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HandWiki. Platelet-activating Factor. Encyclopedia. Available online: https://encyclopedia.pub/entry/29819 (accessed on 25 September 2026).
HandWiki. Platelet-activating Factor. Encyclopedia. Available at: https://encyclopedia.pub/entry/29819. Accessed September 25, 2026.
HandWiki. "Platelet-activating Factor" Encyclopedia, https://encyclopedia.pub/entry/29819 (accessed September 25, 2026).
HandWiki. (2022, October 18). Platelet-activating Factor. In Encyclopedia. https://encyclopedia.pub/entry/29819
HandWiki. "Platelet-activating Factor." Encyclopedia. Web. 18 October, 2022.
Platelet-activating Factor
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The content is sourced from: https://handwiki.org/wiki/Chemistry:Platelet-activating_factor

Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis. It is also involved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, as well as augmentation of arachidonic acid metabolism in phagocytes. PAF is produced by a variety of cells, but especially those involved in host defense, such as platelets, endothelial cells, neutrophils, monocytes, and macrophages. PAF is continuously produced by these cells but in low quantities and production is controlled by the activity of PAF acetylhydrolases. It is produced in larger quantities by inflammatory cells in response to specific stimuli.

platelet aggregation acetylhydrolases acetyl-glyceryl-ether-phosphorylcholine

References

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  2. "Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils". Nature 249 (457): 581–2. Jun 1974. doi:10.1038/249581a0. PMID 4275800. Bibcode: 1974Natur.249..581B.  https://dx.doi.org/10.1038%2F249581a0
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