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Topic Review
Pluripotency Factor Lin28
Lin28 is an RNA-binding protein that can function as a pluripotency factor and is enriched in stem and progenitor cells and embryonic tissues.  Lin28 can regulate protein synthesis by binding mRNAs to regulate their translation, and by governing microRNA production through binding let-7 family precursor microRNAs to block their processing to mature functional microRNAs.   Lin28 was first discovered in C.elegans and is highly evolutionarily-conserved across the animal kingdom.  In most vertebrates, including mammals, there are two Lin28 paralogs, termed Lin28A and Lin28B.   An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade.  In many biological settings, accumulated evidence has revealed that Lin28 can be upregulated from low basal levels in adult tissues following injury or in plastic responses. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research.
  • 1.3K
  • 05 Jan 2021
Topic Review
Diabetic Polyneuropathy
Diabetic polyneuropathy (DPN) is the most common neuropathy manifested in diabetes. Symptoms include allodynia, pain, paralysis, and ulcer formation. No radical treatment has not been established.
  • 1.3K
  • 04 Jan 2021
Topic Review
Peripheral Arterial Disease (PAD)
Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities, which leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest pain, and gangrene requiring limb amputation.
  • 1.3K
  • 19 Jan 2021
Topic Review
VWF, Platelets and Antiphospholipid Syndrome
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPLs). Laboratory criteria for the classification of APS include the detection of lupus anticoagulant (LAC), anti-cardiolipin (aCL) antibodies and anti-β2glycoprotein I (aβ2GPI) antibodies. Clinical criteria for the classification of thrombotic APS include venous and arterial thrombosis, along with microvascular thrombosis. Several aPLs, including LAC, aβ2GPI and anti-phosphatidylserine/prothrombin antibodies (aPS/PT) have been associated with arterial thrombosis. The Von Willebrand Factor (VWF) plays an important role in arterial thrombosis by mediating platelet adhesion and aggregation. Studies have shown that aPLs antibodies present in APS patients are able to increase the risk of arterial thrombosis by upregulating the plasma levels of active VWF and by promoting platelet activation. Inflammatory reactions induced by APS may also provide a suitable condition for arterial thrombosis, mostly ischemic stroke and myocardial infarction.
  • 1.3K
  • 05 May 2021
Topic Review
Secondary Aroma
Aroma profile is one of the main features for the acceptance of wine. Yeasts and bacteria are the responsible organisms to carry out both, alcoholic and malolactic fermentation. Alcoholic fermentation is in turn, responsible for transforming grape juice into wine and providing secondary aromas. Secondary aroma can be influenced by different factors; however, the influence of the microorganisms is one of the main agents affecting final wine aroma profile. Saccharomyces cerevisiae has historically been the most used yeast for winemaking process for its specific characteristics: high fermentative metabolism and kinetics, low acetic acid production, resistance to high levels of sugar, ethanol, sulfur dioxide and also, the production of pleasant aromatic compounds. Nevertheless, in the last years, the use of non-saccharomyces yeasts has been progressively growing according to their capacity to enhance aroma complexity and interact with S. cerevisiae, especially in mixed cultures.
  • 1.3K
  • 27 May 2021
Topic Review
IDA in Celiac Disease
The iron absorption process develops mainly in the proximal duodenum. This portion of the intestine is typically destroyed in celiac disease (CD), resulting in a reduction in absorption of iron and subsequent iron deficiency anemia (IDA). In fact, the most frequent extra-intestinal manifestation (EIM) of CD is IDA, with a prevalence between 12 and 82% (in relation with the various reports) in patients with new CD diagnosis. The primary treatment of CD is the gluten-free diet (GFD), which is associated with adequate management of IDA, if present. Iron replacement treatment historically has been based on oral products containing ferrous sulphate (FS). However, the absorption of FS is limited in patients with active CD and unpredictable in patients on a GFD. Furthermore, a poor tolerability of this kind of ferrous is particularly frequent in patients with CD or with other inflammatory bowel diseases. Normalization from anemic state typically occurs after at least 6 months of GFD, but the process can take up to 2 years for iron stores to replenish.
  • 1.3K
  • 03 Jun 2021
Topic Review
Biofumigation for Fighting Replant Disease
Replant disease is a soil (micro-) biome-based, harmfully-disturbed physiological and morphological reaction of plants to replanting similar cultures on the same sites by demonstrating growth retardation and leading to economic losses especially in Rosaceae plant production. Commonly, replant disease is overcome by soil fumigation with toxic chemicals. With chemical soil fumigation being restricted in many countries, other strategies are needed. Biofumigation, which is characterized by the incorporation of Brassicaceae plant materials into soil, is a promising method. 
  • 1.3K
  • 09 Jun 2021
Topic Review
Lead-Free Perovskite Solar Cells
Next-generation renewable energy sources and perovskite solar cells have revolutionised photovoltaics research and the photovoltaic industry. However, the presence of toxic lead in perovskite solar cells hampers their commercialisation. Lead-free tin-based perovskite solar cells are a potential alternative solution to this problem; however, numerous technological issues must be addressed before the efficiency and stability of tin-based perovskite solar cells can match those of lead-based perovskite solar cells.
  • 1.3K
  • 18 Aug 2021
Topic Review
Climate Change, Security and the Nexus Concept
The nexus concept has been emerging since the Bonn 2011 Conference, “The Water Energy and Food Security Nexus—Solutions for the Green Economy”, with significant involvement from the UN and other international organisations. It has been defined as a “set of context-specific critical interlinkages between two or more natural resources used in delivery chains towards systems of provision”. From a policy perspective, it looks at delivery chains of resources, such as water and energy, in a polycentric manner, i.e., as independent providers based on ecosystem services with interlinkages across delivery stages, but without a presumed hierarchy among those dimensions. Thus, water, energy and food are seen as interrelated and of equal priority for the SDGs, considering the specific conditions of their provision and the strategic interests of relevant actors.
  • 1.3K
  • 15 Oct 2021
Topic Review
System of Indirect Taxation of Exports in Russia
Researchers supplement the theoretical and methodological foundations of the transformation of the system of indirect taxation of exports in the Russian Federation based on the analysis of legal precedents.
  • 1.3K
  • 14 Dec 2021
Topic Review
Evaluation of Fermented Oat as Food Ingredients
This entry describes a study verified the safety of fermented oat (Avena sativa) when used in a dog food as part of the effort toward discovering suitable nutritionally excellent and functional food materials.
  • 1.3K
  • 05 Jan 2022
Topic Review
Genetically Modified Food
The concept of “genetically modified organisms” (GMOs) refers to those organisms whose genome has been altered by inserting a gene from another organism, removing a gene, or changing a gene’s function to generate a desirable trait.
  • 1.3K
  • 25 Mar 2022
Topic Review
Antimicrobial Resistance in Agricultural Soils
Excessive use of antibiotics in the healthcare sector and livestock farming has amplified antimicrobial resistance (AMR) as a major environmental threat in recent years. Abiotic stresses, including soil salinity and water pollutants, can affect AMR in soils, which in turn reduces the yield and quality of agricultural products.
  • 1.3K
  • 28 Apr 2022
Topic Review
Effects of Statins on Cancer via Autophagy
Cancer is one of the main causes of death globally. Most of the molecular mechanisms underlying cancer are marked by complex aberrations that activate the critical cell-signaling pathways that play a pivotal role in cell metabolism, tumor development, cytoskeletal reorganization, and metastasis. The phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of the rapamycin (PI3K/AKT/mTOR) pathway is one of the main signaling pathways involved in carcinogenesis and metastasis. Autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation, plays a dual role in cancer, as either a tumor promoter or a tumor suppressor, depending on the stage of the carcinogenesis. Statins are the group of drugs of choice to lower the level of low-density lipoprotein (LDL) cholesterol in the blood. Experimental and clinical data suggest the potential of statins in the treatment of cancer. In vitro and in vivo studies have demonstrated the molecular mechanisms through which statins inhibit the proliferation and metastasis of cancer cells in different types of cancer. The anticancer properties of statins have been shown to result in the suppression of tumor growth, the induction of apoptosis, and autophagy.
  • 1.3K
  • 09 Jun 2022
Topic Review
Electrospun Nanofibers in Regeneration of Tissues and Organs
Electrospun techniques are promising and flexible technologies to fabricate ultrafine fiber/nanofiber materials from diverse materials with unique characteristics under optimum conditions. These fabricated fibers/nanofibers via electrospinning can be easily assembled into several shapes of three-dimensional (3D) structures and can be combined with other nanomaterials. Therefore, electrospun nanofibers, with their structural and functional advantages, have gained considerable attention from scientific communities as suitable candidates in biomedical fields, such as the regeneration of tissues and organs, where they can mimic the network structure of collagen fiber in its natural extracellular matrix(es). Due to these special features, electrospinning has been revolutionized as a successful technique to fabricate such nanomaterials from polymer media.
  • 1.3K
  • 28 Jun 2022
Topic Review
Nanostructures for Breast Cancer Diagnosis
Breast cancer (BC) is a highly metastatic multifactorial disease with various histological and molecular subtypes. Due to recent advancements, the mortality rate in BC has improved over the past five decades. Detection and treatment of many cancers are now possible due to the application of nanomedicine in clinical practice. Nanomedicine products such as Doxil® and Abraxane® have already been extensively used for BC adjuvant therapy with favorable clinical outcomes. 
  • 1.3K
  • 20 Jul 2022
Topic Review
miR-944 in Cancer
miR-944 is localized in intron 4 of TP63. ΔNp63 in intron 3 of TP63 recruits the transcription factor AP-2 to promote miR-944 gene expression, which mediates epidermal differentiation induction by ΔNp63. miR-944 is dysregulated in various cancers. In squamous cell carcinoma. miR-944 can target and inhibit 27 protein-coding genes, thereby regulating cell cycle, proliferation, apoptosis, epithelial mesenchymal transition, cancer cell invasion and migration, and other cell behaviors. The genes targeted by miR-944 are involved in three signaling pathways, including the Wnt/β-catenin pathway, Jak/STAT3 pathway, and PI3K/AKT pathway. miR-944 was regulated by a total of 11 competing endogenous RNAs, including 6 circular RNAs and 5 long non-coding RNAs. Abnormally expressed miR-944 can act as an independent prognostic factor and is closely related to tumor invasion, lymph node metastasis, TNM staging, and drug resistance. miR-944 is expected to become a critical biomarker with great clinical application value in cancer.
  • 1.3K
  • 15 Sep 2022
Topic Review
Exploration Mission-1
Exploration Mission-1 or EM-1 (previously known as Space Launch System 1 or SLS-1) is the uncrewed first planned flight of the Space Launch System and the second flight of the Orion Multi-Purpose Crew Vehicle. The launch is planned for June 2020 from Launch Complex 39B at the Kennedy Space Center. The Orion spacecraft will spend approximately 3 weeks in space, including 6 days in a retrograde orbit around the Moon. It is planned to be followed by Exploration Mission 2 in 2023.
  • 1.3K
  • 28 Sep 2022
Topic Review
Platelet-activating Factor
Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis. It is also involved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, as well as augmentation of arachidonic acid metabolism in phagocytes. PAF is produced by a variety of cells, but especially those involved in host defense, such as platelets, endothelial cells, neutrophils, monocytes, and macrophages. PAF is continuously produced by these cells but in low quantities and production is controlled by the activity of PAF acetylhydrolases. It is produced in larger quantities by inflammatory cells in response to specific stimuli.
  • 1.3K
  • 18 Oct 2022
Topic Review
Microsoft TypeScript
Microsoft TypeScript is an open-source programming language developed and maintained by Microsoft. It is a strict syntactical superset of JavaScript, and adds optional static typing to the language. TypeScript is designed for development of large applications and transcompiles to JavaScript. As TypeScript is a superset of JavaScript, existing JavaScript programs are also valid TypeScript programs. TypeScript may be used to develop JavaScript applications for both client-side and server-side (Node.js) execution. There are multiple options available for transcompilation. Either the default TypeScript Checker can be used, or the Babel compiler can be invoked to convert TypeScript to JavaScript. TypeScript supports definition files that can contain type information of existing JavaScript libraries, much like C++ header files can describe the structure of existing object files. This enables other programs to use the values defined in the files as if they were statically typed TypeScript entities. There are third-party header files for popular libraries such as jQuery, MongoDB, and D3.js. TypeScript headers for the Node.js basic modules are also available, allowing development of Node.js programs within TypeScript. The TypeScript compiler is itself written in TypeScript and compiled to JavaScript. It is licensed under the Apache 2.0 License. TypeScript is included as a first-class programming language in Microsoft Visual Studio 2013 Update 2 and later, beside C# and other Microsoft languages. An official extension allows Visual Studio 2012 to support TypeScript as well. Anders Hejlsberg, lead architect of C# and creator of Delphi and Turbo Pascal, has worked on the development of TypeScript.
  • 1.3K
  • 19 Oct 2022
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