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Topic Review
SRY Gene
SRY: Sex determining region Y. The SRY gene provides instructions for making a protein called the sex-determining region Y protein.
  • 5.9K
  • 22 Dec 2020
Topic Review
Steroid-Induced Iatrogenic Adrenal Insufficiency
This entry focuses on steroid-induced adrenal insufficiency (SIAI) in children and discusses the latest findings by surveying recent studies. SIAI is a condition involving adrenocorticotropic hormone (ACTH) and cortisol suppression due to high doses or prolonged administration of glucocorticoids. While its chronic symptoms, such as fatigue and loss of appetite, are nonspecific, exposure to physical stressors, such as infection and surgery, increases the risk of adrenal crisis development accompanied by hypoglycemia, hypotension, or shock. The low-dose ACTH stimulation test is generally used for diagnosis, and the early morning serum cortisol level has also been shown to be useful in screening for the condition. 
  • 5.9K
  • 20 Jan 2021
Topic Review
Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefit at best. The below section reviews the incidence, prevalence, healthcare associated cost, and etiologies of HCC. In addition, an overview of the classification, treatment algorithm, and treatment modalities are provided.
  • 5.9K
  • 07 Jan 2021
Topic Review
Smart Systems and IoT for Aquaponics Automation
Aquaponics is an innovative, smart, and sustainable agricultural technology that integrates aquaculture (farming of fish) with hydroponics in growing vegetable crops symbiotically. The correct implementation of aquaponics helps in providing healthy organic foods with low consumption of water and chemical fertilizers. Numerous research attempts have been directed toward real implementations of this technology feasibly and reliably at large commercial scales and adopting it as a new precision technology. For better management of such technology, there is an urgent need to use the Internet of things (IoT) and smart sensing systems for monitoring and controlling all operations involved in the aquaponic systems.
  • 5.9K
  • 11 Aug 2022
Topic Review
Distance Measures (Cosmology)
Distance measures are used in physical cosmology to give a natural notion of the distance between two objects or events in the universe. They are often used to tie some observable quantity (such as the luminosity of a distant quasar, the redshift of a distant galaxy, or the angular size of the acoustic peaks in the cosmic microwave background (CMB) power spectrum) to another quantity that is not directly observable, but is more convenient for calculations (such as the comoving coordinates of the quasar, galaxy, etc.). The distance measures discussed here all reduce to the common notion of Euclidean distance at low redshift. In accord with our present understanding of cosmology, these measures are calculated within the context of general relativity, where the Friedmann–Lemaître–Robertson–Walker solution is used to describe the universe.
  • 5.9K
  • 19 Oct 2022
Topic Review
Bone Structure, Its Properties, and Bone Healing Mechanism
Bones are categorized into two major groups, namely cortical bones, and cancellous bones. Cortical bones are compact bones and are responsible for providing mechanical strength, structural rigidity, and movement. They account for 80% of the mass of the bones in the human body. Cancellous bones, also known as trabecular bones, are soft, spongy bones and are responsible for providing structural support to the cortical bones, flexibility, and reduction in weight. 
  • 5.9K
  • 21 Apr 2022
Topic Review
L-Carnitine in Mitochondria
Mitochondria control cellular fate by various mechanisms and are key drivers of cellular metabolism. Although the main function of mitochondria is energy production, they are also involved in cellular detoxification, cellular stabilization, as well as control of ketogenesis and glucogenesis. Conditions like neurodegenerative disease, insulin resistance, endocrine imbalances, liver and kidney disease are intimately linked to metabolic disorders or inflexibility and to mitochondrial dysfunction. Mitochondrial dysfunction due to a relative lack of micronutrients and substrates is implicated in the development of many chronic diseases. l-carnitine is a vital molecule that is found in all living cells. It is a quaternary amine (3-hydroxy-4-N-trimethylaminobutyrate) whose main function in mammalian cells is the transfer of long chain fatty acids across the inner mitochondrial membrane for β- oxidation and generation of ATP energy. 
  • 5.9K
  • 11 Mar 2022
Topic Review
Mindsponge Mechanism
The mindsponge mechanism (mindsponge framework, mindsponge concept, or mindsponge process) provides a way to explain how and why an individual observes and ejects cultural values conditional on the external setting. The term “mindsponge” derives from the metaphor that the mind is analogized to a sponge that squeezes out unsuitable values and absorbs new ones compatible with its core value. Thanks to the complexity and well-structuring, the mechanism has been used to develop various concepts in multiple disciplines. One such concept is "cultural additivity" (https://www.nature.com/articles/s41599-018-0189-2). Recently, the mindsponge mechanism has been developed into mindsponge theory based on various evidence from natural sciences.
  • 5.9K
  • 01 Sep 2022
Topic Review
Procedures for Extraction of Anthocyanins from Different Food
Anthocyanins are water-soluble pigments characterized by various intense colors found in fruits and vegetables. The extraction and separation of anthocyanins from plants is important, especially due to the instability of plant anthocyanins, selecting and optimizing. Anthocyanins are prone to degradation by several factors, including pH, temperature, oxygen, water activity, co-pigments and enzymes. Unwanted compounds, such as sugars, proteins, lipids, acids and other flavonoids, can also be removed from plant material by appropriate extraction methods. The most used method for anthocyanin extraction is the conventional one, solid–liquid extraction, also known as solvent extraction, during which anthocyanins can be dissolved in polar solvents (methanol/glycolic acid and acetone), followed by their quantification, achieved by using spectrophotometry, the differential pH method, which is a rapid and convenient quantitative assay. Starting from this point, it has developed and there are many anthocyanin-extraction methods, such as conventional solvent extraction (CSE), enzyme-assisted extraction (EAE), fermentation extraction (FE), supercritical fluid extraction (SFE) (CO2) extraction, microwave-assisted extraction (MAE), ultrasonic-assisted extraction (UAE), high-hydrostatic-pressure extraction (HHPE) and pressurized-liquid extraction (PLE). One of the most frequent techniques for obtaining anthocyanins from plants is conventional solvent extraction. In order to meet the demands of safety and environmental sustainability, new extraction technologies with shorter extraction periods and higher yields have been developed (e.g., PLE, EFS, UAE, MAE, EAE, etc.).
  • 5.9K
  • 29 Nov 2022
Topic Review
Twin-Screw Granulation
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology has evolved rapidly due to the flexibility of the equipment design, the selection of the process variables and the wide range of processed materials. Most importantly, TSG offers the benefits of both batch and continuous manufacturing for pharmaceutical products, accompanied by excellent process control, high product quality which can be achieved through the implementation of Quality by Design (QbD) approaches and the integration of Process Analytical Tools (PAT). 
  • 5.9K
  • 18 May 2021
Topic Review
Belief
In sociology, the concept of beliefs refers to the mental acceptance or conviction that certain statements or propositions are true. Beliefs are subjective and personal convictions that individuals hold about the nature of reality, the social world, and various aspects of life. These cognitive constructs play a fundamental role in shaping human behavior, influencing decision-making processes, and contributing to the formation of individual and collective identities within a society.
  • 5.9K
  • 25 Jan 2024
Topic Review
Two-Dimensional Silicon Carbide
Two-dimensional silicon carbide (2D SiC) is a single/few atomic layer of silicon carbide.   2D SiC has a graphene-like honeycomb structure consisting of alternating Si and C atoms. In the monolayer SiC, the C and Si atoms bond through  sp2 hybridization to form the SiC sheet.  As a direct wide bandgap semiconducting material, 2D SiC has the potential to bring revolutionary advances into power electronics, optoelectronic and other SiC-based devices. It can overcome current limitations with silicon, bulk SiC, and gapless graphene. In addition to SiC, which is the most stable form of monolayer silicon carbide, other compositions, i.e. SixCy, are also predicted to be energetically favorable. Depending on the stoichiometry and bonding, monolayer SixCy may behave as a semiconductor, semimetal or topological insulator. With different Si/C ratios, the emerging 2D silicon carbide materials could attain novel electronic, optical, magnetic, mechanical, and chemical properties that go beyond those of graphene, silicene, and already discovered 2D semiconducting materials.
  • 5.9K
  • 08 May 2022
Topic Review
LD-Steelmaking
Basic Oxygen Furnace (BOF) steelmaking is, worldwide, the most frequently applied process. According to the world steel organization statistical report, 2021, it saw a total production share of 73.2%, or 1371.2 million tons per year of the world steel production in 2020. The rest is produced in Electric Arc Furnace (EAF)-based steel mills (26.3%), and only a very few open-hearth and induction furnace-based steel mills. The BOF technology remains the leading technology applied based on its undoubted advantages in productivity and liquid steel composition control. The BOF technology started as the LD process 70 years ago, with the first heat applied in November 1952 in a steel mill in Linz, Austria. The name LD was formed from the first letters of the two sites with the first industrial scale plants, Linz and Donawitz, both in Austria. The history and development of the process have been honored in multiple anniversary publications over the last few decades. Nevertheless, the focus of the steel industry worldwide is significantly changing following a social and political trend and the requirement for fossil-free energy generation and industrial production to be in accordance with the world climate targets committed to in relation to the decades leading up to 2050.
  • 5.9K
  • 09 Jun 2022
Topic Review
Unintended Consequences
In the social sciences, unintended consequences (sometimes unanticipated consequences or unforeseen consequences) are outcomes of a purposeful action that are not intended or foreseen. The term was popularised in the twentieth century by American sociologist Robert K. Merton and expanded by economist Thomas Sowell and psychologist Stuart Vyse. Unintended consequences can be grouped into three types: Unexpected benefit: A positive unexpected benefit (also referred to as luck, serendipity or a windfall). Unexpected drawback: An unexpected detriment occurring in addition to the desired effect of the policy (e.g., while irrigation schemes provide people with water for agriculture, they can increase waterborne diseases that have devastating health effects, such as schistosomiasis). Perverse result: A perverse effect contrary to what was originally intended (when an intended solution makes a problem worse).
  • 5.9K
  • 14 Oct 2022
Topic Review
DRDO Rustom
The DRDO Rustom (English: Warrior) is a Medium Altitude Long Endurance unmanned air vehicle (UAV) being developed by Defence Research and Development Organisation for the three services, Indian Army, Indian Navy and the Indian Air Force of the Indian Armed Forces. Rustom is derived from the NAL's LCRA (Light Canard Research Aircraft) developed by a team under the leadership of late Prof Rustom Damania in the 1980s. The UAV will have structural changes and a new engine. Rustom will replace/supplement the Heron UAVs in service with the Indian armed forces.
  • 5.9K
  • 02 Nov 2022
Topic Review
Disse (Space of Disse)
Space of Disse: a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, nutrients and oxygen, but also debris from our organism, that have acquired great importance in liver disease
  • 5.8K
  • 20 Feb 2021
Topic Review Peer Reviewed
Two-Lane Highways: Indispensable Rural Mobility
Two-lane highways refer to roadways consisting of two lanes in the cross section, one for each direction of travel. Occasionally, passing lanes may be added to one or two sides of the roadway extending the cross section to three or four lanes at those locations. In this entry, two-lane highways strictly refer to roads in rural areas meeting the previous definition and do not include urban and suburban streets.
  • 5.8K
  • 13 Apr 2022
Topic Review
Lagrangian Point
In celestial mechanics, the Lagrangian points (/ləˈɡrɑːndʒiən/ also Lagrange points, L-points, or libration points) are the points near two large bodies in orbit where a smaller object will maintain its position relative to the large orbiting bodies. At other locations, a small object would go into its own orbit around one of the large bodies, but at the Lagrangian points the gravitational forces of the two large bodies, the centripetal force of orbital motion, and (for certain points) the Coriolis acceleration all match up in a way that cause the small object to maintain a stable or nearly stable position relative to the large bodies. There are five such points, labeled L1 to L5, all in the orbital plane of the two large bodies, for each given combination of two orbital bodies. For instance, there are five Lagrangian points L1 to L5 for the Sun–Earth system, and in a similar way there are five different Lagrangian points for the Earth–Moon system. L1, L2, and L3 are on the line through the centers of the two large bodies, while L4 and L5 each act as the third vertex of an equilateral triangle formed with the centers of the two large bodies. L4 and L5 are stable, which implies that objects can orbit around them in a rotating coordinate system tied to the two large bodies. Several planets have trojan satellites near their L4 and L5 points with respect to the Sun. Jupiter has more than a million of these trojans. Artificial satellites have been placed at L1 and L2 with respect to the Sun and Earth, and with respect to the Earth and the Moon. The Lagrangian points have been proposed for uses in space exploration.
  • 5.8K
  • 17 Nov 2022
Topic Review
Bongo Drum
Bongos (Spanish: bongó) are an Afro-Cuban percussion instrument consisting of a pair of small open bottomed hand drums of different sizes. They are struck with both hands, most commonly in an eight-stroke pattern called martillo (hammer). They are mainly employed in the rhythm section of son cubano and salsa ensembles, often alongside other drums such as the larger congas and the stick-struck timbales. Bongo drummers (bongoseros) emerged as the only drummers of son cubano ensembles in eastern Cuba toward the end of the 19th century. The instrument remained important as son groups evolved into larger conjuntos and orchestras in Havana in the 1940s, at which point they began to share the stage with congas. Bongos later reached the United States, where they are commonly played in salsa, Afro-Cuban jazz, Latin rock and other genres. Bongo drums are about 20 centimetres (8 in) high and have diameters of approximately 20 centimetres (8 in) and 25 centimetres (10 in) (the smaller drum is called macho, male, and the larger drum, hembra, female). They are the smallest drums in Latin percussion, some models being only 15 centimetres (6 in) in diameter. The shells of the drums and the bridge (the small block that joins them) are usually made of wood, although fiberglass is also common. The heads are typically made of calfskin and attached to the shells via steel hardware that enables their tuning. Originally, metal tacks were used, so tuning had to be done by heating the skins.
  • 5.8K
  • 02 Nov 2022
Topic Review
Carcharodontosaurus
Carcharodontosaurus (/ˌkɑːrkəroʊˌdɒntoʊˈsɔːrəs/; lit. sharp-toothed lizard) is a genus of large carcharodontosaurid theropod dinosaur that existed during the Cenomanian age of the Late Cretaceous in Northern Africa. The genus Carcharodontosaurus is named after the shark genus Carcharodon, itself composed of the Greek karchar[os] (κάρχαρος, meaning "jagged" or "sharp") and odōn (ὀδών, "teeth"), and the suffix -saurus ("lizard"). It is currently known to have two species: C. saharicus and C. iguidensis.
  • 5.8K
  • 09 Nov 2022
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