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Topic Review
Cinnamon, Clove and Cumin against Urinary Tract Infections
Spices are aromatic plants widely used in Mexico to flavor, color, or preserve food. In particular, the Food and Drug Administration (FDA) Organization defined spices as: “whole, broken or ground aromatic vegetable substances, whose significant function in food is to flavor rather than to nourish”. Most of the beneficial health properties of spices are mediated through the direct action of their phytochemicals, especially polyphenols or polyphenol degradation products. These phytochemicals have broad antioxidant properties and target specific receptors or enzymes involved in various anti-inflammatory pathways or immune responses. Phenolic acids and flavonoids, especially flavones and flavonoids, are spices’ predominant class of polyphenols. Furthermore, the antimicrobial properties of spices are attributed to their unique volatile oils and oleoresins. Because spices are obtained from aromatic plants and herbs, they are generally considered safe (GRAS).
  • 27.0K
  • 28 Apr 2023
Biography
René Sotelo
René Sotelo (6 November 1962) is a Venezuelan robotic surgeon, urologist-oncologist and university professor.[1][2] Sotelo received his medical degree from Central University of Venezuela[3] and his residency in General Surgery and Urology was at Domingo Luciani Hospital, Venezuela. He completed fellowship in Urologic Oncology at the Hospital Padre Machado in Caracas, Venezuela; training in
  • 10.1K
  • 18 Nov 2022
Topic Review
Urinary Tract Infections during the COVID-19 Pandemic
The landscape of management of urinary tract infections (UTI) is changing rapidly. The COVID-19 pandemic draws the attention to the SARS-CoV-2 management with a subsequent reduced attention on bacterial infections. The COVID-19 diffusion containing procedures, such as use of facemasks and handwashing, have reduced spreading of bacteria and bacterial lung infections.
  • 2.7K
  • 21 Mar 2022
Topic Review
Bladder Cancer Biomarkers
The high occurrence of bladder cancer and its tendency to recur combined with lifelong surveillance make the treatment of superficial bladder cancer one of the most expensive and time-consuming. Moreover, carcinoma in situ often leads to muscle invasion with an unfavourable prognosis. Currently, invasive methods including cystoscopy and cytology remain a gold standard. The aim is to find biomarkers with the best specificity and sensitivity, allowing the treatment plan to optimise and have potential applications in clinical practice. Such non-invasive methods can be measure in human body fluids, for example, urine or serum: Cytokeratin fragments (CYFRA 21.1), Excision Repair Cross-Complementation 1 (ERCC1), Tumour Protein p53 (Tp53), Fibroblast Growth Factor Receptor 3 (FGFR3), Tumor-Associated Trypsin Inhibitor (TATI).
  • 2.6K
  • 29 Mar 2022
Topic Review
Lymphatic Drainage of Renal Tissues
Acute kidney injury (AKI), especially if recurring, represents a risk factor for future chronic kidney disease. In intensive care units, increased intra-abdominal pressure is well-recognized as a significant contributor to AKI. Renal interstitial pressure changes synchronously to renal perfusion pressure. The renal parenchyma is primarily drained by the urine conducting and renal venous system. The renal lymphatic system can also contribute to renal compartment syndrome, the functional changes in the lymphatic flow was not investigated in connection with pneumo-peritoneum.
  • 2.4K
  • 17 May 2022
Topic Review
Hyperfiltration
Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). These include obesity, diabetes, hypertension, focal segmental glomerulosclerosis (FSGS), congenital abnormalities and reduced renal mass (low nephron number). Hyperfiltration-associated biomechanical forces directly impact the cell membrane, generating tensile and fluid flow shear stresses in multiple segments of the nephron.
  • 2.4K
  • 01 Mar 2022
Topic Review
Kidney Failure after Liver Transplantation
One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes and a harmful effect on morbidity and mortality before and after liver transplantation. Kidney function does not improve in all patients after liver transplantation, and liver transplant recipients are at a high risk of developing chronic kidney disease. The causes of renal dysfunction can be divided into three groups: pre-operative, perioperative and post-operative factors.
  • 2.3K
  • 22 Sep 2021
Topic Review
Urinary Tract Infections
Urinary tract infections (UTIs) affect any part of the urinary tract and may spread through the urinary tract towards the urethra, bladder and even the kidneys and they are associated with an increase in morbidity and mortality. UTIs may be resolved spontaneously or treated with antibiotics. However, regular use of antibiotics is related to nephrotoxicity and  produces changes in the intestinal flora, alter immunity and metabolism, and finally, gut bacteria become a reservoir of genes for resistance to antibiotics. Regarding this concern, a new group of molecules called drug conjugates have been proposed as an alternative or a complement to de use of just antibiotics such as a new adjuvant in UTIs therapy called Itxasol©.
  • 2.2K
  • 11 Oct 2021
Topic Review
Glucose-Lowering Medications in Erectile Dysfunction
Erectile dysfunction (ED) is a common underestimated complication of diabetes mellitus that affects more than 50% of people with diabetes. Diabetes dramatically raises the risk of developing ED by 2.5-fold. Despite that several studies have explained the pathogenetic mechanisms involved in the generation of erectile failure, few studies to date have described the efficacy of glucose-lowering medications in the restoration of normal sexual activity. Herein, we will present current knowledge about the main starters of the pathophysiology of diabetic ED and explore the role of different anti-diabetes therapies in the potential remission of ED, highlighting specific pathways whose activation or inhibition could be fundamental for sexual care in a diabetes setting.
  • 2.1K
  • 28 Jun 2021
Topic Review
Prostate Cancer Liquid Biopsy Biomarkers
Prostate cancer biomarkers can be measured in urine, blood or tissue. A variety of tests that analyse patients' biomarkers have been developed to improve diagnosis, prognosis and to help stratify individual's risk of prostate cancers. Liquid biopsy biomarkers are easy-to-use and non-invasive. They guide the decision-making process, determine whether the patient requires treatment or can be monitored under active surveillance, and help choose the best treatment option.
  • 1.8K
  • 29 Mar 2022
Topic Review
Fabrication of Organ-on-Chip
Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage, tissue–tissue interaction, and replicating numerous human pathologies.
  • 1.7K
  • 26 Apr 2022
Topic Review
Sodium
Sodium overload is common in end-stage kidney disease (ESKD) and is associated with increased cardiovascular mortality that is traditionally considered a result of extracellular volume expansion.
  • 1.5K
  • 07 Dec 2021
Topic Review
Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease that presents an estimated incidence of 1.3 cases per million per year, with a prevalence of 15.9 cases per million. It is characterized by hemolysis, bone marrow dysfunction with peripheral blood cytopenia, hypercoagulability, thrombosis, renal impairment and arterial and pulmonary hypertension. Hemolysis and subsequent hemosiderin accumulation in tubular epithelium cells induce tubular atrophy and interstitial fibrosis.
  • 1.5K
  • 29 Oct 2020
Topic Review
Pyonephrosis: Ultrasound and Computed Tomography
Ultrasound and computed tomography represent the imaging processes of choice in the diagnosis and staging pyonephrosis in emergency settings. 
  • 1.5K
  • 21 Apr 2021
Topic Review
Different Nerve-Sparing Techniques during Radical Prostatectomy
Nerve-sparing technique during RP has a major impact to both oncological and functional outcomes of the procedure and various different techniques have been developed aiming to optimize its outcomes. Nerve-sparing techniques can be distinguished based on the fascial planes of dissection (intrafascial, interfascial or extrafascial), the direction of dissection (retrograde or antegrade), the timing of the neurovascular bundle dissection off the prostate (early vs. late release), the use of cautery, the application of traction and the number of the neurovascular bundles which are preserved.
  • 1.5K
  • 18 Apr 2022
Topic Review
Implications of Sphingolipid Metabolites in Kidney Diseases
Sphingolipids (SLs) are lipids with complex structures which were named after their sphinx-like structure by Thudichium in 1870. Lipids are major components of membranes in all eukaryotic cells determining the structural and functional integrity of cells. SLs are one of the important structural components of plasma membranes in all eukaryotes, but they also act as bioactive signaling molecules with numerous cellular physiological functions that include cell adhesion, cell proliferation, cell migration, inflammatory response and apoptosis. Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can be lethal to cells. Abnormalities in the levels of sphingolipids are associated with several human diseases including kidney diseases. Several studies demonstrate that sphingolipids play an important role in maintaining proper renal function. Sphingolipids can alter the glomerular filtration barrier by affecting the functioning of podocytes, which are key cellular components of the glomerular filtration barrier. 
  • 1.4K
  • 29 Apr 2022
Topic Review
Prostate-Specific Membrane Antigen
Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in prostate cancer and correlates with the aggressiveness of the disease. PSMA is a promising target for positron emission tomography (PET) imaging and theranostics in prostate cancer patients validated in recent prospective trials. Several clinical trials are currently ongoing to define the role of PSMA targeting radioligands in different settings and to evaluate the potential of other PSMA-based therapeutic modalities in prostate cancer.
  • 1.4K
  • 11 May 2021
Topic Review
Uremic Toxins Control in CKD
Uremic toxins (UTs) are mainly produced by protein metabolized by the intestinal microbiota and converted in the liver or by mitochondria or other enzymes. The accumulation of UTs can damage the intestinal barrier integrity and cause vascular damage and progressive kidney damage. Together, these factors lead to metabolic imbalances, which in turn increase oxidative stress and inflammation and then produce uremia that affects many organs and causes diseases including renal fibrosis, vascular disease, and renal osteodystrophy. This article is based on the theory of the intestinal–renal axis, from bench to bedside, and it discusses nonextracorporeal therapies for UTs, which are classified into three categories: medication, diet and supplement therapy, and complementary and alternative medicine (CAM) and other therapies. The effects of medications such as AST-120 and meclofenamate are described. Diet and supplement therapies include plant-based diet, very low-protein diet, probiotics, prebiotics, synbiotics, and nutraceuticals. The research status of Chinese herbal medicine is discussed for CAM and other therapies. This review can provide some treatment recommendations for the reduction of UTs in patients with chronic kidney disease.
  • 1.4K
  • 10 Sep 2021
Topic Review Peer Reviewed
The Applications of Microphysiological Systems in Biomedicine: Impact on Urologic and Orthopaedic Research
Microphysiological systems (MPSs) are in vitro models that can incorporate dynamic stimuli such as flow, pressure and contraction in cell culture, enabling the formation of cellular architectures and retrieving physiological function often absent in conventional 2D-cell culture. MPS applications saw a substantial growth in recent years, drawing attention from industry as a strategy to optimize pre-clinical drug-development purposes, as well as from biomedical research, to fill a gap between in vivo and in vitro models. Several MPS platforms are now available and are employed in the development of bone and kidney complex systems for urologic and orthopaedic research. These advances have enabled, for example, the in vitro modelling of bone regeneration and renal drug secretion, and have dramatic potential to improve research into both orthopaedic and urology cancers. 
  • 1.2K
  • 16 Jun 2022
Topic Review
Retard Progression of CKD
Chronic kidney disease (CKD), defined as the presence of irreversible structural or functional kidney damages, increases the risk of poor outcomes due to its association with multiple complications, including altered mineral metabolism, anemia, metabolic acidosis, and increased cardiovascular events. The mainstay of treatments for CKD lies in the prevention of the development and progression of CKD as well as its complications.
  • 1.2K
  • 08 Oct 2021
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