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Topic Review
Cytokine Responses in Solid-Tumors Therapy
Precision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultimate effectors of biological functions, and therefore the targets of therapeutics. An additional dimension in precision medicine that considers an individual’s cytokine response to cancer therapeutics is proposed. Cytokine responses to therapy are multifactorial and vary among individuals. Thus, precision is dictated by the nature and magnitude of cytokine responses in the tumor microenvironment exposed to therapy. 
  • 96
  • 13 Mar 2024
Topic Review
Sustainable Supply Chain Management Barriers
Sustainable supply chain management (SSCM) integrates economic, social, and environmental goals within the supply chain to enhance long-term performance. It assists organizations in monitoring their performance concerning social, environmental, and economic factors to bolster sustainability.
  • 122
  • 13 Mar 2024
Topic Review
Pharmaceutical Properties of Gabapentin
Gabapentin (GBP) is a common name for 1-(aminomethyl)cyclohexaneacetic acid (C9H17NO2, CAS Registry No. 60142-96-3), a GABA (γ-aminobutyric acid) derivative and a popular active pharmaceutical ingredient (API). It has a molecular weight of 171.34 and two pKa values of 3.68 and 10.70.
  • 84
  • 13 Mar 2024
Topic Review
Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants
Millions of people around the world are exposed to air pollutants, such as particulate matter 2.5 (PM2.5) and ozone (O3). Such exposure usually does not exclude these two types of pollutants and their harmful effects could be additive or synergistic. O3 is a highly oxidizing gas that reacts with the cellular environment just as PM2.5, triggering nitrooxidative damage.
  • 323
  • 13 Mar 2024
Topic Review
Astrocytes and α-Syn in Parkinson’s Disease
The α-syn protein is a 140-amino-acid protein that comprises an N-terminal region that assumes an α-helical secondary structure upon membrane binding, a non-amyloid-component hydrophobic domain that can adopt a β-sheet conformation, promoting protein aggregation in its monomeric form, and a negatively charged C-terminal domain. Astrocytes greatly contribute to neuronal survival through numerous mechanisms, such as the secretion of neurotrophins and antioxidants, the clearance of α-synuclein, glutamate metabolism, fatty acid metabolism, and the transfer of healthy mitochondria to neurons.
  • 206
  • 13 Mar 2024
Topic Review
Effects of Aging on Taxi Service Performance
The taxi industry is recognized as a sector with substantial potential for sustainable development, involving key stakeholders such as policymakers, regulatory agencies, companies, drivers, and customers. Population aging presents a significant challenge with the aging workforce, potentially impacting the development of various industries.
  • 138
  • 13 Mar 2024
Topic Review
Tackling Infectious Diseases
Infectious diseases (IDs) are a leading cause of death. The diversity and adaptability of microbes represent a continuing risk to health.
  • 145
  • 13 Mar 2024
Topic Review
Influence of Alcohol on Intracerebral Hemorrhage
Alcohol, a key part of human culture since ancient times, has various uses ranging from beverages to antiseptics and fuels. Different types of alcoholic beverages such as wine and beer, being the oldest and probably the most widely used drugs, were known for their therapeutic value in addition to the vital part they played in the daily life of people in ancient times. A standard alcohol unit, used to measure drinking consistently, varies globally. The World Health Organization (WHO) suggests that a standard drink contains 10 g of pure ethanol per day, though this varies (8–20 g) across countries.
  • 134
  • 13 Mar 2024
Topic Review
Dairy Cow Health and Methane Emissions
The dairy industry is facing criticism for its role in exacerbating global GHG emissions, as climate change becomes an increasingly pressing issue. These emissions mostly originate from methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2). An optimal strategy involves the creation of an economical monitoring device to evaluate methane emissions from dairy animals.
  • 109
  • 13 Mar 2024
Topic Review
Somatostatin in Colorectal Cancer
Somatostatin, a somatotropin release inhibiting factor (SST, SRIF), is a widely distributed multifunctional cyclic peptide and acts through a transmembrane G protein-coupled receptor (SST1-SST5). Over the past decades, research has begun to reveal the molecular mechanisms underlying the anticancer activity of this hormonal peptide.
  • 183
  • 13 Mar 2024
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