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Topic Review
Bioelectricity in Developmental Patterning and Size Control
Developmental patterning is essential for regulating cellular events such as axial patterning, segmentation, tissue formation, and organ size determination during embryogenesis. Understanding the patterning mechanisms remains a central challenge and fundamental interest in developmental biology. Ion-channel-regulated bioelectric signals have emerged as a player of the patterning mechanism, which may interact with morphogens.
  • 1.2K
  • 03 Jul 2023
Topic Review
Arbuscular Mycorrhizal Fungi and Strigolactone
Plants, the cornerstone of life on Earth, are constantly struggling with a number of challenges arising from both biotic and abiotic stressors. To overcome these adverse factors, plants have evolved complex defense mechanisms involving both a number of cell signaling pathways and a complex network of interactions with microorganisms. Among these interactions, the relationship between symbiotic arbuscular mycorrhizal fungi (AMF) and strigolactones (SLs) stands as an important interplay that has a significant impact on increased resistance to environmental stresses and improved nutrient uptake and the subsequent enhanced plant growth.
  • 1.2K
  • 06 Dec 2023
Topic Review
Inverse Modeling in Cardiovascular Medicine
Inverse modeling approaches in cardiovascular medicine are a collection of methodologies that can provide non-invasive patient-specific estimations of tissue properties, mechanical loads, and other mechanics-based risk factors using medical imaging as inputs. Its incorporation into clinical practice has the potential to improve diagnosis and treatment planning with low associated risks and costs. Inverse method applications are multidisciplinary, requiring tailored solutions to the available clinical data, pathology of interest, and available computational resources. 
  • 1.2K
  • 18 May 2022
Topic Review
Microenvironments of Parvalbumin-Expressing GABAergic Interneurons
Data suggest that pathological disturbance of the population of fast-spiking, parvalbumin-expressing GABAergic inhibitory interneurons occur in at least some clinical presentations, which leads to disruption of the synchronous oscillatory output of assemblies of pyramidal neurons. Increased expression of the GluN2A NMDA receptor subunit on parvalbumin-expressing interneurons is linked to functional maturation of both these neurons and the perineuronal nets that surround them. Disruption of GluN2A expression shows increased susceptibility to oxidative stress, reflected in redox dysregulation and delayed maturation of PNNs.
  • 1.2K
  • 10 Sep 2021
Topic Review
Bioshell Calcium Oxide Water
Bioshell calcium oxide (BiSCaO) exhibits broad microbicidal activity for instance. In this study, we examined possible utility of BiSCaO Water for that purpose. The produced BiSCaO Water contained nanoparticles, and was colorless and transparent, with a pH > 12.7. In vitro assays demonstrated that BiSCaO Water eliminated more than 99.9% of influenza A (H1N1) and Feline calicivirus, Escherichia coli within 15 min for instance. BiSCaO Water exhibit excellent disinfection activities against pathogenic bacteria and viruses (including both enveloped and nonenveloped viruses).
  • 1.2K
  • 29 Oct 2020
Topic Review
Urban Rain Flood Models
The basis of studying urban rain and flood problems is to establish urban rain and flood models, calibrate and verify the models by simulating and reproducing historical flood events, and then provide technical support for urban hydrological forecasting, urban planning, and water resource utilization. The essence is to alleviate or even solve the problem of urban flood.
  • 1.2K
  • 27 Oct 2020
Topic Review
Ataxia-Telangiectasia and Bone Marrow Transplantation
Ataxia-Telangiectasia (A-T) is a rare autosomal recessive disorder, characterized by a progressive cerebellar neurodegeneration, immunodeficiency, infertility, and cancer predisposition, with high incidence of leukemia and lymphoma.
  • 1.2K
  • 30 Nov 2020
Topic Review
TAZ Gene
Tafazzin: The TAZ gene provides instructions for producing a protein called tafazzin.
  • 1.2K
  • 24 Dec 2020
Topic Review
Belantamab Mafodotin and Multiple Myeloma
Multiple myeloma (MM) is a hematologic malignancy characterized by excessive clonal proliferation of plasma cells. The treatment of multiple myeloma presents a variety of unique challenges due to the complex molecular pathophysiology and incurable status of the disease at this time. Given that MM is the second most common blood cancer with a characteristic and unavoidable relapse/refractory state during the course of the disease, the development of new therapeutic modalities is crucial. Belantamab mafodotin (belamaf, GSK2857916) is a first-in-class therapeutic, indicated for patients who have previously attempted four other treatments, including an anti-CD38 monoclonal antibody, a proteosome inhibitor, and an immunomodulatory agent. In November 2017, the FDA designated belamaf as a breakthrough therapy for heavily pretreated patients with relapsed/refractory multiple myeloma. In August 2020, the FDA granted accelerated approval as a monotherapy for relapsed or treatment-refractory multiple myeloma. The drug was also approved in the EU for this indication in late August 2020. Of note, belamaf is associated with the following adverse events: decreased platelets, corneal disease, decreased or blurred vision, anemia, infusion-related reactions, pyrexia, and fetal risk, among others. Further studies are necessary to evaluate efficacy in comparison to other standard treatment modalities and as future drugs in this class are developed
  • 1.2K
  • 24 Feb 2021
Topic Review
Enhancing Weathering Resistance of Wood
Although weathering is primarily a surface phenomenon, it is an important issue for wood products as it affects their appearance, service life, and wood-coating performance. To encourage the use of wood as a material for joinery and other building components, the results of research into increasing the weathering resistance of wood are extremely significant. The development of weathering protection methods is of great importance to reduce the maintenance requirements for wood exposed outdoors and can have a major environmental impact.
  • 1.2K
  • 30 Jun 2021
Topic Review
Gastroparesis in Parkinson Disease
Patients with Parkinson disease (PD) experience a range of non-motor symptoms, including gastrointestinal symptoms. These symptoms can be present in the prodromal phase of the disease. Recent advances in pathophysiology reveal that α-synuclein aggregates that form Lewy bodies and neurites, the hallmark of PD, are present in the enteric nervous system and may precede motor symptoms. Gastroparesis is one of the gastrointestinal involvements of PD and is characterized by delayed gastric emptying of solid food in the absence of mechanical obstruction. Gastroparesis has been reported in nearly 45% of PD. The cardinal symptoms include early satiety, postprandial fullness, nausea, and vomiting. The diagnosis requires an appropriate test to confirm delayed gastric emptying, such as gastric scintigraphy, or breath test. Gastroparesis can lead to malnutrition and impairment of quality of life. Moreover, it might interfere with the absorption of antiparkinsonian drugs. The treatment includes dietary modifications, and pharmacologic agents both to accelerate gastric emptying and relieve symptoms. 
  • 1.2K
  • 06 Sep 2023
Topic Review
Network Protocol Design for IoT
Wireless Sensor Network (WSN) is one of the key technologies for IoT implementation. Research and development in IoT are progressing from the research and development in Wireless Sensor Network (WSN) and Mobile Ad Hoc Network (MANET), but still have some specific differences. Compared to WSN and MANET, IoT has a wider scope that includes the device, the communication infrastructure, and the cloud. IoT applications are more diverse. They are different from the WSN and MANET applications, which are domain specific. IoT always involves the internet (IP based network) as the point of interest, so that it often requires multiple network interfaces on the gateway side. IoT also tends to use the existing standard of communication technology infrastructure, which is already available for the internet network.
  • 1.2K
  • 05 Aug 2021
Topic Review
Redox-Active Metal Ions
Redox-active metal ions, Cu(I/II) and Fe(II/III), are essential biological molecules for the normal functioning of the brain, including oxidative metabolism, synaptic plasticity, myelination, and generation of neurotransmitters.
  • 1.2K
  • 06 Aug 2021
Topic Review
Nutritional Assessment in Preterm Infants
A practical approach for nutritional assessment in preterm infants under intensive care, based on anthropometric measurements and commonly used biochemical markers, is suggested. 
  • 1.2K
  • 03 Sep 2021
Topic Review
Pathophysiology of Psoriasis
Psoriasis is an immune-mediated inflammatory disease, with a chronic relapsing-remitting course, which affects 2–3% of the worldwide population. Psoriasis vulgaris is a common inflammatory, immune-mediated, chronic, and recurrent dermatosis, caused by the interplay between multiple genetic and environmental risk factors. The clinical feature of psoriasis is dominated by erythematous-squamous plaques which usually, but non-exclusively arise symmetrically on the extensor surfaces of the elbows and knees, scalp, lumbosacral area, and it reflects some pathogenetic mechanisms underlying psoriasis, i.e., inflammation, hyperproliferation, angiogenesis.
  • 1.2K
  • 28 Oct 2021
Topic Review
N-Palmitoyl Serinol
Ceramides, a class of sphingolipids containing a backbone of sphingoid base, are the most important and effective structural component for the formation of the epidermal permeability barrier. While ceramides comprise approximately 50% of the epidermal lipid content by mass, the content is substantially decreased in certain inflammatory skin diseases, such as atopic dermatitis (AD), causing improper barrier function. It is widely accepted that the endocannabinoid system (ECS) can modulate a number of biological responses in the central nerve system, prior studies revealed that activation of endocannabinoid receptor CB1, a key component of ECS, triggers the generation of ceramides that mediate neuronal cell fate. N-palmitoyl Serinol is a kind of N-Acyl amide.  It has the amide bond of AEA(Anandamide) and two hydroxy group of 2-AG(2-Arachidonoyl Glycerol), which is very similar structure with PEA(N-Palmitoyl ethanolamine). 
  • 1.2K
  • 15 Nov 2021
Topic Review
Social Isolation and Loneliness during the COVID-19
The COVID-19 pandemic has resulted in a predominantly global quarantine response that has been associated with social isolation, loneliness, and anxiety. Notwithstanding the efficacy of quarantine as a tool to limit the spread of disease, it also creates social isolation. Social isolation is an objective state in which an individual is alone, and is a sufficient, but not necessary, condition to produce the subjective feeling of loneliness. More specifically, some individuals may be socially isolated but experience this as a natural and healthy state in normal conditions; however, the prolongation of social isolation, particularly in unnatural conditions (e.g., in response to a global pandemic) can become a hazardous state to individual health. Loneliness is a similar yet distinct case: it is a subjective state in which a person feels that their social connections are inadequate (even though they may have a substantial social network). Both of these concepts relate to social connections and the maintenance of a healthy support network. The health implications of social isolation and loneliness during quarantine have a heterogenous and comorbid nature and, as a result, form a link to anxiety.
  • 1.2K
  • 28 Jan 2022
Topic Review
Application of Two-fluid Mode
In two-fluid model (TFM), the granular flows are modeled as continuous fluid flows. The random motions of particles resulting from the interactive collisions of particles has a dominant effect on the flow behavior. The granular interactions are commonly modeled based on the kinetic theory of granular flow (KTGF). 
  • 1.2K
  • 14 Feb 2022
Topic Review
Platform-Based Robot-Assisted Rehabilitation
The use of robotic-assisted rehabilitation has increased significantly. Compared with traditional care, robotic rehabilitation has several potential advantages. Platform-based robotic rehabilitation can help patients recover from musculoskeletal and neurological conditions. Evidence on how platform-based robotic technologies can positively impact on disability recovery is still lacking, and it is unclear which intervention is most effective in individual cases. The Virtual Reality (VR)-based Rutgers Ankle and the Hunova were found to be the effective robots for the rehabilitation of patients with neurological conditions (stroke, spinal cord injury, Parkinson’s disease) and various musculoskeletal ankle injuries. 
  • 1.2K
  • 06 Apr 2022
Topic Review
Intestinal Porcine Epithelial Cell Lines
Numerous bioactive plant additives have shown various positive effects in pigs and chickens. The demand for feed additives of natural origin has increased rapidly in recent years to support the health of farm animals and thus minimize the need for antibiotics and other drugs. Although only in vivo experiments can fully represent their effect on the organism, the establishment of reliable in vitro methods is becoming increasingly important in the goal of reducing the use of animals in experiments. The use of cell models requires strict control of the experimental conditions so that reliability and reproducibility can be achieved. In particular, the intestinal porcine epithelial cell line IPEC-J2 represents a promising model for the development of new additives. It offers the possibility to investigate antioxidative, antimicrobial, anti- or pro-proliferative and antiviral effects.
  • 1.2K
  • 22 Apr 2022
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