Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Formulation Strategies to Improve Pharmacokinetics Profile
The oral route is the most common and practical means of drug administration, particularly from a patient’s perspective. However, the pharmacokinetic profile of oral drugs depends on the rate of drug absorption through the intestinal wall before entering the systemic circulation. However, the enteric epithelium represents one of the major limiting steps for drug absorption, due to the presence of efflux transporters on the intestinal membrane, mucous layer, enzymatic degradation, and the existence of tight junctions along the intestinal linings. These challenges are more noticeable for hydrophilic drugs, high molecular weight drugs, and drugs that are substrates of the efflux transporters. Another challenge faced by oral drug delivery is the presence of first-pass hepatic metabolism that can result in reduced drug bioavailability. Over the years, a wide range of compounds have been investigated for their permeation-enhancing effect in order to circumvent these challenges. There is also a growing interest in developing nanocarrier-based formulation strategies to enhance the drug absorption.
  • 1.4K
  • 26 Aug 2022
Topic Review
Biological Treatment of Pharmaceutical-Based Contaminants with Oxidoreductase Enzymes
The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive deterioration of water quality with adverse impacts on the ecosystem and human health. To address this challenge, there is an evolving trend toward the search for effective methods to ensure efficient purification of both drinking water and wastewater. Biocatalytic transformation of pharmaceuticals using oxidoreductase enzymes, such as peroxidase and laccase, is a promising environmentally friendly solution for water treatment, where fungal species have been used as preferred producers due to their ligninolytic enzymatic systems.
  • 1.4K
  • 20 Oct 2022
Topic Review
Comparison of Source Code Hosting Facilities
A source code repository is a file archive and web hosting facility where a large amount of source code, for software or for web pages, is kept, either publicly or privately. They are often used by open-source software projects and other multi-developer projects to handle various versions. They help developers submit patches of code in an organized fashion. Often these web sites support version control, bug tracking, release management, mailing lists, and wiki-based documentation. People who write software retain their copyright when their software is posted to any code hosting facilities, including the "non-gnu" section of GNU Savannah—with the exception of contributors to Free Software Foundation (FSF)-copyrighted programs at GNU Savannah.
  • 1.4K
  • 27 Oct 2022
Topic Review
Outline of Geophysics
The following outline is provided as an overview of and topical guide to geophysics: Geophysics – the physics of the Earth and its environment in space; also the study of the Earth using quantitative physical methods. The term geophysics sometimes refers only to the geological applications: Earth's shape; its gravitational and magnetic fields; its internal structure and composition; its dynamics and their surface expression in plate tectonics, the generation of magmas, volcanism and rock formation. However, modern geophysics organizations have a broader definition that includes the hydrological cycle including snow and ice; fluid dynamics of the oceans and the atmosphere; electricity and magnetism in the ionosphere and magnetosphere and solar-terrestrial relations; and analogous problems associated with the Moon and other planets.
  • 1.4K
  • 09 Nov 2022
Topic Review
Oregon Petition
The Global Warming Petition Project, also known as the Oregon Petition, is a petition urging the United States government to reject the global warming Kyoto Protocol of 1997 and similar policies. Some consider it to be a political petition designed for disinforming and confusing the public about the scientific results and the consensus of climate change research.
  • 1.4K
  • 02 Dec 2022
Topic Review
Targeted Cytokine Delivery for Cancer Treatment
Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly limit clinical applications. Due to their high specificity and affinity, tumor-specific monoclonal antibodies or their antigen-binding fragments are capable of delivering fused cytokines to tumors and, therefore, of decreasing the number and severity of side effects, as well as of enhancing the therapeutic index. Targeted cytokine-mediated activation of the immune cells may trigger massive cytokine production at the disease site, making the local environmental conditions more favorable for local immune system cell functioning.
  • 1.4K
  • 10 Feb 2023
Topic Review
Non-Steroid Anti-Inflammatory Drugs/Acetylsalicylic Acid-Associated Gastropathy
Drugs are widely used to treat different diseases in modern medicine, but they are often associated with adverse events. Those located in the gastrointestinal tract are common and often mild, but they can be serious or life-threatening and determine the continuation of treatment. The stomach is often affected not only by drugs taken orally but also by those administered parenterally. The first description of the endoscopic picture of the damage to the gastric mucosa associated with the use of aspirin was published by A. Douthwait and J. Lintoff in 1938.
  • 1.4K
  • 18 Jul 2023
Topic Review
Digital Influencers’ Attributes for Sustainable Consumption Behavior
Organizations have become increasingly interested in using digital influencers to promote their brands and disseminate advertising messages with a high impact on their target audience. Digital influencers are beginning to be used as models for sustainable consumption behavior (for example in the fashion, food, and health sectors) by promoting environmental and sustainable values. By promoting sustainable content and disseminating messages of environmental awareness, digital influencers can help achieve the Sustainable Development Goals (SDGs).
  • 1.4K
  • 31 Aug 2023
Topic Review Peer Reviewed
The Evolution of Human Social Behavior
Social life is a key feature in humans; without it, language, science, and technology would not have appeared. The inclination to engage with others is also a main source of pleasure and pain and as such a key factor for quality of life. In this paper, I shall present current knowledge on the evolutionary trajectory leading to the four main types of relations: parent–child, pair-bonding, kinship, and social life (bonding between non-kin for purposes other than breeding). These relationships are not unique to humans; they have evolved independently multiple times across the animal kingdom. In our lineage, the origins of parent–child bonding may be traced back to the early amniotes some 320 Mya (million years ago). Pair-bonding and social life most likely evolved recently. Understanding how these affiliations are rooted in the brain, particularly the role of feelings, provides valuable insights that can help us improve society.
  • 1.4K
  • 28 Feb 2024
Topic Review
Lectin Protein
Lectins are natural proteins with the ability to bind specific carbohydrates related to various microorganisms, including viruses, bacteria, fungi and parasites. Lectins have the ability to agglutinate and neutralize these pathogeneses. The delivery of the encapsulated antiviral agents or vaccines across the cell membrane can be possible by functionalized micellar and liposomal formulations. 
  • 1.4K
  • 14 Apr 2022
Topic Review
Digital Horizon of Smart Agriculture
Agriculture is essential to the existence of the human race, as well as the foundation of our civilization, because it provides food, fuel, fiber, and other resources necessary for survival; however, it is facing critical challenges due to anthropogenic climate change, which hampers food and nutritional security. Several measures have been implemented to enhance agricultural productivity, including plant breeding, genetic engineering, and precision agriculture. The world has witnessed the burgeoning development of novel scientific innovations and technological advancements enabled by drones, smart sensors, robotics, and remote sensing, resulting in a plethora of revolutionary methods that can be applied to real-time crop modeling, high-throughput phenotyping, weather forecasting, yield prediction, fertilizer application, disease detection, market trading, farming practices, and other environmental practices vital to crop growth, yield, and quality. Digitalization is the most significant technological advancement of our time, and it profoundly affects agriculture and other industries. Delivering a comprehensive view of how technology could help in tackling critical issues like environmental degradation and threatened world biodiversity, this perspective emphasizes the perks of digitalization.
  • 1.4K
  • 09 Jan 2024
Topic Review
Sleep in Disorders of Consciousness
Consciousness is a multifaceted concept, involving both wakefulness, i.e., a condition of being alert that is regulated by the brainstem, and awareness, a subjective experience of any thoughts or perception or emotion. Disorders of consciousness (DOC) are usually caused by a severe acquired brain injury that leads to a loss of consciousness lasting at least 24 h. The management of sleep disorders in DOC patients is an increasingly hot topic and deserves careful diagnosis, to allow for the most accurate prognosis and the best medical treatment possible.
  • 1.4K
  • 23 Feb 2023
Topic Review
BPES
Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a condition that mainly affects development of the eyelids. People with this condition have a narrowing of the eye opening (blepharophimosis), droopy eyelids (ptosis), and an upward fold of the skin of the lower eyelid near the inner corner of the eye (epicanthus inversus). In addition, there is an increased distance between the inner corners of the eyes (telecanthus). Because of these eyelid abnormalities, the eyelids cannot open fully, and vision may be limited.
  • 1.4K
  • 04 Jan 2021
Topic Review
Citrus-Derived Polymethoxylated Flavones
Several reports have shown that polymethoxylated flavones (PMFs) derived from citrus fruit, such as nobiletin, tangeretin, and 3,3′,4′,5,6,7,8-heptamethoxyflavone, are promising molecules for the prevention of neurodegenerative and neurological disorders. In various animal models, PMFs have been shown to have a neuroprotective effect and improve cognitive dysfunction with regard to neurological disorders by exerting favorable effects against their pathological features, including oxidative stress, neuroinflammation, neurodegeneration, and synaptic dysfunction as well as its related mechanisms.
  • 1.4K
  • 22 Jan 2021
Topic Review
Ultrasound Contrast Agents for Therapy
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier. Many commercially available ultrasound contrast agents and agents specifically designed for therapeutic purposes have been investigated in ultrasound-mediated blood-brain barrier opening studies. The new generation of sono-sensitive agents, such as liquid-core droplets, can also potentially disrupt the blood-brain barrier after their ultrasound-induced vaporization. 
  • 1.4K
  • 30 Jan 2021
Topic Review
Mycotoxins Beauvericin and Enniatins
Mycotoxins are a structurally diverse group of mostly low-molecular-weight compounds. Their structures range from single heterocyclic rings to irregularly arranged rings of six to eight members and their molecular weights are usually less than 1000 Da. Therefore, they do not induce any response in the human immune system.
  • 1.4K
  • 05 Feb 2021
Topic Review
ROS in Cancer Cell Metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which activates pro-tumorigenic signaling, enhances cell survival and proliferation and drives DNA damage and genetic instability. However, higher ROS levels have been found to promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor cell death. Tumor cells develop a mechanism where they adjust to the high ROS by expressing elevated levels of antioxidant proteins to detoxify them while maintaining pro-tumorigenic signaling and resistance to apoptosis. Therefore, ROS manipulation can be a potential target for cancer therapies as cancer cells present an altered redox balance in comparison to their normal counterparts.
  • 1.4K
  • 22 Sep 2021
Topic Review
Single-Molecule Labeling and Imaging Strategies
Single-molecule imaging is emerging as a revolutionary approach to studying fundamental questions in plants. However, compared with its use in animals, the application of single-molecule imaging in plants is still underexplored. 
  • 1.4K
  • 31 May 2021
Topic Review
Bone-Conducted Ultrasound
Bone-conducted ultrasound (BCU) has unique characteristics since ultrasound is audible when it is presented through bone conduction. The most interesting is its perception in patients with profound deafness. Some patients can perceive it and discriminate speech-modulated BCU. Previous reports have suggested that BCU can be used for a hearing aid or tinnitus sound therapy.
  • 1.4K
  • 09 Jun 2021
Topic Review
Targeting CDK9 for Glioblastoma Treatment
Glioblastoma is the most common and aggressive primary malignant brain tumor, and more than two-thirds of patients with glioblastoma die within two years of diagnosis. The challenges of treating this disease mainly include genetic and microenvironmental features that often render the tumor resistant to treatments. Despite extensive research efforts, only a small number of drugs tested in clinical trials have become therapies for patients. Targeting cyclin-dependent kinase 9 (CDK9) is an emerging therapeutic approach that has the potential to overcome the challenges in glioblastoma management.
  • 1.4K
  • 02 Jul 2021
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback