Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Gene Therapy in Duchenne Muscular Dystrophy
Gene therapy allows for the modulation and correction of specific problem genes which are mutated in severe pathologies. The term “gene therapy” is loosely defined by many sources. The FDA defines it as “products whose effects are transferred through transcription/translation of genetic material via administration as nucleic acids, viruses, or genetically engineered microorganisms”. Duchenne muscular dystrophy (DMD) is a severe X-linked recessive muscle-wasting disease that results from mutations in the DMD gene on chromosome 21. Due to its poor survivorship, many interventions are being researched to improve outcomes for patients with this disease; gene therapy is an emerging field in this regard.
  • 226
  • 13 Mar 2024
Topic Review
Lignocellulolytic Microorganisms in Cereal Crop Residue Decomposition
The global escalation in cereal production, essential to meet growing population demands, simultaneously augments the generation of cereal crop residues, estimated annually at approximately 3107 × 106 Mg/year. Among different crop residue management approaches, returning them to the soil can be essential for various ecological benefits, including nutrient recycling and soil carbon sequestration. However, the recalcitrant characteristics of cereal crop residues pose significant challenges in their management, particularly in the decomposition rate. Microorganisms employ a range of mechanisms, such as the utilization of different enzymes that work in combination, to initiate oxidative attacks on plant litter. Consequently, this serves to reduce the recalcitrance of the lignocellulosic material, hence facilitating subsequent action by depolymerizing enzymes. Both fungi and bacteria have received increased attention for their ability to secrete a diverse range of lignocellulolytic enzymes.
  • 342
  • 13 Mar 2024
Topic Review
Causes of Asphalt Pavement Blistering
No theoretical model effectively explains the blistering process, which provokes functional distress in asphalt pavements worldwide. Over the years, it has been possible to observe blistering on many asphalt pavements, collect information related to the specific contexts of its occurrence, and formulate hypotheses on the potential causes.
  • 173
  • 13 Mar 2024
Topic Review
Muscle Tension Dysphonia
Muscle Tension Dysphonia (MTD) is a relatively new clinical entity that, despite being one of the most frequent causes of functional dysphonia, is little-known by many otorhinolaryngologists. MTD has been defined as a functional voice disorder characterized by excessive tension in the extrinsic laryngeal musculature during phonation but without organic or neurological alterations.
  • 161
  • 13 Mar 2024
Topic Review
Biological Role of FAM111A and FAM111B
Proteases are critical enzymes in cellular processes that regulate intricate events like cellular proliferation, differentiation, and apoptosis. FAM111A is implicated in DNA replication and replication fork protection, thereby maintaining genome integrity. Additionally, FAM111A functions as an antiviral factor against DNA and RNA viruses. FAM111B, a paralog of FAM111A, participates in cell cycle regulation and apoptosis. It influences the apoptotic pathway by upregulating anti-apoptotic proteins and modulating cell cycle-related proteins. Furthermore, FAM111B’s association with nucleoporins suggests its involvement in nucleo-cytoplasmic trafficking and plays a role in maintaining normal telomere length. FAM111A and FAM111B also exhibit some interconnectedness and functional similarity despite their distinct roles in cellular processes and associated diseases resulting from their dysfunction. 
  • 127
  • 13 Mar 2024
Topic Review
A Lightweight Remote Sensing Aircraft Object Detection Network
Remote sensing aircraft object detection is crucial in various applications. In civil aviation and the aerospace industry, it helps identify other aircraft, drones, or obstacles around an aircraft to prevent collisions and enhance aviation safety. It also aids in the real-time monitoring and tracking of civil aviation flights, cargo planes, and private aircrafts to ensure their flight path and status.
  • 195
  • 13 Mar 2024
Topic Review
Management Plan according to EOSS-P
hildhood obesity, affecting 29% of 7–9-year-olds across 33 European countries, is a significant public health challenge. Its persistence into adulthood poses grave health risks influenced by genetic, environmental, and socio-economic factors. Belgium introduced a new care pathway in December 2023, based on the Edmonton Obesity Staging System for Pediatrics (EOSS-P), addressing four health domains and staging obesity severity. This pathway operates across three levels: primary care physicians, Paediatric Multidisciplinary Obesity Management Centres (PMOCs), and Centers of Expertise for Paediatric Obesity Management (CEPOs). Each stage of EOSS-P demands tailored interventions. Early stages involve dietary interventions, physical activity promotion, and behavior modifications. As obesity severity progresses, treatments intensify, encompassing psychological support, anti-obesity medications, and, in some cases, bariatric surgery.
  • 90
  • 13 Mar 2024
Topic Review
Structural Health Monitoring of Solid Rocket Motors
In the realm of space exploration, solid rocket motors (SRMs) play a pivotal role due to their reliability and high thrust-to-weight ratio. Serving as boosters in space launch vehicles and employed in military systems, and other critical & emerging applications, SRMs’ structural integrity monitoring, is of paramount importance. Traditional maintenance approaches often prove inefficient, leading to either unnecessary interventions or unexpected failures. Condition-based maintenance (CBM) emerges as a transformative strategy, incorporating advanced sensing technologies and predictive analytics. By continuously monitoring crucial parameters such as temperature, pressure, and strain, CBM enables real-time analysis, ensuring timely intervention upon detecting anomalies, thereby optimizing SRM lifecycle management. Particularly, photonic sensors and fiber-optic sensors, demonstrate exceptional promise in CBM goals. Their enhanced sensitivity and broad measurement range allow for capturing subtle changes indicative of degradation or potential failures. These sensors enable comprehensive, non-intrusive monitoring of multiple SRM locations simultaneously. Integrated with data analytics, these sensors empower predictive analysis, facilitating SRM behavior prediction and optimal maintenance planning. Ultimately, CBM, bolstered by advanced photonic sensors, promises enhanced operational availability, reduced costs, improved safety, and efficient resource allocation in SRM applications.
  • 110
  • 13 Mar 2024
Topic Review
Latest Existing Schemes on Data Aggregation
The rapid development of the Internet of Things (IoT) has opened the way for transformative advances in numerous fields, including healthcare. IoT-based healthcare systems provide unprecedented opportunities to gather patients’ real-time data and make appropriate decisions at the right time. 
  • 136
  • 13 Mar 2024
Topic Review
Cytokine Responses in Solid-Tumors Therapy
Precision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultimate effectors of biological functions, and therefore the targets of therapeutics. An additional dimension in precision medicine that considers an individual’s cytokine response to cancer therapeutics is proposed. Cytokine responses to therapy are multifactorial and vary among individuals. Thus, precision is dictated by the nature and magnitude of cytokine responses in the tumor microenvironment exposed to therapy. 
  • 96
  • 13 Mar 2024
  • Page
  • of
  • 5488
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Video Production Service
Feedback