crucial for the development of Parkinson’s disease (PD). These AUs target various proteins involved in PD pathogenesis. The K6-, K27-, K29-, and K33-linked polyubiquitination of alpha-synuclein, the main component of Lewy bodies, and DJ-1 (another PD-associated protein) is involved in the formation of insoluble aggregates. Multifunctional protein kinase LRRK2 essential for PD is subjected to K63- and K27-linked ubiquitination. Mitophagy mediated by the ubiquitin ligase parkin is accompanied by K63-linked autoubiquitination of parkin itself and monoubiquitination and polyubiquitination of mitochondrial proteins with the formation of both classical K48-linked ubiquitin chains and atypical K6-, K11-, K27-, and K63-linked polyubiquitin chains. The ubiquitin-specific proteases USP30, USP33, USP8, and USP15, removing predominantly K6-, K11-, and K63-linked ubiquitin conjugates, antagonize parkin-mediated mitophagy. 
  • 1.2K
  • 13 May 2022
Topic Review
Therapies for Pancreatic Ductal Adenocarcinoma
Pancreatic cancer is the fourth leading cause of cancer-related mortality worldwide, with a five-year survival rate of less than 8%. It can be classed into endocrine and exocrine tumours with PDAC, a form of exocrine pancreatic cancer, the most common form. The high mortality rate associated with PDAC is primarily due to delayed diagnosis and tumour resistance to chemotherapy. A broad range of non-specific symptoms are associated with PDAC such as abdominal pain, jaundice, dry/itchy skin, steatorrhoea, and bilirubinuria. Surgery is the primary treatment option, with chemotherapy being administered as adjuvant therapy in select cases.  Resistance to chemotherapy has become a critical problem in the treatment of PDAC, with most patients displaying resistance patterns. 
  • 1.2K
  • 02 Sep 2022
Topic Review
Light and Smoke Compounds in Photoblastic Seeds
Light increases the germinability of positively photoblastic seeds and inhibits the germination of negative ones. In an area where plant-generated smoke from fire is a periodically occurring environmental factor, smoke chemicals can affect the germination of seeds, including those that are photoblastically sensitive. In general, germination is under control of inhibitors involved in seed dormancy (mostly abscisic acid, ABA, and auxin, IAA), while gibberellic acid (GA) stimulates the process. Light, via the phytochrome system positively affects GA and decreases ABA and IAA levels. Similarly, karrikin1 (KAR1), physiologically active smoke compound, regulates some light-induced genes which results in germination of positively photoblastic seeds in darkness. 
  • 1.2K
  • 02 Aug 2022
Topic Review
KCNJ5 Mutation in Aldosterone Producing Adenoma
The discovery of the KCNJ5 somatic mutation in aldosteroene producing adenoma (APA) in 2011 and the development of specific CYP11B2 antibodies in 2012 have greatly advanced our understanding of the pathophysiology of primary aldosteronism. PA leads to abnormalities in the renin-angiotensin-aldosterone system and is known to increase the incidence of atrial fibrillation, heart failure, and stroke by 3.52, 2.05, and 2.58 times compared to hypertension due to essential hypertension.
  • 1.2K
  • 26 Aug 2022
Topic Review
Weekday Cartoon
A weekday cartoon is the colloquial term for the animated series programming that was typically scheduled on weekday mornings and afternoons in the United States on many major television networks and in broadcast syndication since the 1960s.
  • 1.2K
  • 29 Sep 2022
Topic Review
Polyphenols in Metabolic Diseases
Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo and in vitro, as well as reported clinical studies. Considering their free-radical scavenging and anti-inflammatory properties, these substances can be used to treat different kinds of conditions associated with metabolic disorders. Many symptoms of metabolic syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, as well as cancer and neurodegenerative disorders, are substantially relieved by dietary PPs.
  • 1.2K
  • 25 Oct 2022
Topic Review
China Labor Watch
China Labor Watch (CLW) is a New York City , New York-based non-government organization founded by labor activist Li Qiang in October 2000. Its mission is the defense of workers' rights in China . Through research, advocacy and legal assistance, CLW seeks to help China's workers become more informed of their rights and more empowered to realize those rights within their communities.
  • 1.2K
  • 04 Nov 2022
Topic Review
Wearables as Digital Diagnostics
Wearables, which refer to smart consumer devices that record digital health data, are becoming an integral part of our daily lives. This reflects the growing health consciousness among people. Wearable biosensors are low-price, non-invasive, and non-irritating devices that function by continuously measuring a person’s physiological parameters in real time, which can be used for the early as well as in-depth diagnosis of several conditions. Wearable devices contain different types of sensors that collect data on step counts, heart rate, sleep duration, calories burnt, stress, and oxygen levels.
  • 1.2K
  • 29 Nov 2022
Topic Review
Missing Middle Housing
Missing Middle Housing consists of multi-unit housing types such as duplexes, fourplexes, bungalow courts, and mansion apartments that are not bigger than a large house, that are integrated throughout most walkable pre-1940s neighborhoods, often integrated into blocks with primarily single-family homes, and that provide diverse housing choices and generate enough density to support transit and locally-serving commercial amenities. Although many of these are a common feature in pre-war building stocks, these housing types have become much less common.
  • 1.2K
  • 01 Dec 2022
Topic Review
Optical Sensors Based on Plasmonic Techniques in Aquaculture
Aquaculture is an expanding economic sector that nourishes the world’s growing population due to its nutritional significance as a source of high-quality proteins. However, it has faced severe challenges due to significant cases of environmental pollution, pathogen outbreaks, and the lack of traceability that guarantees the quality assurance of its products. Such context has prompted many researchers to work on the development of novel, affordable, and reliable technologies, such as the sensors based on the plasmonic technique are surface plasmon resonance (SPR), localised SPR, and fibre-optic SPR.
  • 1.2K
  • 11 Jan 2023
Topic Review
Effects of Nitric Oxide on Fruit Ripening
Nitric oxide (NO) is a gaseous free radical that has been become a potential tool to maintain the quality of postharvest horticultural produce (such as fruits). It plays important roles in delaying ripening, alleviating chilling injury, preventing browning, and enhancing disease resistance. The regulatory function of NO is achieved through the post-transcriptional modification of proteins, such as tyrosine nitration, S-nitrosylation, and nitroalkylation. Secondly, NO can also induce the expression of stress-related genes by synergistically interacting with other signaling substances, such as Ca2+, ethylene (ETH), salicylic acid (SA), and jasmonic acid (JA). 
  • 1.2K
  • 16 Feb 2023
Topic Review
AI-Powered Diagnosis of Skin Cancer
Skin cancer continues to remain one of the major healthcare issues across the globe. If diagnosed early, skin cancer can be treated successfully. Artificial Intelligence (AI)-based methods can assist in the early detection of skin cancer and can consequently lower its morbidity, and, in turn, alleviate the mortality rate associated with it. Machine learning and deep learning are branches of AI that deal with statistical modeling and inference, which progressively learn from data fed into them to predict desired objectives and characteristics. 
  • 1.2K
  • 27 Feb 2023
Topic Review
Legume Protein Hydrolysates
Consumption of legumes has been shown to enhance health and lower the risk of cardiovascular disease and specific types of cancer. ACE inhibitors, antioxidants, and synthetic anti-inflammatories are widely used today. In vitro and in vivo research has shown the bioactive peptides generated from legume protein hydrolysates, such as antioxidant, anti-hypertensive, anticancer, anti-proliferative, anti-inflammatory, etc., in the context of different disease mitigation. Therefore, researchers describe the recent advances in in vitro and in vivo studies of antioxidant, anti-hypertensive and anti-inflammatory peptides isolated from legume-derived protein hydrolysates. The results indicated that antioxidant legumes peptides are characterized by shortchain sequence amino acids and possess anti-hypertensive properties by reducing systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR).
  • 1.2K
  • 24 Mar 2023
Topic Review
Anti-Inflammatory Properties of Plants
Inflammation is a natural protective response of the human body to a variety of hostile agents and noxious stimuli. Standard anti-inflammatory therapy includes drugs whose usage is associated with a number of side effects. Since ancient times, natural compounds have been used for the treatment of inflammation. Traditionally, the use of medicinal plants is considered safe, inexpensive, and widely acceptable. In Serbia, traditional medicine, based on the strong belief in the power of medicinal herbs, is the widespread form of treatment.
  • 1.2K
  • 04 Apr 2023
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