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Topic Review
Phage Therapy for Resistant Staphylococcus aureus Infections
The production and use of antibiotics increased significantly after the Second World War due to their effectiveness against bacterial infections. However, bacterial resistance also emerged and has now become an important global issue. Those most in need are typically high-risk and include individuals who experience burns and other wounds, as well as those with pulmonary infections caused by antibiotic-resistant bacteria, such as Pseudomonas aeruginosa, Acinetobacter sp, and Staphylococcus sp. With investment to develop new antibiotics waning, finding and developing alternative therapeutic strategies to tackle this issue is imperative. One option remerging in popularity is bacteriophage (phage) therapy. 
  • 1.4K
  • 07 Mar 2023
Topic Review
Human-Hand-like Grippers
Robotics has gained substantial popularity and holds the potential to facilitate a myriad of remarkable tasks. Manipulation, which plays a pivotal role in the realm of robotics, constitutes an emerging and intricate field. In contemporary times, several materials, actuators, and fabrication techniques have been employed to develop grippers. 
  • 1.4K
  • 04 Dec 2023
Topic Review
Solar Hybrid Photovoltaic Thermal System
A Hybrid Photovoltaic Thermal (PVT) system is one of the most emerging and energy-efficient technologies in the area of solar energy engineering. Several cell technologies with spectrum analysis are discussed to understand the application’s ability and energy efficiency.
  • 1.4K
  • 07 Feb 2024
Topic Review
Nanofiber-Based Face Masks and Respirators
Wearing face masks, use of respirators, social distancing, and practicing personal hygiene are all measures to prevent the spread of coronavirus disease (COVID-19). This pandemic has revealed the deficiency of face masks and respirators across the world. Therefore, significant efforts are needed to develop air filtration and purification technologies, as well as innovative, alternative antibacterial and antiviral treatment methods. It has become urgent—in order for humankind to have a sustainable future—to provide a feasible solution to air pollution, particularly to capture fine inhalable particulate matter in the air.
  • 1.4K
  • 24 Aug 2021
Topic Review
Hosts (File)
The computer file hosts is an operating system file that maps hostnames to IP addresses. It is a plain text file. Originally a file named HOSTS.TXT was manually maintained and made available via file sharing by Stanford Research Institute for the ARPANET membership, containing the hostnames and address of hosts as contributed for inclusion by member organizations. The Domain Name System, first described in 1983 and implemented in 1984, automated the publication process and provided instantaneous and dynamic hostname resolution in the rapidly growing network. In modern operating systems, the hosts file remains an alternative name resolution mechanism, configurable often as part of facilities such as the Name Service Switch as either the primary method or as a fallback method.
  • 1.4K
  • 15 Nov 2022
Topic Review
Built Environment for People with Sensory Disabilities
People with sensory disabilities constitute a significant portion of society whose accessibility needs must be prioritized in the design of the built environment. Sensory disabilities cause a gap in the environmental information received, most commonly visual and/or auditory cues, that requires consideration to create equal opportunities and experiences for all. 
  • 1.4K
  • 27 Mar 2024
Topic Review
The Smart Grid perspective Related to Electric Vehicle
Smart grids (SG) is a concept that has been modernizing the energy sector since it allows to establish a bidirectional communication infrastructure, allowing to improve the control, efficiency, and quality of service of power systems.
  • 1.4K
  • 08 Jun 2022
Topic Review
Hidden-Measurements Interpretation
The hidden-measurements interpretation (HMI), also known as the hidden-measurements approach, is a realistic interpretation of quantum mechanics. The basis of the hidden-measurements interpretation (HMI) is the hypothesis that a quantum measurement involves a certain amount of unavoidable fluctuations in the way the measuring system interacts with the measured entity. As a consequence, the interaction is not a priori given in a quantum measurement, but is each time selected (that is, actualized, through a weighted symmetry breaking processes) when the experiment is executed; and since different measurement-interactions can produce different outcomes, this can explain why the output of a quantum measurement can only be predicted in probabilistic terms. (One should not think however of these hidden measurement-interactions to be something similar to, or to be describable in the same way as, the fundamental interactions (fundamental forces) of the standard model of particle physics, mediated by bosonic elementary entities).
  • 1.4K
  • 03 Nov 2022
Topic Review
Carotenoid Colorants from Plants and Microalgae
The substitution of synthetic food dyes with natural colorants continues to be assiduously pursued. The current list of natural carotenoid colorants consists of plant-derived annatto (bixin and norbixin), paprika (capsanthin and capsorubin), saffron (crocin), tomato and gac fruit lycopene, marigold lutein, and red palm oil (α- and β-carotene), along with microalgal Dunaliella β-carotene and Haematococcus astaxanthin and fungal Blakeslea trispora β-carotene and lycopene. Potential microalgal sources are being sought, especially in relation to lutein, for which commercial plant sources are lacking.
  • 1.4K
  • 15 Nov 2023
Topic Review
Aristotelia chilensis (Maqui Berry)
The Aristotelia chilensis (Mol.) Stuntz, also known as Maqui, is an endemic berry native to southern Chile. It is a very popular berry for its nutritional attributes and health benefits, provided mainly by its polyphenols.
  • 1.4K
  • 29 Mar 2024
Topic Review
VR Serious Games and Negative Schizophrenia Symptoms
Schizophrenia is a chronic brain disorder that affects 1 in every 300 people worldwide. VR is an interesting tool that has started to be used in remediation therapies. Although it is typically used as an exposure technique for specific phobias, VR has been applied, with encouraging results, to the study and treatment of schizophrenia. It can offer the potential for a significant therapeutic benefit, since patients are more willing to enter challenging situations and experiment with alternative ways of responding.
  • 1.4K
  • 19 Sep 2022
Topic Review
Immune Checkpoint Inhibitor-Related Pancreatitis
The indications for immune checkpoint inhibitors (ICIs) have expanded to include carcinomas of various organs. ICIs include drugs that target programmed cell death-1 (PD-1), programmed cell death ligand 1 (PDL-1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). The indications for these drugs have been expanded to include many types of cancer, as efficacies have been reported for malignant melanoma and lung, kidney, head and neck, stomach, liver, ovarian, and pancreatic cancers .
  • 1.4K
  • 05 May 2022
Topic Review
Gorlin-Chaudhry-Moss Syndrome
Gorlin-Chaudhry-Moss syndrome is a condition that affects many parts of the body. The signs and symptoms of this disorder are apparent from birth or infancy.
  • 1.4K
  • 23 Dec 2020
Topic Review
Roxadustat
Roxadustat is the first oral drug in the class of new erythropoiesis drugs and a potent HIF-PHD inhibitor, exerted to treat anemia in patients with CKD. In phase 1, 2 and 3 studies with CKD-affected patients, roxadustat was more effective to stimulate erythropoiesis for anemia correction than previously used drugs. Roxadustat can be orally given, unlike other erythropoiesis drugs with parenteral administration only, which grants roxadustat a considerable advantage.
  • 1.4K
  • 16 Mar 2021
Topic Review
Zinc Metalloproteins
Many proteins with zinc-binding domains (ZBDs) are involved in epigenetic modifications such as DNA methylation and histone modifications, which regulate transcription in physiological and pathological conditions. Zinc metalloproteins in epigenetics are mainly zinc metalloenzymes and zinc finger proteins (ZFPs), classified into writers, erasers, readers, editors, and feeders. Altogether, these classes of proteins engage in crosstalk that fundamentally maintains the epigenome's modus operandi. 
  • 1.4K
  • 17 May 2021
Topic Review
Machines Additive Manufacturing
Modern-day machine applications require extraordinary performance parameters such as high power-density, integrated functionalities, improved thermal, mechanical & electromagnetic properties. Additive manufacturing (AM)offers a higher degree of design flexibility to achieve these performance parameters, which is impossible to realize through conventional manufacturing techniques.
  • 1.4K
  • 26 Aug 2021
Topic Review
Injectable Hydrogels for Skin Wound
Functionalized biomaterials which are able to be implanted regardless of the wound deformity  and potentially embark the skin wound management by the ability to be bioinert, self-degradable and non invasive. These 3D network hold a unique characteristics which are able to mimic the skin extracellular matrix (ECM) and has been successfully proven to promote wound healing and skin regeneration.
  • 1.4K
  • 31 May 2021
Topic Review
Esophageal Vagal afferent C-fibers' Functions
Heartburn and non-cardiac chest pain are the predominant symptoms in many esophageal disorders, such as gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), functional heartburn and chest pain, and eosinophilic esophagitis (EoE). At present, neuronal mechanisms underlying the process of interoceptive signals in the esophagus are still less clear. Noxious stimuli can activate a subpopulation of primary afferent neurons at their nerve terminals in the esophagus. The evoked action potentials are transmitted through both the spinal and vagal pathways to their central terminals, which synapse with the neurons in the central nervous system to induce esophageal nociception. Over the last few decades, progress has been made in our understanding on the peripheral and central neuronal mechanisms of esophageal nociception. In this review, we focus on the roles of capsaicin-sensitive vagal primary afferent nodose and jugular C-fiber neurons in processing nociceptive signals in the esophagus. We briefly compare their distinctive phenotypic features and functional responses to mechanical and chemical stimulations in the esophagus. Then, we summarize activation and/or sensitization effects of acid, inflammatory cells (eosinophils and mast cells), and mediators (ATP, 5-HT, bradykinin, adenosine, S1P) on these two nociceptive C-fiber subtypes. Lastly, we discuss the potential roles of capsaicin-sensitive esophageal afferent nerves in processing esophageal sensation and nociception. A better knowledge of the mechanism of nociceptive signal processes in primary afferent nerves in the esophagus will help to develop novel treatment approaches to relieve esophageal nociceptive symptoms, especially those that are refractory to proton pump inhibitors.
  • 1.4K
  • 16 Jul 2021
Topic Review
Flavonoids for Breast Cancer
Breast cancer persists as a diffuse source of cancer despite persistent detection and treatment. Flavonoids, a type of polyphenol, appear to be a productive option in the treatment of breast cancer, because of their capacity to regulate the tumor related functions of class of compounds. Plant polyphenols are flavonoids that appear to exhibit properties which are beneficial for breast cancer therapy. Numerous epidemiologic studies have been performed on the dynamic effect of plant polyphenols in the prevention of breast cancer. There are also subclasses of flavonoids that have antioxidant and anticarcinogenic activity. These can regulate the scavenging activity of reactive oxygen species (ROS) which help in cell cycle arrest and suppress the uncontrolled division of cancer cells. Numerous studies have also been performed at the population level, one of which reported a connection between cancer risk and intake of dietary flavonoids. Breast cancer appears to show intertumoral heterogeneity with estrogen receptor positive and negative cells.
  • 1.4K
  • 01 Sep 2021
Topic Review
Geodiversity and Geoconservation in Central America
Central America is located in a dynamic region where tectonics and volcanism together with the tropical climate and its diverse vegetation have shaped the landscapes. 
  • 1.4K
  • 06 Jan 2022
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