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Topic Review
Principles of the Suzuki Coupling Reaction
The Suzuki coupling is a transition metal-catalyzed, cross-coupling carbon–carbon (C–C) bond forming reaction between organic boron compounds and organic halides. As an operationally simple and versatilely applicable procedure, the Suzuki coupling reaction has found immense applications in drug discovery and development in the pharmaceutical industry. 
  • 5.2K
  • 06 Jan 2023
Topic Review
Paraprobiotics
Paraprobiotics are defined as “inactivated microbial cells (non-viable) that confer a health benefit to the consumer” and hold the ability to regulate the adaptive and innate immune systems, to exhibit anti-inflammatory, antiproliferative and antioxidant properties, and to exert antagonistic effect against pathogens, thus confirming that viability of probiotics is not an absolute pre-requisite for promoting health effects. 
  • 5.2K
  • 05 May 2021
Topic Review
Adipose tissue in the breast
       Breast is a dynamic organ mainly composed of adipose and fibroglandular tissues. The adipose tissue extends from the collarbone to the underarm and around the center of the ribcage. Adipose tissue as an endocrine organ constantly affects the dynamics of the breast. However, the role of adipose tissue in breast has been mostly studied in terms of obesity and cancer.  In this review, we have discussed the role of breast adipose tissue in breast development from embryonic stage to mature breast. Further, we draw attention to the involvement of breast adipose tissue in pregnancy, lactation and involution associated breast changes. Finally, we depict how breast adipose tissue can affect breast cancer. 
  • 5.2K
  • 26 Aug 2020
Topic Review
Preconsolidation Pressure
Preconsolidation pressure is the maximum effective vertical overburden stress that a particular soil sample has sustained in the past. This quantity is important in geotechnical engineering, particularly for finding the expected settlement of foundations and embankments. Alternative names for the preconsolidation pressure are preconsolidation stress, pre-compression stress, pre-compaction stress, and preload stress. A soil is called overconsolidated if the current effective stress acting on the soil is less than the historical maximum. The preconsolidation pressure can help determine the largest overburden pressure that can be exerted on a soil without irrecoverable volume change. This type of volume change is important for understanding shrinkage behavior, crack and structure formation and resistance to shearing stresses. Previous stresses and other changes in a soil's history are preserved within the soil's structure. If a soil is loaded beyond this point the soil is unable to sustain the increased load and the structure will break down. This breakdown can cause a number of different things depending on the type of soil and its geologic history. Preconsolidation pressure cannot be measured directly, but can be estimated using a number of different strategies. Samples taken from the field are subjected to a variety of tests, like the constant rate of strain test (CRS) or the incremental loading test (IL). These tests can be costly due to expensive equipment and the long period of time they require. Each sample must be undisturbed and can only undergo one test with satisfactory results. It is important to execute these tests precisely to ensure an accurate resulting plot. There are various methods for determining the preconsolidation pressure from lab data. The data is usually arranged on a semilog plot of the effective stress (frequently represented as σ'vc) versus the void ratio. This graph is commonly called the e log p curve or the consolidation curve.
  • 5.2K
  • 17 Oct 2022
Topic Review
Removal of Purines from Beer
Beer corresponds to a fermented alcoholic beverage composed of several components, including purine compounds. These molecules, when ingested by humans, can be catabolized into uric acid, contributing to uric acid’s level increase in serum, which may lead to hyperuricemia and gout. To assure a proper management of this disease, physicians recommend restrictive dietary measures, particularly by avoiding the consumption of beer. Therefore, it is of relevance to develop efficient methods to remove purine compounds from alcoholic beverages such as beer. There are several enzymatic, biological, and adsorption methods reported envisaging purine compounds’ removal. Some enzymatic and biological methods present drawbacks, which can be overcome by adsorption methods. Within adsorption methods, adsorbent materials, such as activated carbon or charcoal, have been reported and applied to beer or wort samples, showing an excellent capacity for adsorbing and removing purine compounds. By ensuring the selective removal of purine compounds from this beverage, beer can be taken by hyperuricemic and gouty patients, avoiding restrictive dietary measures, while decreasing the related healthcare economic burden. 
  • 5.2K
  • 23 Nov 2021
Topic Review
Global Warming
Global warming is the ongoing rise of the average temperature of the Earth's climate system. It is a major aspect of climate change which, in addition to rising global surface temperatures, also includes its effects, such as changes in precipitation. While there have been prehistoric periods of global warming, observed changes since the mid-20th century have been unprecedented in rate and scale. The Intergovernmental Panel on Climate Change (IPCC) concluded that "human influence on climate has been the dominant cause of observed warming since the mid-20th century". These findings have been recognized by the national science academies of major nations and are not disputed by any scientific body of national or international standing. The largest human influence has been the emission of greenhouse gases, with over 90% of the impact from carbon dioxide and methane. Fossil fuel burning is the principal source of these gases, with agricultural emissions and deforestation also playing significant roles. Climate sensitivity to these gases is affected by feedbacks, such as loss of snow cover, increased water vapour, and melting permafrost. Land surfaces are heating faster than the ocean surface, leading to heat waves, wildfires, and the expansion of deserts. Increasing atmospheric energy and rates of evaporation are causing more intense storms and weather extremes, damaging infrastructure and agriculture. Surface temperature increases are greatest in the Arctic and have contributed to the retreat of glaciers, permafrost, and sea ice. Environmental impacts include the extinction or relocation of many species as their ecosystems change, most immediately in coral reefs, mountains, and the Arctic. Surface temperatures would stabilize and decline a little if emissions were cut off, but other impacts will continue for centuries, including rising sea levels from melting ice sheets, rising ocean temperatures, and ocean acidification from elevated levels of carbon dioxide. Mitigation efforts to address global warming include the development and deployment of low carbon energy technologies, policies to reduce fossil fuel emissions, reforestation, forest preservation, as well as the development of potential climate engineering technologies. Societies and governments are also working to adapt to current and future global warming impacts, including improved coastline protection, better disaster management, and the development of more resistant crops. Countries work together on climate change under the umbrella of the United Nations Framework Convention on Climate Change (UNFCCC), which has near-universal membership. The goal of the convention is to "prevent dangerous anthropogenic interference with the climate system". The IPCC has stressed the need to keep global warming below 1.5 °C (2.7 °F) compared to pre-industrial levels in order to avoid some irreversible impacts. With current policies and pledges, global warming by the end of the century is expected to reach about 2.8 °C (5.0 °F). At the current greenhouse gas (GHG) emission rate, the carbon budget for staying below 1.5 °C (2.7 °F) would be exhausted by 2028.
  • 5.2K
  • 12 Oct 2022
Topic Review
Birth Certificate
A birth certificate is a vital record that documents the birth of a child. The term "birth certificate" can refer to either the original document certifying the circumstances of the birth or to a certified copy of or representation of the ensuing registration of that birth. Depending on the jurisdiction, a record of birth might or might not contain verification of the event by such as a midwife or doctor.
  • 5.2K
  • 08 Nov 2022
Topic Review
House of Tudor
The House of Tudor was an English royal house of Welsh origin, descended in the male line from the Tudors of Penmynydd. Tudor monarchs ruled the Kingdom of England and its realms, including their ancestral Wales and the Lordship of Ireland (later the Kingdom of Ireland) from 1485 until 1603, with five monarchs in that period. The Tudors succeeded the House of Plantagenet as rulers of the Kingdom of England, and were succeeded by the House of Stuart. The first Tudor monarch, Henry VII of England, descended through his mother from a legitimised branch of the English royal House of Lancaster. The Tudor family rose to power in the wake of the Wars of the Roses, which left the House of Lancaster, to which the Tudors were aligned, extinct. Henry Tudor was able to establish himself as a candidate not only for traditional Lancastrian supporters, but also for the discontented supporters of their rival House of York, and he rose to the throne by the right of conquest. His victory at the Battle of Bosworth Field was reinforced by his marriage to Elizabeth of York, daughter of Edward IV, symbolically uniting the former warring factions under a new dynasty. The Tudors extended their power beyond modern England, achieving the full union of England and the Principality of Wales in 1542 (Laws in Wales Acts 1535 and 1542), and successfully asserting English authority over the Kingdom of Ireland. They also maintained the nominal English claim to the Kingdom of France; although none of them made substance of it, Henry VIII fought wars with France trying to reclaim that title. After him, his daughter Mary I lost control of all territory in France permanently with the fall of Calais in 1558. In total, five Tudor monarchs ruled their domains for just over a century. Henry VIII was the only son of Henry VII to live to the age of maturity. Issues around the royal succession (including marriage and the succession rights of women) became major political themes during the Tudor era. The House of Stuart, descended from Henry VII's daughter Margaret, came to power in 1603 when Elizabeth I died and the Tudor line failed. For analysis of politics, diplomacy and social history, see Tudor period.
  • 5.2K
  • 11 Nov 2022
Topic Review
Odor Removal Technologies
Comparing various methods of odor removal, undoubtedly biological methods of pollution degrada-tion have an advantage over others—chemical and physical. This advantage is manifestedmainly in ecological and economic terms. The possibility of using biological methods to remove H2S and NH3, as the most common emitted by the municipal sector companies, was analyzed in terms of their removal efficiency. The method of bio-purification of air in biotrickling filters is more advan-tageous than the others, due to the high effectiveness of VOCs and odors degradation, lack of secondary pollutants, and economic aspects—it is a method competitive to the commonly used air purification method in biofilters.
  • 5.2K
  • 12 Apr 2021
Topic Review
Orthographic Ligature
In writing and typography, a ligature occurs where two or more graphemes or letters are joined as a single glyph. An example is the character æ as used in English, in which the letters a and e are joined. The common ampersand (&) developed from a ligature in which the handwritten Latin letters e and t (spelling et, from the Latin for "and") were combined.
  • 5.2K
  • 01 Nov 2022
Biography
Sabine Hossenfelder
Sabine Hossenfelder (born 18 September 1976) is a German author and theoretical physicist who researches quantum gravity. She is a Research Fellow at the Frankfurt Institute for Advanced Studies where she leads the Superfluid Dark Matter group. She is the author of Lost in Math: How Beauty Leads Physics Astray, which explores the concept of elegance in fundamental physics and cosmology. Hosse
  • 5.2K
  • 15 Nov 2022
Topic Review
Will
Will, generally, is a faculty of the mind - within philosophy, will is important as one of the parts of the mind, along with reason and understanding. It is considered central to the field of ethics because of its role in enabling deliberate action. One of the recurring questions discussed in the Western philosophical tradition is that of free will - and the related, but more general notion of fate - which asks how the will can be truly free if a person's actions have either natural or divine causes which determine them. In turn, this is directly connected to discussions on the nature of freedom and to the problem of evil.
  • 5.2K
  • 11 Oct 2022
Topic Review
Synergism (Theology)
In Christian theology, synergism is the position of those who hold that salvation involves some form of cooperation between divine grace and human freedom. It stands opposed to monergism, a doctrine most commonly associated with the Lutheran and Reformed Protestant traditions, whose soteriologies have been strongly influenced by the North African bishop and Latin Church Father Augustine of Hippo (354–430). Lutheranism, however, confesses a monergist salvation and synergist damnation (see below). Synergism is upheld by the Orthodox and Roman Catholic Churches, and by the Methodist and Pentecostal traditions of Protestantism. It is an integral part of Arminian theology. Synergism and semipelagianism each teach some collaboration in salvation between God and man, but semipelagian thought teaches that the beginning half of faith is an act of human will. The Council of Orange (529), Lutheran Formula of Concord (1577), and other local councils each condemned semipelagianism as heresy.
  • 5.2K
  • 24 Nov 2022
Topic Review
Sustainability and Sharing Economy
The sharing economy is usually related to sustainability, and it is framed as: (a) an economic opportunity, (b) a more sustainable form of consumption and (c) a pathway to an equitable and sustainable economy. 
  • 5.2K
  • 30 Oct 2024
Topic Review
Sutra
Sutra (Sanskrit: सूत्र, romanized: sūtra, lit. 'string, thread') in Indian literary traditions refers to an aphorism or a collection of aphorisms in the form of a manual or, more broadly, a condensed manual or text. Sutras are a genre of ancient and medieval Indian texts found in Hinduism, Buddhism and Jainism. In Hinduism, sutras are a distinct type of literary composition, a compilation of short aphoristic statements. Each sutra is any short rule, like a theorem distilled into few words or syllables, around which teachings of ritual, philosophy, grammar, or any field of knowledge can be woven. The oldest sutras of Hinduism are found in the Brahmana and Aranyaka layers of the Vedas. Every school of Hindu philosophy, Vedic guides for rites of passage, various fields of arts, law, and social ethics developed respective sutras, which help teach and transmit ideas from one generation to the next. In Buddhism, sutras, also known as suttas, are canonical scriptures, many of which are regarded as records of the oral teachings of Gautama Buddha. They are not aphoristic, but are quite detailed, sometimes with repetition. This may reflect a philological root of sukta (well spoken), rather than sutra (thread). In Jainism, sutras also known as suyas are canonical sermons of Mahavira contained in the Jain Agamas as well as some later (post-canonical) normative texts.
  • 5.2K
  • 13 Nov 2022
Topic Review
Pathophysiology-Based Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of disability and death among children and young adults, with an incidence of approximately 1.7 million per year in the USA, resulting in 52,000 deaths. Survivors of the initial impact must still contend with the consequences of trauma, as not all injury occurs at the time of impact. The primary injury results from forces applied to the head and involve direct structural damage to the brain. This triggers a cascade of events leading to neurological damage that evolves secondary injury. Several external brain insults, both intracranial and systemic, may complicate and worsen the secondary injury.
  • 5.2K
  • 07 Mar 2024
Topic Review
Specific Relative Angular Momentum
In celestial mechanics the specific relative angular momentum [math]\displaystyle{ \vec{h} }[/math] plays a pivotal role in the analysis of the two-body problem. One can show that it is a constant vector for a given orbit under ideal conditions. This essentially proves Kepler's second law. It's called specific angular momentum because it's not the actual angular momentum [math]\displaystyle{ \vec{L} }[/math], but the angular momentum per mass. Thus, the word "specific" in this term is short for "mass-specific" or divided-by-mass: Thus the SI unit is: m2·s−1. [math]\displaystyle{ m }[/math] denotes the reduced mass [math]\displaystyle{ \frac{1}{m} = \frac{1}{m_1}+\frac{1}{m_2} }[/math].
  • 5.2K
  • 11 Nov 2022
Topic Review
Statistical Correlations of Criminal Behaviour
The statistical correlations of criminal behavior explore the associations of specific non-criminal factors with specific crimes. The field of criminology studies the dynamics of crime. Most of these studies use correlational data; that is, they attempt to identify various factors are associated with specific categories of criminal behavior. Such correlational studies led to hypotheses about the causes of these crimes. The Handbook of Crime Correlates (2009) is a systematic review of 5200 empirical studies on crime that have been published worldwide. A crime consistency score represents the strength of relationships. The scoring depends on how consistently a statistically significant relationship was identified across multiple studies. The authors claim that the review summarizes most of what is currently known about the variables associated with criminality. Writing in 2019, criminologist Greg Ridgeway argued that criminology was still trying to conclusively determine what causes crime.
  • 5.2K
  • 29 Nov 2022
Topic Review
Polycrystalline Materials
Polycrystalline materials can be defined as the counterpart of single crystals. These latter  arise from solution crystallization by transfer of a solute from the liquid phase to the crystalline phase. Crystallization from melt originates instead crystallites or grains, that is regular crystalline regions  randomly oriented and separated one anoher by borders with geometric shapes, Polycrystalline materials are the result of a multiple nucleation process, whereas monocrystals are ideally obtainable by dipping a seed crystal into a supercooled melt.  Polycrystalline materials often consist of spherulites, i.e. crystalline aggregates growing with a rounded shape up to impingment with adjacent spherulites. The borders amongst spherulites and the size and the final shape of spherulites affect considerably the properties of polycrystalline materials.
  • 5.2K
  • 12 May 2021
Topic Review
Non-Alcoholic Fermented Cereal Beverage
Fermentation continues to be the most common biotechnological tool to be used in cereal-based beverages, as it is relatively simple and economical. Fermented beverages hold a long tradition and have become known for their sensory and health-promoting attributes. Considering the attractive sensory traits and due to increased consumer awareness of the importance of healthy nutrition, the market for functional, natural, and non-alcoholic beverages is steadily increasing all over the world. This paper outlines the current achievements and technological development employed to enhance the qualitative and nutritional status of non-alcoholic fermented cereal beverages (NFCBs). Following an in-depth review of various scientific publications, current production methods arediscussed as having the potential to enhance the functional properties of NFCBs and their safety, as a promising approach to help consumers in their efforts to improve their nutrition and health status. Moreover, key aspects concerning production techniques, fermentation methods, and the nutritional value of NFCBs are highlighted, together with their potential health benefits and current consumption trends. Further research efforts are required in the segment of traditional fermented cereal beverages to identify new potentially probiotic microorganisms and starter cultures, novel ingredients as fermentation substrates, and to finally elucidate the contributions of microorganisms and enzymes in the fermentation process.
  • 5.2K
  • 02 Sep 2020
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