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Topic Review
Biliary Atresia
The term biliary atresia has substituted the original term of “extrahepatic biliary atresia”, which has been in use for several generations. The concept was related to the often-identified absence of gallbladder with an obliterated cord at the site the extrahepatic biliary system. It is now known that biliary atresia is a necro-inflammatory and fibro-obliterative process of both intrahepatic and extrahepatic biliary tract.
  • 1.4K
  • 11 Feb 2022
Topic Review
Circadian Rhythms and Glioblastomas
Gliomas are solid tumors of the central nervous system (CNS) that originated from different glial cells. The World Health Organization (WHO) classifies these tumors into four groups (I–IV) with increasing malignancy. Glioblastoma (GBM) is the most common and aggressive type of brain tumor classified as grade IV. GBMs are resistant to conventional therapies with poor prognosis after diagnosis even when the Stupp protocol that combines surgery and radiochemotherapy is applied. Nowadays, few novel therapeutic strategies have been used to improve GBM treatment, looking for higher efficiency and lower side effects, but with relatively modest results. The circadian timing system temporally organizes the physiology and behavior of most organisms and daily regulates several cellular processes in organs, tissues, and even in individual cells, including tumor cells.
  • 1.4K
  • 15 Aug 2021
Topic Review
Homocysteine
Homocysteine (Hcy) is a sulfur-containing amino acid generated during methionine metabolism, accumulation of which may be caused by genetic defects or the deficit of vitamin B12 and folate.
  • 1.4K
  • 12 Oct 2021
Topic Review
Human Emotion Recognition System
Emotion recognition becomes an important aspect in the development of human-machine interaction (HMI) systems. Positive emotions impact our lives positively, whereas negative emotions may cause a reduction in productivity. Emotionally intelligent systems such as chatbots and artificially intelligent assistant modules help make our daily life routines effortless. Moreover, a system which is capable of assessing the human emotional state would be very helpful to assess the mental state of a person.
  • 1.4K
  • 28 Jun 2023
Topic Review
Unobtrusive Monitoring of Sleep Cycles
Polysomnography is the gold-standard method for measuring sleep but is inconvenient and limited to a laboratory or a hospital setting. As a result, the vast majority of patients do not receive a proper diagnosis. In an attempt to solve this issue, sleep experts are continually looking for unobtrusive and affordable alternatives that can provide longitudinal sleep tracking. Collecting longitudinal data on sleep can accelerate epidemiological studies exploring the effect of sleep on health and disease. These alternatives can be in the form of wearables (e.g., actigraphs) or nonwearable (e.g., under-mattress sleep trackers). 
  • 1.4K
  • 19 Apr 2022
Topic Review
Autism Care and Intervention Based on Mobile Apps
The mobile apps can be categorized into autism support apps, educational apps, teacher training apps, parental support apps, and data collection apps. The individuals with autism spectrum disorder (ASD) are the primary users of the first two categories of apps. Teachers of children with ASD are the primary users of the teacher training apps. Parents are the primary users of the parental support apps, while individuals with ASD are usually the primary users of the data collection apps and clinicians and autism researchers are the beneficiaries. Gamification, virtual reality, and autism-specific mechanisms have been used to improve the usability of the apps. User-centered design is the most popular approach for mobile app development. Augmentative and alternative communication, video modeling, and various behavior change practices have been used as the theoretical foundation for intervention efficacy.
  • 1.4K
  • 19 Sep 2023
Topic Review
Health-Seeking Behaviors in Mozambique
In settings where traditional medicine is a crucial part of the healthcare system, providing culturally competent healthcare services is vital to improving patient satisfaction and health outcomes. Therefore, here sought to gain insight into how cultural beliefs influence health-seeking behaviors (HSBs) among Mozambicans. Participant observation and in-depth interviews (IDIs) were undertaken using the ethnonursing method to investigate beliefs and views that Mozambicans (living in Pemba City) often take into account to meet their health needs.
  • 1.4K
  • 14 Mar 2022
Topic Review
Fragmentation of Human Embryos
Embryo fragmentation represents a phenomenon generally characterized by the presence of membrane-bound extracellular cytoplasm into the perivitelline space. 
  • 1.4K
  • 18 Feb 2022
Topic Review
Advances in Non-Invasive Neuromodulation: Closed-Loop Vagus Nerve Stimulation
Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation therapy that eliminates the need for internal device implantation, presenting as a favorable therapeutic option. This method relies on electrical surface stimulation, bypassing the need for surgical procedures.
  • 1.4K
  • 18 Jan 2024
Topic Review
Vitamin D on Skin Aging
The normal vitamin D3 status is important for a general prevention of premature aging maintaining a healthful skin aging. Vitamin D3metabolites including its classical (1,25(OH)2D3) and novel (CYP11A1-intitated) D3hydroxyderivatives exert many beneficial protective effects on the skin, which could influence the process of premature aging via many different mechanisms, leading to a delay or attenuation of both chronological skin aging and photoaging. Skin-resident cells (keratinocytes, fibroblasts, and sebocytes) are capable of locally activating vitamin D3and exhibiting a diverse biological effect such as photoprotection and immunosuppression, similar to the UVR-induced one.
  • 1.4K
  • 29 Sep 2021
Topic Review
Urban Green Space and Residents’ Mental Health
As an important part of urban built environment, urban green space has long been recognized in the fields of promoting residents’ mental health. The mediators can be divided into environmental factors, outdoor activity, and social cohesion. From the perspective of heterogeneity, both individual characteristics (e.g., age and gender) and group characteristics (e.g., level of urban development and urban density) of residents are considered to be the cause of various mediating effects. Types of urban green space tend to affect residents’ mental health through different paths.
  • 1.4K
  • 25 Nov 2021
Topic Review
Remote Assessment in Multiple Sclerosis
The provision and adoption of technological solutions and the sharing of information globally has the potential to drive knowledge acquisition and positively affect healthcare worldwide. Digital solutions offer great promise in delivering increasingly individualised, easily accessible, and effective healthcare, with the capacity to evolve with time and adapt to the changing needs of people living with MS (PLwMS) and health care providers (HCPs). The impact of the COVID-19 pandemic has given additional proof of such versatility and usefulness, highlighting how barriers can be overcome through the adoption of digital tools, where capturing digital data remotely may mean that symptom tracking can be maintained even when clinic visits are not possible.
  • 1.4K
  • 07 Oct 2021
Topic Review
Steroid Induced Hyperglycaemia in Hospital
Oral hypoglycaemic agents (OHAs) might be an adequate choice in inpatients with stable and non-critical disease and mild hyperglycaemic excursions. In those with significant hyperglycaemia and severe illness, insulin remains the treatment of choice in the hospital setting as also suggested by the current guidelines for inpatient diabetes management.
  • 1.4K
  • 21 Jun 2021
Topic Review
Infancy Dietary Patterns, Development, and Health
Correct dietary patterns are important for a child’s health from birth to adulthood. Understanding a child’s health as a state of entire physical, mental, and social well-being is essential.
  • 1.4K
  • 01 Aug 2022
Topic Review
Healthy Meals Interventions in Restaurants/Canteens
Out-of-home eating is increasing, but evidence about its healthiness is limited. The present systematic review and meta-analysis aimed to elucidate the effectiveness of full-service restaurant and canteen-based interventions in increasing the dietary intake, food availability, and food purchase of healthy meals. Studies from 2000–2020 were searched in Medline, Scopus, and Cochrane Library using the PRISMA checklist. A total of 35 randomized controlled trials (RCTs) and 6 non-RCTs were included in the systematic review and analyzed by outcome, intervention strategies, and settings (school, community, workplace). The meta-analysis included 16 RCTs (excluding non-RCTs for higher quality). For dietary intake, the included RCTs increased healthy foods (+0.20 servings/day; 0.12 to 0.29; p < 0.001) and decreased fat intake (−9.90 g/day; −12.61 to −7.19; p < 0.001), favoring the intervention group. For food availability, intervention schools reduced the risk of offering unhealthy menu items by 47% (RR 0.53; 0.34 to 0.85; p = 0.008). For food purchases, a systematic review showed that interventions could be partially effective in improving healthy foods. Lastly, restaurant- and canteen-based interventions improved the dietary intake of healthy foods, reduced fat intake, and increased the availability of healthy menus, mainly in schools. Higher-quality RCTs are needed to strengthen the results. Moreover, from our results, intervention strategy recommendations are provided.
  • 1.4K
  • 23 Jun 2021
Topic Review
Robotic Surgery
The advent of robotic surgical systems had a significant impact on every surgical area, especially urology, gynecology, and general and cardiac surgery. 
  • 1.4K
  • 30 Aug 2023
Topic Review
The U.S. Food and Drug Administration (FDA)
The U.S. Food and Drug Administration (FDA) is a pivotal regulatory agency under the Department of Health and Human Services (HHS), responsible for safeguarding public health by ensuring the safety, efficacy, and security of drugs, biologics, medical devices, food, cosmetics, and tobacco products. Established in 1906, the FDA has evolved through significant legislative milestones, such as the Federal Food, Drug, and Cosmetic Act of 1938, expanding its regulatory scope. The agency operates through various centers, including the Center for Drug Evaluation and Research (CDER), the Center for Biologics Evaluation and Research (CBER), and the Center for Devices and Radiological Health (CDRH), each tasked with specific regulatory functions. The FDA's responsibilities encompass drug approval, food safety, medical device regulation, and emergency public health responses, exemplified by its role in the COVID-19 pandemic. Despite facing challenges like balancing regulatory rigor with innovation, transparency concerns, and global supply chain complexities, the FDA remains a global leader in regulatory science. Looking forward, the FDA aims to adapt to technological advances, enhance global collaboration, and ensure equitable access to safe and effective medical products, thereby continuing its crucial role in public health protection.
  • 1.4K
  • 31 Oct 2024
Topic Review
Monitoring and Evaluation of National Vaccination Implementation
An effective Monitoring and Evaluation (M&E) framework helps vaccination programme managers determine progress and effectiveness for agreed indicators against clear benchmarks and targets. Improving national vaccination programme implementation requires collection and analysis of data on relevant vaccination components. Monitoring and evaluation (M&E) or more recent Monitoring, Evaluation, Accountability and Learning (MEAL) frameworks support decision-making by consolidating available information on agreed indicators, benchmarked targets, and methods to collect, analyse, and report necessary data to strengthen vaccination programmes.
  • 1.4K
  • 22 Apr 2022
Topic Review
Diet Quality of Malaysians
Malaysia is a rapidly developing economy experiencing a nutrition transition. It suffers from a double burden of over- and undernutrition, making it essential to understand diet quality in the population. In this scoping review, we have collated the existing literature on Malaysian diet quality, including factors that influence it, and the association between diet quality and health outcomes across the lifespan of Malaysians. Overall, diet quality was poor in all age groups studied. The Healthy Eating Index (HEI) and its iterations were predominantly used in urban and clinical settings to evaluate diet-chronic disease relationships. These indices were significantly associated with cardio-metabolic and disease risks in adults. The Diet Diversity Score (DDS) and Food Variety Score (FVS) were used to gauge diet quality in maternal and child nutrition studies and were associated with appropriate growth and caloric intake. 
  • 1.4K
  • 26 May 2021
Topic Review
oXiris Hemofilter
Critically ill patients with sepsis and severe COVID-19 are commonly characterized by a dysregulated immune response and an acute kidney injury. Continuous renal replacement therapy (CRRT) is proposed as a promising adjuvant therapy to treat these critically ill patients by removing cytokines, pathogen-associated molecular patterns, and damage-associated molecular patterns from the blood. Although multiple hemofilters, including high-cutoff membranes, the oXiris hemofilter, the CytoSorb hemoadsorption device, and the Toraymyxin hemoperfusion cartridge, have been used in clinical practice, the use of the oXiris hemofilter in critically ill patients is of particular interest because it is the only kind of hemofilter that can provide renal replacement therapy, remove endotoxins, and adsorb cytokines simultaneously. 
  • 1.4K
  • 18 Nov 2022
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