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Topic Review
Protein Kinase D
Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the signaling network of the second messenger diacylglycerol. PKD belongs to the Calcium/calmodulin-dependent protein kinases superfamily and consists of three isoforms in mammals, notably, PKD1, PKD2 and PKD3. Activated PKD resides in diverse subcellular locations such as cytosol, Golgi apparatus, nucleus, mitochondria to regulate a number of cellular functions.
  • 1.3K
  • 15 Apr 2021
Topic Review
Fall Prevention for Pediatric Inpatients
Falls account for a high proportion of the safety accidents experienced by hospitalized children. This entry aims to analyze the contents and effects of fall prevention programs for pediatric inpatients to develop more adaptable fall prevention programs.
  • 1.3K
  • 09 Jun 2021
Topic Review
Biological Mechanisms of Fresh Hass Avocado
Researchers identified four primary avocado health effects: (1) reducing cardiovascular disease risk in healthy overweight or obese adults with dyslipidemia by lowering non-HDL-C profiles, triglycerides, LDL oxidation, small atherogenic LDL particles and promoting postprandial vascular endothelial health for better peripheral blood flow; (2) lowering the risk of being overweight or obese, supporting weight loss, and reducing visceral fat tissue in overweight or obese women; (3) improving cognitive function in older normal-weight adults and in young to middle age overweight or obese adults especially in frontal cortex executive function; and (4) stimulating improved colonic microbiota health in overweight or obese adults by promoting healthier microflora and fecal metabolites.
  • 1.3K
  • 21 Dec 2021
Topic Review
Accuracy of 3-Dimensionally Printed Full-Arch Dental Models
Accuracy of 3D printed models varied widely between <100 to >500 μm with the majority of models deemed of clinically acceptable accuracy. The smallest (3.3 μm) and largest (579 μm) mean errors were produced by SLA printers. For digital light processing (DLP), majority of investigated printers (n = 6/8) produced models with <100 μm accuracy. Manufacturing parameters, including layer thickness, base design, postprocessing and storage, significantly influenced the model’s accuracy. 
  • 1.3K
  • 21 Dec 2021
Topic Review
Raman Spectroscopy in Biosensing
The effect of Raman scattering is a result of inelastic light scattering processes, which lead to the emission of scattered light with a different frequency associated with molecular vibrations of the identified molecule. Spontaneous Raman scattering is usually weak, resulting in complexities with the separation of weak inelastically scattered light and intense Rayleigh scattering. These limitations have led to the development of various techniques for enhancing Raman scattering, including resonance Raman spectroscopy (RRS) and nonlinear Raman spectroscopy (coherent anti-Stokes Raman spectroscopy and stimulated Raman spectroscopy). Furthermore, the discovery of the phenomenon of enhanced Raman scattering near metallic nanostructures gave impetus to the development of the surface-enhanced Raman spectroscopy (SERS) as well as its combination with resonance Raman spectroscopy and nonlinear Raman spectroscopic techniques. The combination of nonlinear and resonant optical effects with metal substrates or nanoparticles can be used to increase speed, spatial resolution, and signal amplification in Raman spectroscopy, making these techniques promising for the analysis and characterization of biological samples.
  • 1.3K
  • 07 Jan 2022
Topic Review
Richter Transformation in Chronic Lymphocytic Leukemia
Richter transformation (RT) is defined as the occurrence of an aggressive lymphoma in patients with a previous or concomitant diagnosis of chronic lymphocytic leukemia (CLL). It is characterized by a switch in the histopathology and biology of the original CLL.
  • 1.3K
  • 24 Mar 2022
Topic Review
Preferentially Expressed Antigen in Melanoma and Malignant Melanoma
Preferentially expressed antigen in melanoma (PRAME) is a cancer testis antigen (CTA) identified in 1997 through analysis of the specificity of tumor-reactive T-cell clones derived from a patient with metastatic cutaneous melanoma. Although at first it seemed even more specific, various studies have shown that PRAME can also be expressed in the context of atypical lesions that do not correspond solely to the definition of malignant melanoma. Various studies have shown that PRAME can also be expressed in the context of atypical lesions apart from MM and, for this reason, the diagnostic sensitivity and specificity (hence accuracy) are clearly lower. 
  • 1.3K
  • 28 Apr 2022
Topic Review
Energy-Efficient Building in European States
National legal and political regulation in the field of energy efficiency is closely connected to minimizing energy consumption in buildings. Within the framework of implementing Directive 2018/844/EU on the energy performance of buildings in Europe, the practice of its application differs from country to country. To achieve the sustainable development scenario, all countries of the world must switch to mandatory building energy efficiency laws by the year 2030. Improvements in the energy efficiency of buildings and sustainable development of renewable energy are a must in terms of overcoming the ever-growing energy consumption and the consequences of climate change.
  • 1.3K
  • 30 May 2022
Topic Review
m1A RNA Modification in Gene Expression Regulation
N1-methyladenosine (m1A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m1A RNA modification in gene regulation and biological processes.
  • 1.3K
  • 01 Jun 2022
Topic Review
One Health Tomato Probiotics
Based on the literature and knowledge on the “One Health” concept, a new term for probiotics: “One Health probiotics”, beneficial for the unity of people, animals, and the environment, is suggested. Strains of Lactiplantibacillus plantarum, having an ability to ferment a broad spectrum of plant carbohydrates, probiotic effects in human, and animal health, as well as being found in dairy products, vegetables, sauerkraut, pickles, some cheeses, fermented sausages, fish products, and rhizospheric soil, might be suggested as one of the probable candidates for “One Health” probiotics (beneficial for the unity of people, animals, and the environment) for the utilization in agriculture, food processing, and healthcare.
  • 1.3K
  • 09 Jun 2022
Topic Review
Antiviral Fullerene
Fullerenes were discovered in 1985. They are spherical or ellipsoidal in shape, with hollow cage structures. Fullerene C60, the representative fullerene, is ~0.7 nm in diameter. Three discoverers of fullerene C60 won the Nobel Prize in chemistry in 1996. With the continuous development of fullerene preparation technology, fullerenes have presented unprecedented opportunities in the field of biomedicine. For some common virus, such as human immunodeficiency virus (HIV), herpes simplex virus (HSV), cytomegalovirus (CMV), influenza, Ebola and so on, fullerene and their derivatives exhibit high levels of antiviral activity, inhibiting virus replication in vitro and in vivo. Unlike traditional small molecules, fullerene is a type of promising antiviral nanodrug. 
  • 1.3K
  • 08 Aug 2022
Topic Review
Fear Appeal
Fear appeal is a term used in psychology, sociology and marketing. It generally describes a strategy for motivating people to take a particular action, endorse a particular policy, or buy a particular product, by arousing fear. A well-known example in television advertising was a commercial employing the musical jingle: "Never pick up a stranger, pick up Prestone anti-freeze." This was accompanied by images of shadowy strangers (hitchhikers) who would presumably do one harm if picked up. The commercial's main appeal was not to the positive features of Prestone anti-freeze, but to the fear of what a "strange" brand might do. A fear appeal is a persuasive message that attempts to arouse fear in order to divert behavior through the threat of impending danger or harm. It presents a risk, presents the vulnerability to the risk, and then may, or may not suggest a form of protective action. It is assumed that through a fear appeal the perception of threatening stimuli creates fear arousal. The state of fear is believed to be an unpleasant emotional state that involves physiological arousal that motivates cognitive, affective, and behavioral responses directed towards alleviating the threat or reducing fear. There are many different theoretical models of fear appeal messages. They include: the extended parallel process model, the drive theory, the subjective expected utility theory, the protection motivation theory, the health belief model, the theory of reasoned action, and the transtheoretical model. These models are widely used in substance abuse campaigns, sexual health programs, and many other general health contexts. The persuasive effect of fear appeals is thought to be influenced by several factors such as individual characteristics, self-efficacy, perception of norms, fear strength, perceived threat, perception of treatment efficacy, and defense mechanisms. Mixed results have been produced from studies that attempt to demonstrate the effectiveness of fear appeals for behavior modification, and a recent meta-analysis recommended extreme caution in the use of fear appeals.
  • 1.3K
  • 30 Sep 2022
Topic Review
Pelecanimimus
Pelecanimimus (meaning "pelican mimic") is an extinct genus of basal ("primitive") ornithomimosaurian dinosaur from the Early Cretaceous of Spain . It is notable for possessing more teeth than any other member of the Ornithomimosauria (or any other theropod), most of which were toothless.
  • 1.3K
  • 22 Nov 2022
Topic Review
The Anaphase-Promoting Complex/Cyclosome
The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the components of this protein complex are gradually identified and characterized.
  • 1.3K
  • 23 Dec 2022
Topic Review
Knowledge Management and Tourism Business Enterprise Competitiveness
There has been a growing interest in understanding the correlation concerning knowledge management and competitiveness more so in the area of tourism. A synthesis on theoretical nexus of knowledge management and tourism business enterprise competitiveness is provided by giving an integrated overview of four micro economic related theories that influence competitiveness and knowledge management. 
  • 1.3K
  • 03 Feb 2023
Topic Review
Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia
Alopecia or baldness is a common diagnosis in clinical practice. Alopecia can be scarring or non-scarring, diffuse or patchy. The most prevalent type of alopecia is non-scarring alopecia, with the majority of cases being androgenetic alopecia (AGA) or alopecia areata (AA). AGA is traditionally treated with minoxidil and finasteride, while AA is treated with immune modulators; however, both treatments have significant downsides.
  • 1.3K
  • 08 Aug 2023
Topic Review
Pharmacological and Non-Pharmacological Treatments for Depression in PD
Depression represents one of the most common non-motor disorders in Parkinson’s disease (PD) and it has been related to worse life quality, higher levels of disability, and cognitive impairment, thereby majorly affecting not only the patients but also their caregivers. Available pharmacological therapeutic options for depression in PD mainly include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, and tricyclic antidepressants; meanwhile, agents acting on dopaminergic pathways used for motor symptoms, such as levodopa, dopaminergic agonists, and monoamine oxidase B (MAO-B) inhibitors, may also provide beneficial antidepressant effects. There is a growing interest in non-pharmacological interventions, including cognitive behavioral therapy; physical exercise, including dance and mind–body exercises, such as yoga, tai chi, and qigong; acupuncture; therapeutic massage; music therapy; active therapy; repetitive transcranial magnetic stimulation (rTMS); and electroconvulsive therapy (ECT) for refractory cases.
  • 1.3K
  • 01 Sep 2023
Topic Review
Lithium as an Investment
In 2020, Lithium has been included in the list for Critical global elements critical metal, and will be one of the drivers of the fourth industrial revolution. Lithium company stocks on the worldwide exchanges have rallied from the end of 2020 and through 2021 with many Lithium Explorers/Developers/Producer miners' share prices' rising 1000% to 6000% within 12 months on the ASX: the Australian Securities Stock Exchange. Stocks are expected to continue to rally as a shortfall deficit of Lithium supply world-wide is expected from beginning of 2022. The Battery-grade Lithium deficit is expected to persist to an incredible 2030, as there are not enough mines coming online to supply the demand in EV Batteries & Energy Storage systems to 2030. This makes Lithium a highly lucrative commodity to invest into, the term entered a "Lithium commodities Super-cycle" has been used by industry commentators during 2021 to describe the event, also the term "A Once in a Century" event is occurring in 2021 and will persist till new Energy technologies come online to replace Lithium Batteries, this is not expected till after 2040 as there are no technologies that will be suitable for the diversity of applications for Lithium Energy storage systems. Lithium carbonate prices have made a resurgence from 2019-2020 all time lows, rising some 500% as of 21/11/2021 trading at US$29,000/tonne, Lithium Carbonate/Lithium Hydroxide is a Lithium chemical compound also known as LCE(Lithium Carbonate Equivalent) and is used as a Precursor in the manufacture of Cathode Cells for electric vehicle (EV) batteries. As a result and along with major Governmental new energy policies in 2020, in preparation to the fazing out of fossil fuels & reductions in carbon emissions vehicles & coal power, has kick-started a flurry of renewed investments & Joint Ventures/acquisitions between Miners & Strategic major investor companies throughout the world. Recently the world saw the COP26: Climate Change Summit for Action in Glasgow during November 2021. The agreements signed by all countries involved, has accelerated the action towards renewables adoption & the reforestation among other items & actions. Lithium will play a key & critical role towards the reduction of Carbon emissions, "1.5ToStayAlive" "1.5toSurvive" slogans for maintaining the critical 1.5 degrees & the storage of renewables clean green energy, harnessed from the sustainable wind, solar & hydropower, also tidal. Also big on the COP26 agenda was the fazing out of coal all-together. Lithium is an essential mineral that goes into the manufacture of electric batteries (Lithium-ion battery: portable electronics, EV and renewable ESS). Lithium supply is expected to fall short of the demand for this metal by 2022. Demand/supply discrepancy "the Great divide" ratio has been witnessed in July 2021 when the BMX Spot price Platform went live and the price for Lithium Spodumene Concentrate 6% (SC6) reached a record price of US$1,400/tonne, rising from its lowest of US$395/tonne in September 2020. Today SC6 price(21 November 2021) trades at US$2,550/tonne, Australia's Pilbara Minerals, the company that developed the BMX Spot Sales Platform are commended for this initiative with Ken Brinson, CEO, saying the price for Spodumene Concentrate 6% is now transparent to the market making it a fairer playing field for the Miners and the Chemical Converter Customers. Governments are adopting the New Energy Lithium Technology rapidly as the pressure to meet the Paris Agreement CO2 Carbon emissions reductions. Major Car Manufacturers are planning on a large line-up of new Electric Vehicles by 2025, in what's called the "EV Revolution". The growing adoption of electric vehicles (EVs) is driving the increasing demand for lithium, significant amounts of lithium supply will need to be brought online to meet this demand growth to 2030 and beyond. The situation is seen as critical as the world depends on Lithium. A new technology in the extraction of Lithium from Geothermal brine, the extraction method is called DLE-Direct Lithium Extraction and if/when the technology succeeds in "scale" it will be celebrated as it will help alleviate the pressure on the tight Lithium supply, the technology is not expected for another 4-5 yrs(2025/26) if not longer. See Start-ups Vulcan Energies(ASX:VUL) & Lilac Solutions(USA) for their efforts in DLE. Pond evaporation extraction Technology is considered old & expected to be obsolete as it conflicts with a world turning towards ESG(Environmental Social & Governance) compliance in mining/extractive practices. Products that reduce carbon emissions, including electric batteries, are globally expected to create a $23 Trillion market over the next decade to 2030. Lithium is considered a superior lightweight metal element for its electrochemical properties as a charge carrier in the electric battery, currently there is no known replacement element to achieve such effective performance for automotive battery applications. According to Volkswagen, in the near future lithium will be one of the most sought-after raw metals on earth. Forecasted EV battery demand growth is driving the need to significantly increase battery production globally. Major battery manufacturers have already committed $175Billion by the start of 2021. Even though a significant amount of capital has already been committed, further investment is expected, to satisfy the forecasted growing supply chain demand of batteries to 2030. There has been a trend already with lithium chemicals compounds producing companies, battery manufacturer companies and even major car manufacturers investing or partnering with raw material suppliers/miners. Large investments are flowing into the lithium supply chain from established majors. Companies with partnerships or joint ventures will be more resilient in the long run. Major car manufacturers' plans to spend over $300 billion are being invested and forecasted over the next 4 (2025) to 10 years (2030) during the adoption of electric vehicles (EV). Automakers’ plans to spend at least $300 billion on EVs are driven largely by environmental concerns and government policy for GHG reduction and supported by rapid technological advances that have improved battery cost, range and charging time. Since 2018, we have seen an accelerated rate of industry spending especially through 2020. Most importantly, with the global push for sustainable and low carbon footprint mining, processing and manufacturing, where will the lithium that is ESG sustainably sourced with a GHG low-carbon footprint come from. Necessary to feed the burgeoning energy storage needs for the growing transport and military sector; electronic consumer requirements; and in particular the domestic & commercial automotive supply chain where investment spending and forecasts are $US400 to $US500 billion . Both the drive to decarbonize and the 4IR depend on critical minerals like lithium. The Fourth Industrial Revolution (4IR or Industry 4.0) has been defined as technological developments in cyber-physical systems such as high capacity connectivity; new human-machine interaction modes such as touch interfaces and virtual reality systems; and improvements in transferring digital instructions to the physical world including robotics and 3D printing (additive manufacturing); the Internet of Things (IoT); “big data” and cloud computing; artificial intelligence-based systems; improvements to and the uptake of Off-Grid / Stand-Alone Renewable Energy Systems: solar, wind, wave, hydroelectric and the Lithium-ion electric batteries (for renewable ESS and EV). Speculation in lithium compounds used as feedstocks for major applications. The main intermediates are lithium hydroxide and lithium carbonate, and these are the commodities that the LME has chosen as the most appropriate to establish reference pricing. Speculators hope to make a viable play on a perceived growth in demand for lithium metal due to the widespread adoption of lithium batteries in emerging technologies. Lithium batteries have become a preferred power source for energy-hungry devices such as cell phones because they are more efficient and scalable than previous-generation nickel-metal hydride batteries thus they are in high demand in support of automobile and electronics manufacturing. Factors that could result in limitations affecting overall lithium supply are seen by some as prescient; with predicted supply chain volatility potentially overpowering other market factors and becoming the primary price driver, essentially resulting in a seller's market and thereby making the metal a profitable investment.
  • 1.3K
  • 04 Nov 2022
Topic Review
Polymicrobial-Sepsis
Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH2-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the inflammatory cascade in a murine model of CLP-induced sepsis. CB57BL/6J mice were subjected to CLP or sham operation. Animals were randomized to receive either SP600125 (15 mg/kg) or its vehicle intraperitoneally 1 hour after surgery and repeat treatment every 24 hours. To evaluate survival, a group of animals was monitored every 24 hours for 120 hours. Two other animals were sacrificed 4 or 18 hours after surgical procedures; lung and liver samples were collected for biomolecular and histopathologic analysis. The expression of p-JNK, p-ERK, TNF-α, HMGB-1, NF-κB, Ras, Rho, Caspase 3, Bcl-2, and Bax was evaluated in lung and liver samples; SP600125 improved survival, reduced CLP induced activation of JNK, NF-κB, TNF-α, and HMGB-1, inhibited proapoptotic pathway, preserved Bcl-2 expression, and reduced histologic damage in both lung and liver of septic mice. SP600125 protects against CLP induced sepsis by blocking JNK signalling; therefore, it can be considered a therapeutic approach in human sepsis.
  • 1.3K
  • 01 Nov 2020
Topic Review
WO3 and Ionic Liquids -2
The possibility of using an IL to enhance WO3 dispersion on an inorganic support, ensuring the formation of composites with a very large number of exposed catalytic sites, is reported. In addition, in some cases the IL was demonstrated to be able to direct the morphology of WO3 particles.
  • 1.3K
  • 29 Oct 2020
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