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Topic Review
Oncogenic Potential of SARS-CoV-2
The relationship between viral infections and the risk of developing cancer is well known. Multiple mechanisms participate in and determine this process. The COVID-19 pandemic caused by the SARS-CoV-2 virus has resulted in the deaths of millions of people worldwide.
  • 1.4K
  • 14 Mar 2023
Topic Review
Metals in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia worldwide (60–70% of cases), affecting over 55 million people. The role of metals in the pathogenesis of AD is still debated. Although previous research has linked changes in essential metal homeostasis and exposure to environmental heavy metals to the pathogenesis of AD, more research is needed to determine the relationship between metals and AD.
  • 1.4K
  • 06 May 2023
Topic Review
Treatment of Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia (CAH) is a common genetic disorder in endocrinology, especially its milder clinical presentation, often caused by a partial or total deficiency of the 21-hydroxylase enzyme located in the adrenal cortex. CAH is characterized by the overproduction of androgen, along with variable degrees of cortisol and aldosterone deficiency. The age at diagnosis can provide some information about underlying mutations, with those diagnosed at birth/early infancy more likely to have severe enzymatic defects, which may include adrenal insufficiency, sexual development disorders, short stature in adulthood, hirsutism, and a higher risk for metabolic syndrome and infertility. Non-classic CAH, a milder form of CAH, is usually manifested later in life and is a common differential diagnosis of Polycystic Ovary Syndrome and should be actively evaluated during initial studies of clinical or biochemical hyperandrogenism.
  • 1.4K
  • 05 May 2023
Topic Review
Standardization of Post-Quantum Cryptography
Information security is a fundamental and urgent issue in the digital transformation era. Cryptographic techniques and digital signatures have been applied to protect and authenticate relevant information. However, with the advent of quantum computers and quantum algorithms, classical cryptographic techniques have been in danger of collapsing because quantum computers can solve complex problems in polynomial time. Stemming from that risk, researchers worldwide have stepped up research on post-quantum algorithms to resist attack by quantum computers.
  • 1.4K
  • 14 Sep 2023
Topic Review
Text Line Segmentation from Malayalam Documents
After the pandemic situation created by the novel coronavirus, it has become a necessity to encode the local language, conventionally written in pen and paper, in an electronic format. Optical character recognition (OCR) systems convert handwritten documents to a computer-editable digital form. Optical character recognition (OCR) converts pdf files, scanned documents, images containing text and printed and handwritten documents into editable electronic documents. OCR can be implemented for printed character recognition and handwritten character recognition. The latter is further categorized into online and offline recognition systems. Optical Character Recognition system for Malayalam handwritten documents has become an open research area. A major hindrance for this research is the unavailability of a benchmark database. Therefore, a new database of 402 Malayalam handwritten document images and ground truth images of 7535 text lines is developed for the implementation of the proposed technique. This paper proposes a technique for extracting text lines from handwritten documents in Malayalam language, specifically based on the handwriting of the writer. Text lines are extracted based on horizontal and vertical projection values, size of the handwritten characters, height of the text lines and the curved nature of Malayalam alphabets.
  • 1.4K
  • 22 Sep 2023
Topic Review
Biosynthesis of Non-Canonical Amino Acids
The functional pool of canonical amino acids (cAAs) has been enriched through the emergence of non-canonical amino acids (ncAAs). NcAAs play a crucial role in the production of various pharmaceuticals. The biosynthesis of ncAAs has emerged as an alternative to traditional chemical synthesis due to its environmental friendliness and high efficiency.
  • 1.4K
  • 10 Oct 2023
Topic Review
Leak Detection Using Water Pipeline Vibration Sensor
Water leakage from aging water and wastewater pipes is a persistent problem, necessitating the improvement of existing leak detection and response methods. Artificial intelligence (AI)-based leak detection systems can quickly determine the source and location of a leak by analyzing data collected from various sensors and suggesting the best course of action to resolve it. IoT technology can be utilized to monitor leaks in real-time and respond automatically in conjunction with a centralized control system. 
  • 1.4K
  • 13 Nov 2023
Topic Review
Antibacterial Prodrugs to Overcome Bacterial Resistance
Prodrugs are pharmacologically inactive entities of active drugs that undergo biotransformation before eliciting their pharmacological effects. A prodrug strategy can be used to revive drugs discarded due to a lack of appropriate pharmacokinetic and drug-like properties, or high host toxicity. A special advantage of the use of the prodrug approach in the era of bacterial resistance is targeting resistant bacteria by developing prodrugs that require bacterium-specific enzymes to release the active drug. 
  • 1.4K
  • 29 Feb 2024
Topic Review
Marine Otter
The Marine Otter, also known as Lontra felina, is a charismatic marine mammal native to the coastal regions of South America, particularly Chile and Peru. Renowned for its playful behavior and sleek appearance, the Marine Otter boasts a dense, waterproof fur coat and webbed feet, enabling it to thrive in its coastal habitat. Despite its small size and elusive nature, the Marine Otter plays a vital role in coastal ecosystems as a top predator, primarily feeding on fish, crustaceans, and mollusks.
  • 1.4K
  • 15 Mar 2024
Topic Review
Interventions with polyphenols in osteoarthritis
Polyphenols are plant-derived molecules with established anti-inflammatory and antioxidant properties that have been extensively evaluated in clinical settings and preclinical models in OA. As more knowledge is gained in the research field, an interesting approach in the management of OA is the additive and/or synergistic effects that polyphenols may have in an optimized supplement. 
  • 1.4K
  • 30 Apr 2021
Topic Review
Carbon Capture Storage and/or Utilization
Energy from fossil fuels combustion always generates carbon dioxide, leading to a considerable environmental concern with the values of CO2 produced in the world. The increase in emissions leads to a significant challenge in reducing the quantity of this gas in the atmosphere. To decrease this problem, green and efficient solutions have been extensively studied, such as Carbon Capture Utilization and Storage (CCUS) processes. Broadly recognized as having an enormous potential to meet climate change targets, CCS and CCUS appear as solutions to deliver low carbon heat and power, decarbonize the industry, and, more recently, facilitate the net removal of CO2 from the atmosphere.
  • 1.4K
  • 11 May 2021
Topic Review
Seaweed Diversity and Bioactive Compounds
Seaweed, a miscellaneous group of marine algae, has long been recognized for its rich nutritional composition and bioactive compounds, being considered nutraceutical ingredient. Seaweeds are abundant sources of essential vitamins, minerals, polysaccharides, polyphenols, and unique secondary metabolites, which reveal a wide range of biological activities. These bioactive compounds possess potential therapeutic properties, making them intriguing candidates for drug leads in various medical applications and pharmaceutical drug development.
  • 1.4K
  • 18 Jan 2024
Topic Review
FOXP3 Gene
Forkhead box P3
  • 1.4K
  • 25 Dec 2020
Topic Review
Mycobacterium tuberculosis
Mycobacterium tuberculosis is a bacterium of great medical importance because it causes tuberculosis, a disease that affects millions of people worldwide. Two important features are related to this bacterium: its ability to infect and survive inside the host, minimizing the immune response, and the burden of clinical isolates that are highly resistant to antibiotics treatment. These two phenomena are directly affected by cell envelope proteins, such as proteins from the ATP-Binding Cassette (ABC transporters) superfamily.
  • 1.4K
  • 18 Jan 2021
Topic Review
Epizoochory in Parrots
Plant–animal interactions are key to sustaining whole communities and ecosystem function. However, their complexity may limit our understanding of the underlying mechanisms and the species involved. The ecological effects of epizoochory remain little known compared to other seed dispersal mechanisms given the few vectors identified. In addition, epizoochory is mostly considered non-mutualistic since dispersers do not obtain nutritional rewards. Here, we show a widespread but unknown mutualistic interaction between parrots and plants through epizoochory.
  • 1.4K
  • 21 Apr 2021
Topic Review
Antibiotics for Animal Husbandry
Since the 1950s, antibiotics have been used in the field of animal husbandry for growth promotion, therapy and disease prophylaxis. It is estimated that up to 80% of the antibiotics produced by the pharmaceutical industries are used in food production. Most of the antibiotics are used as feed additives at sub-therapeutic levels to promote growth. However, studies show the indiscriminate use of antibiotics has led to the emergence of multidrug-resistant pathogens that threaten both animal health and human health, including vancomycin-resistant Enterococcus (VRE), Methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE). This scenario is further complicated by the slow progress in achieving scientific breakthroughs in uncovering novel antibiotics following the 1960s. Most of the pharmaceutical industries have long diverted research funds away from the field of antibiotic discovery to more lucrative areas of drug development. If this situation is allowed to continue, humans will return to the pre-antibiotics era and potentially succumb to huge health and economic consequences. Fortunately, studies investigating various alternatives to antibiotics use in livestock show promising results. These alternatives include the application of bacteriophages and phage derived peptidoglycan degrading enzymes, engineered peptides, egg yolk antibodies, probiotics, prebiotics and synbiotics, as well as quorum quenching molecules. Therefore, this review aims to discuss the use of growth-promoting antibiotics and their impact on livestock and provide insights on the alternative approaches for animal husbandry. 
  • 1.4K
  • 27 May 2021
Topic Review
The Coupling in Biological Membranes
Cell membrane structure is proposed as a lipid matrix with embedded proteins, and thus, their emerging mechanical and electrostatic properties are commanded by lipid behavior and their interconnection with the included and absorbed proteins, cytoskeleton, extracellular matrix and ionic media. Structures formed by lipids are soft, dynamic and viscoelastic, and their properties depend on the lipid composition and on the general conditions, such as temperature, pH, ionic strength and electrostatic potentials. The dielectric constant of the apolar region of the lipid bilayer contrasts with that of the polar region, which also differs from the aqueous milieu, and these changes happen in the nanometer scale. Besides, an important percentage of the lipids are anionic, and the rest are dipoles or higher multipoles, and the polar regions are highly hydrated, with these water molecules forming an active part of the membrane. Therefore, electric fields (both, internal and external) affects membrane thickness, density, tension and curvature, and conversely, mechanical deformations modify membrane electrostatics. As a consequence, interfacial electrostatics appears as a highly important parameter, affecting the membrane properties in general and mechanical features in particular.
  • 1.4K
  • 12 Jul 2021
Topic Review
Participatory Budget of Lisbon
Participatory budgets (PBs) allocate a share of the local public budget to citizen-led initiatives. While aiming to get the most marginalised groups of civil society closer to democratic institutions and representatives, the first PBs were celebrated by movements and parties on the left of the political spectrum for their capacity to foster social justice, transparency, and accountability. In the last few decades, PBs have been endorsed by international agencies and contributed significantly to the development of good governance mechanisms. 
  • 1.4K
  • 30 Jul 2021
Topic Review
BET Family Proteins
The BET family of proteins consists of a series of proteins with two N-terminal tandem bromodomains and an exclusive extra terminal domain (ET) that play an important role in gene transcription through epigenetic regulation, with a prominent impact in the control of cell growth and differentiation.
  • 1.4K
  • 05 Aug 2021
Topic Review
Vitamin D on Skin Aging
The normal vitamin D3 status is important for a general prevention of premature aging maintaining a healthful skin aging. Vitamin D3metabolites including its classical (1,25(OH)2D3) and novel (CYP11A1-intitated) D3hydroxyderivatives exert many beneficial protective effects on the skin, which could influence the process of premature aging via many different mechanisms, leading to a delay or attenuation of both chronological skin aging and photoaging. Skin-resident cells (keratinocytes, fibroblasts, and sebocytes) are capable of locally activating vitamin D3and exhibiting a diverse biological effect such as photoprotection and immunosuppression, similar to the UVR-induced one.
  • 1.4K
  • 29 Sep 2021
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