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Topic Review
Mascot
Mascot is a software search engine that uses mass spectrometry data to identify proteins from peptide sequence databases. Mascot is widely used by research facilities around the world. Mascot uses a probabilistic scoring algorithm for protein identification that was adapted from the MOWSE algorithm. Mascot is freely available to use on the website of Matrix Science. A license is required for in-house use where more features can be incorporated.
  • 1.3K
  • 26 Oct 2022
Topic Review
List of Gliders (D)
This is a list of gliders/sailplanes of the world, (this reference lists all gliders with references, where available) Note: Any aircraft can glide for a short time, but gliders are designed to glide for longer.
  • 1.3K
  • 04 Nov 2022
Topic Review
Unmet Needs in Transcatheter Aortic Valve Replacement
Transcatheter aortic valve replacement (TAVR) swiftly evolved from a disrupting technology towards mainstream therapy in the field of severe symptomatic aortic stenosis. A series of randomized evaluations established its role in treating severe aortic stenosis patients across all surgical risk categories, paving the way for an extension of its indications to younger low-risk patients with a longer life expectancy.
  • 1.3K
  • 21 Nov 2022
Topic Review
6-Formylindolo(3,2-b)carbazole
6-Formylindolo[3,2-b]carbazole (FICZ) is a chemical compound with the molecular formula C19H12N2O. It is a nitrogen heterocycle, having an extremely high affinity (Kd = 7 x 10−11M) for binding to the aryl hydrocarbon receptor (AHR). It was originally identified as a photooxidized derivative of the amino acid tryptophan and suggested to be the endogenous ligand of the AHR. Later, also enzymatic formation of FICZ was shown.
  • 1.3K
  • 16 Nov 2022
Topic Review
Zeiss Inner Rail
Zeiss Inner Rail, often simply called Zeiss rail, is a ringless telescopic sight mounting system introduced by Zeiss in 1990 as an alternative to traditional ring mounts. A patent was granted in 1992, and the patent expired in 2008. The mounting system is now also offered on sights sold by other major manufacturers, such as Blaser, Leica, Minox, Meopta, Nikon, Noblex (formerly Docter), Schmidt & Bender and Steiner. It has therefore, in some sense, become the industry standard for scope mounting rails. The system has so far seen most use on the European high end market.
  • 1.3K
  • 30 Nov 2022
Topic Review
Synthesis and Characterization of Proteinoid and Nanocapsules
Proteinoids are random polymers composed of amino acids synthesized by stepwise thermal polymerization. They were discovered and studied in the 1950s by Fox and coworkers, who suggested that they formed spontaneously by high heat at the beginning of life on Earth. Nanocapsules (NCs) form spontaneously by heating proteinoids to about 70 °C in an aqueous solution to completely dissolve the polymers, followed by slow cooling to room temperature.
  • 1.3K
  • 27 Apr 2023
Topic Review
Identification Methods of Entomological Origin of Honey
Honey is a sweet natural product that is produced by managed and wild bees, derived from the nectar of flowers. It is made up of various components such as sugar, protein, vitamins, minerals, aromatic substances, polyphenols, pigments, beeswax, and pollen that contribute to its color, smell, and flavor. However, honey adulteration is a growing concern, including the production of honey by feeding bees with commercial industrial sugar, the addition of foreign sugar, as well as mislabeling. Therefore, traceability of the entomological origin of honey should also be considered in honey quality control protocols. Although several methods exist, such as physicochemical characterization and bioactivity profiling of honey of different entomological origins, the most promising three methods for entomological authentication of honey include protein-based identification, chemical profiling, and a DNA-based method. ll of these methods can be applied for reliable identification of the entomological origin of honey. However, as the honey is a complex matrix, the inconsistency of the results obtained by these methods is a pragmatic challenge, and therefore, the use of each method in all the cases is questionable. Most of these methodologies can be used for authentication of newly harvested honey and it is worth understanding the possibility of using these methods for authentication of relatively old samples. Most probably, using DNA-based methods targeting small fragments of DNA can provide the best result in old samples, however, the species-specific primers targeting short fragments are limited and not available for all species. Therefore, using universal primers in combination with a DNA metabarcoding approach can be a good solution that requires further investigation.
  • 1.3K
  • 07 Jun 2023
Topic Review
Sign Language Recognition
Recognition of hand motion capture is an interesting topic. Hand motion can represent many gestures. In particular, sign language plays an important role in the daily lives of hearing-impaired people. Sign language recognition is essential in hearing-impaired people’s communication. Wearable data gloves and computer vision are partially complementary solutions. However, sign language recognition using a general monocular camera suffers from occlusion and recognition accuracy issues.
  • 1.3K
  • 08 Dec 2023
Topic Review
Nutritional Strategies to Mitigate Post-Weaning Challenges in Pigs
The pig-farming industry faces significant challenges in ensuring the health and growth of piglets, particularly during the weaning phase. This critical period involves multiple stressors, such as environmental changes, dietary shifts, and social separation, which can adversely affect the piglet’s digestive health, immune system, and overall well-being.
  • 1.3K
  • 02 Jan 2024
Topic Review
Pathogenesis of Esophageal Cancer
Esophageal cancer is rapidly increasing across the world. It is the sixth most common cause of death from cancer and is the eighth most common cancer worldwide. Esophageal cancer is a devastating malignancy which can be detected at an early stage but is more often diagnosed as an advanced process. It affects both men and women and inflicts the young and the elderly. There are multiple underlying factors involved in the pathogenesis of this cancer including inflammation.
  • 1.3K
  • 13 Jul 2022
Topic Review
CRISPR/Cas9-Based Genome Editing on Abiotic Stress Tolerance
Plants are subjected to various environmental stresses that negatively impact growth and development and limit crop productivity. Therefore, in order to meet the requirements of the growing world population and food security, it is essential to develop cultivars resistant to abiotic stresses. In recent years, with the availability of genetic databases and the advancement in genome editing techniques, it is feasible to edit target genes with precision and create new opportunities for crop improvement that conventional breeding methods could not achieve. The genome-editing method using CRISPR-Cas systems is very powerful and confers exceptional versatility to develop improved cultivars at abiotic stresses. These efficient gene editing techniques facilitate the cultivation of superior-performing genotypes in challenging environmental conditions without compromising yield.
  • 1.3K
  • 17 Nov 2023
Topic Review
Bi-Ssubstituted Iron Garnet Multilayer Structures
In this encyclopaedia entry, we are reporting on the unconventional magnetic switching properties of sputtered all-garnet multilayer thin film structures. Within the scope of this study, thin magnetic trilayers were fabricated on both garnet and glass substrates, in which magneto-soft material layers are sandwiched in-between two magneto-hard garnet material layers of identical composition type.
  • 1.3K
  • 30 Oct 2020
Topic Review
Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness and fatigue. The cause is a postsynaptic defect of neuromuscular transmission, which brings, in the majority of patients, to develop autoantibodies directed against the postsynaptic nicotinic acetylcholine receptor (AChR).
  • 1.3K
  • 17 Oct 2020
Topic Review
HBA2 Gene
Hemoglobin subunit alpha 2
  • 1.3K
  • 22 Dec 2020
Topic Review
TCHH Gene
Trichohyalin: The TCHH gene provides instructions for making a protein called trichohyalin. This protein is primarily found in hair follicles, which are specialized structures in the skin where hair growth occurs.
  • 1.3K
  • 24 Dec 2020
Topic Review
Complete Androgen Insensitivity Syndrome
Complete androgen insensitivity syndrome (CAIS) is due to complete resistance to the action of androgens, determining a female phenotype in persons with a 46,XY karyotype and functioning testes.
  • 1.3K
  • 18 Sep 2021
Topic Review
Obesity-related Insulin Resistance
Obesity-related IR implicates the PI3-K pathway that confers the metabolic effects of insulin. Numerous and complex pathogenic pathways link obesity with the development of IR, including chronic inflammation, mitochondrial dysfunction (with the associated production of reactive oxygen species and endoplasmic reticulum stress), gut microbiota dysbiosis and adipose extracellular matrix remodelling.
  • 1.3K
  • 23 Feb 2021
Topic Review
MGBA-Associated Neurological Disorders
Microbiota–gut–brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central nervous system. While the MGBA plays a pivotal role in normal development and physiology of the nervous and gastrointestinal system of the host, its dysfunction has been strongly implicated in neurological disorders, where intestinal dysbiosis and derived metabolites cause barrier permeability defects and elicit local inflammation of the gastrointestinal tract, concomitant with increased pro-inflammatory cytokines, mobilization and infiltration of immune cells into the brain, and the dysregulated activation of the vagus nerve, culminating in neuroinflammation and neuronal dysfunction of the brain and behavioral abnormalities.
  • 1.3K
  • 27 Apr 2021
Topic Review
Connected Vehicles
Connected and autonomous vehicles and cooperative intelligent transportation systems (C-ITSs) are new technologies that will impact traffic control and management.
  • 1.3K
  • 07 Jul 2021
Topic Review
Fatigue Shear-band in Metallic Glass
Metallic glass (MG) is a class of metallic material fabricated by the fast-cooling during solidification. This alloy lacks the long-range order characteristic and the crystalline defects including grain boundaries and dislocations. The unique structural feature makes some mechanical properties of MG obviously superior than conventional crystalline alloys, such as strength, hardness, elastic limit, wear resistance, etc. It is estimated that ~90% of all mechanical failures in the structural materials are caused by fatigue. Thus, the fatigue property is an important evaluation index before a new structural material application. Without the dislocations and grain boundaries, the plastic deformation of MG occurs in the form of atomic clusters operation at room temperature, eventually leading to the generation of shear band. It is found that the fatigue damage and fracture of MGs were dominated by shear band. As a result, understanding how shear band evolution under cyclic loading is important for improving the fatigue performance of MGs.
  • 1.3K
  • 16 Jul 2021
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