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Topic Review
Green and Platform Supply Chain Management
Expanding green consumption market and precise data promotion advantages make the platform economy have a significant effect on influencing manufacturers to carry out green R&D and production activities, and government subsidies have a positive incentive effect. A manufacturer invests in green technologies to produce products and sell them through a smart platform supply chain by an agency selling or reselling strategy, in which the platform provides data-driven marketing technology to promote green products.
  • 1.3K
  • 01 Jul 2022
Topic Review
LncRNA-Mediated Adipogenesis in Different Adipocytes
Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely present in eukaryotes. They regulate gene expression at multiple levels through different mechanisms at epigenetic, transcription, translation, and the maturation of mRNA transcripts or regulation of the chromatin structure, and compete with microRNAs for binding to endogenous RNA. 
  • 1.3K
  • 01 Aug 2022
Topic Review
Near-Field WPT Technology in UAV Charging
Unmanned aerial vehicles (UAV) have been widely used in the military and civil fields. However, the battery power is a key factor that restricts the operation range of the UAV. Using wireless power transfer (WPT) technology to power UAVs can improve the endurance of UAVs and enhance their maneuverability and flexibility.
  • 1.3K
  • 12 Aug 2022
Topic Review
Pharmacokinetic of Antibiotics in Preterms
Antibiotics are widely prescribed and administered in preterm neonates. Almost 61.3% of neonates admitted into neonatal intensive care units receive an antibiotic course during hospitalization. Nevertheless, most antibiotics were not investigated in neonatal pharmacokinetic (PK) studies before licensing and, therefore, are used off label. Both population pharmacokinetic (popPK) and  pharmacokinetic (PBPK) models have been developed so far to predict PK behavior and to tailor the dosing regimens of several antibiotics in neonates including preterms.
  • 1.3K
  • 02 Sep 2022
Topic Review
Challenges in Lignin Valorization
The aromatic hetero-polymer lignin is industrially processed in the paper/pulp and lignocellulose biorefinery, acting as a major energy source. It has been proven to be a natural resource for useful bioproducts; its depolymerization and conversion into high-value-added chemicals is the major challenge due to the complicated structure and heterogeneity.
  • 1.3K
  • 27 Sep 2022
Topic Review
Biological Remediation of Polyfluorinated Compounds
Polyfluorinated compounds (PFCs) are a class of anthropogenic emerging persistent organic pollutants that consist of a fully fluorinated hydrophobic alkyl chain attached to a hydrophilic chain end group. The PFCs’ carbon–fluorine (C-F) bond, characterized by strong polarity and strength, make them possess peculiar physicochemical properties such as hydrophobicity and resistance to degradation by heat and acid. Their environmental occurrence particularly in drinking water samples and water receiving bodies, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) being the most detected PFCs is evident that they cannot be completely eradicated by conventional wastewater treatment plants (WWTPs). However, despite the PFCs' stable C-F bond, recent literature suggests that PFCs are susceptible to bioremediation by certain bacterial strain and plant species. A lot of work still needs to be done in the context of understanding the biodegradation pathway of PFOA and PFOS by both bacterial strain and plant species. 
  • 1.3K
  • 16 Dec 2022
Topic Review
Machine Vision Techniques in Agriculture
Introducing machine vision-based automation to the agricultural sector is essential to meet the food demand of a rapidly growing population. Furthermore, extensive labor and time are required in agriculture; hence, agriculture automation is a major concern and an emerging subject. Machine vision-based automation can improve productivity and quality by reducing errors and adding flexibility to the work process. Primarily, machine vision technology has been used to develop crop production systems by detecting stresses and diseases more efficiently.
  • 1.3K
  • 06 Jan 2023
Topic Review
Gelatin and Bioactive Glass Composites
Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds.
  • 1.3K
  • 28 Jan 2023
Topic Review
Long-Term Potentiation Mechanisms of Excitatory and Inhibitory Synapses
Neuronal and glial cells are the main components of the brain. Approximately 50% of the brain is neuronal cells; the other half is glial cells, which all play an important role in the mammalian brain. Billions of neurons are connected and communicate via synapses inextricably linked to behavior, memory, and neurological diseases. Synaptic plasticity is a change in neural connection strength that occurs in response to activity. Reorganization of the structural and functional connections of synapses occurs in response to internal or external stimuli, leading to the strengthening or weakening of synaptic connections via synaptic plasticity. Long-term potentiation (LTP) has been widely used as an ideal model for studying synaptic plasticity, learning, and memory.
  • 1.3K
  • 19 Apr 2023
Topic Review
Mouse Models of Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a prevalence rate of 2.78%, and it is characterized by deficits in sociability and communication and restricted patterns of interests and activities. Remarkably, this psychiatric disorder exhibits a pronounced gender bias, with 80% of children diagnosed with ASD being boys.
  • 1.3K
  • 03 Aug 2023
Topic Review
Photovoltaic-Assisted Photo(electro)catalytic Hydrogen Production
The idea of supporting the Sustainable Development Goals (SDGs) has inspired researchers around the world to explore more environmentally friendly energy generation and production methods, especially those related to solar and hydrogen energy. Among the various available sustainable energy technologies, photo(electro)catalytic hydrogen production has been competitively explored, benefiting from its versatile platform to utilize solar energy for green hydrogen production. Nevertheless, the bottleneck of this photo(electro)catalytic system lies within its high voltage required for water electrolysis (>1.23 V), which affects the economic prospects of this sustainable technology. In this regard, coupling the photo(electro)catalytic system with a solar-powered photovoltaic (PV) system (PV-PEC) to unleash the fascinating properties and readiness of this system has heightened attention among the scientific community. 
  • 1.3K
  • 07 Sep 2023
Topic Review
CCl4-Induced Liver Injury in Brief
Carbon tetrachloride (CCl4) has been a cornerstone in experimental liver research for decades, providing valuable insights into hepatotoxicity, liver fibrosis, and potential therapeutic interventions. This research explores the utility of the CCl4-induced liver injury model, encompassing its methods of induction, key pathological features, underlying mechanisms, and applications in drug development. While this model offers essential insights into liver disease, it presents certain limitations that researchers must consider. By providing an in-depth analysis of CCl4-induced liver injury, this research highlights its significance in advancing liver research and our understanding of liver pathology and repair.
  • 1.3K
  • 08 Oct 2023
Topic Review
Cognitive Function with Nutritional Supplements in Aging
Cognitive impairment and dementia are burgeoning public health concerns, especially given the increasing longevity of the global population. These conditions not only affect the quality of life of individuals and their families, but also pose significant economic burdens on healthcare systems. 
  • 1.3K
  • 02 Jan 2024
Topic Review
Obesity with Infertility
A high-fat diet and obesity, the development of which is encouraged by the western lifestyle, can significantly affect male fertility. An inappropriate diet may be directly related to the increase of oxidative stress, but also contribute to the development of obesity, which is associated with the deterioration of fertility, both in terms of generating oxidative stress as well as hormonal or immunological disorders. In obese individuals, disorders on the hypothalamic-pituitary-gonadal axis are observed, as well as elevated oestrogen levels with simultaneous decrease of testosterone, LH and FSH hormone levels. Weight loss in obese men seems to be the first, and the most basic step in the treatment of male infertility.
  • 1.3K
  • 30 Oct 2020
Topic Review
Mechanisms of Malignant Peripheral Nerve Sheath Tumors Pathogenesis
Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma with limited therapeutic options and a poor prognosis. Although neurofibromatosis type 1 (NF1) and radiation exposure have been identified as risk factors for MPNST, the genetic and molecular mechanisms underlying MPNST pathogenesis have only lately been roughly elucidated. Plexiform neurofibroma (PN) and atypical neurofibromatous neoplasm of unknown biological potential (ANNUBP) are novel concepts of MPNST precancerous lesions, which revealed sequential mutations in MPNST development. 
  • 1.3K
  • 22 Feb 2023
Topic Review
Extracellular Vesicles
Tobacco smoking is prevalent among people living with HIV (PLWH). It is known to increase viral replication and exacerbate HIV associated conditions. Some reports demonstrate a conflicting impact of cigarette smoke on PLWHA in terms of neurocognitive disorders, which further strengthens the necessity to study whether cigarette smoking is a causative factor for HAND in PLWHA. One possible mechanistic pathway of tobacco smoking-induced HIV pathogenesis and HAND could be the transportation of oxidative stress-related agents and inflammatory modulators via extracellular vesicles (EVs). EV are nanosized vesicles, that are formed and released from most of the mammalian cells and these are considered as cellular messengers because of their capability to transport the functional messages from cells to other distant cells. This review focuses on recent advances in the field of EVs with an emphasis on smoking-mediated HIV pathogenesis and HIV-associated neuropathogenesis.
  • 1.3K
  • 06 Jan 2021
Topic Review
Forth Bridge Approach Railways
The Forth Bridge approach railways were railway lines constructed in the period 1887 to 1890 to form new main lines on the opening of the Forth Railway Bridge. The Forth Bridge opened in 1890 at the Queensferry crossing, and only local branch lines approached the location. The North British Railway built new main lines and upgraded some existing lines. The increase in passenger traffic resulted in serious congestion at Edinburgh Waverley, which was extended and modernised in the years following 1890.
  • 1.3K
  • 21 Nov 2022
Topic Review
Calcium’s Role and Signaling in Muscle Aging
Calcium signaling involves the movement of calcium ions within or between cells, which can affect the electrochemical gradients between intra- and extracellular membranes, ligand binding, enzyme activity, and other mechanisms that determine cell fate. Calcium signaling in muscle, as elucidated by the sliding filament model, plays a significant role in muscle contraction. However, as organisms age, alterations occur within muscle tissue. These changes include sarcopenia, loss of neuromuscular junctions, and changes in mineral concentration, all of which have implications for calcium’s role. Additionally, a field of study that has gained recent attention, cellular senescence, is associated with aging and disturbed calcium homeostasis, and is thought to affect sarcopenia progression. 
  • 1.3K
  • 06 Dec 2023
Topic Review
Pediatric Mixed-Phenotype Acute Leukemia
Mixed phenotypic acute leukemias (MPAL) are rare hematological malignancies in children, accounting for less than 5% of pediatric acute leukemias. MPAL are heterogeneous and can exhibit cross-lineage myeloid, B-lymphoid, or T-lymphoid antigen expression on a single blast population (biphenotypic) or have distinct single-lineage blast populations (bilineal). Due to phenotypic and genetic diversity, lack of well-defined diagnostic criteria, treatment resistance, and lineage switch, MPAL often present a diagnostic dilemma, and prove difficult to treat.
  • 1.3K
  • 30 Nov 2021
Topic Review
Protein Intake and Single-Nephron GFR
High protein intake can increase glomerular filtration rate (GFR) in response to excretory overload, which may exacerbate the progression of kidney disease. However, the direct association between glomerular hemodynamic response at the single-nephron level and dietary protein intake has not been fully elucidated in humans. In the present study, we evaluated nutritional indices associated with single-nephron GFR (SNGFR) calculated based on corrected creatinine clearance (SNGFRCr). We retrospectively identified 43 living kidney donors who underwent enhanced computed tomography and kidney biopsy at the time of donation at Jikei University Hospital in Tokyo from 2007 to 2018. Total nephron number was estimated with imaging-derived cortical volume and morphometry-derived glomerular density. SNGFRCr was calculated by dividing the corrected creatinine clearance by the number of non-sclerosed glomeruli (NglomNSG). The mean (± standard deviation) NglomNSG/kidney and SNGFRCr were 685 000 ± 242 000 and 61.0 ± 23.9 nL/min, respectively. SNGFRCr was directly associated with estimated protein intake/ideal body weight (P = 0.005) but not with body mass index, mean arterial pressure, albumin, or sodium intake. These findings indicate that greater protein intake may increase SNGFR and lead to glomerular hyperfiltration.
  • 1.3K
  • 28 Aug 2020
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