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Topic Review
2001 Massacre of Plaza de Mayo
The 2001 Massacre of Plaza de Mayo was a slaughter of people at Plaza de Mayo (May Square), Buenos Aires, Argentina, and around this area that took place on December 20, 2001. Five people were murdered. The names of the fatal victims were: Carlos Almiron, Gustavo Ariel Benedetto, Diego Lamagna, Alberto Marquez and Gaston Marcelo Riva. The perpetrators tried to kill four more people (Marcelo Dorado, Martin Galli, Sergio Ruben Sanchez, and Paula Simonetti), but they did not succeed. A total of 277 injuries was reported.These crimes were committed under Fernando de la Rua’s presidential term in which Argentina was suffering one of its deepest crises and people were rioting in different cities around the nation. These incidents left a total of 39 people that were murdered across the country, among them 7 children.The trial against the 17 defendants started on February 24, 2014.
  • 1.3K
  • 17 Oct 2022
Topic Review
High-functioning Autism
High-functioning autism (HFA) is an autism classification where a person exhibits no intellectual disability, but may exhibit deficits in communication, emotion recognition and expression, and social interaction. HFA is not included in either the American Psychological Association's DSM-5 or the World Health Organization's ICD-10, neither of which subdivides autism based on intellectual capabilities.
  • 1.3K
  • 20 Oct 2022
Topic Review
Workers' Right to Access Restroom
Workers' right to access restroom refers to the rights of employees to take a break when they need to use the toilet. The right to access a toilet is a basic human need. Unless both the employee and employer agree to compensate the employee on rest breaks an employer cannot take away the worker's right to access a toilet room while working. There is limited information on the rights workers have to access public toilets among the world's legal systems. The law is not clear in New Zealand, United Kingdom , or the United States of America as to the amount of time a worker is entitled to use a toilet while working. Nor is there clarification on what constitutes a 'reasonable' amount of access to a toilet. Consequently, the lack of access to toilet facilities has become a health issue for many workers. Issues around workplace allowance to use a toilet has given light on issues such as workers having to ask permission to use a toilet and some workers having their pay deducted for the mere human right of using a toilet when they need to.
  • 1.3K
  • 04 Nov 2022
Topic Review
Macrolide Resistance in Bordetella pertussis
Pertussis is a highly contagious respiratory infection caused by Bordetella pertussis bacterium. The mainstay of treatment is macrolide antibiotics that reduce transmissibility, shorten the duration of symptoms and decrease mortality in infants. 
  • 1.3K
  • 30 Nov 2022
Topic Review
Seed Systems
Seeds are a basic input for all crop production. Good seed is crucial for the global food and nutrition security, for rural development and farmers’ livelihoods and for all green value chains. What “good seed” is depends on individual farmer’s needs. The sustainable availability of seed and seed choice is thus an essential issue for every farmer. Farmers access seeds from multiple sources. Different seed systems have their strengths and vulnerabilities, affecting their resilience.
  • 1.3K
  • 13 Dec 2022
Topic Review
The Clinical Significance of Cyclic Glycine-Proline
Cyclic Glycine-Proline and insulin-like growth factor binding protein (IGFBP)-3 collectively regulate the bioavailability of IGF-1. The molar ratio of cGP/IGF-1 represents the amount of bioavailable and functional IGF-1 in circulation. The cGP/IGF-1 molar ratio is low in patients with age-related conditions, including hypertension, stroke, and neurological disorders with cognitive impairment. Stroke patients with a higher cGP/IGF-1 molar ratio have more favorable clinical outcomes. The elderly with more cGP have better memory retention. An increase in the cGP/IGF-1 molar ratio with age is associated with normal cognition, whereas a decrease in this ratio with age is associated with dementia in Parkinson disease. In addition, cGP administration reduces systolic blood pressure, improves memory, and aids in stroke recovery. These clinical and experimental observations demonstrate the role of cGP in regulating IGF-1 function and its potential clinical applications in age-related brain diseases as a plasma biomarker for—and an intervention to improve—IGF-1 function.
  • 1.3K
  • 07 Feb 2023
Topic Review
eWOM influence on Customer Value and Brand Love
Studying brand love is vital for hospitality establishments because it helps them understand their customers’ feelings and perceptions toward their brands, especially with the growing number of hospitality brands. However, previous hospitality research has neglected the relationship between customer value and brand love. Therefore, the influence of customer value on brand love of fast-food restaurants with a moderating role of electronic word of mouth is discussed.
  • 1.3K
  • 26 May 2023
Topic Review
Digital Transformation Maturity of Electronic Sports Businesses
Digital transformation has become the top priority for 80% of sports companies worldwide, but statistics show that between 70 and 95% of all digital transformation projects fail due to the significant and varied challenges that sports businesses face during the digital transformation process. This is because strategy, not digital technology, drives digital transformation, and without a mature digital transformation model, success is unlikely. Moreover, the digital transformation model of developing and developed countries is not the same, and it cannot be adopted as a blueprint. 
  • 1.3K
  • 25 Aug 2023
Topic Review
Types of Dysrhythmias
Dysrhythmia is a term referring to the occurrence of spontaneous and repetitive changes in potentials with parameters deviating from those considered normal. The term refers to heart anomalies but has a broader meaning. Dysrhythmias may concern the heart, neurological system, digestive system, and sensory organs. Ion currents conducted through ion channels are a universal phenomenon. The occurrence of channel abnormalities will therefore result in disorders with clinical manifestations depending on the affected tissue, but phenomena from other tissues and organs may also manifest themselves. 
  • 1.3K
  • 04 Jan 2024
Topic Review
Nut Allergenicity
Nut allergenic proteins are characterized by their resistance to denaturation and proteolysis.  Food processing is proposed as a tool to modify the allergenicity of nuts, to ensure their safety and to improve their organoleptic properties. The effect of processing (conventional and novel methods) on nut allergenicity is variable by abolishing existing epitopes or generating neoallergens.
  • 1.3K
  • 06 Sep 2021
Topic Review
Remediating Endocrine-Disrupting Compounds
Over the years, the persistent occurrence of superfluous endocrine-disrupting compounds (EDCs) (sub µg L−1) in water has led to serious health disorders in human and aquatic lives, as well as undermined the water quality. At present, there are no generally accepted regulatory discharge limits for the EDCs to avert their possible negative impacts. Moreover, the conventional treatment processes have reportedly failed to remove the persistent EDC pollutants, and this has led researchers to develop alternative treatment methods. Comprehensive information on the recent advances in the existing novel treatment processes and their peculiar limitations is still lacking. In this regard, the various treatment methods for the removal of EDCs are critically studied and reported in this entry.
  • 1.3K
  • 23 Nov 2021
Topic Review
Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders
Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). These are more uncommon than IgE-mediated food allergies, their mechanisms remain largely unknown, and their diagnosis is mainly done by clinical history, due to the lack of specific biomarkers. 
  • 1.3K
  • 27 Dec 2021
Topic Review
Genetic RyR2 Disease
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are required to form the quaternary structure that comprises the functional channel. Numerous mutations in the gene encoding RyR2 protein have been identified and many are linked to a wide spectrum of arrhythmic heart disease. Gain of function mutations result in a hyperactive channel that causes excessive spontaneous SR Ca2+ release, but rare hypoactive loss of function mutations have also been described.
  • 1.3K
  • 17 Aug 2022
Topic Review
General Aspects of Carbon Dot and Polymer Composites
Carbon dot-based composite materials have been extensively developed for versatile biomedical applications, such as drug delivery, tissue engineering, bioimaging, biosensors, and photothermal cancer therapy, owing to their excellent mechanical properties, electrical and thermal conductivity, large surface-to-volume ratio, and biocompatibility. For instance, the hydrophobicity and delocalized π-electrons of carbon dots enable insoluble drug loading in carbon composite-based drug delivery carriers. In addition, carbon dot-based materials are suitable for optical and electrochemical biosensor applications owing to their intrinsic properties.
  • 1.3K
  • 01 Nov 2022
Topic Review
Swallow Detection with Acoustics and Accelerometric-Based Wearable Technology
Swallowing disorders, especially dysphagia, might lead to malnutrition and dehydration and could potentially lead to fatal aspiration. Benchmark swallowing assessments, such as videofluoroscopy or endoscopy, are expensive and invasive. Wearable technologies using acoustics and accelerometric sensors could offer opportunities for accessible and home-based long-term assessment. Identifying valid swallow events is the first step before enabling the technology for clinical applications. 
  • 1.3K
  • 09 Jan 2023
Topic Review
Assessment of Smart Mechatronics Applications in Agriculture
The agriculture sector industry is encountering growing global demand for food but also demand for transparency in food supply chains from food consumers. Because of this, modern, complex methods are necessary, and the significantly increased use of modern mechatronics systems can be recommended. Precision agriculture, a development in mechatronics, is already playing a significant role in agricultural industries, where it has minimized labor requirements and decreased crop production costs by maximizing output. The main benefit of mechatronics system integration in agriculture, however, is a doubling in efficiency compared with manually controlled machines, and this has enabled a revolution in how agricultural crops are established, managed, and harvested 
  • 1.3K
  • 26 Jul 2023
Topic Review
Alternative Proteins for Fish Diets
Aquaculture has been challenged to find alternative ingredients to develop innovative feed formulations that foster a sustainable future growth. Given the most recent trends in fish feed formulation on the use of alternative protein sources to decrease the dependency of fishmeal, it is fundamental to evaluate the implications of this new paradigm for fish health and welfare. 
  • 1.3K
  • 13 May 2022
Topic Review
NetApp Filer
In computer storage, a so called NetApp "filer" was referring to the storage systems product by NetApp, before block protocols were supported. It can serve storage over a network using file-based protocols such as NFS, SMB, FTP, TFTP, and HTTP. But the so-called "Filers" can also serve data over block-based protocol, such as the SCSI command protocol over the Fibre Channel Protocol on a Fibre Channel network, Fibre Channel over Ethernet (FCoE), FC-NVMe or iSCSI transport layer. The product is also known as NetApp Fabric-Attached Storage (FAS) and NetApp All Flash FAS (AFF) NetApp Filers implement their physical storage in large disk arrays. While most large-storage filers are implemented with commodity computers with an operating system such as Microsoft Windows Server, VxWorks or tuned Linux, NetApp filers use highly customized hardware and the proprietary Data ONTAP operating system with WAFL file system, all originally designed by NetApp founders David Hitz and James Lau specifically for storage-serving purposes. Data ONTAP is NetApp's internal operating system, specially optimised for storage functions at high and low level. It boots from FreeBSD as a stand-alone kernel-space module and uses some functions of FreeBSD (command interpreter and drivers stack, for example). All filers have battery-backed non-volatile random access memory or NVDIMM, referred to as NVRAM or NVDIMM, which allows them to commit writes to stable storage more quickly than traditional systems with only volatile memory. Early filers connected to external disk enclosures via parallel SCSI, while modern models ((As of 2009 )) use fibre channel and SAS (Serial Attach SCSI) SCSI transport protocols. The disk enclosures (shelves) use fibre channel hard disk drives, as well as parallel ATA, serial ATA and Serial attached SCSI. Starting with AFF A800 NVRAM PCI card no longer used for NVLOGs, it was replaced with NVDIMM memory directly connected to memory bus. Implementers often organize two filers in a high-availability cluster with a private high-speed link, either Fibre Channel, InfiniBand, 10 Gigabit Ethernet, 40 Gigabit Ethernet or 100 Gigabit Ethernet. One can additionally group such clusters together under a single namespace when running in the "cluster mode" of the Data ONTAP 8 operating system.
  • 1.3K
  • 28 Sep 2022
Topic Review
Bioactive Pentacyclic Triterpenes from Native Mexican Plants
Native Mexican plants are a wide source of bioactive compounds such as pentacyclic triterpenes. Pentacyclic triterpenes biosynthesized through the mevalonate (MVA) and the 2-C-methyl-D-erythritol-phosphate (MEP) metabolic pathways are highlighted by their diverse biological activity. Compounds belonging to the oleanane, ursane, and lupane groups have been identified in about 33 Mexican plants, located mainly in the southwest of Mexico. 45 compounds pentacyclic triterpenes were reported showing antiinflammatory, cytotoxic, anxiolytic, hypoglycemic, and growth-stimulating or allelopathic activities. Extraction is essentially performed by maceration and Soxhlet with organic solvents and consecutive chromatography of silica gel have been used for their whole or partial purification. Nanoparticles and nanoemulsions are the vehicles used in Mexican formulations for drug delivery of the pentacyclic triterpenes until now. Sustainable extraction, formulation, regulation, isolation, characterization, and bioassay facilities are areas of opportunity in pentacyclic triterpenes research in Mexico while the presence of plant and human resources and traditional knowledge are strengths.
  • 1.3K
  • 09 Feb 2023
Topic Review
Fully Autonomous Vehicle
Fully autonomous vehicles (AV) would potentially be one of the most disruptive technologies of our time. The extent of the prospective benefits of AVs is strongly linked to how widely they will be accepted and adopted. Monitoring and tracking of individuals' reactions and intentions to use AVs are critical.
  • 1.3K
  • 10 Dec 2020
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